I-Panobinostat

-Delile

• Ngaphambi kokuthatha i-panobinostat,
• I-Panobinostat ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Panobinostat ingadala uhudo olunzima kanye neminye imiphumela emibi yamathumbu (GI; ethinta isisu noma amathumbu) imiphumela emibi. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: amajaqamba esisu; indle evulekile; isifo sohudo; ukuhlanza; noma umlomo owomile, umchamo omnyama, ukuncipha kokujuluka, isikhumba esomile, nezinye izimpawu zokoma. Khuluma nodokotela wakho ngalokho okufanele ukwenze uma uba nohudo ngenkathi welashwa nge-panobinostat. Futhi khuluma nodokotela wakho ngaphambi kokuthatha noma yimaphi ama-laxatives noma ama-stool softeners ngenkathi uthatha lo muthi.

I-Panobinostat ingadala izinkinga zenhliziyo ezinkulu noma ezisongela impilo ngesikhathi sokwelashwa kwakho. Tshela udokotela wakho uma ngabe usanda kuba nesifo senhliziyo noma une-QT syndrome ende (isimo esandisa ingozi yokuhlaselwa ukushaya kwenhliziyo okungajwayelekile okungadala ukuquleka noma ukufa ngokuzuma), i-angina (ubuhlungu besifuba), noma ezinye izinkinga zenhliziyo. Udokotela wakho uzoku-oda izivivinyo ezifana ne-electrocardiogram (ECG; ukuhlolwa okurekhoda umsebenzi kagesi wenhliziyo) ngaphambi nangesikhathi sokwelashwa kwakho ukubona ukuthi kuphephile yini ukuthi ungathatha i-panobinostat. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ubuhlungu besifuba, ukushaya ngamandla, ukushaya ngamandla, noma ukushaya kwenhliziyo okungajwayelekile, ikhanda elikhanyayo, ukuzizwa uphela amandla, isiyezi, izindebe ezinombala oluhlaza okwesibhakabhaka, ukuphefumula okuncane, noma ukuvuvukala kwezandla, izingalo, izinyawo, amaqakala, noma imilenze engezansi.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho ku-panobinostat.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-panobinostat futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokuthatha i-panobinostat.

I-Panobinostat isetshenziswa ngokuhlangana ne-bortezomib (Velcade) ne-dexamethasone ukwelapha abantu abane-myeloma eminingi (uhlobo lomdlavuza womnkantsha wamathambo) asebevele belashwa eminye imishanguzo emibili, kubandakanya i-bortezomib (Velcade). I-Panobinostat isekilasini lemithi ebizwa nge-histone deacetylase (HDAC) inhibitors. Isebenza ngokubulala amangqamuzana omdlavuza.

IPanobinostat iza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa ngokudla noma ngaphandle kokudla kanye ngosuku ngezinsuku ezithile zomjikelezo wezinsuku ezingama-21. Umjikelezo ungaphindwa kuze kube yimijikelezo engu-16. Thatha i-panobinostat ngasikhathi sinye ngosuku ngalunye oluhleliwe. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-panobinostat njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi ngengilazi yamanzi; ungazichobozi, uzihlafune, noma uzivule. Phatha ama-capsule kancane ngangokunokwenzeka. Uma uthinta i-panobinostat capsule ephukile noma umuthi ose-capsule, geza leyo ndawo yomzimba wakho ngensipho namanzi. Uma umuthi osemgodleni ungena emlonyeni, ekhaleni, noma emehlweni, uwugeze ngamanzi amaningi.

Uma uhlanza ngemuva kokuthatha i-panobinostat, ungathathi omunye umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Udokotela wakho anganciphisa umthamo wakho we-panobinostat noma ayeke ukwelashwa kwakho isikhashana noma unomphela, uma uhlangabezana nemiphumela emibi yomuthi.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-panobinostat,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-panobinostat, noma imiphi eminye imithi, noma yiziphi izithako ezikuma-panobinostat capsules. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qinisekisa ukusho noma yikuphi kokulandelayo: amiodarone (Cordarone, Nexterone, Pacerone); imishanguzo efana ne-itraconazole (i-Onmel, i-Sporanox), i-ketoconazole (i-Nizoral), i-posaconazole (i-Noxafil), ne-voriconazole (i-Vfend); i-atomoxetine (iStrattera); i-bepridil (i-Vascor; ayisatholakali e-U.S.); i-boceprevir (i-Victrelis); carbamazepine (Carbatrol, Tegretol, Teril, nabanye); i-chloroquine (Aralen); i-clarithromycin (i-Biaxin, ku-PrevPac); i-conivaptan (iVaprisol); i-desipramine (i-Norpramin); dextromethorphan; i-disopyramide (iNorpace); i-dolasetron (i-Anzemet); imishanguzo ethile ye-HIV efana ne-indinavir (Crixivan), lopinavir / ritonavir (Kaletra), nelfinavir (Viracept), ritonavir (Norvir, eKaletra, eViekira Pak), saquinavir (Invirase); i-methadone (i-Dolophine, i-Methadose); i-metoprolol (iLopressor, iTrolrol-XL); moxifloxacin (Avelox); i-nebivolol (Bystolic); nefazodone; i-ondansetron (iZofran, iZuplenz); i-perphenazine; ipimozide (i-Orap); i-phenobarbital; i-phenytoin (iDilantin, Phenytek); procainamide; i-quinidine (ku-Nuedexta); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); i-sotalol (iBetapace, iSorine, iSotylize); i-telaprevir (Incivek; ayisatholakali e-U.S.); i-telithromycin (Ketek); thioridazine; i-tolterodine (i-Detrol); kanye ne-venlafaxine (i-Effexor). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma unesifo noma uke waba nezinkinga zokopha noma isifo sesibindi.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. I-Panobinostat ingalimaza umbungu. Sebenzisa ukulawulwa kokuzalwa ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho ne-panobinostat futhi okungenani inyanga engu-1 ngemuva komthamo wokugcina. Uma uyindoda futhi umlingani wakho angakhulelwa, kufanele usebenzise ikhondomu ngenkathi usebenzisa lo muthi kanye nezinsuku ezingama-90 ngemuva kokuba ukwelashwa kwakho kuqediwe. Buza udokotela wakho uma unemibuzo mayelana nezinhlobo zokulawulwa kokuzalwa okuzokusebenzela. Uma ukhulelwa ngenkathi uthatha i-panobinostat, shayela udokotela wakho ngokushesha.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngenkathi uthatha i-panobinostat.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-panobinostat.

Ungadli ihalananda, izithelo zomvini noma isithelo senkanyezi noma uphuze izithelo zomvini noma ipomegranate ngenkathi uthatha lo muthi.

Uma sekuphele amahora ayi-12 noma ngaphansi selokhu behlelelwe ukuthatha umthamo, thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Uma sekudlule amahora angaphezu kwangu-12 kusukela kumthamo wakho ohleliwe, weqa umthamo bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Panobinostat ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuncipha komzimba
• ikhanda

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• okumnyama, okulindile, noma okokuchitha okunegazi
• ukuhlanza okunegazi noma okokuhlanza okubukeka njengezizathu zekhofi
• ukulimaza noma ukopha okungavamile
• umchamo obomvana noma onsundu
• igazi ku-phlegm
• ukudideka
• izinguquko enkulumweni yakho
• umkhuhlane, ukukhwehlela, ukubanda, ukujuluka noma ezinye izimpawu zokutheleleka
• isikhumba esiphaphathekile
• isicanucanu, ukuhlanza, ukungathandi ukudla, umchamo omnyama, ubuhlungu besisu, ukukhathala ngokweqile, ukungabi namandla, noma ukuphuzi kwesikhumba noma amehlo amhlophe

I-Panobinostat ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Ukugcine ekamelweni lokushisa kude nokukhanya, ukushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• isifo sohudo
• isicanucanu
• ukuhlanza
• ukuncipha kokudla

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UFarydak^®