I-CBD yeFibromyalgia

-Delile

• Ucwaningo nge-CBD ye-fibromyalgia
• Izifundo zangaphambilini
• Ucwaningo lwango-2019 lwesiDashi
• Ucwaningo lwe-2019 Israeli
• Izinketho zokwelashwa kwe-CBD
• Imiphumela emibi ye-CBD
• Umbono

Ukuqonda i-cannabidiol (CBD)

I-Cannabidiol (i-CBD) iyinhlanganisela yamakhemikhali eyenziwe nge-cannabis. I-CBD ayisebenzisi ingqondo, ngokungafani ne-tetrahydrocannabinol (THC), enye into eyenziwa yi-cannabis.

I-CBD icatshangelwa ukuthi ivule ama-serotonin receptors. Idlala indima ku:

• ukuqonda ubuhlungu
• ukugcina ukushisa komzimba
• ukunciphisa ukuvuvukala

Ngokwezifundo zakamuva, ne-CBD:

• kusiza ukunciphisa izimpawu zokucindezeleka
• kungavimba izimpawu zengqondo

Lezi zinzuzo yizo ezenza i-CBD ukwelashwa okuhlukile okukhangayo kokuphazamiseka kobuhlungu njenge-fibromyalgia.

Ucwaningo nge-CBD ye-fibromyalgia

I-Fibromyalgia yisifo esingelapheki sobuhlungu esibangela ubuhlungu be-musculoskeletal ngaphezu kwe:

• ukukhathala
• ukuqwasha
• izingqinamba zokuqonda

Kuthinta kakhulu abesifazane, futhi njengamanje alikho ikhambi elaziwayo lalesi simo. Kodwa-ke, kukhona izindlela zokwelashwa ezigxila ekuphathweni kobuhlungu.

I-CBD isetshenziselwe ukunciphisa izimpawu zezinhlungu ezingapheli nokunciphisa ukuvuvukala. Kwethulwa njengenye indlela yokuthatha imiyalo ye-opioid engaba umlutha.

Kodwa-ke, i-Food and Drug Administration (i-FDA) ayivumanga i-CBD njengenketho yokwelashwa kwe-fibromyalgia noma ezinye izimo eziningi. Umuthi kadokotela osuselwa ku-CBD u-Epidiolex, ukwelashwa kwesifo sokuwa, uwukuphela komkhiqizo we-CBD ovunyelwe futhi ulawulwe yi-FDA.

Okwamanje azikho izifundo ezishicilelwe nge-fibromyalgia ezibheka imiphumela ye-CBD iyodwa. Kodwa-ke, olunye ucwaningo lubheka imiphumela ye-cannabis, engaqukatha ama-cannabinoids amaningi, ku-fibromyalgia.

Imiphumela ixubile. Kudingeka izifundo ezingaphezulu zabantu.

Izifundo zangaphambilini

Kutholwe ukuthi i-CBD ingasetshenziselwa ukuqeda ubuhlungu be-neuropathic. Abaphenyi baphetha ngokuthi ama-cannabinoids afana ne-CBD angaba isengezo esiwusizo kweminye imithi yezinhlungu.

Ucwaningo luka-2011 lubheke abantu abangama-56 abane-fibromyalgia. Iningi labahlanganyeli bekungabantu besifazane.

Amalungu ocwaningo ayenamaqembu amabili:

• Iqembu elilodwa lalinabahlanganyeli bokufunda abangama-28 ababengebona abasebenzisi be-cannabis.
• Iqembu lesibili lalinabahlanganyeli bokufunda abangama-28 ababengabasebenzisi be-cannabis. Imvamisa yokusetshenziswa kwabo kwe-cannabis, noma inani le-cannabis abayisebenzisayo, liyahlukahluka.

Ngemuva kwamahora amabili basebenzise insangu, abasebenzisi be-cannabis bathola izinzuzo ezinjenge:

• ukunciphisa ubuhlungu nokuqina
• ukwanda kokulala

Futhi babenezikolo eziphakeme ngokwengeziwe zezempilo yengqondo kunabo abangasebenzisi.

Ucwaningo lwango-2019 lwesiDashi

Ucwaningo lwango-2019 lwesiDashi lubheke umphumela we-cannabis kwabesifazane abangama-20 abane-fibromyalgia. Ngokuqhubeka kocwaningo, umhlanganyeli ngamunye uthole izinhlobo ezine zensangu:

• inani elingacacisiwe lezinhlobonhlobo ze-placebo, ebingenayo i-CBD noma i-THC
• Ama-milligram angama-200 (mg) ezinhlobonhlobo ezinamanani aphezulu we-CBD ne-THC (Bediol)
• I-200 mg yezinhlobonhlobo ezinamanani aphezulu we-CBD namanani aphansi we-THC (iBedrolite)
• I-100 mg yokuhlukahluka ngamanani aphansi e-CBD namanani aphezulu we-THC (Bedrocan)

Abaphenyi bathola ukuthi izinhlungu ezizenzekelayo zabantu abasebenzisa izinhlobonhlobo ze-placebo zazifana nezinhlungu ezizenzekelayo zabantu abasebenzisa ezinye zezinhlobo ezingezona eze-placebo.

Kodwa-ke, iBediol, ephezulu e-CBD ne-THC, yaletha ukukhululeka kubantu abaningi kunaleyo eyenziwa yi-placebo. Kubangele ukuncipha kwamaphesenti angama-30 kobuhlungu bokuzenzakalela kubahlanganyeli abangu-18 kwabangu-20. I-placebo idale ukwehla kwamaphesenti angama-30 wezinhlungu ezizenzekelayo kubahlanganyeli abayi-11.

Ukusetshenziswa kweBediol noma iBedrocan, zombili izinhlobo eziphakeme ze-THC, kuthuthukise kakhulu imibundu yezinhlungu zengcindezi uma kuqhathaniswa ne-placebo.

I-Bedrolite, ephezulu ku-CBD futhi iphansi ku-THC, ayibonisanga bufakazi bokuthi iyakwazi ukudambisa izinhlungu ezizenzekelayo noma ezivelayo.

Ucwaningo lwe-2019 Israeli

Ocwaningweni lwango-2019 lakwa-Israeli, amakhulu abantu abane-fibromyalgia babonwa esikhathini esiyizinyanga okungenani eziyisithupha. Kubahlanganyeli, amaphesenti angama-82 kwakungabesifazane.

Ababambe iqhaza ocwaningweni bathole ukuholwa ngabahlengikazi ngaphambi kokuthatha insangu yezokwelapha. Abahlengikazi banikeze izeluleko ngalokhu:

• izingcindezi zensangu eziyi-14 ezazikhona
• izindlela zokulethwa
• imithamo

Bonke ababambiqhaza baqala ngomthamo ophansi wensangu, futhi imithamo yandiswa kancane kancane phakathi nesikhathi sokufunda. Isilinganiso esivunyelwe semithi yensangu siqale ku-670 mg ngosuku.

Ezinyangeni eziyisithupha, isilinganiso esivunyelwe semithi yensangu sasingu-1,000 mg ngosuku. Umthamo ophakathi ovunyelwe we-THC wawuyi-140 mg, kanti isilinganiso esivunyelwe semidiyani se-CBD sasingu-39 mg ngosuku.

Abaphenyi bavumile ukuthi isifundo sinemikhawulo. Isibonelo, bakwazi kuphela ukulandela cishe amaphesenti ama-70 ababambiqhaza. Ukusetshenziswa kwamagciwane amaningi ahlukene futhi kwenze kwaba nzima ukuqhathanisa imiphumela yezinhlobo ezicebile ze-CBD ne-THC.

Kodwa-ke, basaphetha ngokuthi insangu yezokwelapha iyindlela yokwelashwa ephephile nephumelelayo ye-fibromyalgia.

Ekuqaleni kocwaningo, amaphesenti ama-52.5 wabahlanganyeli, noma abantu abayi-193, bachaze izinga labo lobuhlungu njengeliphezulu. Ekulandelweni kwezinyanga eziyisithupha, amaphesenti ayi-7.9 kuphela alabo abaphendulile, noma abantu abayi-19, ababike amazinga aphezulu obuhlungu.

Izinketho zokwelashwa kwe-CBD

Uma ufuna ukugwema imiphumela yengqondo yensangu, ungathola imikhiqizo ye-CBD equkethe inani elincane kuphela le-THC. Uma uhlala endaweni lapho insangu yezokungcebeleka noma yezokwelapha isemthethweni, ungathola imikhiqizo ye-CBD equkethe ukugxila okuphezulu kwe-THC.

Yize ngamunye enenzuzo ngokwehlukana, kungenzeka ukuthi i-CBD ne-TCH zisebenza kahle kakhulu uma zihlanganisiwe. Ochwepheshe babiza lokhu kusebenzisana, noma ukuxhumana, ngokuthi "umphumela weqembu."

I-CBD iphinde isebenze ngokumelene nama-receptors ahlosiwe yi-THC ukunciphisa imiphumela emibi yensangu, njenge-paranoia nokukhathazeka.

Ungasebenzisa i-CBD ngezindlela eziningi, kufaka phakathi:

• Ukubhema noma ukuqhuma. Uma ufuna ukuqeda izinhlungu ezisheshayo, ukubhema insangu ecebile nge-CBD kuyindlela esheshayo yokunciphisa izimpawu. Imiphumela ingahlala emahoreni ama-3. Ukubhema noma ukuqhuma kukuvumela ukuthi udonsele ngqo i-CBD kusuka esitshalweni se-cannabis, umunce ikhemikhali egazini lakho nasemaphashini.
• Okudliwayo. Okudla kungukudla okuphekwe nesitshalo se-cannabis, noma uwoyela noma ibhotela elifakwe insangu. Kuzothatha isikhathi eside ukuzwa ukukhululeka kwezimpawu, kepha imiphumela yokudla ingadonsa kuze kube ngamahora angu-6.
• Amafutha akhishwe. Amafutha angasetshenziswa phezulu, athathwe ngomlomo, noma ancibilike ngaphansi kolimi futhi angene ezicutshini zomlomo.
• Izihloko. Amafutha e-CBD angafakwa kuma-topical cream noma ama-balms futhi asetshenziswe ngqo esikhunjeni. Le mikhiqizo ye-CBD ingaba yindlela ephumelelayo yokunciphisa ukuvuvukala nokusiza ngobuhlungu bangaphandle.

Kungaba nezingozi zokuphefumula ekubhemeni noma ekuqhumeni insangu. Abantu abane-asthma noma izimo zamaphaphu akufanele basebenzise le ndlela.

Kufanele futhi ulandele imiyalo yesilinganiso ngokucophelela, ikakhulukazi ngokudla, ukugwema imiphumela emibi yokuthatha kakhulu.

Imiphumela emibi ye-CBD

I-Cannabidiol kucatshangwa ukuthi iphephile futhi inemiphumela engemihle emincane. Kodwa-ke, abanye abantu babhekane nemiphumela emibi elandelayo ngemuva kokusebenzisa i-CBD:

• ukukhathala
• isifo sohudo
• izinguquko zokudla
• ukushintsha kwesisindo

Ucwaningo olwenziwe ngamagundane axhumene nokudla kwe-CBD nobuthi besibindi. Kodwa-ke, amanye amagundane akuleso sifundo abephoqelelwe ngenqwaba ye-CBD ngendlela yokukhishwa kwe-cannabis ecebile nge-CBD.

Ukusebenzisana kwezidakamizwa kungenzeka nge-CBD. Bazi uma okwamanje uthatha ezinye izithasiselo noma imishanguzo.

I-CBD, njenge-grapefruit, nayo iphazamisa ama-cytochromes P450 (CYPs). Leli qembu lama-enzyme libalulekile ekusetshenzisweni komzimba kwezidakamizwa.

Umbono

Abaphenyi basacwaninga ukuthi ngabe i-CBD ingakwazi yini ukuphatha kahle izifo ezingamahlalakhona ezibuhlungu. Izifundo ezengeziwe ziyadingeka. Kukhona izindaba ezithile zokuphumelela, kepha i-CBD ayivunyelwe yi-FDA ye-fibromyalgia. Futhi, ucwaningo alukasibonisi imiphumela yesikhathi eside ye-CBD emzimbeni.

Kuze kube yilapho kwaziwa okuningi, kunconywa ukwelashwa kwendabuko kwe-fibromyalgia.

Uma uthatha isinqumo sokusebenzisa imikhiqizo ye-CBD ukuphatha izinhlungu, qiniseka ukuthi ubonane nodokotela kuqala. Bangakusiza ukuthi ugweme imiphumela emibi engemihle noma ukuxhumana okulimazayo nemithi yakho yokwelashwa yamanje.