Inaliti ye-Gemtuzumab Ozogamicin

-Delile

• Ngaphambi kokuthola umjovo we-gemtuzumab ozogamicin,
• Umjovo we-Gemtuzumab ozogamicin ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Umjovo we-Gemtuzumab ozogamicin ungadala ukulimala kwesibindi okunzima noma okusongela ukuphila, kufaka phakathi isifo se-hepatic veno-occlusive (VOD; imithambo yegazi evinjiwe ngaphakathi kwesibindi). Tshela udokotela wakho uma uke waba nesifo sesibindi noma uke waba nokufakelwa kwe-stem-cell ye-hematopoietic (HSCT; inqubo efaka umongo wethambo onesifo ngomnkantsha onempilo). Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukuzuza ngokushesha kwesisindo, ubuhlungu noma ukuvuvukala engxenyeni engenhla kwesokudla yesisu, ukuphuzi kwesikhumba noma kwamehlo, isicanucanu, ukuhlanza, umchamo onombala omnyama, noma ukukhathala okukhulu.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ngaphambi, ngesikhathi, nangemva kokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho kumjovo we-gemtuzumab ozogamicin.

Khuluma nodokotela wakho ngezingozi zokuthatha umjovo we-gemtuzumab ozogamicin.

Umjovo we-Gemtuzumab ozogamicin usetshenziswa wedwa noma uhlanganiswe neminye imishanguzo ye-chemotherapy yokwelapha uhlobo oluthile lwe-acute myeloid leukemia (AML; uhlobo lomdlavuza oqala kumaseli egazi amhlophe) kubantu abadala nasezinyangeni ezineminyaka engu-1 nangaphezulu ababesanda kuba khona kutholakale ukuthi unalo mdlavuza. Ibuye isetshenziswe yodwa ukwelapha uhlobo oluthile lwe-AML kubantu abadala nasezinganeni ezineminyaka engu-2 ubudala nangaphezulu umdlavuza wayo owanda ngesikhathi nangemva kokwelashwa ngeminye imithi ye-chemotherapy. Umjovo we-Gemtuzumab ozogamicin usesigabeni semithi ebizwa ngama-antibody monoclonal. Isebenza ngokusiza ukubulala amangqamuzana omdlavuza.

Umjovo weGemtuzumab ozogamicin uza njengempuphu ezohlanganiswa noketshezi bese unikezwa ngenaliti noma ngepayipi elibekwe emthanjeni. Imvamisa ijovwa kancane esikhathini esingamahora ama-2. Udokotela wakho uzokutshela ukuthi uzowuthola kangaki umjovo we-gemtuzumab ozogamicin. Isheduli yokuncipha incike ekutheni welashwa ngeminye imithi yokwelashwa ngamakhemikhali, uma umdlavuza wakho wawukade uphathwa phambilini, nokuthi umzimba wakho uphendula kanjani kulowo muthi.

Umjovo we-Gemtuzumab ozogamicin ungadala ukusabela okungathi sína noma okusongela ukuphila ngesikhathi sokumnika kuze kube sosuku ngemuva kwalokho. Uzothola imithi ethile yokusiza ukuvimbela ukusabela ngaphambi kokuthola umthamo ngamunye we-gemtuzumab ozogamicin. Udokotela noma umhlengikazi uzokubuka eduze ngenkathi uthola ukumnika futhi ngemuva nje kokufakwa ukuze aqiniseke ukuthi awunampendulo emikhulu emithini. Tshela udokotela wakho noma umhlengikazi ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo ezingase zivele phakathi noma ngaphakathi kwamahora angama-24 ukumenyezelwa: ukuqubuka, imfiva, ukugodola, ukushaya kwenhliziyo okusheshayo, ukuvuvukala kolimi noma umphimbo, ukuphefumula kanzima noma ukuphefumula kanzima.

Udokotela wakho angahle anciphise ukumnika, abambezele, noma ayeke ukwelashwa kwakho ngomjovo we-gemtuzumab ozogamicin, noma akuphathe ngemithi eyengeziwe ngokuya ngempendulo yakho emithini kanye neminye imiphumela emibi ohlangabezana nayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi nangemva kokwelashwa kwakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-gemtuzumab ozogamicin,

• Tshela udokotela kanye nosokhemisi wakho uma une-aleji ku-gemtuzumab ozogamicin, noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-gemtuzumab ozogamicin. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: amiodarone (Cordarone, Nexterone, Pacerone), anagrelide (Agrylin), chloroquine, chlorpromazine, cilostazol, citalopram (Celexa), disopyramide (Norpace), dofetilide (Tikosyn), donepezil (Aricept, in Namzar ), dronedarone (Multaq), escitalopram (Lexapro), flecainide (Tambocor), fluconazole (Diflucan), haloperidol (Haldol), ibutilide (Corvert), methadone (Methadose, Dolophine), ondansetron (Zuplenz, Sofran), pimozide , procainamide, quinidine (eNuedexta), sotalol (Betapace, Sorine, Sotylize), ne-thioridazine. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingaxhumana nomjovo we-gemtuzumab ozogamicin, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• Tshela udokotela wakho uma wena noma omunye emndenini wakho enesifo se-QT eside (isimo esandisa ingozi yokuhlaselwa ukushaya kwenhliziyo okungajwayelekile okungadala ukuquleka noma ukufa ngokuzuma), noma uma uke waba nakho noma wake waba nakho noma ngaphezulu noma okuphansi noma okuphansi kunamazinga ajwayelekile we-sodium, potassium, calcium, noma i-magnesium egazini lakho.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uhlele ukuba nobaba wengane. Akufanele ukhulelwe ngenkathi uthola umjovo we-gemtuzumab ozogamicin. Uzodinga ukuthi ube nokuhlolwa kokukhulelwa okungekuhle ngaphambi kokuthi uqale ukuthola le mithi. Sebenzisa ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho ngomjovo we-gemtuzumab ozogamicin nezinyanga eziyisithupha ngemuva komthamo wakho wokugcina. Uma ungowesilisa futhi umlingani wakho angakhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho nezinyanga ezi-3 ngemuva komthamo wakho wokugcina. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthola umjovo we-gemtuzumab ozogamicin, shayela udokotela wakho.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngenkathi uthola umjovo we-gemtuzumab ozogamicin, kanye nenyanga engu-1 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala kwabesilisa nabesifazane. Khuluma nodokotela wakho ngezingozi zokuthola i-gemtuzumab ozogamicin.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Umjovo we-Gemtuzumab ozogamicin ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuqubuka
• isifo sohudo
• ukuqunjelwa
• isicanucanu
• ukuhlanza
• ikhanda
• ubuhlungu
• ubuhlungu, ukuvuvukala, noma izilonda emlonyeni noma emphinjeni

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukopha okungavamile noma okunzima noma ukulinyazwa
• ukukhwehlela, ukuphefumula okuncane, noma ukuphefumula kanzima
• ukushaya kwenhliziyo okusheshayo
• umkhuhlane, amakhaza, umphimbo obuhlungu, noma ezinye izimpawu zokutheleleka

Umjovo we-Gemtuzumab ozogamicin ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UMylotarg^®