I-Selpercatinib

-Delile

• Ngaphambi kokuthatha i-selpercatinib,
• I-Selpercatinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Selpercatinib isetshenziselwa ukwelapha uhlobo oluthile lomdlavuza wamaphaphu wamangqamuzana ongewona omncane kubantu abadala oluye lwasakazekela kwezinye izingxenye zomzimba kubantu abadala. Ibuye isetshenziselwe ukwelapha uhlobo oluthile lomdlavuza wegilo kubantu abadala nasezinganeni ezineminyaka engu-12 ubudala nangaphezulu oluye lwasakazekela kwezinye izingxenye zomzimba. I-Selpercatinib ibuye isetshenziselwe ukwelapha olunye uhlobo lomdlavuza wegilo osabalalele kwezinye izingxenye zomzimba kubantu abadala nezingane ezineminyaka engu-12 ubudala nangaphezulu abelashwe ngempumelelo nge-iodine enemisebe. I-Selpercatinib isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sephrotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunciphisa noma ukumisa ukusabalala kwamangqamuzana omdlavuza.

I-Selpercatinib iza njenge-capsule ezothathwa ngomlomo. Imvamisa iphuzwa kabili ngosuku (njalo emahoreni ayi-12) ngokudla noma ngaphandle kokudla. Thatha i-selpercatinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-selpercatinib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungazivuli, uzihlafune noma uzichoboze.

Uma uhlanza ngemuva kokuthatha i-selpercatinib, ungathathi omunye umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Udokotela wakho anganciphisa umthamo wakho, noma aphazamise noma ayeke ukwelashwa kwakho. Lokhu kuncike ekutheni umuthi usebenza kanjani kuwe kanye nemiphumela emibi oyitholayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Qhubeka nokusebenzisa i-selpercatinib noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-selpercatinib ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-selpercatinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-selpercatinib, noma imiphi eminye imithi, noma iziphi izithako kuma-selpercatinib capsules. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-antifungal anjenge-fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, ne-voriconazole (Vfend); i-aprepitant (Hlela); carbamazepine (Carbatrol, Tegretol, Equetro, nabanye); i-clarithromycin (i-Biaxin, ku-Prevpac); i-diltiazem (Cardizem, Cartia, Tiazac, abanye); i-erythromycin (E.E.S., E-Mycin, Erythrocin); imishanguzo ethile yegciwane lesandulela ngculazi (i-HIV) noma i-immunodeficiency syndrome (i-AIDS) efaka i-efavirenz (Sustiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, e Kaletra), kanye ne-saquinavir (Invirase) ; nefazodone; i-phenobarbital; i-phenytoin (iDilantin, Phenytek); i-pioglitazone (Actos); i-quinidine (ku-Nuedexta); i-repaglinide (Prandin); i-rifabutin (i-Mycobutin); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); kanye ne-verapamil (Calan, Verelan, abanye). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-selpercatinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• uma uthatha i-H₂ Imithi ye-blocker ye-indigestion, isilungulela, noma izilonda ezifana ne-cimetidine (Tagamet), i-famotidine (i-Pepcid), i-nizatidine (i-Axid), noma i-ranitidine (i-Zantac), thatha i-selpercatinib okungenani amahora amabili ngaphambi noma amahora ayi-10 ngemuva kokuthatha owodwa wale mithi.
• uma uthatha i-antacid equkethe i-aluminium, i-magnesium, i-calcium, noma i-simethicone; noma imishanguzo ebhuqiwe efana ne-aspirin ephukile, thatha i-selpercatinib okungenani amahora amabili ngaphambi noma okungenani amahora amabili ngemuva kokuthatha owodwa wale mithi.
• uma uthatha i-proton-pump inhibitor efana ne-esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), ne-rabeprazole (AcipHex), thatha isilinganiso ngasinye se-selpercatinib kanye nokudla.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• utshele udokotela wakho uma ngabe uke waba nokushaya kwenhliziyo okuhamba kancane, okusheshayo, noma okungajwayelekile; isikhathi se-QT eside (inkinga yenhliziyo engajwayelekile engadala ukushaya kwenhliziyo okungajwayelekile, ukuquleka, noma ukufa ngokuzuma); umfutho wegazi ophakeme; izinkinga zokopha; noma isifo sezinso noma sesibindi.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uma uhlela ukuba ngubaba wengane. Akufanele ukhulelwe ngenkathi uthatha i-selpercatinib. Uma ungowesifazane, kuzodingeka uthathe ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa futhi usebenzise izilawuli zokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nge-selpercatinib nangesonto eli-1 ngemuva komthamo wakho wokugcina. Uma ungowesilisa, wena nomlingani wakho wesifazane kufanele nisebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa nge-selpercatinib nangesonto eli-1 ngemuva komthamo wakho wokugcina. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-selpercatinib, shayela udokotela wakho ngokushesha. I-Selpercatinib ingadala ukulimala kwengane.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngenkathi uthatha i-selpercatinib kanye neviki elilodwa ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala kwabesilisa nabesifazane. Khuluma nodokotela wakho ngezingozi zokuthatha i-selpercatinib.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-selpercatinib. Udokotela wakho angakutshela ukuthi ungathathi i-selpercatinib izinsuku eziyi-7 ngaphambi kokuhlinzwa noma inqubo yakho futhi uzokutshela ukuthi kufanele uqale nini ukuthatha umuthi futhi.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma kungaphakathi kwamahora we-6 wedosi yakho elandelayo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Selpercatinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• umlomo owomile
• isifo sohudo
• ukuqunjelwa
• isicanucanu
• ukuhlanza
• ubuhlungu besisu
• ikhanda
• ukukhathala
• ukukhwehlela
• ukuphelelwa umoya
• ukuvuvukala kwezingalo, imilenze, izandla nezinyawo zakho

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ubuhlungu engxenyeni engenhla yesisu; ukulimaza noma ukopha okungavamile; umchamo omnyama; noma ukuphuzi kwesikhumba neso
• ukushaya kwenhliziyo
• isiyezi noma ikhanda elikhanyayo
• ukuquleka
• ukukhwehlela noma ukuphalaza igazi noma okokusebenza okubukeka njengezizathu zekhofi; ukopha okungavamile noma ukulimaza, okubomvana; umchamo obomvu, noma onsundu; noma okubomvu noma okulindile ukunyakaza kwamathumbu amnyama
• isicanucanu; ukuhlanza; ukuphelelwa umoya; amajaqamba; ubuthakathaka; ukuquleka; noma ukuvuvukala kwezingalo nemilenze
• umkhuhlane, ukuqubuka, noma ubuhlungu bamalunga noma besisipha

I-Selpercatinib ingadala ukuthi amathambo ayeke ukukhula masinyane entsheni esakhula. Khuluma nodokotela wengane yakho ngezingozi zokunikeza ingane yakho lo muthi.

I-Selpercatinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzohlola umfutho wegazi lakho njalo futhi a-oda izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-selpercatinib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Retevmo^®