Olaparib

-Delile

• Ngaphambi kokuthatha i-olaparib,
• I-Olaparib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

Amaphilisi e-Olaparib asetshenziselwa ukusiza ukugcina ukuphendula kwezinhlobo ezithile zama-ovarian (izitho zokuzala zabesifazane lapho kwakhiwa khona amaqanda), ishubhu le-fallopian (ishubhu elihambisa amaqanda akhishwe ama-ovari liye esibelethweni), kanye ne-peritoneal (ungqimba lwezicubu ezigcwala isisu ) umdlavuza kubantu abaphendule ngokuphelele noma abaphendule kancane ekwelashweni kwabo kokuqala noma kamuva kwamakhemikhali. Amaphilisi e-Olaparib nawo asetshenziselwa ukwelapha izinhlobo ezithile zomdlavuza webele osusabalele kwezinye izingxenye zomzimba futhi awuzange uthuthuke noma uye waba mubi ngemuva kokwelashwa ngezinye izindlela zokwelapha. Amaphilisi e-Olaparib asetshenziselwa ukwelapha uhlobo oluthile lomdlavuza wendlala yesinye eselusabalalele kwezinye izingxenye zomzimba, alusabeli ekwelashweni noma ekwelapheni ukwehlisa amazinga e-testosterone, futhi seluthuthuke ngemuva kokwelashwa nge-enzalutamide (Xtandi) noma i-abiraterone (Yonsa , UZytiga). Amaphilisi nama-capsule e-Olaparib nawo asetshenziselwa ukwelapha umdlavuza we-ovari ongakathuthuki noma oye waba mubi ngemuva kokwelashwa ngezinye izindlela zokwelapha okungenani ezintathu. Amaphilisi e-Olaparib asetshenziselwa ukusiza ukugcina ukuphendula kohlobo oluthile lomdlavuza we-pancreatic ongazange usabalale noma uthuthuke ngemuva kokwelashwa kokuqala kwamakhemikhali. I-Olaparib iyi-polyadenosine 5'-diphosphoribose polymerase (PARP) enzyme inhibitor. Isebenza ngokubulala amangqamuzana omdlavuza.

I-Olaparib iza njengethebhulethi noma i-capsule ukuthatha ngomlomo kabili nsuku zonke ngokudla noma ngaphandle kokudla. Zama ukubeka imithamo yakho cishe amahora angama-12 ngokuhlukana. Thatha i-olaparib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-olaparib njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya yonke ithebhulethi noma i-capsule; musa ukuchoboza ukuhlafuna, ukuhlukanisa, noma ukukuqeda.

I-Olaparib iyatholakala njengethebhulethi nanjengephilisi. Amathebulethi namaphilisi aqukethe amanani ahlukene e-olaparib futhi akufanele afakwe komunye nomunye. Khuluma nodokotela wakho noma usokhemisi uma unemibuzo mayelana namalungiselelo ethebhulethi kanye ne-capsule.

Udokotela wakho anganciphisa umthamo wakho we-olaparib noma akutshele ukuthi uyeke ukuthatha i-olaparib isikhathi esithile ngesikhathi sokwelashwa kwakho. Lokhu kuzoya ngokuthi umuthi usebenza kanjani kuwe nakunoma imiphi imiphumela emibi ongase ube nayo. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngenkathi welashwa nge-olaparib.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-olaparib. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ukuthola uMhlahlandlela Wezokwelapha.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-olaparib,

• Tshela udokotela kanye nosokhemisi wakho uma une-allergic ku-olaparib, noma imiphi eminye imithi, noma iziphi izithako ezikumathebulethi noma amaphilisi we-olaparib. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-antibiotic afana ne-ciprofloxacin (Cipro), i-clarithromycin (i-Biaxin, e-Prevpac), i-erythromycin (i-E.E.S., i-Erythrocin, abanye), i-nafcillin, ne-telithromycin (ayisatholakali e-U.S., Ketek); ama-antifungals afana ne-fluconazole (i-Diflucan), i-itraconazole (i-Onmel, i-Sporanox), i-ketoconazole (i-Extina, i-Nizoral, i-Xolegel), i-posaconazole (i-Noxafil), ne-voriconazole (i-Vfend); i-aprepitant (Hlela); imithi ethile yokwelapha ukuquleka okufana ne-carbamazepine (Carbatrol, Epitol, Tegretol, Teril), ne-phenytoin (Dilantin, Phenytek); i-bosentan (iTracleer); i-crizotinib (i-Xalkori); i-diltiazem (Cardizem, Cartia, Tiazac, abanye); imithi ethile yokwelapha i-hepatitis C efana ne-boceprevir (ayisatholakali e-U.S., Victrelis) kanye ne-telaprevir (ayisatholakali e-U.S., Incivek); imishanguzo ethile yokwelapha igciwane lesandulela ngculazi (i-HIV) noma i-immunodeficiency syndrome (i-AIDS) efana ne-amprenavir (ayisatholakali e-US, Agenerase), atazanavir (Reyataz, e-Evotaz), darunavir (Prezista), efavirenz (Sustiva, e-Atripla) , etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir / ritonavir (Kaletra), nelfinavir (Viracept), ritonavir (Norvir, eKaletra), kanye ne-saquinavir (Invirase); imatinib (Gleevec); i-modafinil (i-Provigil); nefazodone; eminye imithi yokwelapha ngamakhemikhali yomdlavuza, i-rifampin (i-Rifadin, i-Rimactane, i-Rifamate, i-Rifater), ne-verapamil (i-Calan, i-Verelan, e-Tarka). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort. Akufanele uthathe i-wort yaseSt.John ngenkathi uthatha i-olaparib.
• Tshela udokotela wakho uma uke waba nezinkinga zamaphaphu noma zokuphefumula, noma isifo sezinso noma sesibindi.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uhlele ukuba nobaba wengane. Ungadinga ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa, Akufanele ukhulelwe ngenkathi uthatha i-olaparib. Kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ukuvimbela ukukhulelwa ngenkathi welashwa nge-olaparib futhi okungenani izinyanga eziyisithupha ngemuva komthamo wakho wokugcina. Uma ungowesilisa futhi umlingani wakho angakhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho ngamaphilisi e-olaparib nezinyanga ezintathu ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ukhulelwa ngenkathi uthatha i-olaparib, shayela udokotela wakho ngokushesha. I-Olaparib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Ungancelisi ibele ngenkathi uthatha i-olaparib nenyanga e-1 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi akufanele unikele ngesidoda ngenkathi uthatha amaphilisi e-olaparib nezinyanga ezi-3 ngemuva komthamo wakho wokugcina.

Ungadli izithelo zomvini noma amawolintshi aseSeville (kwesinye isikhathi asetshenziswe kuma-marmalade), noma uphuze ijusi lamagilebhisi noma ijusi le-orange laseSeville ngenkathi uthatha lo muthi.

Yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa esivamile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Olaparib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• isifo sohudo
• ukuqunjelwa
• isilungulela
• ikhanda
• ukuncipha kokudla
• ubuhlungu bemisipha, obuhlangene noma obuya emuva
• ukukhathala
• ubuhlungu besisu noma ukungaphatheki kahle
• izinguquko zokunambitheka
• ubuhlungu bomlomo noma izilonda
• ukukhathazeka
• ukudana
• isikhumba esomile
• ukulunywa
• ukuqubuka
• ubunzima bokulala noma ukulala
• ukuchama ubuhlungu

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• umkhuhlane, ukuphefumula okuncane, ukukhwehlela noma ukuphefumula
• ukuphelelwa umoya
• ubuthakathaka
• ukukhathala ngokweqile
• ukuncipha komzimba
• ukulimaza noma ukopha okungavamile
• isikhumba esiphaphathekile
• igazi emchameni noma esitulweni
• umkhuhlane, ukubanda, ukukhwehlela, umphimbo obuhlungu, noma ezinye izimpawu zokutheleleka
• ubuhlungu, ubumnene, ubomvu, noma ukuvuvukala emlenzeni owodwa
• ubuhlungu besifuba noma ukuqina; ukuphelelwa umoya; ukukhwehlela igazi; noma ukuphefumula okusheshayo

I-Olaparib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angayalela ukuhlolwa kwelebhu ngaphambi kokuba uqale ukwelashwa kwakho ukuze ubone ukuthi isimo sakho singelashwa nge-olaparib. Udokotela wakho uzo-oda izivivinyo ezithile zebhu ngesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-olaparib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Lynparza^®