I-Cobicistat

-Delile

• Ngaphambi kokuthatha i-cobicistat,
• ICobicistat ingadala imiphumela emibi. Tshela udokotela wakho uma lesi sibonakaliso sinzima noma singapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

I-Cobicistat isetshenziselwa ukukhulisa inani le-atazanavir (Reyataz, e-Evotaz) kubantu abadala nezingane ezinesisindo okungenani esingamakhilogremu angama-35 noma i-darunavir (i-Prezista, e-Prezcobix) kubantu abadala nezingane ezinesisindo okungenani esingamakhilogremu angama-40 igazi lapho le mithi isetshenziselwa ukwelapha igciwane lengculazi (i-HIV). ICobicistat isekilasini lemithi ebizwa nge-cytochrome P450 3A (CYP3A) inhibitors. Isebenza ngokwandisa inani le-atazanavir noma i-darunavir emzimbeni ukuze babe nomthelela omkhulu.

ICobicistat iza njenge-tablet ezothathwa ngomlomo. Imvamisa kuthathwa ngokudla kanye ngosuku kanye ne-atazanavir noma i-darunavir. Thatha i-cobicistat ne-atazanavir noma i-darunavir ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-cobicistat njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Kubalulekile ukuthatha i-cobicistat njalo ngasikhathi sinye ne-atazanavir noma i-darunavir.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-cobicistat,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-cobicistat, noma imuphi omunye umuthi, noma iziphi izithako ezibhebheni ze-cobicistat. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• utshele udokotela wakho uma uthatha noma iyiphi yale mithi elandelayo: i-alfuzosin (i-Uroxatral); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol); i-cisapride (Propulsid) (ayitholakali e-U.S.); i-colchicine (Colcrys, Mitigare, ku-Col-Probenecid); i-dronedarone (iMultaq); imithi ye-ergot efana ne-dihydroergotamine (i-DHE 45, i-Migranal), i-ergotamine (i-Ergomar, eCafergot, eMigergot), ne-methylergonovine (Methergine); lomitapide (Juxtapid); i-lovastatin (Altoprev); i-lurasidone (Latuda); i-midazolam (ihunyushiwe) ngomlomo; i-phenobarbital; i-phenytoin (iDilantin, Phenytek); ipimozide (i-Orap); i-ranolazine (Ranexa); i-rifampin (Rimactane, Rifadin, eRifamate, eRifater); i-sildenafil (uphawu lwe-Revatio kuphela olusetshenziselwa isifo samaphaphu); simvastatin (Flolipid, Zocor); ISt John's wort; noma i-triazolam (Halcion). Uma uthatha i-atazanavir kanye ne-cobicistat, tshela udokotela wakho uma uthatha i-drospirenone ne-ethinyl estradiol (ezinye izindlela zokuvimbela inzalo ezinjengeBeyaz, iSafyral, iYasmin, iYaz, nezinye); indinavir (Crixivan), irinotecan (Camptosar), noma i-nevirapine (Viramune). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-cobicistat uma uthatha noma iyiphi yale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: ama-anticoagulants ('ama-thinner egazi') afana ne-apixaban (Eliquis), amandla powder (Bevyxxa), dabigatran (Pradaxa), edoxaban (Savaysa), rivaroxaban powder (Xarelto), ne-warfarin (Coumadin, Jantoven) ; imishanguzo yama-antiplatelet njenge-clopidogrel (i-Plavix) ne-ticagrelor (i-Brilinta); i-atorvastatin (Lipitor, eCaduet); ama-benzodiazepines afana ne-diazepam (Valium), i-estazolam, i-midazolam enikezwe ngemithambo (emthanjeni), ne-zolpidem (Ambien, Edluar, Intermezzo); ama-beta blocker afana ne-carvedilol (Coreg), metoprolol (Lopressor), ne-timolol; i-boceprevir (i-Victrelis) (ayitholakali e-U.S.); i-bosentan (iTracleer); i-buprenorphine (iBelbuca, i-Butrans, i-Probuphine); i-buprenorphine ne-naloxone (i-Suboxone, iZubsolv); buspirone; ama-calcium channel blocker afana ne-amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Tiazac, others), felodipine, nifedipine (Adalat, Afeditab, Procardia), kanye ne-verapamil (Calan, Verelan, abanye); i-clarithromycin (i-Biaxin, ku-PrevPac); i-corticosteroids efana ne-beclomethasone (i-Beconase AQ), i-budesonide (i-Rhinocort Aqua), i-ciclesonide (i-Omnaris), i-dexamethasone (i-Decadron), i-fluticasone (i-Flonase, i-Flovent), i-methylprednisolone (i-Medrol), i-momentasone (i-Flonase), ne-triamcinolone (i-Nasacort) i-dasatinib (i-Sprycel); i-efavirenz (iSustiva, e-Atripla); i-erythromycin (E.E.S, Erytab, abanye); i-etravirine (Intelence); fentanyl (Abstral, Actiq, Fentora, abanye); itraconazole (Onmel, Sporanox); ketoconazole; imishanguzo yokudangala njenge-amitriptyline, desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), paroxetine (Brisdelle, Paxil, Pexeva), ne-trazodone; imishanguzo yokushaya kwenhliziyo okungajwayelekile njenge-amiodarone (Cordarone, Nexterone, Pacerone), digoxin (Lanoxin), disopyramide (Norpace), flecainide, mexiletine, propafenone (Rythmol), ne-quinidine (eNuedexta); imishanguzo yokuquleka efana ne-clonazepam (iKlonopin), i-eslicarbazepine (i-Aptiom), ne-oxcarbazepine (i-Trileptal); imishanguzo ecindezela amasosha omzimba njenge-cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), ne-tacrolimus (Astagraf, Envarsus XR, Prograf); lopinavir (eKaletra); i-maraviroc (i-Selzentry); i-methadone (i-Dolophine, i-Methadose); i-nilotinib (iTasigna); izinto zokuvimbela inzalo ngomlomo (amaphilisi okuvimbela inzalo); i-perphenazine; i-phosphodiesterase (PDE5) inhibitors efana ne-avanafil (Stendra), i-sildenafil (i-Viagra), i-tadalafil (i-Adcirca, i-Cialis), ne-vardenafil (i-Levitra); i-quetiapine (iSeroquel); i-rifabutin (i-Mycobutin); i-risperidone (i-Risperdal); i-ritonavir (iNorvir, eKaletra); i-Rivaroxaban powder (i-Xarelto); i-rosuvastatin; i-salmeterol (iSerevent, e-Advair); simeprevir (Olysio); i-telaprevir (Incivek) (ayitholakali e-U.S.); i-telithromycin (Ketek); i-tenofovir (Viread, e-Atripla, Complera, Truvada, abanye), thioridazine; i-tramadol (i-Conzip, i-Ultram, ku-Ultracet); vinblastine; i-vincristine (iMarqibo Kit); kanye ne-voriconazole (Vfend). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-cobicistat ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• uma uthatha i-cobicistat ne-atazanavir futhi uthatha nama-antacids (Maalox, Mylanta, Tums, others), thatha amahora amabili ngaphambi noma amahora amabili ngemuva kwe-cobicistat ne-atazanavir.
• uma uthatha i-cobicistat ne-atazanavir futhi uthatha nomuthi we-indigestion, isilungulela, noma izilonda (H₂ blockers) njenge-cimetidine, i-famotidine (i-Pepcid, e-Duexis), i-nizatidine (i-Axid), noma i-ranitidine (i-Zantac), ibathathe ngasikhathi sinye noma okungenani amahora ayi-10 ngemuva kokuthatha i-H₂ vimba.
• uma uthatha i-cobicistat ne-atazanavir futhi uthatha nomuthi we-indigestion, isilungulela, noma izilonda (proton pump inhibitors) njenge-esomeprazole (Nexium, eVimovo), lansoprazole (Prevacid), omeprazole (Prilosec, eZegerid), pantoprazole (Protonix), noma i-rabeprazole (AcipHex) ibathatha okungenani amahora ayi-12 ngemuva kokuthatha i-proton pump inhibitor.
• tshela udokotela wakho uma uke waba nesifo sezinso noma sesibindi.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-cobicistat, shayela udokotela wakho. Akufanele uncelise ibele uma utheleleke nge-HIV noma uma uthatha i-cobicistat.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma umthamo wakho olandelayo ufanele amahora angu-12 noma ngaphezulu, thatha isilinganiso esilahlekile ngokushesha nje lapho usikhumbula. Kodwa-ke, uma umthamo olandelayo uzothathwa ngaphansi kwamahora we-12, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

ICobicistat ingadala imiphumela emibi. Tshela udokotela wakho uma lesi sibonakaliso sinzima noma singapheli:

• isicanucanu

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• ukuphuzi kwesikhumba noma kwamehlo
• ukuqubuka
• ukuncipha kokuchama

ICobicistat ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-cobicistat.

Gcina ukutholakala kwemithi kusesandleni. Ungalindi uze uphelelwe yimithi yokugcwalisa imishanguzo yakho.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Tybost^®

• I-Evotaz^® (equkethe i-Atazanavir, Cobicistat)
• I-Prezcobix^® (equkethe iCobicistat, iDarunavir)