I-Sonidegib

-Delile

• Ngaphambi kokuthatha i-sonidegib,
• I-Sonidegib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukuthatha i-sonidegib bese ushayela udokotela wakho ngokushesha:

Kuzo zonke iziguli:

I-Sonidegib akufanele ithathwe ngabesifazane abakhulelwe noma abangakhulelwa. Kunobungozi obukhulu bokuthi i-sonidegib izodala ukulahleka kokukhulelwa noma idale ukuthi ingane izalwe inokukhubazeka kokuzalwa (izinkinga zomzimba ezikhona ngesikhathi sokuzalwa).

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-sonidegib futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma uvakashele iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Unganikeli ngegazi noma ngemikhiqizo yegazi ngenkathi uthatha i-sonidegib futhi okungenani izinyanga ezingama-20 ngemuva kokwelashwa kwakho.

Khuluma nodokotela wakho ngezingozi zokuthatha i-sonidegib.

Ezigulini zesifazane:

Uma ungakhulelwa, kuzodingeka ugweme ukukhulelwa ngesikhathi sokwelashwa kwakho nge-sonidegib. Kufanele ube nokuhlolwa kokukhulelwa okungekuhle ngaphambi kokuqala kokwelashwa kwakho. Kufanele usebenzise izindlela ezamukelekayo zokulawulwa kokubeletha ngesikhathi sokwelashwa kwakho futhi okungenani izinyanga ezingama-20 ukwelashwa kwakho kuqediwe. Udokotela wakho uzokutshela ukuthi yiziphi izindlela zokulawula ukubeletha ezamukelekayo.

Uma ucabanga ukuthi ukhulelwe, ungaphuthelwa ukuya esikhathini, noma uye ocansini ngaphandle kokulawula ukubeletha ngenkathi uthatha i-sonidegib noma kungakapheli izinyanga ezingama-20 ukwelashwa kwakho, shayela udokotela wakho ngokushesha.

Ezigulini zesilisa:

Kufanele usebenzise ikhondomu, noma ngabe une-vasectomy (ukuhlinzwa ukuvimbela isidoda ekuphumeni emzimbeni wakho futhi kubangele ukukhulelwa), ngaso sonke isikhathi lapho uhlangana ngokocansi nowesifazane okhulelwe noma okwazi ukukhulelwa ngenkathi uthatha i-sonidegib futhi okungenani izinyanga eziyi-8 ngemuva kokwelashwa kwakho. Tshela udokotela wakho ngokushesha uma uye ocansini olungaphephile nowesifazane ongakhulelwa noma uma ucabanga nganoma yisiphi isizathu ukuthi umlingani wakho ukhulelwe. Unganikeli ngesidoda ngenkathi uthatha i-sonidegib noma kungakapheli izinyanga eziyi-8 ngemuva kokwelashwa kwakho.

ISonidegib isetshenziselwa ukwelapha i-basal cell carcinoma (BCC; uhlobo lomdlavuza wesikhumba) kubantu abadala abanomdlavuza obuyile ngemuva kokuhlinzwa noma imisebe, noma kubantu abadala abangakwazi ukwelashwa ngokuhlinzwa noma ngemisebe. I-Sonidegib isekilasini lemithi ebizwa nge-hedgehog pathway inhibitors. Isebenza ngokuvimba ukusebenza kweprotheni ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukumisa noma ukubambezela ukusabalala kwamangqamuzana omdlavuza futhi kungasiza ekunciphiseni izicubu.

ISonidegib iza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa kanye ngosuku esiswini esingenalutho, okungenani ihora eli-1 ngaphambi noma amahora amabili ngemuva kokudla. Thatha i-sonidegib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-sonidegib njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Udokotela wakho angadinga ukuphazamisa noma ayeke ukwelashwa kwakho ngokuya ngempendulo yakho ku-sonidegib kanye neminye imiphumela emibi ohlangabezana nayo.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-sonidegib,

• Tshela udokotela wakho kanye nosokhemisi uma une-allergies ku-sonidegib, noma imiphi eminye imithi, noma iziphi izithako kuma-sonidegib capsules. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela noma ongayinikiwe, amavithamini kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: atazanavir (Reyataz); ezinye izinto zokuvikela ezifana ne-fluconazole (i-Diflucan), i-itraconazole (i-Onmel, i-Sporanox), i-ketoconazole, i-posaconazole (i-Noxafil), ne-voriconazole (i-Vfend); i-diltiazem (Cardizem, Cartia, Tiazac, abanye); i-efavirenz (iSustiva, e-Atripla); i-modafinil (i-Provigil); nefazodone; i-rifabutin (i-Mycobutin); i-rifampin (Rifadin, Rifamate, Rifater, Rimactane); i-saquinavir (i-Invirase); imithi ethile yokuquleka efana ne-carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), phenobarbital, ne-phenytoin (Dilantin, Phenytek); kanye ne-telithromycin (Ketek). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-sonidegib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-wort yaseSt.John ngenkathi uthatha i-sonidegib.
• Tshela udokotela wakho uma uke waba nesifo semisipha noma wake waba naso.
• tshela udokotela wakho uma uncelisa. Udokotela wakho angakutshela ukuthi ungancelisi ibele ngenkathi uthatha i-sonidegib nezinyanga ezingama-20 ngemuva kokwelashwa kwakho.

Khuluma nodokotela wakho ngokudla isithelo samagilebhisi nokuphuza ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa esivamile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Sonidegib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• ubuhlungu besisu
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba
• isicanucanu
• ukuhlanza
• shintsha emandleni okunambitha ukudla
• ukulahleka kwezinwele
• ukulunywa
• ubuthakathaka
• ukukhathala ngokweqile
• ubuhlungu
• uphuthelwe yizikhathi zokuya esikhathini

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukuthatha i-sonidegib bese ushayela udokotela wakho ngokushesha:

• ukuphazamiseka kwemisipha
• ubuhlungu bemisipha obungachazeki, ubumnene noma ubuthakathaka
• umchamo onombala omnyama noma we-cola
• ukuncipha kokuchama
• ukungakwazi ukuchama

I-Sonidegib inganciphisa ukuzala kwabesifazane. Khuluma nodokotela wakho ngezingozi zokuthatha i-sonidegib uma unenkinga mayelana nokuzala.

ISonidegib ingadala ukuthi ukukhula kuyeke kusenesikhathi ezinganeni. Lo muthi awunconywa ukuthi usetshenziswe ezinganeni.

I-Sonidegib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• U-Odomzo^®