I-Baricitinib

-Delile

• Ngaphambi kokuthatha i-baricitinib,
• I-Baricitinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

IBaricitinib okwamanje ifundelwa ukwelashwa kwesifo se-coronavirus 2019 (COVID-19) ngokuhlanganiswa ne-remdesivir (Veklury). I-FDA igunyaze Ukugunyazwa Kokusetshenziswa Okuphuthumayo (i-EUA) ukuvumela ukusatshalaliswa kwe-baricitinib ukwelapha abantu abadala abathile nezingane ezineminyaka emibili kuya phezulu abalala esibhedlela ngegciwane le-COVID-19.

Ukuthatha i-baricitinib kunganciphisa ikhono lakho lokulwa nokutheleleka futhi kwandise ingozi yokuthi uzothola ukutheleleka okungathi sína, kufaka phakathi ukutheleleka okunzima kwe-fungal, bacterial, noma virus okusakazeka emzimbeni. Lezi zifo zingadinga ukwelashwa esibhedlela futhi zingadala nokufa. Tshela udokotela wakho uma uvame ukuthola noma yiluphi uhlobo lokutheleleka noma uma ucabanga ukuthi ungaba nanoma yiluphi uhlobo lokutheleleka manje. Lokhu kufaka ukutheleleka okuncane (njengokusikeka okuvulekile noma izilonda), izifo ezifika zidlule (njengezilonda ezibandayo), kanye nezifo ezingamahlalakhona ezingapheli. Tshela udokotela wakho uma uphuza imishanguzo eyehlisa ukusebenza kohlelo lokuzivikela komzimba njengokulandelayo: i-abatacept (i-Orencia); i-adalimumab (Humira); i-azathioprine (Azasan, Imuran); isitifiketi se-certolizumab (Cimzia); i-cyclosporine (Gengraf, Neoral, Sandimmune); i-etanercept (Enbrel); i-golimumab (iSimponi); infliximab (i-Remicade); leflunomide (Arava); i-methotrexate (i-Otrexup; i-Rasuvo, i-Trexall); i-rituximab (i-Rituxan); sarilumab (Kevzara); ama-steroids afaka i-dexamethasone, i-methylprednisolone (Medrol), i-prednisolone (i-Prelone), ne-prednisone (i-Rayos); i-tocilizumab (Actemra); kanye ne-tofacitinib (Xeljanz).

Udokotela wakho uzokuqapha ngezibonakaliso zokutheleleka ngesikhathi nangemva kokwelashwa kwakho. Uma unezinye zalezi zimpawu ezilandelayo ngaphambi kokuba uqale ukwelashwa kwakho noma uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngokushesha ngemuva kokwelashwa kwakho, shayela udokotela wakho ngokushesha: umkhuhlane; ukujuluka; Ukugodola; ubuhlungu bemisipha; ukukhwehlela; ukuphelelwa umoya; ukuncipha komzimba; isikhumba esifudumele, esibomvu, noma esibuhlungu; izilonda esikhumbeni; imizwa ejwayelekile, ebuhlungu, noma evuthayo ngesikhathi sokuchama; uhudo, noma ukukhathala ngokweqile.

Kungenzeka ukuthi usungenwe yisifo sofuba (i-TB; ukutheleleka okungathi sína kwamaphaphu) kodwa ungenazo izimpawu zesifo. Kulokhu, ukuthatha i-baricitinib kungenza ukutheleleka kwakho kube kubi kakhulu futhi kukwenze ube nezimpawu. Udokotela wakho uzohlola isikhumba ukuze abone ukuthi une-TB engasebenzi yini ngaphambi nangesikhathi sokwelashwa kwakho nge-baricitinib. Uma kunesidingo, udokotela wakho uzokunika imithi yokwelapha lesi sifo ngaphambi kokuba uqale ukuthatha i-baricitinib. Tshela udokotela wakho uma uke waba ne-TB noma wake waba nayo, uma wake wahlala noma wavakashela izwe lapho i-TB ijwayelekile khona, noma uma wake waba seduze komuntu one-TB. Uma unalezi zimpawu ezilandelayo ze-TB, noma uma uba nalezi zimpawu phakathi nokwelashwa kwakho, shayela udokotela wakho ngokushesha: ukukhwehlela, ukukhwehlela amafinyila anegazi, ukwehla kwesisindo, ukulahleka kwethoni lezicubu, noma umkhuhlane.

Ukuthatha i-baricitinib kungandisa ingozi yokuthi uzoba ne-lymphoma (umdlavuza oqala kumaseli alwa nokutheleleka) noma ezinye izinhlobo zomdlavuza. Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo lomdlavuza noma wake waba nalo.

IBaricitinib ingakhuphula ubungozi begazi elibucayi futhi elisongela impilo emaphashini noma emilenzeni. Uma uhlangabezana nanoma yimiphi imiphumela emibi elandelayo, shayela udokotela wakho noma uthole ukwelashwa okuphuthumayo ngokushesha: ukuchoboza ubuhlungu besifuba noma isisindo sesifuba; ukuphelelwa umoya; ukukhwehlela; ubuhlungu, imfudumalo, ubomvu, ukuvuvukala, noma isisa somlenze; noma umuzwa obandayo ezingalweni, ezandleni, noma emilenzeni; noma ubuhlungu bemisipha.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho ku-baricitinib.

Khuluma nodokotela wakho ngengozi (s) yokuthatha i-baricitinib.

I-Baricitinib isetshenziswa yodwa noma neminye imithi yokwelapha i-rheumatoid arthritis (isimo lapho umzimba uhlasela khona amalunga ayo okubangela ubuhlungu, ukuvuvukala, nokulahleka komsebenzi) kubantu abadala abangaphendulanga kahle ku-inhibitor eyodwa noma ngaphezulu ye-tumor necrosis factor (TNF) imithi. UBaricitinib usesigabeni semithi ebizwa ngeJanus kinase (JAK) inhibitors. Isebenza ngokunciphisa umsebenzi wamasosha omzimba.

IBaricitinib iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa noma ngaphandle kokudla kanye ngosuku. Thatha i-baricitinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-baricitinib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Udokotela wakho kungadingeka ukuthi ayeke ukwelashwa okwesikhashana noma unomphela uma uba nemiphumela emibi ethile. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-baricitinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-baricitinib, noma imuphi omunye umuthi, noma iziphi izithako ezikumaphilisi e-baricitinib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imithi efakwe kuhlu esigabeni ESIBALULEKILE SESEXWAYISO noma okulandelayo: i-probenecid (i-Probalan, ku-Col-Probenecid). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma unezinhlungu esiswini ezingakatholakali noma uma uke waba ne-diverticulitis (ukuvuvukala kolwelwesi lwamathumbu amakhulu), i-anemia, i-herpes zoster (ama-shingles; ukuqubuka okungenzeka kubantu ipopox esikhathini esedlule), noma isifo sesibindi noma sezinso.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uma ukhulelwa ngenkathi uthatha i-baricitinib, shayela udokotela wakho.
• tshela udokotela wakho uma uncelisa. Ungancelisi ngesikhathi uthatha i-baricitinib.
• utshele udokotela wakho uma usanda kuthola noma uhlelelwe ukuthola noma yimiphi imigomo. Ungabi nayo imigomo ngesikhathi sokwelashwa kwakho ngaphandle kokukhuluma nodokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Baricitinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• ubuhlungu besisu
• umkhuba wamathumbu uyashintsha

IBaricitinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Ngaphambi kokwenza noma yiluphi uvivinyo lwe-laboratory, tshela udokotela wakho kanye nabasebenzi be-laboratory ukuthi uthatha i-baricitinib.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Olumiant^®