Izinkinga nezingozi zePolycythemia Vera

-Delile

• Ukuhlonza i-PV
• Izinkinga
• I-thrombosis
• Ubende obukhulisiwe nesibindi
• Izinga eliphakeme lamaseli abomvu egazi
• I-Myelofibrosis
• Umdlavuza wegazi
• Izinkinga ezivela ekwelashweni

Ukubuka konke

IPolycythemia vera (PV) iyindlela engalapheki futhi eqhubekayo yomdlavuza wegazi. Ukuxilongwa kusenesikhathi kungasiza ekwehliseni ubungozi bezinkinga ezisongela impilo, njengamahlule egazi nezinkinga zokopha.

Ukuhlonza i-PV

Ukutholakala kokushintshwa kwezakhi zofuzo i-JAK2, i-JAK2 V617F, kusize odokotela ukuxilonga abantu abane-PV. Cishe amaphesenti angama-95 alabo abane-PV nabo banalokhu kuguqulwa kwezakhi zofuzo.

Ukuguqulwa kwe-JAK2 kubangela ukuthi amangqamuzana abomvu egazi akhiqize ngendlela engalawulwa. Lokhu kubangela ukuthi igazi lakho likhule ngokweqile. Igazi elijiyile livimbela ukugeleza kwalo liye ezithweni zakho nasezicubu zakho. Lokhu kungancisha umzimba umoya-mpilo. Kungadala namahlule egazi.

Ukuhlolwa kwegazi kungakhombisa uma amaseli akho egazi engajwayelekile noma uma amazinga akho okubalwa kwegazi ephezulu kakhulu. Ukubalwa kwamaseli amhlophe egazi kanye neplatelet kungathintwa yi-PV. Kodwa-ke, inani lamaseli abomvu egazi anquma ukuxilongwa. I-hemoglobin enkulu kune-16.0 g / dL kwabesifazane noma ngaphezulu kuka-16.5 g / dL emadodeni, noma i-hematocrit engaphezu kwamaphesenti angama-48 kwabesifazane noma ngaphezulu kwamaphesenti angama-49 emadodeni angakhombisa i-PV.

Ukuthola izimpawu kungaba yisizathu sokwenza i-aphoyintimenti futhi uhlolwe igazi. Lezi zimpawu zingafaka:

• ikhanda
• isiyezi
• umbono uyashintsha
• ukulunywa umzimba wonke
• ukuncipha komzimba
• ukukhathala
• ukujuluka okweqile

Uma udokotela wakho ecabanga ukuthi une-PV, bazokudlulisela ku-hematologist. Lo ngoti wegazi uzokusiza ekunqumeni uhlelo lwakho lokwelashwa. Lokhu ngokuvamile kuqukethe i-phlebotomy yesikhathi esithile (ukudweba igazi), kanye ne-aspirin yansuku zonke neminye imithi.

Izinkinga

I-PV ikubeka engcupheni yezinkinga ezahlukahlukene. Lokhu kungafaka:

I-thrombosis

I-Thrombosis ingenye yezinkinga ezibucayi kakhulu ku-PV. Kungukujiwa kwegazi emithanjeni noma emithanjeni yakho. Ubukhulu beqhwa legazi kuncike lapho ihlwili lakheke khona. Ingubo ku:

• ubuchopho bungadala isifo sohlangothi
• inhliziyo ingaholela ekuhlaselweni yinhliziyo noma isiqephu senhliziyo
• amaphaphu angadala ukubumbana kwamaphaphu
• Imithambo ejulile ingaba yi-vein thrombosis ejulile (i-DVT)

Ubende obukhulisiwe nesibindi

Ubende lwakho lusengxenyeni engenhla kwesobunxele esiswini sakho. Omunye wemisebenzi yawo ukuhlunga amaseli egazi asekhulile emzimbeni. Ukuzwa ukuvuvukala noma ukugcwala kalula yizimpawu ezimbili ze-PV ezibangelwa ubende obukhulisiwe.

Ubende lwakho luyakhuliswa lapho luzama ukuhlunga inani eleqile lamaseli egazi owakhiwa umnkantsha wakho. Uma ubende lwakho lungabuyeli kusayizi walo ojwayelekile ngemithi ejwayelekile ye-PV, kungadingeka ukuthi lususwe.

Isibindi sakho siphezulu engxenyeni engakwesokudla yesisu sakho. Njengesipele, singakhuliswa naku-PV. Lokhu kungaba ngenxa yoshintsho ekugelezeni kwegazi kuye esibindini noma emsebenzini owengeziwe okufanele wenziwe yisibindi ku-PV. Isibindi esikhulisiwe singadala izinhlungu zesisu noma uketshezi oluthe xaxa ukwakha ngaphakathi

Izinga eliphakeme lamaseli abomvu egazi

Ukwanda kwamangqamuzana abomvu egazi kungadala ukuvuvukala okuhlangene, ngokugxila, ikhanda, izinkinga zokubona, nokuba ndikindiki nokushosheka ezandleni nasezinyaweni zakho. Udokotela wakho wegazi uzophakamisa izindlela zokwelapha lezi zimpawu.

Ukumpontshelwa igazi ngezikhathi ezithile kungasiza ukugcina amangqamuzana abomvu egazi asezingeni elamukelekayo. Uma le nketho ingasebenzi noma imithi ingasizi, udokotela wakho angancoma ukufakelwa kwe-stem cell ukuphatha lesi sifo.

I-Myelofibrosis

I-Myelofibrosis, ebizwa nangokuthi "isigaba esichithwe" se-PV, ithinta cishe amaphesenti ayi-15 alabo abatholakala bene-PV. Lokhu kwenzeka lapho umnkantsha wakho ungasakhiqizi amaseli aphilile noma asebenza kahle. Esikhundleni somnkantsha wakho kufakwa izicubu ezibomvu. I-Myelofibrosis ayithinti kuphela inani lamaseli abomvu egazi, kepha namaseli akho amhlophe egazi nama-platelet.

Umdlavuza wegazi

I-PV yesikhathi eside ingaholela ku-leukemia enamandla, noma umdlavuza wegazi nomnkantsha wamathambo. Le nkinga ayijwayelekile kune-myelofibrosis, kepha ingozi yayo inyuka ngokuhamba kwesikhathi. Uma umuntu ene-PV isikhathi eside, inkulu ingozi yokuba ne-leukemia.

Izinkinga ezivela ekwelashweni

Ukwelashwa kwe-PV nakho kungadala izinkinga kanye nemiphumela emibi.

Ungaqala ukuzizwa ukhathele noma ukhathele ngemuva kwe-phlebotomy, ikakhulukazi uma wenza le nqubo kaningi. Imithambo yakho nayo ingalimala ngenxa yokuthi le nqubo iphindaphindwe.

Kwezinye izimo, uhlobo lwemithi ephansi lwe-aspirin lungaholela ekuphumeni kwegazi.

I-Hydroxyurea, eyindlela yokwelashwa ngamakhemikhali, yehlisa isibalo segazi lakho elibomvu nelimhlophe nama-platelet ngokweqile. I-Hydroxyurea iyindlela yokwelashwa okungekho ilebula ye-PV. Lokhu kusho ukuthi umuthi awuvunyelwe ukwelashwa kwe-PV, kepha kukhonjisiwe ukuthi kuwusizo kubantu abaningi. Imiphumela emibi ejwayelekile yokwelashwa kwe-hydroxyurea ku-PV ingabandakanya ubuhlungu besisu, ubuhlungu bamathambo, nesiyezi.

I-Ruxolitinib (Jakafi), okuwukuphela kokwelapha okugunyaziwe kwe-FDA kwe-myelofibrosis ne-PV, nakho kungacindezela ukubalwa kwegazi lakho okuphelele kakhulu. Eminye imiphumela emibi ingafaka isiyezi, ikhanda, ukukhathala, ukuqina kwemisipha, ubuhlungu besisu, ukuphefumula kanzima, kanye.

Uma uhlangabezana nemiphumela emibi kakhulu kunoma yikuphi ukwelashwa noma imishanguzo yakho, khuluma nethimba lakho lezokwelapha. Wena nodokotela wakho wegazi ungathola izinketho zokwelashwa ezisebenza kangcono kuwe.