IVandetanib

-Delile

• Ngaphambi kokuthatha i-vandetanib,
• IVandetanib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

IVandetanib ingadala ukwandiswa kwe-QT (isigqi senhliziyo esingajwayelekile esingaholela ekuphelelweni amandla, ekulahlekelweni ukwazi, kokuquleka, noma ekufeni okungazelelwe). Tshela udokotela wakho uma wena noma omunye emndenini wakho enesifo se-QT eside (isimo esizuzwe njengefa lapho umuntu kungenzeka abe ne-QT prolongation) noma uke waba namazinga aphansi e-calcium, i-potassium noma i-magnesium ku igazi lakho, ukushaya kwenhliziyo okungajwayelekile, ukwehluleka kwenhliziyo, noma isifo senhliziyo. Tshela udokotela kanye nosokhemisi wakho uma usebenzisa i-chloroquine (Aralen); i-clarithromycin (i-Biaxin, ku-Prevpac); i-haloperidol (iHaldol); imishanguzo yokushaya kwenhliziyo okungajwayelekile njenge-amiodarone (Cordarone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), procainamide, ne-sotalol (Betapace); imithi ethile yesicanucanu efana ne-dolasetron (i-Anzemet) ne-granisetron (i-Sancuso); i-methadone (i-Dolophine, i-Methadose); moxifloxacin (Avelox); kanye ne-pimozide (i-Orap). Uma uhlangabezana nalezi zimpawu ezilandelayo, yeka ukuthatha i-vandetanib bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo: ukushesha, ukushaya ngamandla, noma ukushaya kwenhliziyo okungajwayelekile; ukuquleka; ikhanda elikhanyayo; noma ukulahlekelwa ukwazi. IVandetanib ingahlala emzimbeni wakho izinyanga ezimbalwa ngemuva kokuyeka ukuthatha umuthi, ngakho-ke ungaqhubeka nokuba sengozini yemiphumela emibi ngaleso sikhathi.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile, njengokuhlolwa kwegazi kanye nama-electrocardiograms (EKGs, izivivinyo ezirekhoda umsebenzi kagesi wenhliziyo) ngaphambi nangejwayelekile ngesikhathi sokwelashwa kwakho ukuze uqiniseke ukuthi kuphephile yini kuwe ukuthatha i-vandetanib. Udokotela wakho uzophinde a-oda lezi zivivinyo nganoma yisiphi isikhathi lapho umthamo wakho we-vandetanib ushintshiwe noma uma uqala ukuthatha imishanguzo emisha ethile.

Uhlelo olubizwa ngeCaprelsa Risk Evaluation and Mitigation Strategy (REMS) selusungulwe ukuphatha ubungozi balo muthi. Uzokwazi ukuthola i-vandetanib kuphela uma udokotela onika umuthi wakho ebhalisile ohlelweni. Ungathola kuphela umuthi ekhemisi elibamba iqhaza ohlelweni. Buza udokotela wakho uma unemibuzo mayelana nokuhlanganyela kulolu hlelo noma ukuthi ungayithola kanjani imithi yakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-vandetanib futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokuthatha i-vandetanib.

IVandetanib isetshenziselwa ukwelapha uhlobo oluthile lomdlavuza wegilo ongalapheki ngokuhlinzwa noma osabalale kwezinye izingxenye zomzimba. IVandetanib isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sephrotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunciphisa noma ukumisa ukusabalala kwamangqamuzana omdlavuza.

IVandetanib iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa nokudla noma ngaphandle kokudla kanye ngosuku. Thatha i-vandetanib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-vandetanib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi ngengilazi yamanzi. Musa ukuhlukanisa, ukuhlafuna, noma ukuchoboza. Uma ithebhulethi ichotshozwe ngengozi, gwema ukuxhumana nesikhumba sakho. Uma kwenzeka kukhona oxhumana naye, geza indawo ethintekile kahle ngamanzi.

Uma ungakwazi ukugwinya wonke amaphilisi, ungawaqothula emanzini. Beka ithebhulethi engilazini equkethe ama-ounces ama-2 wamanzi okuphuza angenalutho. Ungasebenzisi noma yiluphi olunye uketshezi ukuncibilikisa ithebhulethi. Hlanganisa ingxube cishe imizuzu eyi-10 kuze ithebhulethi ibe yizicucu ezincane kakhulu; ithebhulethi ngeke incibilike ngokuphelele. Phuza ingxube ngokushesha. Hlanza ingilazi ngamanye ama-ounces ama-4 wamanzi angenawo amakhabhoni bese uphuza amanzi okugeza ukuze uqiniseke ukuthi uyawugwinya wonke umuthi.

Udokotela wakho anganciphisa umthamo wakho we-vandetanib noma akutshele ukuthi uyeke ukuthatha i-vandetanib isikhathi esithile ngesikhathi sokwelashwa kwakho. Lokhu kuncike ekutheni umuthi usebenza kanjani kuwe kanye nemiphumela emibi oyitholayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Qhubeka nokuthatha i-vandetanib noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-vandetanib ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-vandetanib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-vandetanib, noma imuphi omunye umuthi, noma yiziphi izithako ezibhebheni ze-vandetanib. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi uyayisho imithi ebhalwe esigabeni ESIBALULEKILE SESEXWAYISO nanoma yikuphi okulandelayo: carbamazepine (Tegretol, Carbatrol, Equetro), dexamethasone, phenobarbital, phenytoin (Dilantin, Phenytek), rifabutin (Mycobutin), rifampin (Rifadin, , i-rifapentin (Priftin), namahomoni wegilo njenge-levothyroxine (Synthroid). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-vandetanib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi iSt. Johns Wort.
• utshele udokotela wakho uma usanda kukhwehlela igazi noma unolunye uhlobo lwezinkinga zokopha futhi uma uke waba nengcindezi ephezulu yegazi, noma yiluphi uhlobo lwesifo sesikhumba, ukuquleka, noma amaphaphu, isifo sezinso noma sesibindi.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Akufanele ukhulelwe ngenkathi uthatha i-vandetanib futhi okungenani izinyanga ezine ngemuva kokwelashwa kwakho. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma ukhulelwa ngenkathi uthatha i-vandetanib, shayela udokotela wakho ngokushesha. IVandetanib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-vandetanib.
• kufanele wazi ukuthi i-vandetanib ingakwenza uzizwe ukozela, ubuthakathaka, noma ikwenze ungaboni kahle. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.
• hlela ukugwema ukuvezwa yilanga ngokungadingekile noma isikhathi eside futhi ugqoke izingubo zokuzivikela, izibuko zelanga, nesikhumba selanga. IVandetanib ingenza isikhumba sakho sizwele ekukhanyeni kwelanga ngesikhathi sokwelashwa kwakho futhi okungenani izinyanga ezine ngemuva kokumisa ukwelashwa kwakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma umthamo wakho olandelayo ufanele amahora angu-12 noma ngaphezulu, thatha isilinganiso esilahlekile ngokushesha nje lapho usikhumbula. Kodwa-ke, uma umthamo olandelayo uzothathwa ngaphansi kwamahora we-12, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

IVandetanib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• isilungulela
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba
• ubuhlungu besisu
• ikhala eligijimayo
• ukukhathala ngokweqile
• ubuthakathaka
• ubunzima bokulala noma ukulala
• ukudana

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• isifo sohudo
• ukuqubuka noma induna
• yomile, iyaxebuka noma isikhumba silume
• amabhamuza noma izilonda esikhunjeni noma emlonyeni
• ububomvu ebusweni, ezandleni, noma ematheni ezinyawo
• ubuhlungu bemisipha noma obuhlangene
• imfiva
• Ubuhlungu besifuba (obungahle bubi kakhulu ngokuphefumula okujulile noma ukukhwehlela)
• ama-hiccups noma ukuphefumula okusheshayo
• ukuphefumula ngokuzumayo
• ukukhwehlela okuphikelelayo
• ukuvuvukala kwezandla, izinyawo, amaqakala, noma imilenze engezansi
• ukuzuza kwesisindo ngokungazelelwe
• ukuba ndikindiki noma ukubuthakathaka kobuso, ingalo, noma umlenze, ikakhulukazi ohlangothini olulodwa lomzimba
• ukudideka okungazelelwe
• kunzima ukukhuluma noma ukuqonda
• inkathazo engazelelwe yokubona kwelinye noma kuwo womabili amehlo
• ukuhamba ngokungazelelwe noma ukulinganisa
• ikhanda elibuhlungu ngokuzumayo
• isithuthwane
• ukulimaza noma ukopha okungavamile

IVandetanib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-vandetanib. Udokotela wakho uzobuye ahlole umfutho wegazi lakho njalo ngenkathi welashwa nge-vandetanib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• ICaprelsa^®