Inaliti ye-Siltuximab

-Delile

• Ngaphambi kokuthola umjovo we-siltuximab,
• Umjovo we-Siltuximab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezisesigabeni se-HOW, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Umjovo we-Siltuximab usetshenziselwa ukwelapha isifo se-Castleman's multicentric's (MCD; ukukhula okungajwayelekile kwamangqamuzana e-lymph ezingxenyeni ezingaphezu kweyodwa zomzimba ezingadala izimpawu futhi kungakhuphula ubungozi bokutheleleka kakhulu noma umdlavuza) kubantu abangenayo i-immunodeficiency yabantu igciwane (i-HIV) kanye ne-human herpesvirus-8 (HHV-8) ukutheleleka. I-Siltuximab isekilasini lemithi ebizwa ngama-antibody monoclonal. Isebenza ngokuvimba ukusebenza kwento yemvelo ebangela ukukhula kwamangqamuzana e-lymph kubantu abane-MCD.

Umjovo weSiltuximab uza njengoketshezi oluzofakwa ngaphakathi (emthanjeni) ngaphezu kwehora eli-1 ngumhlinzeki wezokunakekelwa kwempilo esibhedlela noma ehhovisi lezokwelapha. Imvamisa inikezwa kanye njalo emavikini ama-3.

Ungase uzwe ukusabela lapho uthola umjovo we-siltuximab. Uma uhlangabezana nokusabela, umhlinzeki wakho wezokunakekelwa kwempilo uzomisa ukumnika kwakho futhi uzokunika imithi yokwelapha ukusabela kwakho. Uma ukusabela kwakho kunzima, umhlinzeki wakho wezokunakekelwa kwempilo angeke akunikeze okunye ukungena kwe-siltuximab. Tshela umhlinzeki wakho wezokunakekelwa kwempilo noma uthole ukwelashwa okuphuthumayo uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi sokumnika noma ngemuva kokumnika: ukukhathazeka ukuphefumula; ukuqina kwesifuba; ukushaya; isiyezi noma ikhanda elikhanyayo; ukuvuvukala kobuso, izindebe, ulimi noma umphimbo; ukuqubuka; ukulunywa; ikhanda; ukuhlungu obusemhlane; ubuhlungu besifuba; isicanucanu; ukuhlanza; ukuqhuma; ukubomvu kwesikhumba; noma ukushaya kwenhliziyo.

Umjovo weSiltuximab ungasiza ukulawula i-MCD kepha ayiyelaphi. Qhubeka nokugcina ama-aphoyintimenti ukuthola umjovo we-siltuximab noma ngabe uzizwa uphilile.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-siltuximab,

• Tshela udokotela wakho kanye nosokhemisi uma une-aleji kumjovo we-siltuximab, noma imiphi eminye imithi, noma yiziphi izithako zomjovo we-siltuximab. Buza usokhemisi wakho noma hlola imininingwane yesiguli somkhiqizi ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: ama-anticoagulants ('ama-thinner egazi') afana ne-warfarin (Coumadin, Jantoven), atorvastatin (Lipitor), cyclosporine (Gengraf, Neoral, Sandimmune), lovastatin (e-Altoprev), izindlela zokuvimbela inzalo ngomlomo amaphilisi), kanye ne-theophylline (Theo-24, Uniphyl). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma unanoma yiluphi uhlobo lokutheleleka ngaphambi kokuqala ukwelashwa kwakho ngomjovo we-siltuximab, noma uma ubona noma yiziphi izimpawu zokutheleleka ngesikhathi sokwelashwa kwakho. Phinda utshele udokotela wakho uma ngabe uke waba nanoma yisiphi isimo esithinta isisu noma amathumbu akho njengezilonda (izilonda kulolwelwesi lwesisu noma amathumbu) noma i-diverticulitis (izikhwama ezincane ezingaphakathi kolwelwesi ezingase zivuthe).
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Kufanele usebenzise ukulawulwa kokuzalwa ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho ngomjovo we-siltuximab futhi izinyanga ezintathu ngemuva kokwelashwa kwakho. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ukhulelwa ngenkathi uthola umjovo we-siltuximab, shayela udokotela wakho ngokushesha. I-Siltuximab ingalimaza umbungu.
• ungenayo imigomo ngaphandle kokukhuluma nodokotela wakho. Phinda utshele udokotela wakho uma usanda kuthola imijovo. Khuluma nodokotela wakho mayelana nokuthi kufanele yini uthole noma yimiphi imigomo ngaphambi kokuba uqale ukwelashwa kwakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa i-aphoyintimenti yokwamukela umjovo we-siltuximab, shayela udokotela wakho ngokushesha okukhulu.

Umjovo we-Siltuximab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukufiphaza kwesikhumba
• isikhumba esomile
• ukuqunjelwa
• ubuhlungu bomlomo noma bomphimbo
• ukuzuza kwesisindo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezisesigabeni se-HOW, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• umkhuhlane, umphimbo obuhlungu, amakhaza, noma ezinye izimpawu zokutheleleka
• ukulimaza noma ukopha okungavamile
• ukuvuvukala kwezandla, izingalo, izinyawo, amaqakala, noma imilenze engezansi

Umjovo we-Siltuximab ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho kumjovo we-siltuximab.

Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nomjovo we-siltuximab.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Sylvant^®