I-Biologics ye-AS: Yiziphi Izinketho Zakho?

-Delile

• Yini i-biologics ye-AS?
• 1. Izicubu ze-Tumor necrosis factor (TNF)
• 2. Izivimbeli ze-Interleukin 17 (IL – 17)
• Inikezwa kanjani i-biologics ye-AS?
• Izindleko ze-biologics ye-AS
• Imiphumela emibi ye-biologics ye-AS
• Ungayithola kanjani indlela efanele yokwelashwa kwe-biologic ye-AS
• Ukudla okudlela endlini

I-Ankylosing spondylitis (AS) isifo esingapheliyo sokuzivikela komzimba esithinta kakhulu amalunga omgogodla, kepha amalunga amakhulu, njengezinqulu namahlombe, nawo angabandakanyeka.

Ukuvuvukala, okuvela emsebenzini wamasosha omzimba, kubangela ukuxubana ngokuhlangene ezingxenyeni zomgogodla, okuvame ukuholela ebuhlungu, ukuvuvukala nokuqina.

Lokhu kungakhawulela ukuhamba, kwenze kube nzima ukuqeda imisebenzi yansuku zonke.

Alikho ikhambi lalesi sifo, kepha ukwelashwa okuhlukile kunganciphisa ukuqhubeka futhi kukusize uphile impilo esebenzayo. Umhlinzeki wakho wezokunakekelwa kwempilo uzokwenzela uhlelo lokwelashwa ngemuva kokuxilongwa.

Ngenxa yokuthi izimpawu ze-AS zingahluka ukusuka kokuncane kuya kokubi, abanye abantu bangakwazi ukuphatha izimpawu zabo ngemithi engeyona yokuvuvukala (ama-NSAID), njenge-ibuprofen (Motrin, Advil) ne-naproxen sodium (Aleve).

Uma izimpawu zakho zingaphenduli kulezo zidakamizwa, imishanguzo kadokotela iyindlela elandelayo yokuzivikela.

Imithi kadokotela esetshenziselwa i-AS ifaka phakathi izidakamizwa eziguqula izifo ezilwa nerheumatic (DMARDs) ukwehlisa ukuvuvukala komzimba.

Yize bengakwazi ukukhomba imbangela ngqo yayo, ama-NSAID nama-DMARD womabili enzelwe ukumisa ukuvuvukala.

Kwesinye isikhathi ubuhlungu nokuqina AS okukulethayo akuphenduli kule mithi kadokotela. Ukukusiza ukuphatha izimpawu, udokotela wakho angancoma uhlobo oluthile lwezokwelapha olubizwa nge-biologics.

Yini i-biologics ye-AS?

I-biologics ngamaphrotheni enzelwe izakhi zofuzo adalwe kusuka ezintweni eziphilayo ezilingisa imisebenzi ejwayelekile yemvelo.

Zenzelwe ukwelashwa okubhekiswe kumaprotheni athile kumasosha omzimba akhiqiza ukuvuvukala, okungukuthi:

• isimila necrosis factor (TNF)
• i-interleukin 17 (IL-17)

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kwavuma i-biologic yokuqala ngo-1988 ukwelapha isifo samathambo. Kusukela lapho, kuye kwenziwa ezinye izinto eziphilayo eziningana.

Njengamanje, izinhlobo eziyisikhombisa ze-biologics zivunyelwe ukwelashwa kwe-AS. Lokhu kufaka phakathi:

1. Izicubu ze-Tumor necrosis factor (TNF)

• i-adalimumab (Humira)
• isitifiketi se-certolizumab (Cimzia)
• i-etanercept (Enbrel)
• igolimumab (iSimponi, iSimponi Aria)
• infliximab (i-Remicade)

2. Izivimbeli ze-Interleukin 17 (IL – 17)

• secukinumab (Cosentyx)
• ixekizumab (Taltz)

Inikezwa kanjani i-biologics ye-AS?

I-biologics kufanele ihanjiswe kuzicubu ngaphansi kwesikhumba noma ekujuleni kwemisipha. Azitholakali ngephilisi noma ngomlomo. Ubathola ngemijovo noma ngemijovo.

Imvamisa yemijovo noma i-infusions edingekayo izokwehluka ngokuya ngohlobo oluthile lokwelashwa kwe-biologic.

Ungathola ukumnika njalo ezinyangeni ezimbalwa. Noma, ungadinga imijovo eminingi yokuqalisa bese ulandela imijovo unyaka wonke.

Isibonelo, i-biologic Simponi idinga imijovo emithathu yokuqala:

• imijovo emibili ngosuku lokuqala lokwelashwa
• umjovo owodwa emasontweni amabili kamuva

Ngemuva kwalokho, uzozinika umjovo owodwa njalo emavikini amane.

Ngakolunye uhlangothi, uma uthatha uHumira, uzozinika umjovo owodwa njalo ngesonto ngemuva kwamanani amane okuqala.

Udokotela wakho uzokutshela ukuthi uzodinga kaningi kangakanani ukwelashwa nge-biologic, futhi bazokunikeza iziyalezo zendlela yokujova imijovo yakho.

I-Biologics ayizenzi ngcono izimpawu ze-AS ngobusuku obubodwa, kepha kufanele uqale ukuzizwa ungcono cishe emavikini ayi-4 kuye kwayi-12, kwesinye isikhathi ngokushesha.

Inhloso yokwelashwa ukucindezela izimpawu zakho ukuze isimo singaphazamisi impilo yakho. Kubalulekile ukuqaphela ukuthi i-biologics ngeke iyelaphe i-AS.

Izindleko ze-biologics ye-AS

I-Biologics ivame ukusebenza kahle, kodwa iyabiza kakhulu e-United States. Ngokwesilinganiso, izindleko ze-biologics futhi kwesinye isikhathi zingaphezulu kakhulu kwama-ejenti abiza kakhulu.

Umshuwalense kungenzeka uhlanganise ingxenye yezindleko, yize kuzoya ngokuthi utholakala kanjani.

Khuluma nodokotela wakho ngezinketho zama-biosimilars (ukwakheka okufanayo ne-biologics) kanye nanoma yiziphi izinhlelo zosizo lwesiguli ngokusebenzisa abenzi bezidakamizwa.

Imiphumela emibi ye-biologics ye-AS

Kukhona ubungozi bemiphumela emibi noma ukungezwani komzimba nezinhlobo eziningi zemithi, futhi i-biologics nayo iyahlukile.

Imiphumela emibi yokwelashwa kwe-biologic ingafaka:

• ubuhlungu, ububomvu, ukuqubuka, noma ukulinyazwa endaweni yokujova
• ikhanda
• isifuba noma ukuqubuka
• ubuhlungu besisu
• ukuhlungu obusemhlane
• isicanucanu
• ukukhwehlela noma umphimbo obuhlungu
• umkhuhlane noma amakhaza
• ukuphefumula kanzima
• umfutho wegazi ophansi

Le miphumela emibi ivame ukuba mncane futhi imane yehle futhi ekugcineni ihambe.

Kodwa-ke, kufanele ushayele udokotela wakho uma unezimpawu ezifana nesifuba, ukuvuvukala, noma ukuphefumula kanzima. Lokhu kungaba yizimpawu zokuphendula okweqile.

Ngoba i-biologics icindezela amasosha akho omzimba, angakhuphula ubungozi bokutheleleka kanye nomdlavuza.

Udokotela wakho angalawula ukuhlolwa kwelebhu ngaphambi komjovo wakho wokuqala noma ukumnika ukuze uhlole:

• isifo sofuba
• i-hepatitis B no-C
• ezinye izifo

Bheka udokotela wakho uma uthuthukisa izimpawu zokutheleleka ngemuva kokuqala ukwelashwa, njenge:

• imfiva
• Ukugodola
• ukuphelelwa umoya
• ukukhwehlela

Futhi, yazisa udokotela wakho uma ungachazwanga:

• ukulinyazwa
• ukuncipha komzimba
• ukukhathala okungavamile

I-Biologics ingakhuphula ubungozi bokuthuthukisa umdlavuza wegazi njenge-lymphoma.

Ungayithola kanjani indlela efanele yokwelashwa kwe-biologic ye-AS

Yize yonke i-biologics ye-AS ihloselwe ukunciphisa ukukhula kwesifo nokuyeka ukuvuvukala, i-biologics ayisebenzi ngokufanayo kuwo wonke umuntu.

Uma uqala ukwelashwa nge-biologic, udokotela wakho angakuqala ngohlobo olulodwa futhi aqaphe isimo sakho ezinyangeni ezintathu ezizayo ukuze abone ukuthi kukhona yini ukuthuthuka.

Ungazizwa udangele uma izimpawu zakho zinganciphi ngemuva kokungenwa kwakho kokuqala noma imijovo. Uma i-AS yakho ingathuthuki, udokotela wakho angase asikisele ukushintshela ku-biologic ehlukile evunyelwe i-AS.

Ukwelashwa nge-Biologic kukodwa akuyona inketho kuphela.

Akufanele uthathe i-biologic engaphezu kweyodwa ngesikhathi ngenxa yobungozi bokutheleleka, kodwa ungathatha i-biologics neminye imithi ye-AS. Ukuthola ukukhululeka ku-AS kwesinye isikhathi kuyindaba yokulinga nephutha.

Iba nesineke. Kungathatha isikhathi ukuthola inhlanganisela elungile yezidakamizwa.

Isibonelo, yize izimpawu zakho zingazange zithuthuke ngenkathi uthatha ama-NSAID noma ama-DMARD, ukuhlanganisa i-biologic nale mithi kungasebenza.

Ukudla okudlela endlini

Ngaphandle kokwelashwa okufanele, i-AS ingathuthuka kancane kancane futhi ibangele ukwanda kobuhlungu, ukuqina, nokulinganiselwa kokunyakaza.

Khuluma nodokotela wakho uma unomuzwa wokuthi ukwelashwa kwakho kwamanje akusebenzi. Ungahle ube yilunga le-biologics.

Kepha ngaphambi kokuqala ukwelashwa kwe-biologic (njenganoma yikuphi ukwelashwa), qiniseka ukuthi uyazi izinketho zakho bese ubuza imibuzo.