I-Trifluridine ne-Tipiracil

-Delile

• Ngaphambi kokuthatha i-trifluridine ne-tipiracil,
• I-Trifluridine ne-tipiracil kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Inhlanganisela ye-trifluridine ne-tipiracil isetshenziselwa ukwelapha i-colon (amathumbu amakhulu) noma umdlavuza we-rectal osabalalele kwezinye izingxenye zomzimba kubantu asebevele belashwa ngeminye imishanguzo ye-chemotherapy noma abangakwazi ukuthola le mithi yokwelashwa ngamakhemikhali. Inhlanganisela ye-trifluridine ne-tipiracil nayo isetshenziselwa ukwelapha izinhlobo ezithile zomdlavuza wesisu noma umdlavuza osendaweni lapho isisu sihlangana khona nomphimbo (ishubhu eliphakathi komphimbo nesisu) esisabalalele kwezinye izingxenye zomzimba kubantu isivele ithole okungenani ezinye izindlela zokwelashwa ngamakhemikhali ezimbili. I-Trifluridine isekilasini lemithi ebizwa nge-thymidine-based nucleoside analogues. Isebenza ngokumisa ukukhula kwamangqamuzana omdlavuza. I-Tipiracil isekilasini lemithi ebizwa nge-thymidine phosphorylase inhibitors. Isebenza ngokunciphisa ukubola kwe-trifluridine ngumzimba.

Inhlanganisela ye-trifluridine ne-tipiracil iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa kabili ngosuku ngokudla izinsuku ezi-5 zilandelana, kulandelwe ikhefu lezinsuku ezi-2. Lolu hlelo lokulinganisa luyaphindwa bese lulandelwa ikhefu lamaviki amabili. Lo mjikelezo wezinsuku ezingama-28 ungaphindwa kuye ngokuthi lo muthi usebenza kanjani kuwe kanye nemiphumela emibi oyitholayo. Thatha i-trifluridine ne-tipiracil ngezikhathi ezifanayo nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-trifluridine ne-tipiracil njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Amathebulethi e-Trifluridine ne-tipiracil anamandla amabili ahlukene. Udokotela wakho angafuna ukuthi uthathe inhlanganisela yamandla womabili wamaphilisi ukwenza umthamo wakho ogcwele. Qiniseka ukuthi uyazi ukuthi uhlobo ngalunye lwethebhulethi lubukeka kanjani nokuthi uzothatha kangaki ngalunye. Buza udokotela wakho noma usokhemisi uma unemibuzo.

Udokotela wakho angabambezela ukwelashwa kwakho noma anciphise umthamo wakho we-trifluridine ne-tipiracil kuye ngemiphumela emibi oyitholayo. Qiniseka ukuthi ukhuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Ungayeki ukuthatha i-trifluridine ne-tipiracil ngaphandle kokukhuluma nodokotela wakho.

Geza izandla zakho ngemuva kokuphatha amaphilisi e-trifluridine kanye ne-tipiracil. Uma omunye umuntu ephatha amaphilisi akho e-trifluridine kanye ne-tipiracil, kufanele afake amagilavu ​​enjoloba noma e-latex ukuze isikhumba sawo singathintani namaphilisi.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-trifluridine ne-tipiracil,

• Tshela udokotela wakho kanye nosokhemisi uma une-aleji ku-trifluridine ne-tipiracil, noma imuphi omunye umuthi, noma iziphi izithako ezikumathebulethi e-trifluridine kanye ne-tipiracil. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha.
• utshele udokotela wakho uma uneminyaka engama-65 noma ngaphezulu, noma uke waba nesifo sesibindi noma sezinso.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uma uhlela ukuba nobaba wengane. Wena noma umlingani wakho akufanele ukhulelwe ngesikhathi sokwelashwa kwakho nge-trifluridine ne-tipiracil. Uma ungowesifazane, kuzodingeka ukuthi uhlolwe ukukhulelwa ngaphambi kokuqala ukwelashwa, futhi kufanele usebenzise ukuvimbela inzalo ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nezinyanga eziyisithupha ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma uyindoda futhi umlingani wakho angakhulelwa, kufanele usebenzise ikhondomu ngenkathi usebenzisa lo muthi, futhi izinyanga ezintathu ngemuva kokwelashwa kwakho. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthola i-trifluridine ne-tipiracil, shayela udokotela wakho ngokushesha. I-Trifluridine ne-tipiracil zingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Udokotela wakho uzokutshela ukuthi ungancelisi ngesikhathi sokwelashwa kwakho nosuku olungu-1 ngemuva komthamo wakho wokugcina.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa umthamo we-trifluridine ne-tipiracil, ungathathi omunye umthamo ukwenzela umthamo ongabanjwanga. Shayela udokotela wakho imiyalo yokuthi wenzeni ngomthamo olahlekile.

I-Trifluridine ne-tipiracil kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukulahleka kwezinwele
• shintsha ngendlela izinto ezinambitha ngayo
• ukulahlekelwa isifiso sokudla
• izilonda zomlomo noma ukuvuvukala emlonyeni
• ukungabi namandla
• ukukhathala ngokweqile

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• umkhuhlane, ubuhlungu bomzimba, amakhaza noma ezinye izimpawu zokutheleleka
• isicanucanu, ukuhlanza, isifo sohudo, noma ubuhlungu besisu obunzima noma obungapheli
• ubuthakathaka noma ukuphefumula kanzima lapho uzivocavoca
• isikhumba esiphaphathekile
• ubuhlungu besifuba
• ubuhlungu ngokuphefumula okujulile
• ekhwehlela igazi
• ukopha okungajwayelekile noma ukulinyazwa

I-Trifluridine ne-tipiracil kungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona.Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Uma ugcine lo muthi ngaphandle kwesitsha ungene, lahla wonke amaphilisi angasetshenziswanga ngemuva kwezinsuku ezingama-30.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-trifluridine ne-tipiracil.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Lonsurf^®