Umjovo wePolatuzumab vedotin-piiq

-Delile

• Ngaphambi kokuthola umjovo we-polatuzumab vedotin-piiq,
• IPolatuzumab vedotin-piiq ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezisohlwini lwe-HOW section, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Umjovo wePolatuzumab vedotin-piiq usetshenziswa kanye ne-bendamustine (Belrapzo, Treanda) ne-rituximab (Rituxan) kubantu abadala ukwelapha uhlobo oluthile lwe-non-Hodgkin's lymphoma (NHL; uhlobo lomdlavuza oqala ngohlobo lwamaseli amhlophe egazi ajwayelekile fights infection) okungazange kuthuthuke noma kuthuthuke kepha kubuyiswe ngemuva kokwelashwa okungenani ngeminye imithi emibili yokwelashwa ngamakhemikhali. IPolatuzumab vedotin-piiq isekilasini lemithi ebizwa ngama-anti-drug conjugates. Isebenza ngokubulala amangqamuzana omdlavuza.

IPolatuzumab vedotin-piiq iza njengempuphu ezoxutshwa noketshezi futhi ifakwe ngomjovo (emthanjeni) ngudokotela noma umhlengikazi endaweni yezokwelapha. Imvamisa inikezwa ngaphezulu kwemizuzu engama-30 kuye kwengu-90 ngosuku 1 lomjikelezo wezinsuku ezingama-21. Umjikelezo ungaphindwa izikhathi eziyisithupha noma isikhathi eside njengoba kunconywe udokotela wakho. Ubude bokwelashwa kwakho buncike ekutheni umzimba wakho uphendula kahle kanjani emithini nasemiphumeleni oyitholayo.

Ungahle uthole ukuphendula okungathi sína noma okusongela impilo ngenkathi uthola umjovo womjovo we-polatuzumab vedotin-piiq noma kungakapheli amahora angama-24 uthole umthamo. Udokotela wakho angakutshela ukuthi uthathe imithi ethile ngaphambi kokuthola umthamo wakho ukuvimbela lokhu kuphendula. Udokotela noma umhlengikazi uzokubheka eduze ukuze abone ukuthi umzimba wakho uphendula kanjani ku-polatuzumab vedotin-piiq. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho ngomjovo we-polatuzumab vedotin-piiq. Udokotela wakho angakunikeza eminye imithi ukusiza ukuvimbela noma ukukhulula lezi zimpawu. Uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi sokumnika noma ngemuva kokumfakelwa, tshela udokotela wakho ngokushesha: ukugodola, ukulunywa, isifuba, umkhuhlane, ukuqhuma, ukuqhuma, ukuphefumula kanzima, ukuphefumula okuncane, noma ukuphefumula.

Udokotela wakho angadinga ukubambezela ukwelashwa kwakho, ukulungisa umthamo wakho, noma ukumisa ukwelashwa kwakho uma uhlangabezana nemiphumela ethile emibi. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngenkathi welashwa nge-polatuzumab vedotin-piiq.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-polatuzumab vedotin-piiq,

• Tshela udokotela wakho kanye nosokhemisi uma une-aleji ku-polatuzumab vedotin-piiq, noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-polatuzumab vedotin-piiq. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: carbamazepine (Equetro, Tegretol, Teril); i-clarithromycin (i-Biaxin, ku-PrevPac); imithi yokwelapha i-HIV kubandakanya i-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nevirapine (Viramune), ritonavir (Norvir, eKaletra), kanye ne-saquinavir (Invirase); itraconazole (Onmel, Sporanox), ketoconazole; nefazodone; phenobarbital, phenytoin (Dilantin, Phenytek); i-pioglitazone (Actos); i-rifabutin (i-Mycobutin); kanye ne-rifampin (Rifadin, Rimactane, eRifamate). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-polatuzumab vedotin-piiq, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi iSt John's Wort.
• utshele udokotela wakho uma unesifo noma unesifo sesibindi noma uke waba naso.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Akufanele uqale ukuthola umjovo we-polatuzumab vedotin-piiq kuze kufike ukuhlolwa kokukhulelwa ukuthi awukhulelwe. Uma ungowesifazane okwaziyo ukukhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho nezinyanga ezi-3 ngemuva komthamo wakho wokugcina. Uma ungowesilisa nomlingani wesifazane ongakhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho nezinyanga ezi-5 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthola umjovo we-polatuzumab vedotin-piiq, shayela udokotela wakho. Umjovo wePolatuzumab vedotin-piiq ungalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Ungancelisi ibele ngesikhathi sokwelashwa kwakho nezinyanga ezi-2 ngemuva komthamo wakho wokugcina.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthola umjovo we-polatuzumab vedotin-piiq.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa i-aphoyintimenti ukuthola umthamo we-polatuzumab vedotin-piiq, shayela udokotela wakho khona manjalo.

IPolatuzumab vedotin-piiq ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• ukuhlanza
• isiyezi
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba
• ubuhlungu obuhlangene

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezisohlwini lwe-HOW section, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukudideka; isiyezi noma ukulahlekelwa ibhalansi; ubunzima bokukhuluma noma ukuhamba; noma ushintsho embonweni
• ukuba ndikindiki noma ukuncinza kwezandla noma kwezinyawo; noma ubuthakathaka bemisipha, ubuhlungu, noma ukushiswa
• ukulinyazwa okulula noma ukopha; ukuphuma ezinsinini noma emakhaleni; noma igazi emchameni noma esitulweni
• isicanucanu, ukuhlanza, isifo sohudo nokukhathala
• isikhumba esiphaphathekile noma ukukhathala okungajwayelekile noma ubuthakathaka
• umkhuhlane, umphimbo obuhlungu, amakhaza, ubuhlungu lapho uchama, nezinye izimpawu zokutheleleka
• ukukhathala ngokweqile; ukuphuzi kwesikhumba noma kwamehlo; ukulahlekelwa ukudla; umchamo omnyama; noma ubuhlungu engxenyeni engaphezulu kwesokudla yesisu

Umjovo wePolatuzumab vedotin-piiq ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho kumjovo we-polatuzumab vedotin-piiq.

Buza usokhemisi wakho noma imiphi imibuzo onayo ngomjovo we-polatuzumab vedotin-piiq.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UPolivy^®