Injection yeNusinersen

-Delile

• Ngaphambi kokuthatha umjovo we-nusinersen,
• Umjovo weNusinersen ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

Umjovo weNusinersen usetshenziselwa ukwelashwa kwe-spinal muscular atrophy (isimo esizuzwe njengefa esinciphisa amandla emisipha nokunyakaza) ezinganeni, ezinganeni nakubantu abadala. Umjovo weNusinersen usesigabeni semithi ebizwa nge-antisense oligonucleotide inhibitors. Isebenza ngokwandisa inani lamaprotheni athile adingekayo ukuze imisipha nezinzwa zisebenze ngokujwayelekile.

Umjovo weNusinersen uza njengesisombululo (uketshezi) ukujova nge-intrathecally (esikhaleni esigcwele uketshezi lomsele womgogodla). Umjovo weNusinersen unikezwa udokotela ehhovisi lezokwelapha noma emtholampilo. Imvamisa inikezwa njengemithamo yokuqala engu-4 (kanye njalo emavikini ama-2 ezilinganisweni zokuqala ezi-3 futhi futhi ezinsukwini ezingama-30 ngemuva komthamo wesithathu) bese inikezwa kanye ezinyangeni ezi-4 ngemuva kwalokho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha umjovo we-nusinersen,

• Tshela udokotela kanye nosokhemisi wakho uma une-aleji ku-nusinersen, noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-nusinersen. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma uke waba nesifo sezinso noma wake waba naso.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthola umjovo we-nusinersen, shayela udokotela wakho.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthola umjovo we-nusinersen.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa i-aphoyintimenti yokuthola umjovo we-nusinersen, shayela udokotela wakho khona manjalo ukuze uhlele kabusha isikhathi sakho. Udokotela wakho mhlawumbe uzokutshela ukuthi uqalise kabusha uhlelo lwakho lwangaphambilini ukuthola umjovo we-nusinersen, okungenani izinsuku eziyi-14 phakathi kwezilinganiso zokuqala ezi-4 nezinyanga ezi-4 phakathi kwemithamo yakamuva.

Umjovo weNusinersen ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuqunjelwa
• igesi
• ukuncipha komzimba
• ikhanda
• ukuhlanza
• ukuhlungu obusemhlane
• ukuwa
• ikhala eligobayo noma eligxishiwe, ukuthimula, umphimbo obuhlungu
• ubuhlungu bendlebe, umkhuhlane, noma ezinye izimpawu zokutheleleka endlebeni
• imfiva

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• ukopha okungajwayelekile noma ukulinyazwa
• ukuncipha kokuchama; umchamo ombala ophuzi, opinki noma onsundu; ukuvuvukala ezandleni, ebusweni, ezinyaweni noma esiswini
• ukuchama njalo, okuphuthumayo, okunzima, noma okubuhlungu
• ukukhwehlela, ukuphelelwa umoya, umkhuhlane, amakhaza

Umjovo weNusinersen unganciphisa ukukhula kwengane. Udokotela wengane yakho uzobuka ukukhula kwakhe ngokucophelela. Khuluma nodokotela wengane yakho uma unezinkinga ngokukhula kwengane yakho ngenkathi ithola lo muthi.

Umjovo weNusinersen ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda amalebhu athile ngaphambi kokuqala ukwelashwa, ngaphambi kokuthola umthamo ngamunye, futhi njengoba kudingeka ngesikhathi sokwelashwa ukuhlola impendulo yomzimba wakho kumjovo we-nusinersen.

Buza usokhemisi wakho noma imiphi imibuzo onayo ngomjovo we-nusinersen.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Spinraza^®