Isilinganiso se-CoQ10: Kufanele Uthathe Malini Ngosuku?

-Delile

• Iyini i-CoQ10?
• Izincomo Zesilinganiso Esenziwa Isimo Sezempilo
• Ukusetshenziswa Kwemithi Ye-Statin
• Isifo senhliziyo
• Migraine Ikhanda
• Ukuguga
• Isifo sikashukela
• Ukungabi nenzalo
• Ukuzivocavoca Ukusebenza
• Okuqhamuka uma udla imishanguzo
• Okusemqoka

ICoenzyme Q10 - eyaziwa kangcono njengeCoQ10 - iyinhlanganisela eyenziwa ngumzimba wakho ngokwemvelo.

Idlala izindima eziningi ezibalulekile, njengokukhiqizwa kwamandla nokuvikelwa ekulimaleni kweseli kwe-oxidative.

Iphinde ithengiswe ngefomu lokwengeza ukwelapha izimo ezehlukene zezempilo kanye nokugula.

Ngokuya ngesimo sempilo ozama ukusithuthukisa noma ukusixazulula, izincomo zesilinganiso se-CoQ10 zingahluka.

Lo mbhalo ubukeza imithamo engcono kakhulu yeCoQ10 ngokuya ngezidingo zakho.

Iyini i-CoQ10?

ICoenzyme Q10, noma iCoQ10, iyisithako esinamandla esincibilika esinamafutha esikhona kuwo wonke amangqamuzana omuntu, esinokuhlushwa okuphezulu kakhulu e-mitochondria.

IMitochondria - evame ukubizwa njengezindlu zamandla zamaseli - yizakhiwo ezikhethekile ezikhiqiza i-adenosine triphosphate (ATP), okuwumthombo oyinhloko wamandla asetshenziswa amaseli akho ().

Kunezinhlobo ezimbili ezihlukile zeCoQ10 emzimbeni wakho: ubiquinone kanye ne-ubiquinol.

I-Ubiquinone iguqulwa ibe yimo yayo esebenzayo, ubiquinol, ebese imuncwa kalula futhi isetshenziswe ngumzimba wakho ().

Ngaphandle kokukhiqizwa ngokwemvelo ngumzimba wakho, i-CoQ10 ingatholwa ngokudla okubandakanya amaqanda, inhlanzi enamafutha, inyama yomzimba, amantongomane nezinkukhu ().

I-CoQ10 idlala indima ebalulekile ekukhiqizeni amandla futhi isebenza njenge-antioxidant enamandla, evimbela ukukhiqizwa kwamahhala okukhululekile nokuvimbela ukonakala kwamaseli ().

Yize umzimba wakho wenza i-CoQ10, kunezici eziningana ezinganciphisa amazinga ayo. Isibonelo, izinga lokukhiqizwa kwalo lehla kakhulu ngeminyaka, elihlotshaniswa nokuqala kwezimo ezihlobene nobudala njengesifo senhliziyo nokwehla kwengqondo ().

Ezinye izimbangela zokuqedwa kwe-CoQ10 kufaka phakathi ukusetshenziswa kwemithi ye-statin, isifo senhliziyo, ukushoda kwezakhi, ukuguquka kwezakhi zofuzo, ukucindezeleka okwenziwe nge-oxidative nomdlavuza ().

Ukwengeza nge-CoQ10 kukhonjisiwe ukuvimbela ukulimala noma ukuthuthukisa izimo ezihlobene nokushoda kule nhlanganisela ebalulekile.

Ngokwengeziwe, njengoba kubandakanyeka ekukhiqizeni amandla, izithasiselo ze-CoQ10 zikhonjisiwe ukukhulisa ukusebenza kwezemidlalo nokunciphisa ukuvuvukala kubantu abaphilile abangantuli neze ().

ICoQ10 iyinhlanganisela enemisebenzi eminingi ebalulekile emzimbeni wakho. Izici ezahlukahlukene zingaqeda amazinga e-CoQ10, yingakho izithasiselo zingadingeka.

Izincomo Zesilinganiso Esenziwa Isimo Sezempilo

Yize kunconywa ama-90-200 mg we-CoQ10 ngosuku, izidingo zingahluka ngokuya ngomuntu nesimo aselashwa ngaso).

Ukusetshenziswa Kwemithi Ye-Statin

Izitatimende yiqembu lemithi esetshenziselwa ukwehlisa amazinga aphezulu egazi e-cholesterol noma i-triglycerides ukuvikela isifo senhliziyo ().

Yize le mithi ivame ukubekezelelwa kahle, ingadala imiphumela emibi, njengokulimala kakhulu kwemisipha nokulimala kwesibindi.

Izitatimende ziphazamisa nokukhiqizwa kwe-mevalonic acid, esetshenziselwa ukwakha iCoQ10. Lokhu kuboniswe ukuthi kwehle kakhulu amazinga we-CoQ10 ezicutshini zegazi nezicubu ().

Ucwaningo lukhombisile ukuthi ukufaka i-CoQ10 kunciphisa ubuhlungu bemisipha kulabo abathatha imishanguzo ye-statin.

Ucwaningo olwenziwe kubantu abangama-50 abathatha imishanguzo ye-statin luthole ukuthi umthamo ka-100 mg we-CoQ10 ngosuku izinsuku ezingama-30 wehlise ngempumelelo ubuhlungu bemisipha obuhlobene ne-statin ku-75% weziguli ().

Kodwa-ke, olunye ucwaningo alukhombisanga mthelela, kugcizelela isidingo sokwenza ucwaningo olwengeziwe ngalesi sihloko ().

Kubantu abathatha imishanguzo ye-statin, izincomo ezijwayelekile zesilinganiso se-CoQ10 zingama-30-200 mg ngosuku ().

Isifo senhliziyo

Labo abanezimo zenhliziyo, njengokuhluleka kwenhliziyo kanye ne-angina, bangazuza ngokuthatha isithasiselo se-CoQ10.

Ukubuyekezwa kwezifundo eziyi-13 kubantu abanokwehluleka kwenhliziyo kutholile ukuthi i-100 mg ye-CoQ10 ngosuku amasonto ayi-12 ithuthukise ukugeleza kwegazi kusuka enhliziyweni ().

Futhi, ukwengeza kukhonjisiwe ukunciphisa inani lokuvakashelwa esibhedlela kanye nengozi yokufa ngezinkinga ezihlobene nenhliziyo kubantu abanenkinga yenhliziyo ().

I-CoQ10 iyasebenza futhi ekunciphiseni ubuhlungu obuhambisana ne-angina, okubuhlungu besifuba obubangelwa yimisipha yenhliziyo yakho engatholi i-oxygen eyanele ().

Ngaphezu kwalokho, isengezo singanciphisa izici eziyingozi zesifo senhliziyo, njengokunciphisa i-cholesterol "embi" ye-LDL ().

Kubantu abanokwehluleka kwenhliziyo noma i-angina, izincomo ezijwayelekile zesilinganiso se-CoQ10 zingama-60-300 mg ngosuku ().

Migraine Ikhanda

Uma isetshenziswa yodwa noma ihlanganiswe nezinye izakhi zomzimba, njenge-magnesium ne-riboflavin, i-CoQ10 iboniswe ukuthi ithuthukise izimpawu ze-migraine.

Kutholakale futhi ukuthi kunciphisa ikhanda ngokunciphisa ukucindezeleka okwenziwe nge-oxidative kanye nokukhiqizwa kwamahhala okukhululekile, okungenzeka ukuthi kubangele i-migraines.

I-CoQ10 inciphisa ukuvuvukala emzimbeni wakho futhi ithuthukise umsebenzi we-mitochondrial, osiza ukunciphisa ubuhlungu obuhlobene ne-migraine ().

Ucwaningo lwezinyanga ezintathu kwabesifazane abangama-45 lukhombisile ukuthi labo abaphathwa nge-400 mg ye-CoQ10 ngosuku babone ukwehliswa okukhulu kwimvamisa, ubunzima nobude be-migraines, uma kuqhathaniswa neqembu le-placebo ().

Ekwelapheni i-migraines, izincomo ezijwayelekile zesilinganiso se-CoQ10 zingama-300-400 mg ngosuku ().

Ukuguga

Njengoba kushiwo ngenhla, amazinga e-CoQ10 ngokwemvelo aguga ngeminyaka.

Ngokujabulisayo, ama-supplements angakhuphula amazinga akho we-CoQ10 futhi angahle athuthukise ikhwalithi yakho yonke yokuphila.

Abantu abadala asebekhulile abanamazinga aphezulu egazi e-CoQ10 bavame ukusebenza ngokwengeziwe futhi babe namazinga aphansi okucindezeleka okwenziwe nge-oxidative, okungasiza ekuvikeleni isifo senhliziyo kanye nokwehla kwengqondo ().

Izithako ze-CoQ10 zikhonjisiwe ukuthuthukisa amandla emisipha, amandla nokusebenza komzimba kubantu abadala asebekhulile ().

Ukuphikisana nokuncipha okuhlobene nobudala be-CoQ10, kunconywa ukuthatha u-100-200 mg ngosuku ().

Isifo sikashukela

Kokubili ukucindezelwa kwe-oxidative kanye nokungasebenzi kahle kwe-mitochondrial kuxhunywe ekuqaleni nasekuqhubekeni kwesifo sikashukela kanye nezinkinga ezihlobene nesifo sikashukela ().

Ngaphezu kwalokho, labo abanesifo sikashukela bangaba namazinga aphansi we-CoQ10, kanti nemithi ethile elwa nesifo sikashukela ingaqhubeka nokuqothula izitolo zomzimba zale nto ebalulekile ().

Ucwaningo lukhombisa ukuthi ukufaka i-CoQ10 kusiza ekwehliseni ukukhiqizwa kwama-radicals amahhala, angama-molecule angaqiniseki angalimaza impilo yakho uma amanani awo ephezulu kakhulu.

I-CoQ10 ibuye isize ukuthuthukisa ukumelana ne-insulin futhi ilawule amazinga kashukela egazini kubantu abanesifo sikashukela.

Ucwaningo lwamaviki ayi-12 kubantu abangama-50 abanesifo sikashukela luthole ukuthi labo abathola u-100 mg we-CoQ10 ngosuku banciphise kakhulu ushukela wegazi, omaka bokuxineka kwe-oxidative kanye nokumelana ne-insulin, uma kuqhathaniswa neqembu elilawulayo ().

Imithamo ye-100-300 mg ye-CoQ10 ngosuku ibonakala ithuthukisa izimpawu zesifo sikashukela ().

Ukungabi nenzalo

Ukulimala okwenziwe nge-oxidative kungenye yezimbangela ezinkulu zokungazali kwabesilisa nabesifazane ngokuthinta kabi isidoda nekhwalithi yamaqanda (,).

Isibonelo, ukucindezelwa okwenziwe nge-oxidative kungadala ukulimala kwesidoda se-DNA, okungahle kube nomphumela wokungabi nenzalo kwabesilisa noma ukulahleka kokukhulelwa okuphindaphindiwe ().

Ucwaningo luthole ukuthi ama-antioxidants ekudleni - kufaka phakathi i-CoQ10 - angasiza ekunciphiseni ukucindezeleka okwenziwe nge-oxidative futhi athuthukise ukuzala kwabesilisa nabesifazane.

Ukwengeza nge-200-300 mg ngosuku lwe-CoQ10 kukhonjisiwe ukuthi kuthuthukisa ukugxila kwesidoda, ukuminyana kanye nokushukumiseka kwamadoda anokuzala ().

Ngokufanayo, lezi zithasiselo zingathuthukisa ukuzala kwabesifazane ngokuvuselela impendulo ye-ovari futhi zisize ukuguga kwe-ovarian ().

Amanani we-CoQ10 we-100-600 mg akhonjisiwe ukusiza ukukhulisa ukuzala ().

Ukuzivocavoca Ukusebenza

Njengoba i-CoQ10 ibandakanyeka ekukhiqizeni amandla, kuyisengezo esidumile phakathi kwabasubathi nalabo abafuna ukukhulisa ukusebenza komzimba.

Izithako ze-CoQ10 zisiza ukunciphisa ukuvuvukala okuhambisana nokuvivinya umzimba okunzima futhi kungasheshisa nokululama ().

Ucwaningo lwamaviki ayisithupha kubasubathi abangu-100 baseJalimane luthole ukuthi labo abenezela nge-300 mg ye-CoQ10 nsuku zonke babone ukuthuthuka okuphawulekayo ekusebenzeni komzimba - okulinganiswa njengokukhishwa kwamandla - kuqhathaniswa neqembu le-placebo ().

ICoQ10 nayo ikhonjisiwe ukunciphisa ukukhathala nokwandisa amandla emisipha kwabangewona abagijimi ().

Imithamo ye-300 mg ngosuku ibonakala isebenza kakhulu ekukhuliseni ukusebenza kwezemidlalo ezifundweni zocwaningo ().

Izincomo zesilinganiso se-CoQ10 ziyahlukahluka kuye ngezidingo nezinjongo zomuntu ngamunye. Khuluma nodokotela wakho ukunquma isilinganiso esifanele.

Okuqhamuka uma udla imishanguzo

I-CoQ10 ivame ukubekezelelwa kahle, noma ngamanani aphezulu kakhulu we-1,000 mg ngosuku noma ngaphezulu ().

Kodwa-ke, abanye abantu abazwela kule nhlanganisela bangaba nemiphumela engemihle, njengohudo, ikhanda elibuhlungu, isicanucanu nokuqubuka kwesikhumba ().

Kumele kuqashelwe ukuthi ukuthatha i-CoQ10 eduze nesikhathi sokulala kungadala ukuqwasha kwabanye abantu, ngakho-ke kungcono ukuyithatha ekuseni noma ntambama ().

Izithako ze-CoQ10 zingasebenzisana nemithi ethile ejwayelekile, kufaka phakathi ama-thinner egazi, ama-anti-depressants kanye nemithi yokwelapha ngamakhemikhali. Xhumana nodokotela wakho ngaphambi kokuthatha i-CoQ10 eyengeziwe (,).

Njengoba incibilika emafutheni, labo abenezela ngeCoQ10 kufanele bakhumbule ukuthi kungcono ukumuncwa lapho kuthathwa ngokudla noma isidlo esingumthombo onamafutha.

Ngokwengeziwe, qiniseka ukuthi uthenga izithasiselo eziletha i-CoQ10 ngendlela ye-ubiquinol, okuyi-absorbable kakhulu ().

Yize iCoQ10 ivame ukubekezelelwa kahle, abanye abantu bangaba nemiphumela emibi efana nesicanucanu, uhudo kanye nekhanda, ikakhulukazi uma uthatha imithamo ephezulu. Ukwengeza kungabuye kuhlanganyele nemithi ejwayelekile, ngakho-ke khuluma nodokotela wakho kuqala.

Okusemqoka

ICoenzyme Q10 (CoQ10) ixhunyaniswe nokuthuthuka okuthuthukile, ukusebenza kokuzivocavoca, impilo yenhliziyo, isifo sikashukela, ukuzala kanye ne-migraines. Kungaphikisana nemiphumela emibi yemithi ye-statin.

Imvamisa, kunconywa ama-90-200 mg we-CoQ10 ngosuku, noma ngabe ezinye izimo zingadinga imithamo ephakeme ka-300-600 mg.

I-CoQ10 iyisengezo esibekezeleleke kahle futhi esiphephile esingazuzisa abantu abahlukahlukene abafuna indlela yemvelo yokuthuthukisa impilo.