Dala uKinase

-Delile

• Kuyini ukuhlolwa kwe-creatine kinase (CK)?
• Kusetshenziselwa ini?
• Kungani ngidinga ukuhlolwa kwe-CK?
• Kwenzekani ngesikhathi sokuhlolwa kwe-CK?
• Ngabe kukhona engizodinga ukukwenza ukulungiselela isivivinyo?
• Ingabe zikhona izingozi esivivinyweni?
• Isho ukuthini imiphumela?
• Ngabe kukhona okunye engidinga ukukwazi ngokuhlolwa kwe-CK?
• Izinkomba

Kuyini ukuhlolwa kwe-creatine kinase (CK)?

Lokhu kuhlolwa kukala inani le-creatine kinase (CK) egazini. I-CK wuhlobo lwamaprotheni, olwaziwa nge-enzyme. Kutholakala kakhulu emisipheni yakho yamathambo nasenhliziyweni, ngamanani amancane ebuchosheni. Imisipha yamathambo yimisipha enamathele emathanjeni akho. Asebenza ngamathambo akho ukukusiza unyakaze futhi unike umzimba wakho amandla. Imisipha yenhliziyo ipompa igazi ngaphakathi nangaphandle kwenhliziyo.

Kunezinhlobo ezintathu zama-enzyme e-CK:

• I-CK-MM, itholakala ikakhulu emisipheni yamathambo
• I-CK-MB, etholakala ikakhulu emisipheni yenhliziyo
• I-CK-BB, etholakala ikakhulu kwizicubu zobuchopho

Inani elincane le-CK egazini lijwayelekile. Inani eliphakeme lingasho inkinga yezempilo. Ngokuya ngohlobo nezinga le-CK elitholakele, kungasho ukuthi unomonakalo noma isifo semisipha yamathambo, inhliziyo, noma ubuchopho.

Amanye amagama: CK, inani eliphelele le-CK, i-creatine phosphokinase, i-CPK

Kusetshenziselwa ini?

Ukuhlolwa kwe-CK kuvame ukusetshenziselwa ukuxilonga nokuqapha ukulimala kwemisipha nezifo. Lezi zifo zibandakanya:

• Imisipha dystrophy, isifo esingajwayelekile esizuzwe njengefa esidala ubuthakathaka, ukuwohloka, kanye nokulahleka kokusebenza kwemisipha yamathambo. Kwenzeka kakhulu kwabesilisa.
• IRhabdomyolis, ukuwohloka okusheshayo kwezicubu zemisipha. Kungabangelwa ukulimala okungathi sína, isifo semisipha, noma esinye isifo.

Isivivinyo singasetshenziselwa ukusiza ukuxilonga isifo senhliziyo, noma kungenjalo kaningi. Ukuhlolwa kwe-CK bekuyindlela evamile yokuhlaselwa yisifo senhliziyo. Kepha olunye uvivinyo, olubizwa nge-troponin, lutholakale lungcono ekutholeni ukulimala kwenhliziyo.

Kungani ngidinga ukuhlolwa kwe-CK?

Ungadinga ukuhlolwa kwe-CK uma unezimpawu zesifo semisipha. Lokhu kufaka phakathi:

• Ubuhlungu bemisipha kanye / noma amajaqamba
• Ubuthakathaka bemisipha
• Izinkinga zebhalansi
• Ukuba ndikindiki noma ukuncinza

Ungase futhi udinge lokhu kuhlolwa uma ngabe ulimele imisipha noma unhlangothi. Amazinga e-CK kungenzeka angakhuphuki kuze kufike ezinsukwini ezimbili ngemuva kokulimala okuthile, ngakho-ke kungadingeka ukuthi uhlolwe izikhathi ezimbalwa. Lokhu kuhlolwa kungasiza ukukhombisa uma ngabe unomonakalo enhliziyweni yakho noma kwenye imisipha.

Kwenzekani ngesikhathi sokuhlolwa kwe-CK?

Uchwepheshe wezempilo uzothatha isampula yegazi emthanjeni osengalweni yakho, esebenzisa inaliti encane. Ngemuva kokuthi kufakwe inaliti, kuzoqoqwa inani elincane legazi kufakwe ithubhu yokuhlola noma isitsha. Ungase uzizwe uluma kancane lapho inaliti ingena noma iphuma. Lokhu ngokuvamile kuthatha imizuzu engaphansi kwemihlanu.

Ngabe kukhona engizodinga ukukwenza ukulungiselela isivivinyo?

Awudingi amalungiselelo akhethekile wokuhlolwa kwe-CK.

Ingabe zikhona izingozi esivivinyweni?

Kunengozi encane kakhulu yokuhlolwa kwegazi. Ungaba nobuhlungu obuncane noma ukulimaza lapho kufakwe khona inaliti, kepha izimpawu eziningi ziyaphela ngokushesha.

Isho ukuthini imiphumela?

Uma imiphumela yakho ikhombisa ukuthi unezinga eliphakeme kunelejwayelekile le-CK, kungasho ukuthi unokulimala noma isifo semisipha, senhliziyo, noma sobuchopho. Ukuthola eminye imininingwane, umhlinzeki wakho anga-oda ukuhlolwa ukuze ahlole amazinga ama-enzyme athile we-CK:

• Uma une-enzyme ephakeme kakhulu kune-CK-MM, kungasho ukuthi unokulimala kwemisipha noma isifo, njenge-muscular dystrophy noma i-rhabdomyolis.
• Uma une-enzyme ephakeme kakhulu kune-CK-MB, kungasho ukuthi unokuvuvukala kwemisipha yenhliziyo noma unesifo senhliziyo noma usanda kuba naso.
• Uma une-enzyme ephakeme kakhulu kune-CK-BB, kungasho ukuthi uke walimala uhlangothi noma ukulimala ebuchosheni.

Ezinye izimo ezingadala amazinga aphezulu we-CK afaka phakathi:

• Amahlule egazi
• Izifo
• Ukuphazamiseka kwamahomoni, kufaka phakathi ukuphazamiseka kwendlala yegilo neyama-adrenal
• Ukuhlinzwa isikhathi eside
• Imithi ethile
• Ukuzivocavoca okunzima

Uma unemibuzo ngemiphumela yakho, khuluma nomhlinzeki wakho wezokunakekelwa kwempilo.

Funda kabanzi mayelana nokuhlolwa kwelabhorethri, ububanzi bezinkomba, nemiphumela yokuqonda.

Ngabe kukhona okunye engidinga ukukwazi ngokuhlolwa kwe-CK?

Okunye ukuhlolwa kwegazi, okufana nephaneli ye-electrolyte kanye nokuhlolwa kokusebenza kwezinso, kunga-oda kanye nokuhlolwa kweCK.

Izinkomba

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2. I-KidsHealth evela kuNemours [Internet]. Isisekelo seNemours; c1995-2019. Imisipha Yakho; [kucashunwe ngo-2019 Juni 19]; [cishe izikrini ezi-3]. Kutholakala kusuka: https://kidshealth.org/en/kids/muscles.html
3. Ukuhlolwa Kwelebhu Ku-inthanethi [i-Intanethi]. IWashington DC: I-American Association for Clinical Chemistry; c2001–2019. I-Creatine Kinase (CK); [kubuyekezwe i-2019 Meyi 3; icashunwe ngo-2019 Jun 12]; [cishe izikrini ezi-2]. Kutholakala kusuka: https://labtestsonline.org/tests/creatine-kinase-ck
4. Uhlobo Lokuthengwa Kwamakhasimende we-Merck [Internet]. IKenilworth (NJ): IMerck & Co, Inc .; c2019. Ukuhlolwa Kokukhubazeka Kwemisipha; [kubuyekezwe ngo-2017 Dec; icashunwe ngo-2019 Jun 12]; [cishe izikrini ezi-2]. Kutholakala kusuka: https://www.merckmanuals.com/home/bone,-joint,-and-muscle-disorders/diagnosis-of-musculoskeletal-disorders/tests-for-musculoskeletal-disorders?query=creatine%20kinase
5. Inhlangano Ye-Muscular Dystrophy [Inthanethi]. IChicago: Inhlangano Yezihlunu Zemisipha; c2019. Okumane Kumiswe: Isivivinyo se-Creatine Kinase; I-2000 Jan 31 [icashunwe ngo-2019 Jun 12]; [cishe izikrini ezi-4]. Kutholakala kusuka: https://www.mda.org/quest/article/simply-stated-the-creatine-kinase-test
6. I-National Heart, Lung, ne-Blood Institute [i-Intanethi]. I-Bethesda (MD): UMnyango Wezempilo kanye Nezinsizakalo Zabantu e-U.S. Ukuhlolwa Kwegazi; [kucashunwe ngo-2019 Juni 12]; [cishe izikrini ezi-3]. Kutholakala kusuka: https://www.nhlbi.nih.gov/health-topics/blood-tests
7. Isikhungo Sikazwelonke Sokuphazamiseka Kwemizwa Ne-Stroke [i-Intanethi]. I-Bethesda (MD): UMnyango Wezempilo kanye Nezinsizakalo Zabantu e-U.S. Imisipha Dystrophy: Ithemba Ngokucwaninga; [kubuyekezwe i-2019 Meyi 7; icashunwe ngo-2019 Jun 12]; [cishe izikrini ezi-3]. Kutholakala kusuka: https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Hope-Through-Research/Muscular-Dystrophy-Hope-Through-Research
8. Impilo ye-UF: University of Florida Health [Internet]. IGainesville (FL): Inyuvesi yaseFlorida Impilo; c2019. Dala isivivinyo se-phosphokinase: Ukubuka konke; [kubuyekezwe i-2019 Jun 12; icashunwe ngo-2019 Jun 12]; [cishe izikrini ezi-2]. Kutholakala kusuka: https://ufhealth.org/creatine-phosphokinase-test
9. I-University of Rochester Medical Center [i-Inthanethi]. URochester (NY): Isikhungo Sezokwelapha sase-University of Rochester; c2019. I-Health Encyclopedia: I-Creatine Kinase (Igazi); [kucashunwe ngo-2019 Juni 12]; [cishe izikrini ezi-2]. Kutholakala kusuka: https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=167&ContentID=creatine_kinase_blood
10. I-UW Health [Inthanethi]. UMadison (WI): Izibhedlela zase-University of Wisconsin kanye neGunya Lemitholampilo; c2019. Imininingwane Yezempilo: I-Creatine Kinase: Ukubuka konke kokuhlolwa; [kubuyekezwe i-2018 Jun 25; icashunwe ngo-2019 Jun 12]; [cishe izikrini ezi-2]. Kutholakala kusuka: https://www.uwhealth.org/health/topic/medicaltest/creatine-kinase/abq5121.html
11. I-UW Health [Inthanethi]. UMadison (WI): Izibhedlela zase-University of Wisconsin kanye neGunya Lemitholampilo; c2019. Imininingwane Yezempilo: I-Creatine Kinase: Kungani Kwenziwa; [kubuyekezwe i-2018 Jun 25; icashunwe ngo-2019 Jun 12]; [cishe izikrini ezi-3]. Kutholakala kusuka: https://www.uwhealth.org/health/topic/medicaltest/creatine-kinase/abq5121.html#abq5123

Imininingwane ekulesi siza akufanele isetshenziswe esikhundleni sezokunakekelwa kwezokwelapha noma iseluleko. Xhumana nomhlinzeki wezempilo uma unemibuzo ngempilo yakho.