I-Ivabradine

-Delile

• Ngaphambi kokuthatha i-ivabradine,
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Ivabradine isetshenziselwa ukwelapha abantu abadala abanesifo senhliziyo (isimo lapho inhliziyo ingakwazi ukupompa igazi elanele kwezinye izingxenye zomzimba) ukunciphisa ubungozi bokuthi isimo sabo sizoba sibi futhi sidinga ukwelashwa esibhedlela. Ibuye isetshenziselwe ukwelapha uhlobo oluthile lokwehluleka kwenhliziyo ezinganeni ezinezinyanga eziyisithupha ubudala nangaphezulu ngenxa ye-cardiomyopathy (isimo lapho imisipha yenhliziyo iba buthakathaka futhi ikhuliswe). I-Ivabradine isekilasini lemithi ebizwa nge-hyperpolarization-activated cyclic nucleotide-gated (HCN) block blockers. Isebenza ngokunciphisa izinga lokushaya kwenhliziyo ukuze inhliziyo ikwazi ukumpompa igazi eliningi emzimbeni njalo lapho ishaya.

I-Ivabradine iza njengethebhulethi futhi njengesisombululo somlomo (uketshezi) ukuthatha ngomlomo. Imvamisa kuthathwa ngokudla kabili ngosuku. Thatha i-ivabradine ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-ivabradine njengoba nje kuqondisiwe. Ungayithathi kancane, noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Amanye amaphilisi e-ivabradine eza nolayini phakathi nendawo. Uma udokotela wakho ekutshela ukuthi uthathe uhhafu wethebhulethi, wephule ngokucophelela kulayini. Thatha uhhafu wethebhulethi njengoba uqondisiwe, bese ugcine enye ingxenye ngomthamo wakho olandelayo.

Sebenzisa isirinji yomlomo (ithuluzi lokulinganisa) nenkomishi yomuthi ukukala ngokunembile futhi uthathe umthamo wakho wesisombululo se-ivabradine. Buza usokhemisi wakho ngenkomishi yomuthi uma eyodwa ingafakwanga nemithi yakho. Usokhemisi wakho uzokunikeza isirinji yomlomo esebenza kangcono ukukala umthamo wakho. Khipha sonke isixazululo esivela kuma-ampule (o) kuya enkomishini yemithi. Linganisa umthamo wakho kusuka enkomishini yemithi usebenzisa isirinji yomlomo. Landela imiyalelo yomkhiqizi mayelana nokuthi ungayisebenzisa kanjani futhi uyihlanze kanjani isirinji yomlomo. Buza udokotela wakho noma usokhemisi uma unemibuzo.

Uma uhlanza noma ukhafula ngemuva kokuthatha i-ivabradine, ungathathi omunye umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Udokotela wakho angakhuphula noma anciphise umthamo wakho ngemuva kwamasonto amabili kuye ngokuthi umuthi usebenza kanjani kuwe, kanye nemiphumela emibi oyitholayo. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngenkathi welashwa nge-ivabradine.

I-Ivabradine ilawula izimpawu zokwehluleka kwenhliziyo kepha ayiyelaphi. Qhubeka uthathe i-ivabradine noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-ivabradine ngaphandle kokukhuluma nodokotela wakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-ivabradine futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-ivabradine,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-ivabradine, noma imuphi omunye umuthi, noma iziphi izithako ezikumathebulethi e-ivabradine nesisombululo somlomo. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthatha ama-antibiotics athile afana ne-clarithromycin (Biaxin, e-Prevpac) ne-telithromycin (Ketek), ezinye izinto zokuvikela ezifana ne-itraconazole (i-Onmel, i-Sporanox), i-HIV protease inhibitors ethile efana ne-nelfinavir (i-Viracept) ne-nefazodone. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-ivabradine uma uphuza eyodwa noma ngaphezulu yale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: amiodarone (Nexterone, Pacerone); ama-beta blocker anjenge-atenolol (Tenormin, in Tenoretic), carteolol, labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, Corzide), propranolol (Inderal, InnoPran XL, Hemangeol, e-Inderide), i-sotalol (iBetapace, iSorine, iSotylize), ne-timolol; i-digoxin (i-Lanoxin); i-diltiazem (Cardizem, Cartia, Tiazac, abanye); i-phenobarbital; i-phenytoin (iDilantin, Phenytek); i-rifampin (Rifadin, Rifamate, Rifater, Rimactane); kanye ne-verapamil (Calan, Verelan, eTarka). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-ivabradine, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma unesifo senhliziyo esingajwayelekile noma esisheshayo, umfutho wegazi ophansi, i-pacemaker, izimpawu zokwehluleka kwenhliziyo ezisanda kuba zimbi, noma isifo sesibindi. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-ivabradine.
• utshele udokotela wakho uma uke waba nezinkinga zenhliziyo noma wake waba nazo.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Akufanele ukhulelwe ngenkathi uthatha i-ivabradine. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma ukhulelwa ngenkathi uthatha i-ivabradine shayela udokotela wakho.
• kufanele wazi ukuthi i-ivabradine ingathinta umbono wakho, ikakhulukazi lapho ukukhanya kokukhanya okuzungezile kushintsha. Lokhu kungafaka ukubona izindawo ezikhanyayo, imibuthano ekhanyayo ezungeze amalambu, amalambu anemibala egqamile, ukubona okuphindiwe, nezinye izinkinga ezingajwayelekile ngombono wakho. Lezi zinkinga zombono zivame kakhulu lapho uqala ukuthatha i-ivabradine futhi zivame ukuhamba ngemuva kwezinyanga ezimbalwa zokwelashwa ngalo muthi. Ungashayeli imoto, ikakhulukazi ebusuku, noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Uma ukhohlwa umthamo we-ivabradine, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla
• ukushaya kwenhliziyo okuhamba kancane noma okumile
• ubuhlungu besifuba noma ingcindezi
• ukuphefumula okuya kusiba kubi
• isiyezi
• ukukhathala ngokweqile
• ukungabi namandla
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe namehlo
• ubunzima bokugwinya noma ukuphefumula
• ukushaqeka

I-Ivabradine ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Lahla noma isiphi isisombululo somlomo esingasetshenzisiwe esisele enkomishini yemithi noma i-ampule.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ukushaya kwenhliziyo okuhamba kancane
• isiyezi
• ukukhathala ngokweqile
• ukungabi namandla

Gcina wonke ama-aphoyintimenti nodokotela wakho. Udokotela wakho uzohlola ukushaya kwenhliziyo yakho nomfutho wegazi ngezikhathi ezithile ukuze ahlole impendulo yomzimba wakho ku-ivabradine.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Corlanor^®