I-Clozapine

-Delile

• Ngaphambi kokuthatha i-clozapine,
• I-Clozapine ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo noma lezo ezibalwe eziXWAYISWENI EZIBALULEKILE noma ezingxenyeni ezithile zokuqapha, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Clozapine ingadala isimo esibi segazi. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi kokuqala ukwelashwa kwakho, ngesikhathi sokwelashwa kwakho, futhi okungenani amasonto ama-4 ngemuva kokwelashwa kwakho. Udokotela wakho uzo-oda izivivinyo zelebhu kanye ngesonto ekuqaleni futhi angalawula izivivinyo kaningi njengoba ukwelashwa kwakho kuqhubeka. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukukhathala ngokweqile; ubuthakathaka; umkhuhlane, umphimbo obuhlungu, amakhaza, noma ezinye izimpawu zomkhuhlane noma ukutheleleka; ukuphuma okungavamile noma ukuluma kwesisu; izilonda emlonyeni noma emphinjeni; amanxeba athatha isikhathi eside ukuphola; ubuhlungu noma ukushisa ngenkathi uchama; izilonda noma ubuhlungu endaweni yakho ezungeze unxande; noma ubuhlungu besisu.

Ngenxa yezingozi zalo muthi, i-clozapine itholakala kuphela ngohlelo olukhethekile lokusabalalisa olukhawulelwe. Uhlelo selusungulwe ngabakhiqizi be-clozapine ukuze kuqinisekiswe ukuthi abantu abayithathi i-clozapine ngaphandle kokuqapha okudingekayo okubizwa nge-Clozapine Risk Evaluation and Mitigation Strategies (REMS) Programme. Udokotela wakho kanye nosokhemisi wakho kufanele babhaliswe nohlelo lwe-Clozapine REMS, futhi usokhemisi wakho ngeke akhiphe imithi yakho ngaphandle kokuthi athole imiphumela yokuhlolwa kwegazi lakho. Buza udokotela wakho ukuthola eminye imininingwane ngalolu hlelo nokuthi uzoyithola kanjani imithi yakho.

I-Clozapine ingadala ukuquleka. Tshela udokotela wakho uma uke waquleka noma wake waquleka. Ungashayeli imoto, sebenzisa imishini, ukubhukuda, noma ukhuphuke ngenkathi uthatha i-clozapine, ngoba uma ungazelele ungazelele, ungazilimaza wena noma abanye. Uma uthola ukuquleka, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo.

I-Clozapine ingadala i-myocarditis (ukuvuvukala kwemisipha yenhliziyo engaba yingozi) noma i-cardiomyopathy (ikhulisiwe noma iqine imisipha yenhliziyo emisa inhliziyo ekupompa igazi ngokujwayelekile). Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukukhathala ngokweqile; umkhuhlane njengezimpawu; ukuphefumula kanzima noma ukuphefumula okusheshayo; imfiva; ubuhlungu besifuba; noma ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla.

I-Clozapine ingadala isiyezi, ikhanda elikhanyayo, noma ukuquleka lapho usukuma, ikakhulukazi lapho uqala ukuyithatha noma lapho umthamo wakho wanda. Tshela udokotela wakho uma ngabe uke wahlaselwa yinhliziyo, wahluleka yinhliziyo, noma washaya kancane, engajwayelekile ukushaya kwenhliziyo noma uthatha imishanguzo yomfutho wegazi ophezulu. Phinda utshele udokotela wakho uma uhlanza kakhulu noma uhudo noma izimpawu zokuphelelwa amandla emzimbeni manje, noma uma uba nalezi zimpawu noma kunini ngesikhathi sokwelashwa kwakho. Udokotela wakho kungenzeka akuqale ngomthamo ophansi we-clozapine futhi kancane kancane akhuphule umthamo wakho ukuze unike umzimba wakho isikhathi sokuzivumelanisa nemithi futhi wehlise ithuba lokuthi uzokuzwa lo mphumela ohlangothini. Khuluma nodokotela wakho uma ungathathi i-clozapine izinsuku ezimbili noma ngaphezulu. Udokotela wakho mhlawumbe uzokutshela ukuthi uqale kabusha ukwelashwa kwakho ngomthamo ophansi we-clozapine.

Sebenzisa Kwabadala Abadala:

Ucwaningo lukhombisile ukuthi abantu abadala asebekhulile abanenkinga yokuwohloka komqondo (ukuphazamiseka ebuchosheni okuthinta amandla okukhumbula, ukucabanga kahle, ukuxhumana, nokwenza imisebenzi yansuku zonke futhi lokho kungadala ushintsho esimweni sengqondo nobuntu) abathatha imishanguzo yokuthithibula (imishanguzo yokugula ngengqondo) njenge-clozapine babe nethuba elandayo lokufa ngesikhathi sokwelashwa.

I-Clozapine ayivunyelwe yi-Food and Drug Administration (FDA) ekwelapheni izinkinga zokuziphatha kubantu abadala asebekhulile abanenkinga yokuwohloka komqondo. Khuluma nodokotela onqume i-clozapine uma wena, ilungu lomndeni, noma umuntu omnakekelayo enesifo sengqondo sokuphazamiseka ngokomqondo futhi ethatha lo muthi. Ngeminye imininingwane vakashela iwebhusayithi ye-FDA: http://www.fda.gov/Drugs

I-Clozapine isetshenziselwa ukwelapha izimpawu ze-schizophrenia (ukugula kwengqondo okubangela ukuphazamiseka noma ukucabanga okungajwayelekile, ukuphelelwa yintshisekelo empilweni, kanye nemizwa enamandla noma engafanele) kubantu abangazange basizwe eminye imithi noma abazame ukuzibulala futhi kungenzeka bazame ukuzibulala noma ukuzilimaza futhi. I-Clozapine isekilasini lemithi ebizwa nge-atypical antipsychotic. Isebenza ngokushintsha ukusebenza kwezinto ezithile zemvelo ebuchosheni.

I-Clozapine iza njengethebhulethi, ithebhulethi ehlukaniswa ngomlomo (ithebhulethi encibilika ngokushesha emlonyeni), kanye nokumiswa ngomlomo (uketshezi) ukuthatha ngomlomo. Kuvame ukuthathwa kanye noma kabili nsuku zonke. Thatha i-clozapine cishe ngesikhathi esifanayo (ama) nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-clozapine njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Ungazami ukusunduza ithebhulethi ehlakazeka ngomlomo ngokusebenzisa ukufakwa kwe-foil. Esikhundleni salokho, sebenzisa izandla ezomile ukuze ubuye ubuye ucwecwe. Khipha ngokushesha ithebhulethi bese uyibeka olimini lwakho. Ithebhulethi izoncibilika ngokushesha futhi ingagwinywa ngamathe. Awekho amanzi adingekayo ukugwinya amaphilisi ahlukanisayo.

Ukukala ukumiswa komlomo kwe-clozapine, landela lezi zinyathelo:

1. Qiniseka ukuthi ikepisi liqinile esitsheni sokumiswa ngomlomo ngokujikisa ikepisi ngokwewashi (ngakwesokudla). Nyakazisa ibhodlela ubheke phezulu naphansi imizuzwana eyi-10 ngaphambi kokulisebenzisa.
2. Susa ikepisi lebhodlela ngokucindezela phansi kukepisi, bese uliphendulela ngakwesokudla (ngakwesokunxele). Isikhathi sokuqala uvula ibhodlela elisha, cindezela i-adaptha ungene ebhodleleni kuze kube yilapho phezulu kwe-adaptha kufakwe phezulu kwebhodlela.
3. Uma umthamo wakho uyi-1 mL noma ngaphansi, sebenzisa isirinji yomlomo encane (1 mL). Uma umthamo wakho ungaphezu kwe-1 mL, sebenzisa isirinji yomlomo enkudlwana (9 mL).
4. Gcwalisa isirinji yomlomo ngomoya ngokubuyisela emuva i-plunger. Bese ufaka ichopho evulekile yesirinji yomlomo ku-adaptha. Phusha wonke umoya usuka kwisirinji yomlomo ungene ebhodleleni ngokucindezela phansi kuplunger.
5. Ngenkathi ubambe isirinji yomlomo endaweni, jikisa ngokucophelela ibhodlela ubheke phansi. Dweba eminye yemithi ngaphandle kwebhodlela iye kwisirinji yomlomo ngokudonsela emuva ku-plunger. Qaphela ukuthi ungadonsi i-plunger yonke indlela.
6. Uzobona inani elincane lomoya eduze kokuphela kweplunger esirinji yomlomo. Phusha ku-plunger ukuze umuthi ubuyele ebhodleleni bese umoya unyamalala. Donsela emuva ku-plunger ukuze udonse umthamo wakho olungile wemithi esirinji yomlomo.
7. Ngenkathi usabambe isirinji yomlomo ebhodleleni, bhekisa ibhodlela phezulu ngokucophelela ukuze isipetu siphezulu. Susa isipetu somlomo ku-adaptha yebhodlela lentamo ngaphandle kokucindezela ku-plunger. Thatha imithi ngokushesha ngemuva kokuyidonsela kusirinji yomlomo. Ungalungiseleli umthamo bese uwugcina esirinji ukuze uzowusebenzisa kamuva.
8. Beka ithiphu evulekile yesirinji yomlomo ohlangothini olulodwa lomlomo wakho. Vala izindebe zakho eduze kwesirinji yomlomo bese ucindezela ku-plunger kancane lapho uketshezi lungena emlonyeni wakho. Gwinya imithi kancane njengoba ingena emlonyeni wakho.
9. Shiya i-adaptha ebhodleleni. Beka ikepisi emuva ebhodleleni bese uliphendulela ngokwewashi (ngakwesokudla) ukuze uliqinise.
10. Hlanza isirinji yomlomo ngamanzi afudumele ompompi ngemuva kokusetshenziswa ngakunye. Gcwalisa inkomishi ngamanzi bese ufaka ichopho lesipontsho lomlomo emanzini asenkomishini. Donsela emuva ku-plunger bese udonsela amanzi kusirinji yomlomo. Phusha ku-plunger ukukhipha amanzi kusinki noma esitsheni esihlukile kuze kube yilapho isirinji yomlomo ihlanzekile. Vumela umoya wesirinji yomlomo womile bese ulahla noma yimaphi amanzi asele asuselwe.

IClozapine ilawula i-schizophrenia kepha ayiyelaphi. Kungathatha amasonto ambalwa noma ngaphezulu ngaphambi kokuthi uzwe inzuzo ephelele ye-clozapine. Qhubeka uthathe i-clozapine noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-clozapine ngaphandle kokukhuluma nodokotela wakho. Udokotela wakho mhlawumbe uzofuna ukwehlisa umthamo wakho kancane kancane.

Lo muthi akufanele unikezwe okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-clozapine,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-clozapine, noma imuphi omunye umuthi, noma yiziphi izithako ezikumaphilisi e-clozapine. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukubalula labo abalwe esigabeni ESIBALULEKILE SESEXWAYISO nakokulandelayo: ama-antihistamine afana ne-diphenhydramine (Benadryl); ama-antibiotic afana ne-ciprofloxacin (Cipro) ne-erythromycin (E.E.S., E-Mycin, amanye); i-benztropine (Cogentin); i-cimetidine (Tagamet); i-bupropion (Aplenzin, Wellbutrin, Zyban, ku-Contrave); i-cyclobenzaprine (Amrix); i-escitalopram (iLexapro); imishanguzo yokukhathazeka, umfutho wegazi ophakeme, ukugula ngengqondo, ukugula, noma isicanucanu; imishanguzo yokushaya kwenhliziyo okungajwayelekile njenge-encainide, i-flecainide, i-propafenone (i-Rythmol), ne-quinidine (e-Nuedexta); izinto zokuvimbela inzalo ngomlomo; imishanguzo yokuquleka efana ne-carbamazepine (i-Equetro, iTegretol, iTeril, abanye) noma i-phenytoin (iDilantin, Phenytek); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); isidambisi; i-serotonin reuptake inhibitors (SSRIs) ekhethiwe njenge-duloxetine (Cymbalta), i-fluoxetine (i-Prozac, i-Sarafem, i-Selfemra, abanye), i-fluvoxamine (i-Luvox), i-paroxetine (i-Brisdelle, i-Paxil, i-Pexeva) ne-sertraline (i-Zoloft); amaphilisi okulala; i-terbinafine (iLamisil); kanye nezithambisi. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• ngaphezu kwesimo esisohlwini lwesigaba ESIBALULEKILE SESEXWAYISO, tshela udokotela wakho uma wena noma omunye umuntu emndenini wakho eke waba nesikhathi esikude se-QT (inkinga yenhliziyo engajwayelekile engadala ukushaya kwenhliziyo okungajwayelekile, ukuquleka, noma ukufa okungazelelwe) noma isifo sikashukela. Tshela udokotela wakho uma unesifo sokuqunjelwa, isicanucanu, ukuhlanza, noma ubuhlungu besisu noma ukuphazamiseka; noma uma uke waba nezinkinga ngohlelo lwakho lokuchama noma i-prostate (indlala yokuzala yowesilisa); i-dyslipidemia (amazinga aphezulu e-cholesterol); ileus ekhubazekile (isimo lapho ukudla kungakwazi ukuhamba khona emathunjini); i-glaucoma; umfutho wegazi ophakeme noma ophansi; unenkinga yokugcina ibhalansi yakho; noma isifo senhliziyo, sezinso, samaphaphu noma sesibindi. Phinda utshele udokotela wakho uma wake wakuyeka ukuthatha umuthi wokugula ngengqondo ngenxa yemiphumela emibi kakhulu.
• Tshela udokotela wakho uma ukhulelwe, ikakhulukazi uma usezinyangeni ezimbalwa ezedlule zokukhulelwa kwakho, noma uma uhlela ukukhulelwa noma ukuncelisa. Uma ukhulelwa ngenkathi uthatha i-clozapine, shayela udokotela wakho. I-Clozapine ingadala izinkinga ezinganeni ezisanda kuzalwa ngemuva kokubeletha uma zithathwa ezinyangeni zokugcina zokukhulelwa.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-clozapine.
• kufanele wazi ukuthi utshwala bungangezela ukozela okubangelwa yilomuthi.
• utshele udokotela wakho uma usebenzisa imikhiqizo kagwayi. Ukubhema ugwayi kunganciphisa ukusebenza kwalo muthi.
• kufanele wazi ukuthi ungathola i-hyperglycemia (iyanda kushukela wakho wegazi) ngenkathi uthatha lo muthi, noma ngabe awunaso vele isifo sikashukela. Uma une-schizophrenia, kungenzeka ukuthi ube nesifo sikashukela kunabantu abangenayo i-schizophrenia, futhi ukuthatha i-clozapine noma imishanguzo efanayo kungakhuphula le ngozi. Tshela udokotela wakho ngokushesha uma unanoma iyiphi yalezi zimpawu ezilandelayo ngenkathi uthatha i-clozapine: ukoma ngokweqile, ukuchama njalo, ukulamba ngokweqile, ukungaboni kahle, noma ubuthakathaka. Kubaluleke kakhulu ukubiza udokotela wakho ngokushesha uma unezinye zalezi zimpawu, ngoba ushukela ophakeme wegazi ungadala isimo esibi esibizwa nge-ketoacidosis. I-Ketoacidosis ingasongela impilo uma ingelashwa kusenesikhathi. Izimpawu ze-ketoacidosis zifaka phakathi: umlomo owomile, isicanucanu nokuhlanza, ukuphefumula okuncane, ukuphefumula okunuka izithelo, nokuncipha kokwazi.
• uma une-phenylketonuria (i-PKU, isimo esizuzwe njengefa lapho kufanele kulandelwe ukudla okukhethekile ukuvimbela ukubola kwengqondo), kufanele wazi ukuthi amaphilisi ahlukaniswa ngomlomo aqukethe i-aspartame eyakha i-phenylalanine.

Khuluma nodokotela wakho ngokuphuza iziphuzo ezine-caffeine ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

Uma uphuthelwa ukuthatha i-clozapine izinsuku ezingaphezu kwezingu-2, kufanele ushayele udokotela wakho ngaphambi kokuthatha eminye imithi. Udokotela wakho angafuna ukuqala kabusha imithi yakho ngomthamo ophansi.

I-Clozapine ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukozela
• isiyezi, ukuzizwa ungagxilile, noma unenkinga yokugcina ibhalansi yakho
• ukwanda kwamathe
• umlomo owomile
• ukungahlaliseki
• ikhanda

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo noma lezo ezibalwe eziXWAYISWENI EZIBALULEKILE noma ezingxenyeni ezithile zokuqapha, shayela udokotela wakho ngokushesha:

• ukuqunjelwa; isicanucanu; ukuvuvukala kwesisu noma ubuhlungu; noma ukuhlanza
• ukuxhawula izandla ongeke ukwazi ukuzilawula
• ukuquleka
• ukuwa
• ubunzima bokuchama noma ukulahlekelwa ukulawula isinye
• ukudideka
• izinguquko embonweni
• ukuqhaqhazela
• ukuqina okukhulu kwemisipha
• ukujuluka
• izinguquko ekuziphatheni
• ukopha okungajwayelekile noma ukulinyazwa
• ukulahlekelwa isifiso sokudla
• isisu esibuhlungu
• ukuphuzi kwesikhumba noma kwamehlo
• ubuhlungu engxenyeni engenhla kwesokudla yesisu
• ukungabi namandla

I-Clozapine ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Yigcine ekamelweni lokushisa kude nokukhanya nokushisa okweqile nomswakama (hhayi endlini yangasese). Ungafaki esiqandisini noma umise ukumiswa okomlomo.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• isiyezi
• ukuquleka
• ukuphefumula kancane
• shintsha ekushayeni kwenhliziyo
• ukulahlekelwa ukwazi

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-clozapine.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UClozaril^®
• FazaClo^® ODT
• I-Versacloz^®