Inaliti ye-Pegvaliase-pqpz

-Delile

• Ngaphambi kokusebenzisa umjovo we-pegvaliase-pqpz,
• Umjovo wePegvaliase-pqpz ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, yeka ukusebenzisa umjovo we-pegvaliase-pqpz bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Umjovo wePegvaliase-pqpz ungadala ukusabela okweqile noma okusongela impilo. Lokhu kusabela kungenzeka ngemuva nje kokujova kwakho noma nganoma yisiphi isikhathi lapho welashwa. Umthamo wokuqala kufanele unikezwe udokotela noma umhlengikazi endaweni yokunakekelwa kwezempilo lapho lezi zindlela zokuphathwa zingelashwa nalapho ungabhekelwa khona okungenani ihora elilodwa ngemuva komjovo. Udokotela wakho angakunika imithi ethile ngaphambi kokuthola umjovo we-pegvaliase-pqpz ukusiza ukuvimbela ukusabela. Udokotela wakho uzokunika umshini wokufaka umjovo othomathikhi we-epinephrine (i-Adrenaclick, i-Auvi-Q, i-EpiPen, abanye) ukwelapha ukusabela okwehlisa impilo. Udokotela wakho uzokufundisa wena kanye nomnakekeli wakho ukuthi ungayisebenzisa kanjani le mithi nokuthi ungazibona kanjani izimpawu zempendulo engezwani. Phatha umjovo we-epinephrine ngaso sonke isikhathi. Uma uhlangabezana nalezi zimpawu ezilandelayo nganoma yisiphi isikhathi ngesikhathi sokwelashwa kwakho, sebenzisa umjovo we-epinephrine futhi uthole ukunakekelwa kwezimo eziphuthumayo ngokushesha: ubunzima bokugwinya noma ukuphefumula; ukuphelelwa umoya; ukushaya; ukushaqeka; ukuvuvukala kobuso, umphimbo, ulimi noma izindebe; isifuba; ukuqhuma noma ukubomvu ngokungazelelwe kobuso, intamo noma isifuba esingenhla; ukuqubuka; ukulunywa; ukubomvu kwesikhumba; ukuquleka; isiyezi; ubuhlungu besifuba noma ukungahambi kahle; ukuqina komphimbo noma isifuba; ukuhlanza; isicanucanu; isifo sohudo; noma ukulahlekelwa ukulawula isinye.

Ngenxa yezingozi zalo muthi, umjovo we-pegvaliase-pqpz utholakala kuphela ngohlelo olukhethekile lokusabalalisa olukhawulelwe olubizwa ngePalynziq^® Uhlelo Lokuhlola Izingozi Namasu Okunciphisa (REMS). Wena, udokotela wakho, kanye nosokhemisi wakho kufanele nibhalise kulolu hlelo ngaphambi kokuba nithole umjovo we-pegvaliase-pqpz. Buza udokotela wakho uma unemibuzo mayelana nokuthi uzowuthola kanjani umuthi wakho.

Umhlinzeki wakho wezokunakekelwa kwezempilo uzokunikeza iPalynziq^® ikhadi lokuphepha lesiguli elichaza izimpawu zokungezwani komzimba ongaba nazo ngalo muthi. Phatha leli khadi njalo ngezikhathi zokwelashwa kwakho. Kubalulekile ukukhombisa iPalynziq yakho^® ikhadi lokuphepha lesiguli kunoma yimuphi omunye umhlinzeki wezokunakekelwa kwempilo okwelapha.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho kumjovo we-pegvaliase-pqpz.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa ngomjovo we-pegvaliase-pqpz futhi isikhathi ngasinye lapho uthola umuthi. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Umjovo wePegvaliase-pqpz usetshenziswa kanye nokudla okuthile ukunciphisa amazinga e-phenylalanine egazi kubantu abane-phenylketonuria (PKU; isimo esingokwemvelo lapho i-phenylalanine ingakha egazini futhi ibangele ukwehla kobuhlakani kanye nokwehla kwekhono lokugxila, ukukhumbula, kanye ukuhlela imininingwane) futhi abanamazinga wegazi phenylalanine angalawulwa. Umjovo wePegvaliase-pqpz usesigabeni semithi ebizwa ngama-enzyme. Isebenza ngokusiza ukunciphisa inani le-phenylalanine emzimbeni.

Umjovo wePegvaliase-pqpz uza njengesisombululo (uketshezi) ukujova ngomgogodla (ngaphansi nje kwesikhumba). Imvamisa ijovwa kanye ngesonto amasonto ama-4, bese inyuka kancane kancane emasontweni ama-5 alandelayo iye kanye ngosuku. Udokotela wakho uzoshintsha umthamo wakho ngokususelwa ekuphenduleni komzimba wakho emithini. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Sebenzisa umjovo we-pegvaliase-pqpz njengoba kuqondisiwe. Ungayisebenzisi ngaphezulu noma ngaphansi kwayo noma uyisebenzise kaningi kunokuyalelwa ngudokotela wakho.

Ngaphambi kokusebenzisa umjovo we-pegvaliase-pqpz, bheka isixazululo eduze. Umuthi kufanele ucacele ophuzi okhanyayo futhi ungenazinhlayiya ezintantayo. Uma umuthi unamafu, ukhaliphile, noma uqukethe izinhlayiya, ungawusebenzisi. Unganyakazisi isirinji oyithandayo.

Ungajova umjovo we-pegvaliase-pqpz ngaphambili kwamathanga akho noma kuphi esiswini sakho ngaphandle kwenkaba yakho (inkinobho yesisu) nendawo engamasentimitha ama-2 ukuyizungeza. Uma omunye umuntu ejova umuthi wakho, ingaphezulu lesinqe nendawo engaphandle yezingalo ezingaphezulu nayo ingasetshenziswa. Ungawufaki umuthi esikhumbeni esithambile, esilimele, esibomvu, esiqinile, noma esingaphelele, noma esinezibazi, izinsumpa, ama-tattoos, noma imihuzuko. Khetha indawo ehlukile njalo lapho ufaka umuthi, okungenani amasentimitha ama-2 ukusuka endaweni oyisebenzise ngaphambili. Uma kudingeka umjovo ongaphezu koyedwa ngomthamo owodwa, amasayithi wokujova kufanele okungenani abe ngamasentimitha ama-2 ukusuka komunye nomunye kepha angaba sengxenyeni eyodwa yomzimba noma engxenyeni ehlukile yomzimba.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa umjovo we-pegvaliase-pqpz,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-pegvaliase, noma imiphi eminye imithi, noma yiziphi izithako zomjovo we-pegvaliase-pqpz. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: eminye imithi ye-PEGylated efana ne-griseofulvin (Gris-Peg), medroxyprogesterone (Depo-Provera, kwabanye), noma imithi ye-peg-interferon (Pegasys, Peg-Intron, Sylatron, abanye). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi usebenzisa umjovo we-pegvaliase-pqpz, shayela udokotela wakho.

Landela uhlelo lwakho lokudla ngokucophelela. Udokotela wakho uzoqapha inani lamaprotheni ne-phenylalanine olidlayo futhi uliphuze ngesikhathi sokwelashwa kwakho.

Uma umthamo ungabanjwanga, jovelela umthamo wakho olandelayo njengoba kuhleliwe. Musa ukujova umthamo ophindwe kabili ukwenzela okulahlekile.

Umjovo wePegvaliase-pqpz ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ububomvu, ukulunywa, ubuhlungu, ukulinyazwa, ukuqubuka, ukuvuvukala, isisa endaweni yomjovo
• ubuhlungu obuhlangene
• ikhanda
• ubuhlungu besisu
• ubuhlungu bomlomo nomphimbo
• ngizizwe ngikhathele
• ukukhathazeka
• ukulahleka kwezinwele

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, yeka ukusebenzisa umjovo we-pegvaliase-pqpz bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuqubuka, ukulunywa, isifuba, noma ubomvu besikhumba okuhlala okungenani izinsuku eziyi-14

Umjovo wePegvaliase-pqpz ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ukuze ivikele ekukhanyeni, ivalwe ngokuqinile, futhi ingafinyeleleki ezinganeni. Yigcine esiqandisini; ungafrizi. Futhi ingagcinwa ekamelweni lokushisa izinsuku ezingama-30. Lapho umuthi usugcinwe ekamelweni lokushisa, ungawubuyiseli esiqandisini.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ungavumeli omunye umuntu asebenzise imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Palynziq^®