Cladribine

-Delile

• Ngaphambi kokuthatha i-cladribine,
• I-Cladribine ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Cladribine ingandisa ingozi yokuthi uzoba nomdlavuza. Tshela udokotela wakho uma uke waba nomdlavuza noma wake waba nawo. Udokotela wakho angakutshela ukuthi ungathathi i-cladribine.Khuluma nodokotela wakho ngalokho okufanele ukwenze ukuze uhlole izimpawu zomdlavuza ezifana nokuzihlola nokuhlolwa kokuhlolwa.

Khuluma nodokotela wakho ngezingozi zokuthatha i-cladribine.

Ungathathi i-cladribine uma ukhulelwe noma uhlela ukukhulelwa. Uma ukhulelwa ngenkathi uthatha i-cladribine, yeka ukuthatha i-cladribine bese ushayela udokotela wakho ngokushesha. Kukhona ingozi yokuthi i-cladribine ingadala ukulahleka kokukhulelwa noma ibangele ukuthi ingane izalwe inokukhubazeka kokuzalwa (izinkinga zomzimba ezikhona lapho kuzalwa).

Udokotela wakho uzohlola ukuthi ngabe ukhulelwe ngaphambi kokuba uqale inkambo ngayinye yokwelashwa. Kufanele usebenzise ukulawulwa kokuzalwa ukuvimbela ukukhulelwa phakathi nenkambo ngayinye yokwelashwa nge-cladribine futhi okungenani izinyanga eziyisithupha ngemuva komthamo wakho wokugcina wesifundo ngasinye sokwelapha. Uma usebenzisa izindlela zokuvimbela inzalo ze-hormonal (estrogen) (amaphilisi okulawula ukubeletha, amapeshi, izindandatho, okufakelwa emzimbeni, noma imijovo) kufanele futhi usebenzise enye indlela yokulawula ukubeletha phakathi nenkambo ngayinye yokwelashwa nge-cladribine futhi okungenani amasonto ama-4 ngemuva komthamo wakho wokugcina inkambo ngayinye yokwelashwa. Uma ungowesilisa onomlingani wesifazane ongakhulelwa, qiniseka ukusebenzisa ukulawulwa kokubeletha phakathi nenkambo ngayinye yokwelashwa nge-cladribine futhi okungenani izinyanga eziyisithupha ngemuva komthamo wakho wokugcina wesifundo ngasinye sokwelapha. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi nangemva kokwelashwa kwakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-cladribine futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

I-Cladribine isetshenziselwa ukwelapha abantu abadala abanezinhlobo ezibuyela emuva ze-multiple sclerosis (MS; isifo lapho izinzwa zingasebenzi kahle futhi abantu bangathola ubuthakathaka, ukuba ndikindiki, ukulahleka kokuhlangana kwemisipha, nezinkinga ngombono, ukukhuluma, nokulawula isinye), kufaka phakathi amafomu okubuyisela emuva (izifo lapho izimpawu zivela khona ngezikhathi ezithile) kanye namafomu asebenzayo okuqhubekayo okuqhubekayo (inkambo yesifo elandela inkambo yokubuyisela emuva lapho izimpawu ziba zimbi kakhulu ngokuhamba kwesikhathi). I-Cladribine ivame ukusetshenziswa ezigulini esezizame olunye ukwelashwa kwe-MS. I-Cladribine ekilasini lemithi ebizwa nge-purine antimetabolites. Isebenza ngokumisa amaseli athile amasosha omzimba ekulimaleni kwemizwa.

I-Cladribine iza njengethebhulethi yokuphuza ngomlomo ngamanzi. Imvamisa kuthathwa nokudla noma ngaphandle kokudla, kanye ngosuku izinsuku ezine noma ezi-5 zilandelana umjikelezo owodwa wokwelashwa. Umjikelezo wesibili wokwelashwa kufanele uphindwe ngemuva kwezinsuku ezingama-23 kuye kwezingu-27 ukuqeda inkambo eyodwa yokwelashwa. Inkambo yesibili (imijikelezo yokwelashwa emi-2) ivame ukunikezwa okungenani amasonto angama-43 ngemuva komthamo wokugcina womjikelezo wesibili. Thatha i-cladribine ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-cladribine njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Susa ithebhulethi kuphakethe le-blister ngezandla ezomile bese ugwinya ithebhulethi khona lapho. Nciphisa isikhathi lapho ithebhulethi ixhumana khona nesikhumba sakho. Gwema ukuthinta amakhala, amehlo, nezinye izitho zomzimba wakho. Ngemuva kokuthatha umuthi, geza izandla zakho kahle ngamanzi. Uma ithebhulethi ihlangana nanoma yiziphi izindawo noma ezinye izingxenye zomzimba wakho, zigeze kahle ngamanzi zisuka.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-cladribine,

• Tshela udokotela wakho kanye nosokhemisi uma ungenwe i-cladribine, noma imiphi eminye imithi, noma yiziphi izithako ezisemaphilisi e-cladribine. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: i-cilostazol; i-dipyridamole (i-Persantine, ku-Aggrenox); i-elrombopag (i-Promacta); i-furosemide (i-Lasix); i-gabapentin (i-Gralise, i-Horizant, i-Neurontin); ibuprofen (Advil, Midol, Motrin, abanye); i-interferon beta (Avonex, Betaseron, Extavia, Rebif); i-lamivudine (i-Epivir, ku-Epzicom); imishanguzo ecindezela amasosha omzimba njenge-azathioprine (Azasan), cyclosporine (Gengraf, Neoral, Sandimmune), methotrexate (Otrexup, Rasuvo, Trexall, Xatmep), sirolimus (Rapamune), ne-tacrolimus (Astagraf, Envarsus, Prograf); i-nifedipine (i-Adalat, iProcardia); nimodipine (Nymalize); qamba kabusha; i-ribavirin (iRebetol, iRibasphere, iVirazole); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); i-ritonavir (iNorvir, eKaletra, eTechnivie, eViekira); i-stavudine (iZerit); ama-steroids afana ne-dexamethasone (i-Decadron, i-Dexpak), i-methylprednisolone (i-Medrol), ne-prednisone (i-Rayos); sulindac; kanye ne-zidovudine (Retrovir, eCombivir, eTrizivir). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingase futhi ihlanganyele ne-cladribine, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• uma usebenzisa noma imuphi omunye umuthi ngomlomo, wuphuze amahora amathathu ngaphambi noma ngemuva kwamahora amathathu ngemuva kokufakwa kwi-cladribine.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi i-curcumin neSt.
• Tshela udokotela wakho uma unegciwane lengculazi (i-HIV), i-hepatitis (igciwane elithelela isibindi futhi lingadala ukulimala kwesibindi), isifo sofuba (i-TB; ukutheleleka okungathi sína okuthinta amaphaphu kwesinye isikhathi nezinye izingxenye zomzimba), noma nezinye izifo eziqhubekayo. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-cladribine.
• utshele udokotela wakho uma uke waba nesifo sesibindi, sezinso, noma senhliziyo.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngesikhathi somjikelezo wokwelashwa, nangezinsuku eziyi-10 ngemuva komthamo wokugcina womjikelezo wokwelashwa.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-cladribine.
• awunawo umuthi wokugoma phakathi kwamasonto amane kuya kwayisithupha ngaphambi, ngesikhathi, noma ngemuva kokwelashwa kwakho nge-cladribine ngaphandle kokukhuluma nodokotela wakho. Khuluma nodokotela wakho mayelana nokuthi kufanele yini uthole noma yimiphi imigomo ngaphambi kokuba uqale ukwelashwa kwakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje uma uwukhumbula ngosuku olufanayo. Kodwa-ke, uma kungathathiwanga ngosuku oluhleliwe, bese uthatha umthamo ongabanjwanga ngosuku olulandelayo bese ufaka olunye usuku kulowo mjikelezo wokwelashwa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Cladribine ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• isicanucanu
• ukuhlungu obusemhlane
• ubuhlungu obuhlangene nokuqina
• ubunzima bokulala noma ukulala
• ukudana
• ukulahleka kwezinwele
• ukuluma, ukulunywa, noma ukushisa izilonda ezinsinini, ezindebeni, noma emlonyeni

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• umkhuhlane, umphimbo obuhlungu, amakhaza, imisipha ebuhlungu noma ebuhlungu, ukukhwehlela, noma ezinye izimpawu zokutheleleka
• ukukhwehlela, ubuhlungu besifuba, ukukhwehlela igazi noma amafinyila, ubuthakathaka noma ukukhathala, ukuncipha komzimba, ukungathandi ukudla, ukugodola, umkhuhlane, ukujuluka ebusuku
• ukuqubuka okubuhlungu okunamabhamuza
• ukushisa, ukuqaqamba, ukuba ndikindiki, noma ukulunywa kwesikhumba
• ukuqubuka, ukuphefumula kanzima noma ukugwinya, ukuvuvukala noma ukulunywa kobuso, izindebe, ulimi, noma umphimbo
• Ukugodola, umkhuhlane, isicanucanu, ukuhlanza, izinhlungu emhlane, ohlangothini, noma emgodini, ukuchama kaningi futhi okubuhlungu
• ukopha okungajwayelekile noma ukulinyazwa
• ubuthakathaka ohlangothini olulodwa lomzimba wakho, ukulahleka kokuxhumanisa ezingalweni noma emilenzeni, ukunciphisa amandla, izinkinga ngokulinganisela, ukudideka, izinguquko kumbono wakho, ukucabanga, inkumbulo, noma ubuntu
• ukuphefumula, ukushaya kwenhliziyo okusheshayo, ikhanda elibuhlungu, isiyezi, isikhumba esiphaphathekile, ukudideka, ukukhathala
• isicanucanu, ukuhlanza, ukukhathala ngokweqile, ukulahlekelwa isifiso sokudla, ubuhlungu engxenyeni engaphezulu kwesokudla yesisu, ukuphuzi kwesikhumba noma kwamehlo, umchamo omnyama
• ukuphefumula, ukushaya kwenhliziyo okusheshayo noma okungajwayelekile, ukuvuvukala engxenyeni ethile yomzimba wakho

I-Cladribine ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti odokotela kanye ne-laboratory. Udokotela wakho uzoku-oda izivivinyo ezithile ngaphambi kokwelashwa kwakho, ngesikhathi nangemva kwaso ukuze uqiniseke ukuthi kuphephile kuwe ukuthatha i-cladribine nokuhlola impendulo yomzimba wakho ku-cladribine.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Mavenclad^®