I-Tazemetostat

-Delile

• Ngaphambi kokuthatha i-tazemetostat,
• I-Tazemetostat ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Tazemetostat isetshenziselwa ukwelapha i-epithelioid sarcoma (umdlavuza wezicubu ezithambile ongandile, okhula kancane) kubantu abadala nasezinganeni ezineminyaka engu-16 ubudala nangaphezulu osakaze kwizicubu eziseduze noma kwezinye izingxenye zomzimba futhi awukwazi ukwelashwa ngempumelelo ngokuhlinzwa. Ibuye isetshenziselwe ukwelapha izinhlobo ezithile ze-follicular lymphoma (FL; uhlobo lomdlavuza oluqala kumaseli amhlophe egazi) kubantu abadala abanomdlavuza obuyile noma ongaphendulanga kweminye imithi emibili. I-Tazemetostat isetshenziselwa ukwelapha i-follicular lymphoma kubantu abadala ebuyile noma engaphendulanga ekwelashweni uma kungekho ezinye izindlela zokwelashwa ezitholakalayo. I-Tazemetostat isekilasini lemithi ebizwa nge-EZH2 inhibitors. Kuyasiza ukunqanda ukusabalala kwamangqamuzana omdlavuza.

I-Tazemetostat iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa kabili ngosuku noma ngaphandle kokudla. Thatha i-tazemetostat ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-tazemetostat njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Uma uhlanza ngokushesha ngemuva kokuthatha i-tazemetostat, ungathathi omunye umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Udokotela wakho angamisa ukwelashwa kwakho okwesikhashana noma unomphela noma anciphise umthamo wakho we-tazemetostat kuye ngemiphumela emibi oyitholayo. Qiniseka ukuthi ukhuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Ungayeki ukuthatha i-tazemetostat ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-tazemetostat,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-tazemetostat, noma imuphi omunye umuthi, noma iziphi izithako ezikumathebulethi e-tazemetostat. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: aprepitant (Emend), carbamazepine (Carbatrol, Teril, others), clarithromycin (Biaxin, e-Prevpac), diltiazem (Cardizem, Cartia, Diltzac, others), efavirenz (Sustiva, in Atripla), i-erythromycin (i-EES, i-PCE, abanye), izindlela zokuvimbela inzalo zamahomoni (amaphilisi okulawula ukubeletha, amabala, izindandatho, noma imijovo), indinavir (Crixivan), itraconazole (Onmel, Sporanox), ketoconazole, modafinil (Provigil), nefazodone, nelfinavir (Viracept), nevirapine (Viramune), phenobarbital, phenytoin (Dilantin, Phenytek), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, eRifamate), ritonavir (Norvir, eKaletra), saquinavir (Fortovase, Invirase), , UVerelan). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-tazemetostat, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• utshele udokotela wakho uma uke waba nesifo sesibindi noma wake waba naso.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uhlele ukuba nobaba wengane. I-Tazemetostat ingaphazamisa ukusebenza kwezindlela zokuvimbela inzalo zamahomoni (amaphilisi okulawula ukubeletha, amabala, izindandatho, okufakwayo noma imijovo), ngakho-ke akufanele usebenzise lokhu njengendlela yakho kuphela yokulawula ukubeletha ngesikhathi sokwelashwa kwakho. Uma ungowesifazane, kuzofanele uthathe ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa bese usebenzisa i-non-hormonal control (into evimba isidoda ukuthi singene esibelethweni njengekhondomu) ukuvikela ukukhulelwa ngesikhathi sokwelashwa kwakho nezinyanga eziyisithupha ngemuva umthamo wokugcina. Uma ungowesilisa, wena kanye nomlingani wakho wesifazane kufanele nisebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho nezinyanga ezi-3 ngemuva komthamo wakho wokugcina. Buza udokotela wakho ukuthi akusize ukhethe indlela yokulawula ukubeletha ezokusebenzela wena noma umlingani wakho. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-tazemetostat, shayela udokotela wakho ngokushesha. I-Tazemetostat ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngesikhathi sokwelashwa kwakho nangesonto eli-1 ngemuva komthamo wakho wokugcina.

Ungadli inani elikhulu lamagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa esivamile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Tazemetostat ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukulahlekelwa isifiso sokudla
• isicanucanu
• ukuhlanza
• ukuqunjelwa
• isifo sohudo
• ubuhlungu besisu
• ukuncipha komzimba
• ukukhwehlela
• ikhanda
• ukukhathala
• ubuhlungu bemisipha, bethambo, noma bamalunga

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukukhathala, ukulimazeka okulula, umkhuhlane, ubuhlungu bamathambo, noma isikhumba esiphaphathekile
• ukopha okungavamile
• ukutheleleka kwesikhumba
• ukuphelelwa umoya

I-Tazemetostat ingadala ingozi yokwanda komdlavuza. Khuluma nodokotela wakho ngezingozi zokuthatha lo muthi.

I-Tazemetostat ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Kwezinye izimo, udokotela wakho uzo-oda ukuhlolwa kwelebhu ngaphambi kokuthi uqale ukwelashwa kwakho ukuze ubone ukuthi umdlavuza wakho ungelashwa nge-tazemetostat. Udokotela wakho angaphinde a-ode izivivinyo ezithile zebhu ukuhlola impendulo yomzimba wakho ku-tazemetostat.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Tazverik^®