Upadacitinib

-Delile

• Ngaphambi kokuthatha i-upadacitinib,
• I-Upadacitinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Ukuthatha i-upadacitinib kunganciphisa ikhono lakho lokulwa nokutheleleka futhi kwandise ingozi yokuthi uzothola ukutheleleka okungathi sína, kufaka phakathi ukutheleleka okunzima, ukutheleleka kwamagciwane, noma igciwane elisakazeka emzimbeni. Lezi zifo zingadinga ukwelashwa esibhedlela futhi zingadala nokufa. Tshela udokotela wakho uma uvame ukuthola noma yiluphi uhlobo lokutheleleka noma uma ucabanga ukuthi ungaba nanoma yiluphi uhlobo lokutheleleka manje. Lokhu kufaka ukutheleleka okuncane (njengokusikeka okuvulekile noma izilonda), izifo ezifika zidlule (njengezilonda ezibandayo), kanye nezifo ezingamahlalakhona ezingapheli. Phinda utshele udokotela wakho uma uke waba nesifo sikashukela noma unesifo sikashukela, i-human immunodeficiency virus (HIV), uthola i-immunodeficiency syndrome (i-AIDS), isifo samaphaphu, noma esinye isimo esithinta amasosha akho omzimba. Kufanele futhi utshele udokotela wakho uma uhlala noma owake wahlala ezindaweni ezinjengezigodi zemifula i-Ohio noma iMississippi lapho ukutheleleka okunzima kwefungal kuvame kakhulu. Buza udokotela wakho uma ungaqiniseki ukuthi lezi zifo zivamile yini endaweni yangakini. Tshela udokotela wakho uma uthatha imishanguzo eyehlisa ukusebenza kohlelo lomzimba njengokulandelayo: azathioprine (Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), hydroxychloroquine (Plaquenil), leflunomide (Arava), methotrexate (Otrexup, Rasuvo , Trexall); ama-steroids afaka i-dexamethasone, i-methylprednisolone (Medrol), i-prednisolone (i-Prelone), ne-prednisone (i-Rayos); i-sulfasalazine; noma i-tacrolimus (Astagraf, Envarsus XR, Prograf).

Udokotela wakho uzokuqapha ngezibonakaliso zokutheleleka ngesikhathi nangemva kokwelashwa kwakho. Uma unezinye zalezi zimpawu ezilandelayo ngaphambi kokuba uqale ukwelashwa kwakho noma uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngokushesha ngemuva kokwelashwa kwakho, shayela udokotela wakho ngokushesha: umkhuhlane; ukujuluka; Ukugodola; ubuhlungu bemisipha; ukukhwehlela; ukuphelelwa umoya; ukuncipha komzimba; isikhumba esifudumele, esibomvu, noma esibuhlungu; izilonda esikhumbeni; imizwa ejwayelekile, ebuhlungu, noma evuthayo ngesikhathi sokuchama; uhudo, noma ukukhathala ngokweqile.

Kungenzeka ukuthi usungenwe yisifo sofuba (i-TB; ukutheleleka okungathi sína kwamaphaphu) kodwa ungenazo izimpawu zesifo. Kulokhu, ukuthatha i-upadacitinib kungenza ukutheleleka kwakho kube kubi kakhulu futhi kukwenze ube nezimpawu. Udokotela wakho uzohlola isikhumba ukuze abone ukuthi une-TB engasebenzi yini ngaphambi kokuba uqale ukwelashwa kwakho nge-upadacitinib. Uma kunesidingo, udokotela wakho uzokunika imithi yokwelapha lesi sifo ngaphambi kokuqala ukusebenzisa i-upadacitinib. Tshela udokotela wakho uma uke waba ne-TB noma wake waba nayo, uma wake wahlala noma wavakashela izwe lapho i-TB ijwayelekile khona, noma uma wake waba seduze komuntu one-TB. Uma unalezi zimpawu ezilandelayo ze-TB, noma uma uba nalezi zimpawu phakathi nokwelashwa kwakho, shayela udokotela wakho ngokushesha: ukukhwehlela, ukukhwehlela amafinyila anegazi, ukwehla kwesisindo, ukulahleka kwethoni lezicubu, noma umkhuhlane.

Ukuthatha i-upadacitinib kungandisa ingozi yokuthi uzoba ne-lymphoma (umdlavuza oqala kumaseli alwa nokutheleleka) noma ezinye izinhlobo zomdlavuza njengomdlavuza wesikhumba. Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo lomdlavuza noma wake waba nalo.

I-Upadacitinib ingakhuphula ubungozi begazi elibucayi futhi elisongela impilo emaphashini noma emilenzeni. Uma uhlangabezana nanoma yimiphi imiphumela emibi elandelayo, shayela udokotela wakho noma uthole ukwelashwa okuphuthumayo ngokushesha: ukuchoboza ubuhlungu besifuba noma isisindo sesifuba; ukuphelelwa umoya; ukukhwehlela; ubuhlungu, imfudumalo, ubomvu, ukuvuvukala, noma isisa somlenze; noma umuzwa obandayo ezingalweni, ezandleni, noma emilenzeni; noma ubuhlungu bemisipha.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula izivivinyo ezithile zelebhu ngaphambi, ngesikhathi, nangemva kokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-upadacitinib.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-upadacitinib futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngengozi (s) yokuthatha i-upadacitinib.

I-Upadacitinib isetshenziswa yodwa noma neminye imithi yokwelapha i-rheumatoid arthritis (isimo lapho umzimba uhlasela khona amalunga ayo okubangela ubuhlungu, ukuvuvukala, nokulahleka komsebenzi) kubantu abangaphendulanga kahle kwi-methotrexate (Otrexup, Rasuvo, Trexall). I-Upadacitinib isekilasini lemithi ebizwa ngeJanus kinase (JAK) inhibitors. Isebenza ngokunciphisa umsebenzi wamasosha omzimba.

I-Upadacitinib iza njengethebhulethi ekhishwa isikhathi eside (esebenza isikhathi eside). Imvamisa kuthathwa noma ngaphandle kokudla kanye ngosuku. Thatha upadacitinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha upadacitinib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi akhululiwe; ungawahlukanisi, ungawahlafune noma uwagxoze.

Udokotela wakho kungadingeka ukuthi ayeke ukwelashwa okwesikhashana noma unomphela uma uba nemiphumela emibi ethile. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-upadacitinib,

• Tshela udokotela wakho kanye nosokhemisi uma une-allergies ku-upadacitinib, noma imiphi eminye imishanguzo, noma iziphi izithako ezikumathebulethi wokukhululwa we-upadacitinib. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: imishanguzo ethile yokubulala izinhlungu efana ne-itraconazole (i-Onmel, i-Sporanox) ne-ketoconazole; i-aspirin neminye imishanguzo yokulwa nokuvuvukala (ama-NSAID) njenge-ibuprofen (Advil, Motrin) ne-naproxen (Naprosyn, Aleve); ama-barbiturate afana ne-phenobarbital noma i-phenytoin (iDilantin, Phenytek); carbamazepine (Carbatrol, Tegretol, Equetro, nabanye); i-clarithromycin (i-Biaxin, ku-Prevpac); enzalutamide (Xtandi); imishanguzo ethile ye-HIV kubandakanya i-efavirenz (Sustiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, eKaletra), kanye ne-saquinavir (Invirase); nefazodone; i-rifabutin (i-Mycobutin); noma i-rifampin (i-Rifadin, i-Rimactane, e-Rifamate, e-Rifater). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-upadacitinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi iSt John's Wort.
• Tshela udokotela wakho uma unezilonda (izilonda ezingxenyeni zesisu noma amathumbu akho), i-diverticulitis (ukuvuvukala kwendwangu yamathumbu amakhulu), i-herpes zoster (ama-shingles; ukuqubuka okungenzeka kubantu abake baba ne-chickenpox esikhathini esedlule ), noma i-anemia (inani eliphansi kunelejwayelekile lamaseli abomvu egazi), noma isifo sesibindi, kufaka phakathi i-hepatitis B noma i-C.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uzodinga ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa nge-upadacitinib. Kufanele usebenzise ukulawulwa kokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho futhi okungenani amasonto ama-4 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa. Uma ukhulelwa, shayela udokotela wakho ngokushesha. I-Upadacitinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngesikhathi sokwelashwa kwakho nge-upadacitinib nezinsuku eziyisithupha ngemuva komthamo wakho wokugcina.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-upadacitinib.
• utshele udokotela wakho uma usanda kuthola noma uhlelelwe ukuthola noma yimiphi imigomo. Uma udinga noma yikuphi ukugoma, kungadingeka ukuthi uthole ukugoma bese ulinda isikhathi esithile ngaphambi kokuqala ukwelashwa kwakho nge-upadacitinib. Ungabi nayo imigomo ngesikhathi sokwelashwa kwakho ngaphandle kokukhuluma nodokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Upadacitinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhala eligcwele noma eligijimayo
• isicanucanu

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuphuzi kwesikhumba noma kwamehlo, ukungathandi ukudla, umchamo omnyama, noma ukunyakaza kwamathumbu anombala wobumba
• ukuphefumula, ukukhathala, noma isikhumba esiphaphathekile

I-Upadacitinib ingadala ukwanda kwamazinga egazi egazini lakho. Udokotela wakho uzo-oda izivivinyo zokuqapha amazinga akho e-cholesterol ngesikhathi sokwelashwa kwakho nge-upadacitinib. Khuluma nodokotela wakho ngezingozi zokuthatha lo muthi.

I-Upadacitinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Yigcine esiqandisini noma ekamelweni lokushisa kanye nokushisa okuthe xaxa nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Rinvoq^®