Buza Uchwepheshe: Uphawu noma imiphumela emibi?

-Delile

• 1. Uyini umehluko omkhulu phakathi kokuzamazama nedyskinesia?
• Ukuzamazama kokuphumula kukaParkinson
• 2. Ngabe kukhona izindlela ezibonakalayo zokwehlukanisa ukuzamazama kwi-dyskinesia?
• 3. Yiziphi izimpawu ze-dyskinesia eyenziwe yizidakamizwa?
• Ukuzamazama kweParkinson
• 4.Kungani ezinye izidakamizwa zeparkinson's cause dyskinesia?
• 5. Ngingayiphatha kanjani i-dyskinesia eyenziwe yizidakamizwa? Iyeke?
• I-dyskinesia eyenziwe nge-Parkinson
• 6. Yiziphi ezinye izinkinga ze-dyskinesia?

1. Uyini umehluko omkhulu phakathi kokuzamazama nedyskinesia?

Ukundindizela okubonwa yisifo sikaParkinson kungenye yezinto ezivelele zalesi simo. Ngenye yezimpawu zezimoto zikaParkinson ezibonisa ukuthuthuka ngemithi.

Ngakolunye uhlangothi, i-dyskinesia ijwayele ukuvela ngokuhamba kwesikhathi esifundweni njengomphumela wesikhathi eside wemithi esetshenziselwa ukwelapha iParkinson's. Kwesinye isikhathi kungaba nzima ukusho ukuthi ukunyakaza okungavamile ukuthuthumela noma i-dyskinesia.

Ukuzamazama kokuphumula kukaParkinson

Imvamisa, ngeParkinson's, lo muntu uye wathuthumela kakhulu lapho izandla zisaphumule noma zisekelwa ngumzimba ngokumelene namandla adonsela phansi bese ziyathuthuka lapho izingalo zihamba.

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2. Ngabe kukhona izindlela ezibonakalayo zokwehlukanisa ukuzamazama kwi-dyskinesia?

Umehluko omkhulu ukuthi ukuzamazama kunesigqi ekunyakazeni kwayo, ikakhulukazi ezungeze ilunga elilodwa. I-Dyskinesia ayigcini ngokuzibandakanya, kepha futhi ivame ukuphazamiseka. Ukuthuthumela okuhambisana neParkinson kuvame ukucindezelwa ngokunyakaza nomsebenzi, kanti i-dyskinesia ayinjalo.

3. Yiziphi izimpawu ze-dyskinesia eyenziwe yizidakamizwa?

Zenzeka ngokwelashwa isikhathi eside kwemithi yesifo sikaParkinson, ikakhulukazi i-levodopa (iSinemet, iDuopa). Isikhathi eside umuntu abe nalesi simo futhi isikhathi eside aphuza imishanguzo (ikakhulukazi ngemithamo ephezulu), iba sengozini enkulu yokuthola i-dyskinesia eyenziwe yizidakamizwa.

Ukuzamazama kweParkinson

Ukucindezeleka, isasasa, kanye nezinga lokuphumula konke kuthinta ukuqina kokuthuthumela kukaParkinson.

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4.Kungani ezinye izidakamizwa zeparkinson's cause dyskinesia?

Akuqondakali kahle ukuthi kungani imithi ye-Parkinson imbangela yedyskinesia. Ngaphansi kwezimo ezijwayelekile, kunokukhuthaza okuqhubekayo nge-dopamine. E-Parkinson's, isinali le-dopamine liyashoda. Kodwa-ke, imithi eklanyelwe ukufaka esikhundleni isignali ye-dopamine iphumela "emapulini" okufakelwa e-dopamine. Kucatshangwa ukuthi ukudonsa okuya phezulu naphansi kwesiginali ye-dopamine kunesibopho se-dyskinesia eyenziwe yizidakamizwa.

5. Ngingayiphatha kanjani i-dyskinesia eyenziwe yizidakamizwa? Iyeke?

Ukuphatha i-dyskinesia eyenziwe yizidakamizwa kungaba yinselele. Enye indlela ephumelelayo ukunciphisa umthamo wemithi, ikakhulukazi i-levodopa. Kodwa-ke, lokhu kungadala ukuthi ezinye zezimpawu zezimoto ezihlobene neParkinson’s zibuye.

Ukwakhiwa okusha nezindlela zokuletha imishanguzo kunikeza ukukhishwa okuqhubekayo komuthi futhi kusize ukunciphisa izimpawu ze-dyskinesia. Ukwakhiwa kokuqina okusimeme kanye nokufakwa ngaphakathi okuqondile kwamathumbu kuyizibonelo zezindlela ezinjalo.

Izizukulwane ezintsha zemithi engeyona i-levodopa, efana ne-safinamide, igama le-Xadago (i-monoamine oxidase B inhibitor), ne-opicapone (i-catechol-O-methyltransferase inhibitor) nayo ikhombise isithembiso ekwehliseni i-dyskinesia.

Ukuhlinzwa kweParkinson's, njengokujula kwengqondo okujulile (i-DBS), nakho kuphumela ekwehliseni izimpawu ze-dyskinesia. Lokhu kungenzeka ngoba i-DBS ivame ukusiza ukunciphisa inani lemithi edingekayo kweParkinson's.

I-dyskinesia eyenziwe nge-Parkinson

Ngokusetshenziswa isikhathi eside kwemithi kaParkinson, njenge-levodopa, umuntu angakhula ukuphazamiseka kokunyakaza okuthuthukile, noma ngabe umuthi ubusize izimpawu zikaParkinson ekuqaleni kwesifo.

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6. Yiziphi ezinye izinkinga ze-dyskinesia?

Njengezinye izimpawu zesifo sikaParkinson, i-dyskinesia ingaphazamisa imisebenzi yansuku zonke njengokudla nokuphuza. Kodwa-ke, i-dyskinesia uqobo ayilona uphawu lwengozi eyimbangela. Kubonisa ukuqhubeka kwesifo.

Ingcuphe enkulu yokuthuthukisa i-dyskinesia eyenziwe yizidakamizwa ukuthi umuntu unesikhathi esingakanani eba noParkinson. Lapho i-dyskinesia ibonakala, kungasho nokuthi umuntu kungenzeka ukuthi akaphenduli kangako emithini ejwayelekile yalesi simo. Kungasho ukuthi badinga ukulungisa uhlelo lwabo lokulinganisa noma ukwakheka kwezidakamizwa.

UDkt Seunggu Jude Han ungumsizi kaprofesa wezokuhlinzwa kwezinzwa e-Oregon Health and Sciences University ePortland, e-Oregon. Usebenze kubasebenzi ababuyekeza ezokwelapha eHealthline kusukela ngo-2016 futhi ubuyekeze ama-athikili angaphezu kwama-200.