IGlyburide neMetformin

-Delile

• Ngaphambi kokuthatha i-glyburide ne-metformin,
• Lo muthi ungadala ushintsho kushukela wakho wegazi. Kufanele wazi izimpawu zikashukela wegazi ophansi futhi ophakeme nokuthi yini okufanele uyenze uma unalezi zimpawu.
• I-Glyburide ne-metformin kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Uma uhlangabezana nalezi zimpawu ezilandelayo noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka phakathi izimpawu ze-hypoglycemia kanye nokulandelayo:

I-Metformin ingahle ingabangi isimo esibi, esisongela impilo esibizwa nge-lactic acidosis. Tshela udokotela wakho uma unesifo sezinso. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-glyburide ne-metformin. Futhi, tshela udokotela wakho uma uneminyaka engaphezu kwengama-65 ubudala futhi uma wake wahlaselwa yinhliziyo; unhlangothi; i-ketoacidosis yesifo sikashukela (ushukela wegazi ophakeme ngokwanele ukudala izimpawu ezinzima futhi kudinga ukwelashwa okuphuthumayo); ikhoma; noma isifo senhliziyo noma sesibindi. Tshela udokotela wakho uma uthatha i-acetazolamide (Diamox), i-dichlorphenamide (Keveyis), i-methazolamide, i-topiramate (i-Topamax, e-Qsymia), noma i-zonisamide (i-Zonegran).

Tshela udokotela wakho uma ngabe usanda kuba nalezi zimo ezilandelayo, noma uma uzenza ngesikhathi sokwelashwa: ukutheleleka okunzima; uhudo olunzima, ukuhlanza, noma imfiva; noma uma uphuza uketshezi oluncane kakhulu kunokujwayelekile nganoma yisiphi isizathu. Kungadingeka uyeke ukuthatha i-glyburide ne-metformin uze ululame.

Uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, noma noma iyiphi inqubo enkulu yezokwelapha, tshela udokotela ukuthi uthatha i-glyburide ne-metformin. Futhi, tshela udokotela wakho uma uhlela ukuba nenqubo ethile ye-x-ray lapho kufakwa khona udayi, ikakhulukazi uma uphuza noma wake waphuza utshwala obuningi noma unesifo sesibindi noma ukwehluleka kwenhliziyo. Ungadinga ukuyeka ukuthatha i-glyburide ne-metformin ngaphambi kwenqubo bese ulinda amahora angama-48 ukuqala kabusha ukwelashwa. Udokotela wakho uzokutshela kahle ukuthi kufanele uyeke nini ukuthatha i-glyburide ne-metformin nokuthi kufanele uqale nini ukuyithatha futhi.

Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, yeka ukuthatha i-glyburide ne-metformin bese ufonela udokotela wakho ngokushesha: ukukhathala ngokweqile, ubuthakathaka, noma ukungaphatheki kahle; isicanucanu; ukuhlanza; ubuhlungu besisu; ukuncipha kokudla; ukuphefumula okujulile nokusheshayo noma ukuphefumula okuncane; isiyezi; ikhanda elikhanyayo; ukushaya kwenhliziyo okusheshayo noma okuhamba kancane; ukuqhuma kwesikhumba; ubuhlungu bemisipha; noma uzizwa ubanda ezandleni noma ezinyaweni zakho.

Tshela udokotela wakho uma uphuza njalo utshwala noma kwesinye isikhathi uphuza utshwala obuningi ngesikhathi esifushane (ukuzitika ngokweqile). Ukuphuza utshwala kwandisa ingozi yokuba ne-lactic acidosis noma kungadala ukwehla kweshukela egazini. Ukuphuza utshwala ngenkathi uthatha i-glyburide ne-metformin nakho kungajwayelekile kungadala izimpawu ezifana nokugobhoza (ukubomvu kobuso), ikhanda elibuhlungu, isicanucanu, ukuhlanza, ubuhlungu besifuba, ubuthakathaka, ukungaboni kahle, ukudideka kwengqondo, ukujuluka, ukuquma, ubunzima bokuphefumula nokukhathazeka. Buza udokotela wakho ukuthi ungakanani utshwala obuphephile ukuphuza ngenkathi uthatha i-glyburide ne-metformin.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ngaphambi nangesikhathi sokwelashwa ukuze abheke ukuthi izinso zakho zisebenza kahle kangakanani nempendulo yomzimba wakho ku-glyburide ne-metformin. Khuluma nodokotela wakho ngezingozi zokuthatha i-glyburide ne-metformin.

Inhlanganisela ye-glyburide ne-metformin isetshenziselwa ukwelapha uhlobo lwesifo sikashukela sohlobo 2 (isimo lapho umzimba ungasebenzisi i-insulin ngokujwayelekile ngakho-ke awukwazi ukulawula inani likashukela egazini) kubantu abanesifo sikashukela esingalawulwa ngokudla nangokuzivocavoca umzimba kuphela. IGlyburide ingeyesigaba semithi esibizwa ngokuthi yi-sulfonylureas, kanti i-metformin isesigabeni semithi ebizwa ngama-biguanides. IGlyburide yehlisa ushukela wegazi ngokubangela amanyikwe ukuthi akhiqize i-insulin (into engokwemvelo edingekayo yokwehlisa ushukela emzimbeni) nokusiza umzimba ukuthi usebenzise i-insulini kahle. Lo muthi uzosiza kuphela ukwehlisa ushukela wegazi kubantu abanemizimba ekhiqiza i-insulin ngokwemvelo. I-Metformin isiza umzimba wakho ukulawula inani le-glucose (ushukela) egazini lakho. Iyanciphisa inani le-glucose oyiphuzayo ekudleni kwakho kanye nenani le-glucose elenziwe yisibindi sakho. Kuyasiza futhi umzimba wakho ukusebenzisa i-insulin yayo ngempumelelo. I-Glyburide ne-metformin azisetshenziselwa ukwelapha uhlobo lwesifo sikashukela sohlobo 1 (isimo lapho umzimba ungakhiqizi i-insulin ngakho-ke awukwazi ukulawula inani likashukela egazini) noma i-ketoacidosis yesifo sikashukela (isimo esibi kakhulu esingavela uma ushukela wegazi ongelashwa ).

Inhlanganisela ye-Glyburide ne-metformin iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa kanye noma kabili ngosuku nsuku zonke ngokudla. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-glyburide ne-metformin njengoba nje kuyalelwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Udokotela wakho kungenzeka akuqale ngomthamo ophansi we-glyburide ne-metformin futhi angakhuphula kancane umthamo wakho, hhayi ngaphezu kwesisodwa njalo emavikini amabili. kuya ngempendulo yakho. Bheka i-glucose yakho yegazi eduze.

Inhlanganisela ye-Glyburide ne-metformin ilawula isifo sikashukela kepha ayiselaphi. Qhubeka uthathe i-glyburide ne-metformin noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-glyburide ne-metformin ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi kwesinye isikhathi ubekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-glyburide ne-metformin,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-glyburide, metformin, noma iziphi izithako ezikumaphilisi e-glyburide kanye ne-metformin, noma eminye imithi. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthatha i-bosentan (Tracleer). Udokotela wakho angakutshela ukuthi ungathathi i-glyburide uma uphuza lo muthi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: i-amiloride (Midamor); i-angiotensin-converting enzyme (ACE) inhibitors efana ne-benazepril (Lotensin, eLotrel), i-captopril, i-enalapril (i-Vasotec, ngesi-Vaseretic), i-fosinopril, i-lisinopril (e-Zestoretic), i-moexipril (i-Univasc), i-perindopril (i-Aceon) , ramipril (Altace), kanye ne-trandolapril (Mavik); ama-anticoagulants (’ama-thinner egazi’) njenge-warfarin (i-Coumadin, i-Jantoven); i-aspirin noma ezinye izidakamizwa ezingezona ukuvuvukala (ama-NSAID) njenge-ibuprofen (Advil, Motrin) noma naproxen (Aleve, Naprosyn); ama-beta-blockers anjenge-atenolol (Tenormin), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard, eCorzide), nepropranolol (Hemangeol, Inderal, InnoPran); ama-calcium channel blocker anjenge-amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Diltzac, others), felodipine, isradipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab CR, Procardia), noma verapamil (Calan, Covera, Verelan, in ITarka); i-chloramphenicol; i-cimetidine (Tagamet); i-clarithromycin (i-Biaxin, ku-Prevpac); i-cyclosporine (Gengraf, Neoral, Sandimmune); i-digoxin (i-Lanoxin); i-disopyramide (iNorpace); isisu (‘amaphilisi amanzi’); i-fluconazole (iDiflucan); i-fluoxetine (i-Prozac, iSarafem, i-Selfemra); i-furosemide (i-Lasix); ukwelashwa kwe-hormone esikhundleni; i-insulin noma eminye imithi yesifo sikashukela; i-isoniazid (iLaniazid, eRifamate, eRifater); Ama-inhibitor e-MAO afana ne-isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), ne-tranylcypromine (iParnate); imithi yokwaliwa yizifo, i-asthma, nemikhuhlane; imithi yokugula ngengqondo kanye nesicanucanu; miconazole (Lotrimin, Monistat, abanye); i-morphine (i-MS Contin, abanye); i-niacin; izinto zokuvimbela inzalo ngomlomo (amaphilisi okuvimbela inzalo); i-steroids yomlomo efana ne-dexamethasone, i-methylprednisolone (i-Medrol), ne-prednisone (i-Rayos); i-phenytoin (iDilantin, Phenytek); ama-probenecid (iBenemid, eColbenemid); procainamide; i-quinidine (ku-Nuedexta); i-quinine; ama-antibiotic e-quinolone ne-fluoroquinolone njenge-cinoxacin (ayisatholakali e-US, Cinobac), ciprofloxacin (Cipro), enoxacin (ayisatholakali e-US, Penetrex), gatifloxacin, levofloxacin (Levaquin), lomefloxacin (ayisatholakali e-US , Maxaquin), moxifloxacin (Avelox), nalidixic acid (ayisatholakali e-US, NegGram), norfloxacin (ayisatholakali e-US, Noroxin), ofloxacin (ayisatholakali e-US, Floxin), sparfloxacin (ayisekho iyatholakala e-US, Zagam), inhlanganisela ye-trovafloxacin ne-alatrofloxacin (ayisatholakali e-US, eTrovan); i-ranitidine (iZantac); i-rifampin; ubuhlungu be-salicylate buqeda njenge-choline magnesium trisalicylate, i-choline salicylate (Arthropan), i-diflunisal, i-magnesium salicylate (i-Doan's, abanye), noma i-salsalate (i-Argesic, i-Disalcid, i-Salgesic); i-sulfa antibiotic efana ne-cotrimoxazole (Bactrim, Septra); i-sulfasalazine (i-Azulfidine); imishanguzo yegilo; i-triamterene (Dyrenium, eMaxzide, abanye); i-trimethoprim (Primsol, eBactrim, ngo-Septra); noma i-vancomycin (i-Vancocin, abanye).
• ngaphezu kwezimo ezibalwe esigabeni SOKUXWAYISA OKUBALULEKILE, tshela udokotela wakho uma wena noma elinye lamalungu omndeni wakho ninokushoda kwe-G6PD (isimo esizuzwe njengefa esidala ukubhujiswa ngaphambi kwesikhathi kwamangqamuzana egazi abomvu noma i-hemolytic anemia); futhi utshele udokotela wakho uma uke waba nezinkinga ze-hormone ezibandakanya i-adrenal, pituitary, noma i-thyroid gland; noma i-acidosis engapheli noma engapheli.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-glyburide ne-metformin, shayela udokotela wakho.
• hlela ukugwema ukuvezwa yilanga ngokungadingekile noma isikhathi eside futhi ugqoke izingubo zokuzivikela, izibuko zelanga, nesikhumba selanga. I-Glyburide ne-metformin zingenza isikhumba sakho sizwele elangeni.
• tshela udokotela wakho uma udla kancane noma uzivocavoca umzimba kunokujwayelekile. Lokhu kungathinta ushukela wegazi lakho. Udokotela wakho uzokunika imiyalo uma lokhu kwenzeka.

Qiniseka ukuthi ulandela zonke izincomo zokuzivocavoca nezokudla ezenziwa ngudokotela wakho noma udokotela odlayo. Kubalulekile ukudla ukudla okunempilo.

Ngaphambi kokuba uqale ukuthatha i-glyburide ne-metformin, cela udokotela wakho ukuthi enzeni uma ukhohlwa ukuthatha umthamo noma ngephutha uthathe umthamo owengeziwe. Bhala lezi zinkomba phansi ukuze ukwazi ukubheka kuzo ngokuhamba kwesikhathi.

Njengomthetho ojwayelekile, thatha isilinganiso esilahlekile ngokushesha nje lapho usikhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

Lo muthi ungadala ushintsho kushukela wakho wegazi. Kufanele wazi izimpawu zikashukela wegazi ophansi futhi ophakeme nokuthi yini okufanele uyenze uma unalezi zimpawu.

I-Glyburide ne-metformin kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubuhlungu besisu
• isicanucanu noma ukuhlanza
• isifo sohudo
• isiyezi

Uma uhlangabezana nalezi zimpawu ezilandelayo noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• ubuhlungu besifuba
• ukuqubuka
• ukuphuzi kwesikhumba noma kwamehlo
• indle enombala okhanyayo
• umchamo omnyama
• ubuhlungu engxenyeni engenhla yesisu
• ukopha okungajwayelekile noma ukulinyazwa
• imfiva
• Umphimbo obuhlungu
• ukuvuvukala kwamehlo, ubuso, izindebe, ulimi, noma umphimbo

Kokunye ukuhlola, abantu abathathe umuthi ofana ne-glyburide ukwelapha isifo sikashukela babesengozini yokufa ngezinkinga zenhliziyo kunabantu ababelashwa i-insulin nezinguquko zokudla.

I-Glyburide ne-metformin kungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Yigcine ekamelweni lokushisa kude nokukhanya, ukushisa okweqile, nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka phakathi izimpawu ze-hypoglycemia kanye nokulandelayo:

• isithuthwane
• ukulahlekelwa ukwazi
• ukukhathala ngokweqile
• ubuthakathaka
• ukungakhululeki
• ukuhlanza
• isicanucanu
• ubuhlungu besisu
• ukuncipha kokudla
• ukuphefumula okujulile, okusheshayo
• ukuphelelwa umoya
• isiyezi
• ubumhlophe
• ukushaya kwenhliziyo okusheshayo noma okuhamba kancane
• ukuqhuma kwesikhumba
• ubuhlungu bemisipha
• ngizwe kubanda

Udokotela wakho uzokutshela ukuthi ungayihlola kanjani impendulo yakho ku-glyburide ne-metformin ngokulinganisa amazinga kashukela egazini lakho ekhaya. Landela le miyalo ngokucophelela.

Kufanele njalo ufake isongo lokuhlonza isifo sikashukela ukuze uqiniseke ukuthi uthola ukwelashwa okufanele esimeni esiphuthumayo.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Glucovance^® (equkethe iGlyburide, Metformin)