UDuvelisib

-Delile

• Ngaphambi kokuthatha i-duvelisib,
• I-Duvelisib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Duvelisib ingadala izifo ezinkulu noma ezisongela impilo. Tshela udokotela wakho uma unesifo, noma uma uke waba ne-cytomegalovirus (CMV; ukutheleleka ngegciwane okungadala izimpawu ezigulini ezinamasosha omzimba abuthakathaka). Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: umkhuhlane, umphimbo obuhlungu, ukugodola, ukuphelelwa umoya, noma ezinye izimpawu zokutheleleka.

I-Duvelisib ingadala isifo sohudo noma i-colitis (ukuvuvukala kwamathumbu amakhulu). Tshela udokotela wakho uma unesifo sohudo noma uma uke waba nesifo sokudlikiza noma ezinye izimo ezithinta isisu noma amathumbu akho. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukwanda kwenani lokuhamba kwamathumbu ngosuku, igazi esitokisini sakho, noma yisiphi isisu noma ubuhlungu besisu.

I-Duvelisib ingadala ukusabela kwesikhumba okungathi sína noma okusongela ukuphila. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukuqubuka okusha noma okuba kubi kakhulu, ukuqubuka ngomkhuhlane, ukuqubuka okunesilonda, amabhamuza noma isikhumba esikhanyayo, noma izilonda ezibuhlungu noma izilonda esikhunjeni sakho, ezindebeni, noma emlonyeni wakho.

I-Duvelisib ingadala i-pneumonitis ebucayi noma esongela impilo (ukuvuvukala kwamaphaphu). Tshela udokotela wakho uma unesifo samaphaphu noma unenkinga yokuphefumula. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukukhwehlela okusha noma okuya kuba kubi, ukuphefumula kanzima, ukuphefumula, noma ukuphefumula okuncane.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho ku-duvelisib.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-duvelisib futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

I-Duvelisib isetshenziselwa ukwelapha i-lymphocytic leukemia (CLL; uhlobo lomdlavuza oluqala kumaseli amhlophe egazi) noma i-lymphocytic lymphoma (SLL; uhlobo lomdlavuza oluqala kakhulu kuma-lymph node) olubuyile noma olungaphenduli ku ezinye izindlela zokwelashwa okungenani ezimbili. Ibuye isetshenziselwe ukwelapha izinhlobo ezithile ze-follicular lymphoma (FL; uhlobo lomdlavuza oluqala kumaseli amhlophe egazi) kubantu abadala abanomdlavuza obuyile noma ongaphenduli kokunye okungenani ukwelashwa okubili. UDuvelisib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba amasiginali abangela ukuthi amangqamuzana omdlavuza ande. Lokhu kusiza ukunqanda ukusabalala kwamangqamuzana omdlavuza.

UDuvelisib uza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa kabili ngosuku noma ngaphandle kokudla. Thatha i-duvelisib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-duvelisib njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya lonke iphilisi; ungavuli, ungahlafunisi noma uwaphule.

Udokotela wakho anganciphisa umthamo wakho we-duvelisib noma akutshele ukuthi uyeke ukuthatha umuthi isikhashana noma unomphela uma uba nemiphumela emibi ngesikhathi sokwelashwa kwakho. Lokhu kuncike ekutheni umuthi usebenza kanjani kuwe kanye nemiphumela emibi oyitholayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Qhubeka uthathe i-duvelisib noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-duvelisib ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-duvelisib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-duvelisib, noma imuphi omunye umuthi, noma iziphi izithako ezikuma-duvelisib capsules. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunomsoco, okwenzayo noma ohlela ukukuthatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: carbamazepine (Epitol, Tegretol, Teril, others); i-clarithromycin (i-Biaxin); imishanguzo esetshenziselwa ukwelapha igciwane lesandulela-ngculazi (i-HIV) njenge-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ne-ritonavir (Norvir, kwezinye); itraconazole (Onmel, Sporanox); ketoconazole, midazolam; nefazodone; i-phenobarbital; i-phenytoin (iDilantin, Phenytek); i-pioglitazone (Actos); i-rifabutin (i-Mycobutin); kanye ne-rifampin (Rifadin, Rimactane, eRifamate). Eminye imithi eminingi ingase futhi ihlanganyele ne-duvelisib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• utshele udokotela wakho uma uke waba nesifo sesibindi noma wake waba naso.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Kufanele uhlolwe ukukhulelwa ngaphambi kokuba uqale ukuthatha i-duvelisib. Akufanele ukhulelwe ngesikhathi sokwelashwa kwakho nge-duvelisib. Uma ungowesifazane, kufanele usebenzise ukuvimbela inzalo ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nge-duvelisib futhi okungenani inyanga eyodwa ngemuva komthamo wakho wokugcina. Uma ungowesilisa futhi umlingani wakho angakhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho nenyanga engu-1 ngemuva komthamo wakho wokugcina. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-duvelisib, shayela udokotela wakho ngokushesha. UDuvelisib angalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngenkathi uthatha i-duvelisib futhi okungenani inyanga eyodwa ngemuva komthamo wakho wokugcina.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa umthamo we-duvelisib ngaphansi kwamahora angu-6, thatha isilinganiso esilahlekile ngokushesha nje lapho usikhumbula bese uthatha umthamo olandelayo ngesikhathi esihleliwe. Kodwa-ke, uma uphuthelwa umthamo ngaphezu kwamahora we-6, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Duvelisib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• ukuqunjelwa
• ukukhathala
• ikhanda
• imisipha noma ukujoyina ubuhlungu

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• amehlo aphuzi noma isikhumba; ubuhlungu besisu; ukulinyazwa noma ukopha okungachazwanga; ukulahlekelwa ukudla; umchamo ophuzi noma onsundu; indle ephaphathekile; noma ubuhlungu engxenyeni engaphezulu kwesokudla yesisu

I-Duvelisib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• ICopiktra^®