I-Acalabrutinib

-Delile

• Ngaphambi kokuthatha i-acalabrutinib,
• I-Acalabrutinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu yeka ukuthatha i-acalabrutinib bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Acalabrutinib isetshenziselwa ukwelapha abantu abane-mantle cell lymphoma (i-MCL; umdlavuza okhula ngokushesha oqala kumaseli amasosha omzimba) asebevele belashwa okungenani ngomunye umuthi wokwelashwa ngamakhemikhali. Ibuye isetshenziswe yodwa noma nge-obinutuzumab (Gazyva) ukwelapha i-leukemia engapheli (i-CLL; uhlobo lomdlavuza oqala kumaseli amhlophe egazi) kanye ne-lymphocytic lymphoma (SLL: uhlobo lomdlavuza oqala kumaseli amhlophe egazi) . I-Acalabrutinib isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba ukusebenza kweprotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunqanda ukusabalala kwamangqamuzana omdlavuza.

I-Acalabrutinib iza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa noma ngaphandle kokudla njalo emahoreni ayi-12 (kabili ngosuku) inqobo nje uma udokotela wakho encoma ukuthi uthole ukwelashwa. Thatha i-acalabrutinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-acalabrutinib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi ngengilazi yamanzi; ungavuli, ungahlafunisi noma uwaphule.

Udokotela wakho angamisa ukwelashwa kwakho okwesikhashana noma unomphela noma anciphise umthamo wakho we-acalabrutinib ngokuya ngemiphumela oyitholayo. Qiniseka ukuthi ukhuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Ungayeki ukuthatha i-acalabrutinib ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-acalabrutinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-acalabrutinib, noma imiphi eminye imithi, noma yiziphi izithako kuma-capsules e-acalabrutinib. Buza usokhemisi wakho noma uhlole Imininingwane Yesiguli ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imishanguzo ye-anticoagulant ('blood thinner') efana ne-warfarin (Coumadin); imishanguzo yama-antiplatelet ('blood thinners') njenge-aspirin, i-cilostazol, i-clopidogrel (i-Plavix), i-dipyridamole (i-Persantine, ku-Aggrenox), i-prasugrel (i-Effient), i-ticagrelor (i-Brilinta), ne-ticlodipine; diltiazem (Cardizem, Cartia, Diltzac, abanye); i-erythromycin (E.E.S., Eryc, Erythrocin, abanye); i-fluconazole (iDiflucan); itraconazole (Onmel, Sporanox); proton pump inhibitors njenge-dexlansoprazole (Dexilant), esomeprazole (Nexium, eVimovo), lansoprazole (Prevacid, e-Prevpac), omeprazole (Prilosec, e-Yosprala, Zegerid), pantoprazole (Protonix), ne-rabeprazole (Aciphex) kanye ne-rifampin (Rifadin, Rimactane, eRifater, Rifamate). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-acalabrutinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• uma uthatha i-cimetidine (Tagamet), i-famotidine (i-Pepcid, e-Duexis), i-nizatidine (i-Axid), noma i-ranitidine (i-Zantac) ithatha i-acalabrutinib okungenani amahora amabili ngaphambi kokuthatha le mithi.
• uma uthatha ama-antacids (Maalox, Mylanta, Tums, others) thatha i-acalabrutinib okungenani amahora amabili ngaphambi noma ngemuva kokuthatha le mithi.
• Tshela udokotela wakho uma unesifo noma uke wahlinzwa muva nje, noma uma uke waba nesifo sesibindi noma i-hepatitis B, izinkinga zesigqi senhliziyo yakho, noma izinkinga zokopha.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Akufanele ukhulelwe ngenkathi uthatha i-acalabrutinib. Akufanele uqale ukuthatha i-acalabrutinib kuze kube yilapho ukuhlolwa kokukhulelwa kubonise ukuthi awukhulelwe futhi kufanele usebenzise ukuvimbela ukukhulelwa ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho futhi okungenani isonto elilodwa ngemuva komthamo wakho wokugcina. I-Acalabrutinib ingalimaza ingane yakho engakazalwa. Uma ukhulelwa ngenkathi uthatha i-acalabrutinib, shayela udokotela wakho ngokushesha.
• tshela udokotela wakho uma uncelisa. Udokotela wakho angakutshela ukuthi ungancelisi ngesikhathi sokwelashwa kwakho kanye namaviki amabili ngemuva komthamo wakho wokugcina.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-acalabrutinib. Udokotela wakho angakutshela ukuthi uyeke ukuthatha i-acalabrutinib isikhathi esithile ngaphambi nangemva kokuhlinzwa noma inqubo.
• hlela ukugwema ukuvezwa yilanga ngokungadingekile noma isikhathi eside futhi ugqoke izingubo zokuzivikela, izibuko zelanga, nesikhumba selanga. I-Acalabrutinib ingenza isikhumba sakho sizwele emiphumeleni eyingozi yokukhanya kwelanga, futhi singakhuphula ubungozi bokuba nomdlavuza wesikhumba.

Khuluma nodokotela wakho ngokudla isithelo samagilebhisi nokuphuza ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekudlule amahora angaphezu kwamathathu selokhu umthamo ongabanjwanga, yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa okujwayelekile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Acalabrutinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• isicanucanu
• ukuhlanza
• ukuqunjelwa
• isifo sohudo
• ubuhlungu besisu
• ukuqubuka
• ukulinyazwa okuncane noma izindawo ezincane ezibomvu noma nsomi esikhunjeni
• ubuhlungu obuhlangene noma besisipha
• ukukhathala ngokweqile

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu yeka ukuthatha i-acalabrutinib bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• umkhuhlane, umphimbo obuhlungu, amakhaza, noma ezinye izimpawu zokutheleleka
• ukukhwehlela, ukuphelelwa umoya, ubuhlungu besifuba lapho uphefumula noma ukhwehlela, umkhuhlane
• ukushaya kwenhliziyo okusheshayo noma okungajwayelekile, ukushaya kwenhliziyo, ukuzwa ikhanda elincane noma isiyezi, ukuquleka, ukuphefumula, ubuhlungu besifuba
• ukopha okungavamile noma okunzima noma ukulinyazwa
• igazi kwizitulo zakho noma emnyama, izitulo zokulinda; umchamo obomvana noma onsundu; ukuhlanza igazi noma ikhofi emhlabathini; ekhwehlela igazi
• ukuzizwa unesiyezi, ubuthakathaka, noma udidekile; izinguquko enkulumweni; ikhanda elithatha isikhathi eside

I-Acalabrutinib ingakhuphula ubungozi bokuthola amanye amagciwane. Khuluma nodokotela wakho ngezingozi zokuthatha lo muthi.

I-Acalabrutinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-acalabrutinib.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Calquence^®