UGilteritinib

-Delile

• Ngaphambi kokuthatha i-gilteritinib,
• IGilteritinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Gilteritinib ingadala iqembu lezimpawu ezibucayi noma ezisongela ukuphila elibizwa nge-differentiation syndrome. Udokotela wakho uzokuqapha ngokucophelela ukuze abone ukuthi uyayihlakulela yini le syndrome. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: umkhuhlane, ukukhwehlela, ukuqubuka, ukukhuluphala okungazelelwe, isiyezi, ukuncipha kokuchama, ukuvuvukala kwezingalo noma imilenze yakho, ukuphefumula kanzima, ukuphefumula kanzima, ubuhlungu besifuba, noma ubuhlungu bamathambo. Lezi zimpawu zingavela ezinyangeni ezintathu ngemuva kokuqala ukwelashwa nge-gilteritinib. Esibonakalisweni sokuqala sokuthi uthuthukisa isifo sokuhlukanisa, udokotela wakho uzokunikeza imithi yokwelapha lesi sifo, futhi angakutshela ukuthi uyeke ukuthatha i-gilteritinib isikhathi esithile.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-gilteritinib futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo.Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

I-Gilteritinib isetshenziselwa ukwelapha uhlobo oluthile lwe-acute myeloid leukemia (AML) eye yambi kakhulu noma yabuyela emuva kokwelashwa ngeminye imithi ye-chemotherapy. UGilteritinib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sento ethile eyenzeka ngokwemvelo engadingeka ukusiza amangqamuzana omdlavuza ukuba ande.

IGilteritinib iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa kanye ngosuku noma ngaphandle kokudla okungenani izinyanga eziyisithupha. Thatha i-gilteritinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-gilteritinib njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya amaphilisi wonke ngamanzi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Udokotela wakho angalungisa umthamo wakho noma ayeke ukwelashwa kwakho okwesikhashana noma unomphela kuye ngokuthi umuthi usebenza kanjani kuwe futhi uma uhlangabezana neminye imiphumela emibi. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Qhubeka uthathe i-gilteritinib noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-gilteritinib ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-gilteritinib,

• Tshela udokotela wakho kanye nosokhemisi uma une-allergil ku-gilteritinib, noma imuphi omunye umuthi, noma iziphi izithako kumaphilisi e-gilteritinib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi kokulandelayo: ama-antifungal athile afana ne-fluconazole (Diflucan), i-itraconazole (i-Onmel, i-Sporanox), ne-ketoconazole; i-clarithromycin (i-Biaxin, ku-PrevPac); i-escitalopram (iLexapro); i-fluoxetine (i-Prozac); imishanguzo ethile yegciwane lesandulela-ngculazi (i-HIV) noma i-immunodeficiency syndrome (i-AIDS) efana ne-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, e Kaletra), kanye i-saquinavir (i-Invirase); imithi ethile yokuquleka efana ne-carbamazepine (Carbatrol, Epitol, Tegretol, abanye), phenobarbital, ne-phenytoin (Dilantin, Phenytek); nefazodone; i-pioglitazone (Actos); i-rifabutin (i-Mycobutin); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); kanye ne-sertraline (iZoloft). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingase futhi ihlanganyele ne-gilteritinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma ngabe uke waba nesikhathi esandisiwe se-QT (isigqi senhliziyo esingajwayelekile esingaholela ekuqulekeni, ekulahlekelweni ukwazi, kokuquleka, noma ekufeni okungazelelwe); ukushaya kwenhliziyo okuhamba kancane, okusheshayo, noma okungajwayelekile; noma amazinga aphansi we-potassium noma i-magnesium egazini lakho.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uma uhlela ukuba nobaba wengane. Wena noma umlingani wakho akufanele ukhulelwe ngenkathi uthatha i-gilteritinib. Uma ungowesifazane, kuzodingeka uhlolwe ukukhulelwa okungenani ezinsukwini eziyi-7 ngaphambi kokuqala ukwelashwa, futhi kufanele usebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa kwakho nezinyanga eziyisithupha ngemuva komthamo wakho wokugcina. Uma ungowesilisa, wena nomlingani wakho kufanele nisebenzise ukuvimbela inzalo ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nezinyanga ezi-4 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-gilteritinib, shayela udokotela wakho. IGilteritinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngesikhathi sokwelashwa kwakho nge-gilteritinib nezinyanga ezimbili ngemuva komthamo wakho wokugcina.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma kungaphansi kwamahora angu-12 ngaphambi komthamo wakho olandelayo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

IGilteritinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubuhlungu obuhlangene noma besisipha
• ukukhathala ngokweqile
• isicanucanu
• ukuhlanza
• isifo sohudo
• izilonda zomlomo
• shintsha emandleni okunambitha ukudla
• ikhanda
• ukulahlekelwa isifiso sokudla
• ubunzima bokulala noma ukulala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuquleka; ikhanda; ukunciphisa ukuqapha; ukudideka; noma izinguquko zombono
• ukushesha, ukushaya ngamandla, noma ukushaya kwenhliziyo okungajwayelekile; ukuquleka; ukulahlekelwa ukwazi; noma ukuquleka
• ubuhlungu obuqhubekayo obuqala endaweni yesisu kepha bungasabalala buye emuva okungenzeka noma ngaphandle kwesicanucanu nokuhlanza

IGilteritinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzoku-oda ukuhlolwa kwelebhu ngaphambi kokuba uqale ukwelashwa kwakho ukuze ubone ukuthi umdlavuza wakho ungelashwa nge-gilteritinib. Udokotela wakho uzophinde a-ode izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-gilteritinib. Udokotela wakho angaphinde ahlele i-electrocardiogram (ECG; ukuhlolwa okulinganisa umsebenzi kagesi enhliziyweni) ngaphambi nangesikhathi sokwelashwa kwakho.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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