Asparaginase Erwinia chrysanthemi

-Delile

• Ngaphambi kokuthatha i-asparaginase U-Erwinia chrysanthemi,
• I-Asparaginase ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Asparaginase U-Erwinia chrysanthemi isetshenziswa neminye imishanguzo yokwelapha ngamakhemikhali ukwelapha i-acute lymphocytic leukemia (BONKE; uhlobo lomdlavuza wamaseli amhlophe egazi). Isetshenziswa ezigulini eziye zaba nezinhlobo ezithile zokungezwani komzimba nemithi efana ne-asparaginase U-Erwinia chrysanthemi njenge (asparaginase [Elspar] noma i-pegaspargase [Oncaspar]). Asparaginase U-Erwinia chrysanthemi iyi-enzyme ephazamisa izinto zemvelo ezidingekayo ekukhuleni kweseli lomdlavuza. Isebenza ngokubulala noma ngokumisa ukukhula kwamangqamuzana omdlavuza.

Asparaginase U-Erwinia chrysanthemi iza njengempuphu ezokwengezwa kuketshezi futhi ijojowe emsipheni ngudokotela noma umhlengikazi esikhungweni sezokwelapha. Imvamisa inikezwa kathathu ngesonto.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-asparaginase U-Erwinia chrysanthemi,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-asparaginase U-Erwinia chrysanthemi, noma imuphi omunye umuthi, noma iziphi izithako ku-asparaginase U-Erwinia chrysanthemi impuphu. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha.
• Tshela udokotela wakho uma uke waba ne-pancreatitis (ukuvuvukala kwamanyikwe), amahlule egazi, noma ukuphuma kwegazi okunzima, ikakhulukazi uma lokhu kwenzeka ngesikhathi ukwelashwa nge-asparaginase (Elspar) noma i-pegaspargase (i-Oncaspar). Udokotela wakho mhlawumbe ngeke afune ukuthi uthole i-asparaginase U-Erwinia chrysanthemi.
• tshela udokotela wakho uma uke waba nesifo sikashukela noma wake waba naso.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthola i-asparaginase U-Erwinia chrysanthemi, shayela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa isikhathi sokuqokwa ukuze uthole umthamo we-asparaginase U-Erwinia chrysanthemi, shayela udokotela wakho ngokushesha.

I-Asparaginase ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• imfiva

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• isifuba
• ukuqubuka
• ukulunywa
• ukuphefumula kanzima noma ukugwinya
• ubuhlungu obuqhubekayo obuqala endaweni yesisu, kepha bungasabalala baye emuva
• ukoma ngokweqile
• ukuchama kaningi
• indlala eyeqile
• ubuthakathaka
• ukungaboni kahle
• ikhanda
• ukuvuvukala kwengalo noma umlenze
• ukuphelelwa umoya
• ubuhlungu besifuba
• ukopha okungavamile
• ukuphuzi kwesikhumba noma kwamehlo
• ubuhlungu engxenyeni engenhla kwesokudla yesisu
• umchamo onombala omnyama
• ukulahlekelwa isifiso sokudla
• ukungabi namandla
• ukudlikiza

Asparaginase U-Erwinia chrysanthemi kungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-asparaginase U-Erwinia chrysanthemi.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• U-Erwinaze^®