Lenvatinib

-Delile

• Ngaphambi kokuthatha i-lenvatinib,
• ILenvatinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Lenvatinib isetshenziselwa ukwelapha uhlobo oluthile lomdlavuza we-thyroid obuyile noma osusabalalele kwezinye izingxenye zomzimba futhi awukwazi ukwelashwa nge-iodine enemisebe. ILenvatinib nayo isetshenziswa kanye ne-everolimus (Afinitor, Zortress) ukwelapha i-renal cell carcinoma (RCC, uhlobo lomdlavuza oluqala ezinso) kubantu abake bathola ukwelashwa ngomunye umuthi wokwelapha ngamakhemikhali. ILenvatinib ibuye isetshenziselwe ukwelapha i-hepatocellular carcinoma (HCC; uhlobo lomdlavuza wesibindi) olungaphathwa ngokuhlinzwa. ILenvatinib nayo iyasetshenziswa kanye ne-pembrolizumab (Keytruda) ukwelapha uhlobo oluthile lomdlavuza we-endometrium (ulwelwesi lwesibeletho) olusabalale lwaya kwezinye izingxenye zomzimba noma lwadlanga phakathi noma ngemuva kokwelashwa ngemithi ye-chemotherapy noma engakwazi ukwelashwa ukuhlinzwa noma ukwelashwa ngemisebe. U-Lenvatinib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sephrotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunqanda ukusabalala kwamangqamuzana omdlavuza.

ILenvatinib iza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa kanye ngosuku noma ngaphandle kokudla. Thatha i-lenvatinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-lenvatinib njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungazivuli, uzihlafune noma uzichoboze.

Uma ungakwazi ukugwinya amaphilisi, uwafake engilazini encane bese ufaka isipuni esisodwa samanzi noma ijusi le-apula. Ungawaphuli noma uwaphule amaphilisi. Shiya amaphilisi kuketshezi okungenani imizuzu eyi-10 bese unyakazisa okuqukethwe okungenani imizuzu emithathu. Phuza ingxube. Ngemuva kokuphuza ingxube, engeza esinye isipuni samanzi noma ijusi le-apula engilazini. Swayipha okuqukethwe izikhathi ezimbalwa bese ugwinya ingxubevange.

Udokotela wakho anganciphisa umthamo wakho we-lenvatinib noma akutshele ukuthi uyeke ukuthatha umuthi isikhashana noma unomphela uma uba nemiphumela emibi kakhulu. Qiniseka ukuthi ukhuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngenkathi welashwa nge-lenvatinib.

Ubude bokwelashwa kwakho buncike ekutheni usabela kanjani emithini kanye nemiphumela emibi oyitholayo. Qhubeka uthathe i-lenvatinib noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-lenvatinib ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-lenvatinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane kulenvatinib, noma imiphi eminye imithi, noma iziphi izithako ezikuma-lenvatinib capsules. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha.Qiniseka ukuthi usho noma yikuphi okulandelayo: imithi ethile yokushaya kwenhliziyo okungajwayelekile okubandakanya i-amiodarone (Nexterone, Pacerone), disopyramide (Norpace), procainamide, quinidine (eNuedexta), ne-sotalol (Betapace, Betapace AF, Sorine, Sotylize). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma uke wahlaselwa yisifo sokuwa, umfutho wegazi ophakeme, isifo sohlangothi, isifo senhliziyo, ikhanda elibuhlungu, izinguquko embonweni, ikakhulukazi lezo ngenxa yamahlule egazi, i-fistula (ukuxhumana okungajwayelekile phakathi kwezitho ezimbili ngaphakathi komzimba wakho noma phakathi isitho kanye nengaphandle lomzimba wakho), izinyembezi odongeni lwesisu sakho noma emathunjini akho, ukwanda kwesikhawu se-QT (isigqi senhliziyo esingajwayelekile esingaholela ekuphelelweni amandla, ekulahlekelweni ukwazi, ekuqulekeni, noma ekufeni okungazelelwe), ukwehluleka kwenhliziyo, amazinga aphansi we-calcium, i-potassium, noma i-magnesium egazini lakho, izinkinga zokopha, noma inhliziyo, izinso, noma isifo sesibindi. Phinda utshele udokotela wakho uma uke welashwa ngemithi yokwelashwa ngemisebe.
• kufanele wazi ukuthi i-lenvatinib inganciphisa ukuzala kwabesilisa nabesifazane. Kodwa-ke, akufanele ucabange ukuthi wena noma umlingani wakho anikwazi ukukhulelwa. Tshela udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uzodinga ukuhlolwa kokukhulelwa ngaphambi kokuba uqale ukwelashwa nge-lenvatinib. Uma ungakhulelwa, kufanele usebenzise ukulawulwa kokubeletha ngenkathi welashwa nge-lenvatinib futhi okungenani amasonto ama-4 ngemuva komthamo wakho wokugcina. Uma ukhulelwa ngenkathi uthatha i-lenvatinib, shayela udokotela wakho ngokushesha. ILenvatinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa noma uhlela ukuncelisa. Akufanele uncelise ibele ngenkathi uthatha i-lenvatinib
• utshele udokotela wakho uma uhlela ukuhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo. Udokotela wakho mhlawumbe uzokutshela ukuthi umise ukwelashwa kwakho nge-lenvatinib okungenani ezinsukwini eziyisithupha ngaphambi kokuhlinzwa kwakho okuhleliwe ngoba kungathinta ukuphulukiswa kwesilonda. Udokotela wakho uzokutshela ukuthi uzoqala nini ukuthatha i-lenvatinib futhi ngemuva kokuhlinzwa kwakho.
• kufanele wazi ukuthi umfutho wegazi wakho ungakhuphuka ngenkathi welashwa nge-lenvatinib. Udokotela wakho mhlawumbe uzoqapha ukucindezelwa kwakho kwegazi ngesikhathi sokwelashwa kwakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma umthamo wakho olandelayo ufanele amahora angu-12 noma ngaphezulu, thatha isilinganiso esilahlekile ngokushesha nje lapho usikhumbula. Kodwa-ke, uma umthamo olandelayo uzothathwa ngaphansi kwamahora we-12, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

ILenvatinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukukhathala noma ukukhathala
• ukuqubuka, ububomvu, ukulunywa, noma ukuxebuka kwesikhumba ezintendeni zezandla nasematheni ezinyawo
• isicanucanu
• ukuqunjelwa
• isilungulela
• ukuncipha kokudla
• ukuncipha komzimba
• shintsha emandleni okunambitha ukudla
• ukukhwehlela
• ukushaqeka
• izilonda zomlomo
• umlomo owomile
• ikhanda
• Ubuhlungu bamalunga nemisipha
• ubunzima bokulala noma ukulala
• ukulahleka kwezinwele
• imfiva
• ukuvutha ngesikhathi sokuchama
• ukuqubuka

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuphelelwa umoya
• ukuvuvukala kwemilenze namaqakala
• ubuhlungu besifuba
• ukuba ndikindiki noma ukubuthakathaka kobuso, ingalo, noma umlenze ohlangothini olulodwa lomzimba wakho
• ubuhlungu ezingalweni, emhlane, entanyeni, noma emhlathini
• ngokuzumayo, ikhanda elibi kakhulu
• inkulumo ehamba kancane noma enzima
• izinguquko ezingazelelwe embonweni
• isifo sohudo esibi
• ukuphuzi kwesikhumba noma kwamehlo
• ubuhlungu besisu
• umchamo omnyama (onetayi)
• indle enombala okhanyayo
• isithuthwane
• ubuthakathaka
• ukudideka
• ukuphuma kwempumu okunzima nokuphikelelayo
• ukuhlanza okunegazi
• okumnyama, okulindile, noma okokuchitha okunegazi
• ukukhwehlela igazi noma amahlule egazi
• ukuphuma kwegazi okunzima
• ukuhlanza, isifo sohudo, noma izimpawu zokoma
• amanxeba angapholi

ILenvatinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-lenvatinib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Lenvima^®