Inaliti ye-Buprenorphine

-Delile

• Ngaphambi kokuthola umjovo we-buprenorphine,
• Umjovo wokukhishwa okwandisiwe kwe-Buprenorphine ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

Umjovo wokukhishwa okwandisiwe kweBuprenorphine utholakala kuphela ngohlelo olukhethekile lokusabalalisa olubizwa ngeSublocade REMS. Udokotela wakho kanye nekhemisi lakho kumele babhalise kulolu hlelo ngaphambi kokuthi uthole umjovo we-buprenorphine. Buza udokotela wakho ukuthola eminye imininingwane ngalolu hlelo nokuthi uzoyithola kanjani imithi yakho.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho anga-oda izivivinyo ezithile ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho kumjovo wokukhishwa okwandisiwe we-buprenorphine.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa ngomjovo wokukhishwa okwandisiwe we-buprenorphine futhi isikhathi ngasinye lapho ugcwalisa khona incwadi kadokotela. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ukuthola uMhlahlandlela Wezokwelapha.

Umjovo wokukhishwa okwandisiwe kwe-Buprenorphine usetshenziselwa ukwelapha ukuncika kwe-opioid (ukuluthwa yizidakamizwa ze-opioid, kufaka phakathi i-heroin kanye ne-painkillers ye-narcotic) kubantu abathole i-buccal noma i-buprenorphine yezilimi ezingezansi okungenani izinsuku eziyi-7. Umjovo wokukhishwa okwandisiwe kweBuprenorphine usekilasini lemithi ebizwa ngama-opiate agonists ayingxenye. Kusebenza ukuvimbela izimpawu zokuhoxa lapho umuntu eyeka ukuthatha izidakamizwa ze-opioid ngokukhiqiza imiphumela efanayo kule mithi.

Umjovo we-Buprenorphine enwetshiwe (osebenza isikhathi eside) uza njengesisombululo (uketshezi) sokujovwa ngomgogodla (ngaphansi kwesikhumba) ngumhlinzeki wezokunakekelwa kwempilo endaweni yesisu. Imvamisa inikezwa kanye ngenyanga okungenani izinsuku ezingama-26 phakathi kwamanani. Umjovo ngamunye we-buprenorphine ukhipha kancane kancane umuthi emzimbeni wakho ngaphezu kwenyanga.

Ngemuva kokuthola umthamo womjovo wokukhishwa okwandisiwe we-buprenorphine, ungaqaphela isigaxa endaweni yokujova amasonto ambalwa, kepha kufanele sehle ngosayizi ngokuhamba kwesikhathi. Ungahlikihli noma uhlikihle isiza somjovo. Qiniseka ukuthi ibhande noma okhalweni lwakho akufaki ingcindezi endaweni lapho umjovo wafakwa khona.

Udokotela wakho angakhuphula noma anciphise umthamo wakho ngokuya ngokuthi umuthi usebenza kanjani kuwe, kanye neminye imiphumela emibi oyitholayo. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho ngomjovo wokukhishwa okwandisiwe we-buprenorphine.

Uma ukukhishwa okwandisiwe kwe-buprenorphine kuzomiswa, udokotela wakho mhlawumbe uzokwehlisa umthamo wakho kancane kancane. Ungaba nezimpawu zokuhoxa okubandakanya ukungabi nakuphumula, amehlo ahlengezela izinyembezi, ukujuluka, ukugodola, ukunwetshwa kwabafundi (imibuthano emnyama phakathi kwamehlo), ukucasuka, ukukhathazeka, iqolo, ubuthakathaka, isisu, ubunzima bokulala noma ukulala, isicanucanu, ukulahlekelwa isifiso sokudla, ukuhlanza, isifo sohudo, ukuphefumula okusheshayo, noma ukushaya kwenhliziyo okusheshayo. Lezi zimpawu zokuhoxa zingavela ngenyanga engu-1 noma ngaphezulu ngemuva komthamo womjovo wakho wokugcina wokukhipha i-buprenorphine.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-buprenorphine,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-buprenorphine, noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-buprenorphine. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi kokulandelayo: ama-antihistamines; i-benzodiazepines efana ne-alprazolam (i-Xanax), i-chlordiazepoxide (i-Librium, e-Librax), i-clonazepam (i-Klonopin), i-diazepam (i-Valium), i-estazolam, i-flurazepam, i-lorazepam (i-Ativan), i-oxazepam, i-temazepam (i-Restoril), i-triazil) carbamazepine (Carbatrol, Tegretol, Teril, nabanye); isisu (‘amaphilisi amanzi’); i-erythromycin (E.E.S., Eryc, PCE, abanye); Imithi ye-HIV efana ne-atazanavir (Reyataz, e-Evotaz), delavirdine (Rescriptor), efavirenz (Sustiva, e-Atripla), etravirine (Intelence), indinavir (Crixivan), nevirapine (Viramune), ritonavir (Norvir, e Kaletra), nase saquina (I-Invirase); imishanguzo ethile yokushaya kwenhliziyo okungajwayelekile kubandakanya i-amiodarone (Nexterone, Pacerone), i-disopyramide (i-Norpace), i-dofetilide (iTikosyn), i-procainamide (i-Procanbid), i-quinidine (e-Nuedexta), ne-sotalol (i-Betapace, i-Betapace AF, i-Sorine); imithi ye-glaucoma, ukugula ngengqondo, ukugula okunyakazayo, isifo sikaParkinson, izilonda, noma izinkinga zomchamo; ketoconazole, eminye imithi yezinhlungu; imithi yezinhlungu ze-migraine ezifana ne-almotriptan (Axert), i-eletriptan (i-Relpax), i-frovatriptan (i-Frova), i-naratriptan (i-Amerge), i-rizatriptan (i-Maxalt), i-sumatriptan (i-Imitrex, i-Treximet), ne-zolmitriptan (iZomig); ukuphumula kwemisipha; i-phenobarbital; i-phenytoin (iDilantin, Phenytek); i-rifampin (i-Rifadin, i-Rimactane); isidambisi; amaphilisi okulala; 5HT3 i-serotonin blocker efana ne-alosetron (Lotronex), i-dolasetron (i-Anzemet), i-granisetron (i-Kytril), i-ondansetron (i-Zofran, i-Zuplenz), noma i-palonosetron (i-Aloxi); i-serotonin-reuptake inhibitors ekhethiwe njenge-citalopram (Celexa), i-escitalopram (Lexapro), i-fluoxetine (i-Prozac, i-Sarafem, e-Symbyax), i-fluvoxamine (i-Luvox), i-paroxetine (i-Brisdelle, i-Prozac, i-Pexeva) ne-sertraline (i-Zoloft); i-serotonin ne-norepinephrine reuptake inhibitors efana ne-duloxetine (Cymbalta), desvenlafaxine (Khedezla, Pristiq), milnacipran (Savella), ne-venlafaxine (Effexor); i-tramadol; okokunciphisa umzimba; i-trazodone; noma i-tricyclic antidepressants (’mood elevators’) njenge-amitriptyline, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactiline), ne-trimipramine. Phinda utshele udokotela noma usokhemisi wakho uma uthatha noma uthola ama-inhibitors alandelayo e-monoamine oxidase (MAO) noma uma uyekile ukuwaphuza emasontweni amabili edlule: isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil) , selegiline (i-Eldepryl, i-Emsam, iZelapar), noma i-tranylcypromine (iParnate). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingaxhumana ne-buprenorphine, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• Tshela udokotela wakho uma wena noma ilunga lomndeni liphuza noma wake waphuza utshwala obuningi noma uke waba ne-QT syndrome isikhathi eside (isimo esandisa ubungozi bokuba nokushaya kwenhliziyo okungajwayelekile okungadala ukulahlekelwa ukwazi noma ukufa ngokuzuma). Futhi, tshela udokotela wakho uma uke waba namazinga aphansi we-potassium noma i-magnesium egazini; ukwehluleka kwenhliziyo; ukushaya kwenhliziyo okuhamba kancane noma okungajwayelekile; isifo esingelapheki samaphaphu (COPD; iqembu lezifo ezithinta amaphaphu nemigwaqo yomoya); ezinye izifo zamaphaphu; ukulimala ekhanda; isimila ebuchosheni; noma isiphi isimo esandisa inani lengcindezi ebuchosheni bakho; izinkinga ze-adrenal ezifana nesifo se-Addison (isimo lapho i-adrenal gland ikhiqiza i-hormone encane kunokujwayelekile); i-benign prostatic hypertrophy (BPH, ukukhulisa i-prostate gland); ubunzima bokuchama; ukubona izinto ezingekho (ukubona izinto noma ukuzwa amazwi angekho); ijika emgogodleni elenza kube nzima ukuphefumula; noma isifo se-thyroid, gallbladder, noma sesibindi.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uma uthola umjovo wokukhishwa okwandisiwe kwe-buprenorphine njalo ngesikhathi ukhulelwe, ingane yakho ingathola izimpawu zokuhoxa ezisongela impilo ngemuva kokuzalwa. Tshela udokotela wengane yakho khona manjalo uma ingane yakho ihlangabezana nalezi zimpawu ezilandelayo: ukucasuka, ukukhathazeka ngokweqile, ukulala okungavamile, ukukhala okuphakeme, ukuzamazama okungalawuleki kwengxenye yomzimba, ukuhlanza, isifo sohudo, noma ukwehluleka ukukhuluphala.
• tshela udokotela wakho uma uncelisa. Tshela udokotela wengane yakho ngokushesha uma ingane yakho ilele ngaphezu kokujwayelekile noma inenkinga yokuphefumula ngenkathi uthola lo muthi.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala kwabesilisa nabesifazane. Khuluma nodokotela wakho ngezingozi zokusebenzisa umjovo wokukhishwa okwandisiwe kwe-buprenorphine.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthola umjovo wokukhishwa okwandisiwe we-buprenorphine.
• kufanele wazi ukuthi umjovo wokukhipha i-buprenorphine enwetshiwe ungakwenza ukozele. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.
• akufanele uphuze utshwala noma usebenzise izidakamizwa zasemgwaqeni ngenkathi welashwa. Ukuphuza utshwala, ukuthatha imishanguzo kadokotela noma engeyona imishanguzo equkethe utshwala, noma ukusebenzisa izidakamizwa zasemgwaqeni ngenkathi welashwa ngomjovo we-buprenorphine kwandisa ingozi yokuthi uzohlangabezana nezinkinga zokuphefumula ezinzima nezisongela impilo.
• kufanele wazi ukuthi i-buprenorphine ingadala isiyezi, ikhanda elikhanyayo, nokuquleka lapho uvuka ngokushesha okukhulu kusuka endaweni elele. Ukugwema le nkinga, phuma embhedeni kancane, uphumule izinyawo zakho phansi imizuzu embalwa ngaphambi kokuma.
• kufanele wazi ukuthi i-buprenorphine ingadala ukuqunjelwa. Khuluma nodokotela wakho ngokushintsha indlela odla ngayo noma usebenzise eminye imithi ukuvimbela noma ukwelapha ukuqunjelwa ngenkathi usebenzisa umjovo we-buprenorphine.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa umthamo we-buprenorphine owandisiwe wokukhipha umjovo, kufanele ushayele udokotela wakho ukuthola umthamo ngokushesha okukhulu. Umthamo wakho olandelayo kufanele unikezwe okungenani ezinsukwini ezingama-26 kamuva.

Umjovo wokukhishwa okwandisiwe kwe-Buprenorphine ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• ikhanda
• ukukhathala
• ubuhlungu, ukulunywa, ukuvuvukala, ukungakhululeki, ububomvu, ukulimaza, noma izigaxa kusiza somjovo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuphefumula kanzima
• ukuyaluza, ukubona izinto ezingekho (ukubona izinto noma ukuzwa amazwi angekho), umkhuhlane, ukujuluka, ukudideka, ukushaya kwenhliziyo okusheshayo, ukuqhaqhazela, ukukhuluma okungaqinile, ukuqina kwemisipha okunzima noma ukudikiza, ukulahlekelwa ukuhlangana, isicanucanu, ukuhlanza noma isifo sohudo
• isicanucanu, ukuhlanza, ukungathandi ukudla, ukuba buthakathaka, noma isiyezi
• ukungakwazi ukuthola noma ukugcina ukwakhiwa
• ukuya esikhathini okungajwayelekile
• kwehle isifiso sobulili
• ukuqubuka
• isifuba
• ukulunywa
• inkulumo engahambi kahle
• ukungaboni kahle
• izinguquko ekushayeni kwenhliziyo
• ubuhlungu engxenyeni engenhla kwesokudla yesisu
• ukuphuzi kwesikhumba noma kwamehlo
• umchamo onombala omnyama
• indle enombala okhanyayo

Umjovo wokukhishwa okwandisiwe kwe-Buprenorphine ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ukunciphisa noma ukunweba kwabafundi (imibuthano emnyama maphakathi neso)
• ukuphuza kancane noma ubunzima bokuphefumula
• ukulala ngokweqile noma ukozela
• ikhoma (ukulahlekelwa ukwazi isikhathi esithile)
• ukushaya kwenhliziyo okuhamba kancane

Ngaphambi kokwenza noma yiluphi uvivinyo lwe-laboratory (ikakhulukazi lezo ezibandakanya i-methylene blue), tshela udokotela wakho kanye nabasebenzi be-laboratory ukuthi usebenzisa umjovo we-buprenorphine.

Esimweni esiphuthumayo, ilungu lomndeni noma umnakekeli kufanele atshele abasebenzi bezokwelapha eziphuthumayo ukuthi uncike ngokomzimba ku-opioid futhi uthola ukwelashwa ngomjovo wokukhishwa okwandisiwe we-buprenorphine.

Umjovo wokukhishwa okwandisiwe kweBuprenorphine yinto elawulwayo. Qiniseka ukuthi uhlela ama-aphoyintimenti nodokotela wakho njalo ukuthola imijovo yakho. Buza usokhemisi wakho uma unemibuzo.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Sublocade^®