Encorafenib

-Delile

• Ngaphambi kokuthatha i-encorafenib,
• I-Encorafenib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Encorafenib isetshenziswa kanye ne-binimetinib (Mektovi) ukwelapha izinhlobo ezithile ze-melanoma (uhlobo lomdlavuza wesikhumba) oluye lwasakazekela kwezinye izingxenye zomzimba noma olungasuswa ngokuhlinzwa. Ibuye isetshenziswe ne-cetuximab (i-Erbitux) ukwelapha uhlobo oluthile lomdlavuza wekoloni kubantu abadala oluye lwasakazeka kwezinye izingxenye zomzimba ngemuva kolunye ukwelashwa. I-Encorafenib isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba ukusebenza kweprotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukumisa noma ukubambezela ukusabalala kwamangqamuzana omdlavuza.

I-Encorafenib iza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa noma ngaphandle kokudla kanye ngosuku. Thatha i-encorafenib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-encorafenib njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Uma uhlanza ngemuva kokuphuza umuthi, ungathathi omunye umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Udokotela wakho angancipha noma ayeke ukwelashwa kwakho okwesikhashana noma unomphela kuye ngokuthi uhlangabezana yini neminye imiphumela engemihle. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngenkathi welashwa nge-encorafenib.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-encorafenib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-encorafenib, noma imiphi eminye imishanguzo, noma iziphi izithako ezikuma-encorafenib capsules. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• utshele udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi} oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: amiodarone (Nexterone, Pacerone), carbamazepine (Carbatrol, Teril, others), citalopram (Celexa), clarithromycin (Biaxin, e-Prevpac), diltiazem (Cardizem, Cartia, Diltzac, others), disopyramide (Norpace), erythromycin (EES, PCE, abanye), efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), itraconazole (Onmel, Sporanox), ketoconazole, modafinil (Provigil), nefazodone, nelfinavir (Viracept) ), phenobarbital, phenytoin (Dilantin, Phenytek), procainamide, quinidine (eNuedexta), rifampin (Rifadin, Rimactane, eRifamate, eRifater), ritonavir (Norvir, eKaletra), sotalol (Betapace, Sotapilize), UCalan, uVerelan, eTarka). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-encorafenib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma uke waba nesikhathi esandisiwe se-QT (isigqi senhliziyo esingajwayelekile esingaholela ekuphelelweni amandla, ekulahlekelweni ukwazi, ekuqulekeni, noma ekufeni okungazelelwe), amazinga aphansi we-potassium noma i-magnesium egazini lakho, ukwehluleka kwenhliziyo, noma isifo sesibindi.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Kuzofanele wenze ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa. Kufanele usebenzise ukulawulwa kokuzalwa okungenayo i-hormonal ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nge-encorafenib kanye namasonto ama-2 ngemuva komthamo wakho wokugcina. I-Encorafenib inganciphisa ukusebenza kahle kokuvimbela inzalo ngomlomo (amaphilisi okulawula ukubeletha), ngakho-ke kubaluleke kakhulu ukusebenzisa indlela yokulawula ukubeletha engeyona eyehomoni. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ukhulelwa ngenkathi uthatha i-encorafenib, shayela udokotela wakho ngokushesha. I-Encorafenib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Ungancelisi ibele ngenkathi uthatha i-encorafenib namasonto ama-2 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala emadodeni. Khuluma nodokotela wakho ngezingozi zokuthatha i-encorafenib.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma kungaphakathi kwamahora angu-12 womthamo olandelayo, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Encorafenib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukukhathala
• imfiva
• isicanucanu
• ubuhlungu besisu
• ukuqunjelwa
• ikhanda
• isiyezi
• ububomvu, ukuvuvukala, ukuba ndikindiki nokuxobuka kwesikhumba nezinyawo zakho
• ukuqina kwesikhumba
• ukuqubuka
• isikhumba esomile
• ukulahleka kwezinwele
• ubuhlungu obuhlangene noma besisipha
• shintsha ukunambitheka
• ukuhlungu obusemhlane
• induna
• ukuphuma kwamakhala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• isiyezi, ukuquleka, noma ukuzwa ukuquleka
• umbono uyashintsha
• izinguquko zesikhumba ezifana ne-wart entsha, iqhubu elibuhlungu noma elibomvu elingapholi, ushintsho kusayizi noma kumbala wemvukuzane
• ukopha okungajwayelekile noma ukulinyazwa
• okumnyama, okulindile, noma okokuchitha okunegazi
• ekhwehlela igazi

I-Encorafenib ingadala ingozi yokwanda komdlavuza, kufaka phakathi umdlavuza wesikhumba. Udokotela wakho uzohlola isikhumba sakho ngaphambi kokwelashwa, njalo ezinyangeni ezimbili ngenkathi welashwa, futhi kuze kube izinyanga eziyisithupha ngemuva komthamo wakho wokugcina we-encorafenib ukuthola izimpawu zomdlavuza wesikhumba. Khuluma nodokotela wakho ngezingozi zokuthatha lo muthi.

I-Encorafenib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Ungayisusi i-desiccant (i-agent eyomisa) ebhodleleni.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina konke ukubonana nodokotela wakho, udokotela wamehlo, kanye nelabhorethri. Udokotela wakho uzoku-oda ukuhlolwa kwelebhu ngaphambi kokuba uqale ukwelashwa kwakho ukuze ubone ukuthi umdlavuza wakho ungelashwa nge-encorafenib. Udokotela wakho angalawula izivivinyo ezithile zelebhu, kufaka phakathi izivivinyo zamehlo, ukuhlola impendulo yomzimba wakho ku-encorafenib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UBraftovi^®