Ukujova kwe-Axicabtagene Ciloleucel

-Delile

• Ngaphambi kokuthola umjovo we-axicabtagene ciloleucel,
• I-Axicabtagene ciloleucel ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

Umjovo we-Axicabtagene ciloleucel ungadala impendulo ebucayi noma esongela impilo ebizwa nge-cytokine release syndrome (CRS). Udokotela noma umhlengikazi uzokuqapha ngokucophelela ngesikhathi sokumnika kwakho futhi okungenani amasonto ama-4 ngemuva kwalokho. Tshela udokotela wakho uma unesifo sokuvuvukala noma uma une noma ucabanga ukuthi ungaba nanoma yiluphi uhlobo lokutheleleka manje. Uzonikezwa imithi imizuzu engama-60 ngaphambi kokufakwa kwakho ukusiza ukuvimbela ukusabela ku-axicabtagene ciloleucel. Uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi sokumenyezelwa nangemuva kokumnika, tshela udokotela wakho ngokushesha: umkhuhlane, ukugodola, ukushaya kwenhliziyo okusheshayo noma okungajwayelekile, ukuqhaqhazela, isifo sohudo, ukukhathala, ubuthakathaka, ukuphefumula kanzima, ukuphefumula okuncane, ukudideka, isicanucanu, ukuhlanza, isiyezi , noma ikhanda elikhanyayo.

Umjovo we-Axicabtagene ciloleucel ungadala ukusabela okunzima noma okusongela ukuphila kohlelo oluphakathi lwezinzwa. Lokhu kusabela kungenzeka ngemuva kokwelashwa nge-axicabtagene ciloleucel. Tshela udokotela wakho uma uke wahlaselwa noma wahlaselwa isifo sohlangothi, noma ulahlekelwe yimemori. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, tshela udokotela wakho ngokushesha: ikhanda, isiyezi, ubunzima bokulala noma ukulala, ukungahlaliseki, ukudideka, ukukhathazeka, ukuthuthumela okungalawuleki kwengxenye ethile yomzimba, ukulahlekelwa ukwazi, ukuphazamiseka, ukuquleka, ukulahlekelwa ukulinganisela, ukuqonda ubunzima, noma ukukhuluma kanzima.

Umjovo we-Axicabtagene ciloleucel utholakala kuphela ngohlelo olukhethekile lokusabalalisa olukhawulelwe ngenxa yezingozi zeCRS kanye nobuthi bezinzwa. Ungathola kuphela umuthi kudokotela nasendaweni yokunakekelwa kwezempilo ebamba iqhaza kulolu hlelo. Buza udokotela wakho uma unemibuzo ngalolu hlelo.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-axicabtagene ciloleucel. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Umjovo we-Axicabtagene ciloleucel usetshenziselwa ukwelapha uhlobo oluthile lwe-non-Hodgkin's lymphoma (umdlavuza oqala kumaseli amhlophe egazi avame ukulwa nokutheleleka) obuyile noma ongaphenduli kolunye ukwelashwa kubantu asebevele belashwa okungenani eminye imithi emibili yokwelashwa ngamakhemikhali. Umjovo we-Axicabtagene ciloleucel usesigabeni semithi ebizwa nge-autologous cell immunotherapy, uhlobo lomuthi olungiselelwe kusetshenziswa amaseli avela egazini lesiguli uqobo. Isebenza ngokubangela amasosha omzimba omzimba (iqembu lamaseli, izicubu, nezitho ezivikela umzimba ekuhlaselweni amagciwane, amagciwane, amangqamuzana omdlavuza, nezinye izinto ezibangela izifo) ukulwa namaseli omdlavuza.

Umjovo we-Axicabtagene ciloleucel uza njengokumiswa (uketshezi) okuzofakwa ngaphakathi (emthanjeni) ngudokotela noma umhlengikazi ehhovisi likadokotela noma esikhungweni sokumnika. Imvamisa inikezwa isikhathi esifinyelela kumizuzu engama-30 njengomthamo wesikhathi esisodwa. Ngaphambi kokuthola umthamo wakho we-axicabtagene ciloleucel, udokotela wakho noma umhlengikazi uzokuphathisa eminye imithi yokwelapha ngamakhemikhali ukulungiselela umzimba wakho i-axicabtagene ciloleucel.

Ngaphambi kokuba unikezwe umjovo wakho we-axicabtagene ciloleucel, kuzothathwa isampula lamaseli akho amhlophe esikhungweni sokuqoqa amaseli kusetshenziswa inqubo ebizwa nge-leukapheresis (inqubo esusa amangqamuzana amhlophe egazi emzimbeni). Ngoba lo muthi wenziwa ngamaseli akho, kufanele unikezwe wena kuphela. Kubalulekile ukuthi ufike ngesikhathi futhi ungaphuthelwa ukuqokwa kwama (cell) okuhleliwe noma ukuthola umuthi wakho wokwelashwa. Kufanele uhlele ukuhlala eduze nalapho uthole khona ukwelashwa kwakho kwe-axicabtagene ciloleucel okungenani amasonto ama-4 ngemuva komthamo wakho. Umhlinzeki wakho wezokunakekelwa kwempilo uzohlola ukuthi ngabe ukwelashwa kwakho kuyasebenza yini futhi akubheke nganoma yimiphi imiphumela emibi engaba khona. Khuluma nodokotela wakho mayelana nokuthi ungayilungiselela kanjani i-leukapheresis nokuthi yini ongayilindela ngesikhathi nangemva kwenqubo.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-axicabtagene ciloleucel,

• Tshela udokotela wakho kanye nosokhemisi uma une-alexicabtagene ciloleucel, i-gentamicin, noma imuphi omunye umuthi, i-dimethyl sulfoxide (DMSO), noma ezinye izithako zomjovo we-axicabtagene ciloleucel. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-steroids efana ne-dexamethasone, i-methylprednisolone (i-Medrol), i-prednisolone, ne-prednisone (i-Rayos). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho uma ngabe uke waba nezinkinga zokuphefumula noma amaphaphu, izinso, inhliziyo, noma isifo sesibindi.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uzodinga ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa kwe-axicabtagene ciloleucel. Uma ukhulelwa ngenkathi uthola umjovo we-axicabtagene ciloleucel, shayela udokotela wakho ngokushesha.
• kufanele wazi ukuthi umjovo we-axicabtagene ciloleucel ungakwenza ukozele futhi ubangele ukudideka, ubuthakathaka, isiyezi, ukuqumba nezinkinga zokuhlanganisa. Ungashayeli imoto noma usebenzise imishini okungenani amasonto ayi-8 ngemuva komthamo wakho we-axicabtagene ciloleucel.
• unganikeli ngegazi, izitho, izicubu, noma amaseli ukufakelwa kabusha ngemuva kokuthola umjovo wakho we-axicabtagene ciloleucel.
• thintana nodokotela wakho ukuze ubone uma ngabe udinga ukuthola noma yimiphi imigomo. Ungabi nayo imigomo ngaphandle kokukhuluma nodokotela wakho okungenani amasonto ayisithupha ngaphambi kokuqala i-chemotherapy, ngesikhathi sokwelashwa kwe-axicabtagene ciloleucel, futhi kuze kube yilapho udokotela wakho ekutshela ukuthi amasosha omzimba wakho aseluleme.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa isikhathi sokuqokwa kwamaseli akho, kufanele ushayele udokotela wakho kanye nendawo yokuqoqa khona manjalo. Uma uphuthelwa ukuqokwa ukuze uthole umthamo wakho we-axicabtagene ciloleucel, kufanele ushayele udokotela wakho khona manjalo.

I-Axicabtagene ciloleucel ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuqunjelwa
• ubuhlungu besisu
• ukuhlungu obusemhlane
• ubuhlungu obuhlangene noma besisipha
• umlomo owomile
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• igazi emchameni
• ukopha kalula kunokujwayelekile
• umkhuhlane, umphimbo obuhlungu, amakhaza, noma ezinye izimpawu zokutheleleka
• kunciphise imvamisa yokuchama noma inani
• isikhumba esiphaphathekile
• ukukhathala
• ukuvuvukala kwamehlo, ubuso, izindebe, ulimi, umphimbo, izingalo, izandla, izinyawo, amaqakala noma imilenze engezansi
• ubunzima bokugwinya
• ukuqubuka
• isifuba
• ukulunywa

Umjovo we-Axicabtagene ciloleucel ungakhuphula ingozi yokuba nomdlavuza othile. Khuluma nodokotela wakho ngezingozi zokuthola lo muthi.

I-Axicabtagene ciloleucel ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina konke ukubonana nodokotela wakho, isikhungo sokuqoqwa kwamaseli, kanye nelabhorethri. Udokotela wakho anga-oda izivivinyo ezithile zelebhu ngaphambi, ngesikhathi, nangemva kokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho kumjovo we-axicabtagene ciloleucel.

Ngaphambi kokwenza noma yiluphi uvivinyo lwelabhoratri, tshela udokotela wakho nabasebenzi belebhuthi ukuthi uthola umjovo we-axicabtagene ciloleucel. Lo muthi ungathinta imiphumela yokuhlolwa okuthile kwelebhu.

Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nomjovo we-axicabtagene ciloleucel.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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