Ukujova kweCarfilzomib

-Delile

• Ngaphambi kokuthola umjovo we-carfilzomib,
• Umjovo weCarfilzomib ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwezigaba ZOKUQAPHA NOKUKHETHEKILE, shayela udokotela wakho:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

Umjovo weCarfilzomib usetshenziswa wedwa futhi uhlanganiswe ne-dexamethasone, daratumumab ne-dexamethasone, noma i-lenalidomide (Revlimid) ne-dexamethasone ukwelapha abantu abane-multiple myeloma (uhlobo lomdlavuza womnkantsha wamathambo) asebevele belashwa ngeminye imithi. UCarfilzomib usesigabeni semithi ebizwa nge-proteasome inhibitors. Isebenza ngokumisa noma ukunciphisa ukukhula kwamangqamuzana omdlavuza emzimbeni wakho.

ICarfilzomib iza njengempuphu ezohlanganiswa noketshezi oluzofakwa ngaphakathi (emthanjeni). ICarfilzomib inikezwa ngudokotela noma umhlengikazi ehhovisi lezokwelapha noma emtholampilo imvamisa esikhathini semizuzu eyi-10 noma engama-30. Inganikezwa izinsuku ezi-2 zilandelana isonto ngalinye amasonto ama-3 ilandelwe isikhathi sokuphumula sezinsuku eziyi-12 noma inganikezwa kanye ngesonto amasonto ama-3 ilandelwe isikhathi sokuphumula sezinsuku eziyi-13. Ubude bokwelashwa buzoncika ekutheni umzimba wakho uphendula kanjani emithini.

Umjovo weCarfilzomib ungadala ukusabela okunzima noma okusongela impilo kuze kube ngamahora angama-24 ngemuva kokuthola umthamo womuthi. Uzothola imithi ethile yokusiza ukuvimbela ukusabela ngaphambi kokuthola umthamo ngamunye we-carfilzomib. Tshela udokotela wakho ngokushesha uma uhlangabezana nenye yalezi zimpawu ngemuva kokwelashwa kwakho: imfiva, ukugodola, ubuhlungu bamalunga noma imisipha, ukuqhuma noma ukuvuvukala kobuso, ukuvuvukala noma ukuqina komphimbo, ukuhlanza, ubuthakathaka, ukuphelelwa umoya, isiyezi noma ukuquleka, ukuqina kwesifuba noma ubuhlungu.

Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Udokotela wakho angamisa ukwelashwa kwakho isikhashana noma anciphise umthamo wakho we-carfilzomib uma uhlangabezana nemiphumela emibi yomuthi.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-carfilzomib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-carfilzomib, noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-carfilzomib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: izindlela zokuvimbela inzalo ngamahomoni (amaphilisi okulawula ukubeletha, amabala, izindandatho, okufakelwa kanye nemijovo) noma i-prednisone (iRayos). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho uma ngabe uke wahluleka yinhliziyo, wamelwa yinhliziyo, ukushaya kwenhliziyo okungajwayelekile, noma ezinye izinkinga zenhliziyo; umfutho wegazi ophakeme; noma ukutheleleka kwe-herpes (izilonda ezibandayo, ama-shingles, noma izilonda zangasese). Phinda utshele udokotela wakho uma unesifo sesibindi noma sezinso noma uku-dialysis.
• tshela udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa, noma uma uhlela ukuba nobaba wengane. Wena noma umlingani wakho akufanele ukhulelwe ngenkathi uthola i-carfilzomib. Uma ungowesifazane, kufanele uhlolwe ukukhulelwa ngaphambi kokuqala ukwelashwa futhi kufanele usebenzise ukuvimbela ukukhulelwa ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nge-carfilzomib nezinyanga eziyisithupha ngemuva komthamo wakho wokugcina. Uma ungowesilisa, wena nomlingani wakho kufanele nisebenzise izindlela zokulawula inzalo ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nge-carfilzomib nezinyanga ezintathu ngemuva komthamo wakho wokugcina. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthola lo muthi, shayela udokotela wakho. ICarfilzomib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Ungancelisi ngesikhathi uthola umjovo we-carfilzomib kanye namasonto ama-2 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi i-carfilzomib ingakwenza ukozele, ube nesiyezi, noma ube nekhanda elikhanyayo, noma ikubangele ukuquleka. Ungashayeli noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.

Phuza uketshezi oluningi ngaphambi nangezinsuku zonke ngenkathi welashwa nge-carfilzomib, ikakhulukazi uma uhlanza noma uhanjiswa yisisu.

Umjovo weCarfilzomib ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukukhathala
• ikhanda
• ubuthakathaka
• isifo sohudo
• ukuqunjelwa
• ukuqhuma kwemisipha
• ubuhlungu ezandleni noma emilenzeni

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwezigaba ZOKUQAPHA NOKUKHETHEKILE, shayela udokotela wakho:

• ukukhwehlela
• umlomo owomile, umchamo omnyama, ukuncipha kokujuluka, isikhumba esomile, nezinye izimpawu zokoma
• izinkinga zokuzwa
• ukuvuvukala kwezinyawo zemilenze
• ubuhlungu, ubumnene, noma ubomvu emlenzeni owodwa
• ukuphefumula okuncane noma ukuphefumula kanzima
• ubuhlungu besifuba
• ubuhlungu, ukuvutha, ukuba ndikindiki, noma ukuncinza ezandleni noma ezinyaweni
• isicanucanu
• ukukhathala ngokweqile
• ukopha okungajwayelekile noma ukulinyazwa
• ukungabi namandla
• ukulahlekelwa isifiso sokudla
• ubuhlungu engxenyeni engenhla kwesokudla yesisu
• ukuphuzi kwesikhumba noma kwamehlo
• izimpawu ezinjengomkhuhlane
• ezinegazi noma ezimnyama, izitulo zokulinda
• ukuqubuka kwamabala abomvu ngokububende akhombe ngokukhomba, imvamisa emilenzeni engezansi
• igazi emchameni
• ukuncipha kokuchama
• isithuthwane
• umbono uyashintsha
• ubunzima bokulala noma ukulala
• ukudideka, ukulahleka kwenkumbulo, isiyezi noma ukulahlekelwa ibhalansi, ubunzima bokukhuluma noma ukuhamba, ukuguquka kombono, ukwehla kwamandla noma ubuthakathaka ngakolunye uhlangothi lomzimba

Umjovo weCarfilzomib ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• Ukugodola
• isiyezi
• ukuncipha kokuchama

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzohlola umfutho wegazi lakho njalo futhi a-oda izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho ku-carfilzomib.

Buza usokhemisi wakho noma imiphi imibuzo onayo ngomjovo we-carfilzomib.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Kyprolis^®