Umlobi: Randy Alexander
Usuku Lokudalwa: 25 Epreli 2021
Ukuvuselela Usuku: 14 Unovemba 2024
Anonim
Cyclosporine - Transplant Medication Education
Ividiyo: Cyclosporine - Transplant Medication Education

-Delile

Amaphuzu avelele we-cyclosporine

  1. ICyclosporine capsule yomlomo iyatholakala njengesidakamizwa esijwayelekile futhi njengezidakamizwa ezinegama lomkhiqizo. Amagama omkhiqizo: IGengraf, Neoral, Sandimmune. Sicela wazi ukuthi i-Neoral ne-Gengraf (i-cyclosporine modified) ayifakwanga ngendlela efanayo ne-Sandimmune (cyclosporine non-modified), ngakho-ke le mithi ayikwazi ukusetshenziswa ngokungafani.
  2. ICyclosporine iza njengephilisi lomlomo, isisombululo somlomo, amaconsi wamehlo, nefomu lokujova.
  3. ICyclosporine oral capsule isetshenziselwa ukwelapha ukuvuvukala kwesifo samathambo kanye ne-psoriasis. Ibuye isetshenziselwe ukuvimbela ukwenqatshwa kokufakelwa komzimba.

Yini i-cyclosporine?

I-cyclosporine isidakamizwa esikhishwe odokotela. Kuza njenge-capsule yomlomo, isisombululo somlomo, namaconsi wamehlo. Kubuya nangefomu lokujova, elinikezwa kuphela ngumhlinzeki wezokunakekelwa kwempilo.

ICyclosporine oral capsule iyatholakala njengezidakamizwa ezinegama lomkhiqizo IGengraf, I-Neoral, futhi USandimmune. Iphinde itholakale njengomuthi ojwayelekile.


Imithi ejwayelekile ijwayele ukubiza imali encane kunohlobo lwamagama. Kwezinye izimo, kungenzeka zingatholakali ngawo wonke amandla noma amafomu njengomuthi wegama lomkhiqizo.

Sicela wazi ukuthi iNeoral neGengraf azinakusetshenziswa ngokungafaniyo neSandimmune.

Kungani kusetshenziswa

I-cyclosporine isetshenziselwa ukuvimbela ukwenqatshwa kwesitho esitshalwe kabusha. Ibuye isetshenziselwe ukunciphisa ukuvuvukala ku-rheumatoid arthritis (RA) kanye ne-psoriasis enamandla.

Uhlobo lwegama lomkhiqizo olubizwa ngeSandimmune lusetshenziswa kuphela ukuvimbela ukwenqatshwa kwesitho esithwelwe kabusha.

Isebenza kanjani

ICyclosporine ingeyesigaba semithi ebizwa ngama-immunosuppressants. Isigaba semithi siyiqembu lemithi esebenza ngendlela efanayo. Le mithi ivame ukusetshenziselwa ukwelapha izimo ezifanayo.

ICyclosporine isebenza ngokwenza buthakathaka amasosha omzimba wakho. Amaseli egazi amhlophe, ingxenye yamasosha akho omzimba, ngokuvamile alwa nezinto ezisemzimbeni wakho ezingekho lapho ngokwemvelo, njengezitho ezifakwe kabusha. ICyclosporine imisa amaseli amhlophe egazi ekuhlaseleni isitho esitshalwe kabusha.


Endabeni yeRA noma i-psoriasis, i-cyclosporine imisa amasosha akho omzimba ekuhlaseleni ngephutha izicubu zomzimba wakho.

Imiphumela emibi ye-cyclosporine

ICyclosporine ingadala imiphumela emibi noma emibi. Uhlu olulandelayo luqukethe eminye yemiphumela emibi engaba khona ngenkathi uthatha i-cyclosporine.

Lolu hlu alubandakanyi yonke imiphumela emibi engaba khona. Ngeminye imininingwane ngemiphumela engemihle ye-cyclosporine, noma amathiphu wokuthi ungabhekana kanjani nemiphumela emibi ekhathazayo, khuluma nodokotela wakho noma usokhemisi.

ICyclosporine capsule yomlomo ayibangeli ukozela.

Imiphumela emibi ejwayelekile

Imiphumela emibi ejwayelekile eyenzeka nge-cyclosporine ifaka:

  • umfutho wegazi ophakeme
  • amazinga aphansi we-magnesium emzimbeni wakho
  • amahlule egazini ezinso zakho
  • ubuhlungu besisu
  • ukukhula kwezinwele ezindaweni ezithile
  • induna
  • ukuthuthumela
  • ikhanda
  • usayizi owandisiwe wezinsini zakho

Uma le miphumela imnene, ingahle ihambe zingakapheli izinsuku ezimbalwa noma amasonto ambalwa. Uma zinzima kakhulu noma zingahambi, khuluma nodokotela wakho noma usokhemisi.


Imiphumela emibi kakhulu

Shayela udokotela wakho ngokushesha uma unemiphumela emibi kakhulu. Shayela ku-911 uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha. Imiphumela emibi kanye nezimpawu zayo zingafaka okulandelayo:

Ukulimala kwesibindi. Izimpawu zingafaka:

  • igazi emchameni
  • umchamo omnyama
  • indle ephaphathekile
  • ukuphuzi kwesikhumba sakho noma okumhlophe kwamehlo akho
  • ubuhlungu esiswini sakho esingenhla

Ukulimala kwezinso. Izimpawu zingafaka:

  • igazi emchameni

Izinkinga zenhliziyo. Izimpawu zingafaka:

  • ukuvuvukala kwezinyawo zakho noma imilenze engezansi

Izinkinga zamaphaphu. Izimpawu zingafaka:

  • inkinga yokuphefumula

Ungayithatha kanjani i-cyclosporine

Umthamo we-cyclosporine odokotela wakho obekiwe uzoncika ezicini ezithile. Lokhu kufaka phakathi:

  • uhlobo nobukhali besimo osisebenzisayo ukwelapha i-cyclosporine
  • iminyaka yakho
  • uhlobo lwe-cyclosporine oyithathayo
  • ezinye izimo zezokwelapha ongahle ube nazo

Imvamisa, udokotela wakho uzokuqala ngomthamo ophansi futhi awulungise ngokuhamba kwesikhathi ukufinyelela umthamo okulungele wena. Ekugcineni bazonquma isilinganiso esincane kunazo zonke esihlinzeka ngomphumela oyifunayo.

Imininingwane elandelayo ichaza imithamo esetshenziswa kakhulu noma enconywayo. Kodwa-ke, qiniseka ukuthatha isilinganiso udokotela wakho akubekela sona. Udokotela wakho uzonquma isilinganiso esihle kakhulu ukuhlangabezana nezidingo zakho.

Yonke imithamo namafomu okungenzeka angafakwa lapha.

Isilinganiso se-rheumatoid arthritis

Okujwayelekile: ICyclosporine

  • Ifomu: i-capsule yomlomo
  • Amandla: Ama-milligram ama-25 (mg), ama-50 mg, ne-100 mg

Umkhiqizo: IGengraf

  • Ifomu: i-capsule yomlomo
  • Amandla: 25 mg no-100 mg

Umkhiqizo: I-Neoral

  • Ifomu: i-capsule yomlomo
  • Amandla: 25 mg no-100 mg

Isilinganiso sabadala (abaneminyaka engu-18 nangaphezulu)

Umthamo usekelwe kusisindo.

  • Isilinganiso sokuqala sokuqala: Ama-milligram ama-2.5 ikhilogremu (mg / kg) ngosuku, ahlukaniswe ngamanani amabili (1.25 mg / kg ngomthamo ngamunye).
  • Umthamo omkhulu: 4 mg / kg ngosuku.
  • Qaphela: Uma ungenayo imiphumela emihle ngemuva kwamasonto ayishumi nane ukwelashwa, udokotela wakho uzokuyeka uyeke ukuthatha i-cyclosporine.

Isilinganiso sengane (iminyaka yobudala engu-0-17)

Isilinganiso asikasungulelwa abantu abangaphansi kweminyaka engu-17 ubudala.

Isikali se-psoriasis

Okujwayelekile: ICyclosporine

  • Ifomu: i-capsule yomlomo
  • Amandla: 25 mg, 50 mg, no-100 mg

Umkhiqizo: IGengraf

  • Ifomu: i-capsule yomlomo
  • Amandla: 25 mg no-100 mg

Umkhiqizo: I-Neoral

  • Ifomu: i-capsule yomlomo
  • Amandla: 25 mg no-100 mg

Isilinganiso sabadala (abaneminyaka engu-18 nangaphezulu)

Umthamo usekelwe kusisindo.

  • Isilinganiso sokuqala sokuqala: 2.5 mg / kg ngosuku, ihlukaniswe ngamanani amabili (1.25 mg / kg ngomthamo ngamunye).
  • Umthamo omkhulu: 4 mg / kg ngosuku.
  • Qaphela: Uma ungenayo imiphumela emihle ngemuva kwamaviki ayisithupha kumthamo omkhulu obekezelelwe, udokotela wakho uzokuyeka uyeke ukuthatha i-cyclosporine.

Isilinganiso sengane (iminyaka yobudala engu-0-17)

Isilinganiso asikasungulelwa abantu abangaphansi kweminyaka engu-17 ubudala.

Isikali ukuvimbela ukwenqatshwa kwezinso, isibindi, nokufakwa kwenhliziyo

Okujwayelekile: ICyclosporine

  • Ifomu: i-capsule yomlomo
  • Amandla: 25 mg, 50 mg, no-100 mg

Umkhiqizo: IGengraf

  • Ifomu: i-capsule yomlomo
  • Amandla: 25 mg no-100 mg

Umkhiqizo: I-Neoral

  • Ifomu: i-capsule yomlomo
  • Amandla: 25 mg no-100 mg

Umkhiqizo: USandimmune

  • Ifomu: i-capsule yomlomo
  • Amandla: 25 mg no-100 mg

Isilinganiso sabadala (abaneminyaka engu-18 nangaphezulu)

Umthamo we-cyclosporine ungahluka, kuya ngesisindo somzimba wakho, isitho esifakelwe kabusha, neminye imithi oyiphuzayo.

  • I-Neoral, i-Gengraf, ne-generics: Isilinganiso singahluka. Umthamo ojwayelekile wansuku zonke ungama-milligram ayi-7-9 ngakhilogremu (mg / kg) wesisindo somzimba othathwe ngamanani amabili ahlukaniswe ngokulinganayo usuku lonke.
  • I-sandimmune ne-generic:
    • Thatha umthamo wakho wokuqala emahoreni angama-4-12 ngaphambi kokufakelwa kwakho. Lo mthamo uvame ukuba yi-15 mg / kg. Udokotela wakho angakunika isilinganiso esingu-10-14 mg / kg ngosuku.
    • Qhubeka nokuthatha isilinganiso esifanayo ngemuva kokuhlinzwa kwakho kokufakelwa amasonto ayi-1-2. Ngemuva kwalokho, yehlisa ngamaphesenti ama-5 ngeviki kumthamo wesondlo ka-5-10 mg / kg ngosuku.

Isilinganiso sengane (iminyaka eyi-1-17)

Umthamo we-cyclosporine uzohluka ngokuya ngesisindo somzimba wengane yakho, isitho esifakelwe kabusha, kanye neminye imithi ingane yakho eyiphuzayo.

  • I-Neoral, i-Gengraf, ne-generics: Isilinganiso singahluka. Isilinganiso esivamile sokuqala sansuku zonke singama-7-9 milligram ngekhilogremu (mg / kg) wesisindo somzimba ahlukaniswe ngemithamo emibili elinganayo yansuku zonke.
  • I-sandimmune ne-generic:
    • Thatha umthamo wakho wokuqala emahoreni angama-4-12 ngaphambi kokufakelwa kwakho. Lo mthamo uvame ukuba yi-15 mg / kg. Udokotela wakho angakunika isilinganiso esingu-10-14 mg / kg ngosuku.
    • Qhubeka nokuthatha isilinganiso esifanayo ngemuva kokuhlinzwa kwakho kokufakelwa amasonto ayi-1-2. Ngemuva kwalokho, yehlisa ngamaphesenti ama-5 ngeviki kumthamo wesondlo ka-5-10 mg / kg ngosuku.

Isilinganiso sengane (iminyaka yobudala engu-0-11 izinyanga)

Isilinganiso asikasungulelwa izingane ezingaphansi kwezinyanga eziyi-12.

Ukucatshangelwa okukhethekile komthamo

  • Kubantu abanenkinga yezinso: ICyclosporine ingadala isifo sezinso. Uma usuvele unezinkinga zezinso, udokotela wakho angakunikeza isilinganiso esincishisiwe se-cyclosporine.
  • Kubantu abanenkinga yesibindi: ICyclosporine ingadala isifo sesibindi. Uma usuvele unenkinga yesibindi, udokotela wakho angakunikeza isilinganiso esincishisiwe se-cyclosporine.

Thatha njengoba kuqondisiwe

ICyclosporine isetshenziselwa ukwelashwa isikhathi eside. Kuza nezingozi ezinkulu uma ungayithathi njengokuyalelwe.

Uma uyeka ukuthatha lo muthi noma ungawuthathi nhlobo: Umzimba wakho ungasenqaba isitho sakho esitshalwe kabusha noma izimpawu zakho zeRA noma i-psoriasis zingabuya.

Uma uphuthelwa imithamo noma ungayithathi ngesikhathi: Umzimba wakho ungakwala ukufakelwa kwakho, kubangele izinkinga ezinkulu zempilo. Noma izimpawu zakho ze-RA noma i-psoriasis zingabuya.

Uma uthatha kakhulu: Ungaba namazinga ayingozi omuthi emzimbeni wakho. Izimpawu zokweqisa izidakamizwa zalesi sidakamizwa zingafaka:

  • ukuphuzi kwesikhumba sakho noma okumhlophe kwamehlo akho
  • ukuvuvukala kwezingalo zakho, izandla, izinyawo, amaqakala, noma imilenze ephansi

Uma ucabanga ukuthi uthathe kakhulu lo muthi, shayela udokotela wakho noma funa ukuholwa yi-American Association of Poison Control Centers ku-800-222-1222 noma ngethuluzi labo eliku-inthanethi. Kepha uma izimpawu zakho zinzima, shayela ku-911 noma uye egumbini lezimo eziphuthumayo eliseduze ngokushesha.

Okufanele ukwenze uma uphuthelwa umthamo: Uma uphuthelwa umthamo, wuthathe ngokushesha ngangokunokwenzeka. Kodwa-ke, uma kungamahora ambalwa kuze kufike umthamo wakho olandelayo, weqa umthamo ongabanjwanga.

Ungazami ukubamba ngokuthatha imithamo emibili ngasikhathi sinye. Lokhu kungaholela emiphumeleni emibi eyingozi.

Ungasho kanjani ukuthi umuthi uyasebenza: Ungahle ukwazi ukutshela ukuthi umuthi uyasebenza uma:

  • umzimba wakho awusenqabeli isitho esitshalwe kabusha noma izicubu
  • unezimpawu ezimbalwa ze-RA
  • unamacwecwe ambalwa e-psoriasis

Izexwayiso ze-Cyclosporine

Lesi sidakamizwa siza nezixwayiso ezahlukahlukene.

Izexwayiso ze-FDA

  • Lo muthi unezixwayiso zebhokisi elimnyama. Isexwayiso sebhokisi elimnyama yisixwayiso esibi kakhulu esivela ku-Food and Drug Administration (FDA). Isexwayiso sebhokisi elimnyama sazisa odokotela neziguli ngemiphumela yezidakamizwa engaba yingozi.
  • Isixwayiso sokutheleleka. ICyclosporine ingakhuphula ubungozi bokutheleleka ngezibi. Kungakhuphula nengozi yakho yokuthola isimila noma umdlavuza wesikhumba.
  • Isexwayiso sesifo sesikhumba. Uma une-psoriasis futhi welashwa nge-psoralen kanye ne-ultraviolet A therapy, i-methotrexate, i-tar tar, i-radiation therapy, noma i-ultraviolet light therapy, ungaba nethuba eliphakeme lokuthola isifo sesikhumba ngenkathi uthatha ama-cyclosporine capsules.
  • Umfutho wegazi ophakeme kanye nesixwayiso sesifo sezinso. Lo muthi ungadala umfutho wegazi ophakeme nesifo sezinso.
  • Isixwayiso sodokotela abanolwazi. Abahlinzeki bokunakekelwa kwezempilo kuphela abanolwazi ekuphathweni kwe-systemic therapy ye-immunosuppressive therapy yesifo esibonisiwe okufanele banikeze i-cyclosporine. "Systemic immunosuppressive therapy" ukwelashwa kwezifo ezizimele (lapho amasosha omzimba womuntu ehlasela umzimba wakhe).
  • Isexwayiso sokutholakala kokutholakala kokungabikho. Ukumuncwa kwamaphilisi we-Sandimmune (cyclosporine non-modified) nesisombululo somlomo ngesikhathi sokusetshenziswa kwesikhathi eside kungahle kungalindelekile. Kunconywa ukuthi abantu abathatha ama-sandimmune capsules noma i-oral solution esikhathini esithile baqashwe ngamazinga egazi le-cyclosporine ukugwema ubuthi kanye nokwaliwa kwesitho okungenzeka.
  • Isexwayiso seGengraf neNeoral. I-Gengraf ne-Neoral (i-cyclosporine modified) imuncwa kakhulu ngumzimba uma iqhathaniswa namaphilisi we-Sandimmune nesisombululo somlomo. Ngakho-ke le mithi ayikwazi ukusetshenziswa ngokungafani ngaphandle kokuqondiswa ngumhlinzeki wezokunakekelwa kwempilo.

Isexwayiso sokulimala kwesibindi

Ukuthatha i-cyclosporine kungadala ukulimala kwesibindi nokuhluleka kwesibindi, ikakhulukazi uma uthatha imithamo ephezulu. Kungaze kubulale.

Isexwayiso samazinga aphezulu e-potassium

Ukuthatha lo muthi kungakhuphula amazinga akho e-potassium.

Isexwayiso sokusebenzisana kokudla

Gwema ukudla isithelo samagilebhisi noma ukuphuza ijusi lamagilebhisi lapho uthatha lo muthi. Ukudla imikhiqizo yamagilebhisi kungakhuphula inani le-cyclosporine emzimbeni wakho.

Izexwayiso zabantu abanezimo ezithile zempilo

Kubantu abanezinkinga zezinso nezesibindi: ICyclosporine ingadala isifo sezinso nesibindi. Uma usuvele unezinkinga zezinso noma zesibindi, imithamo ephezulu ye-cyclosporine ingayenza ibe yimbi kakhulu.

Kubantu abanezifo ezimbi: ICyclosporine ingakhuphula ubungozi bokutheleleka ngamagciwane abucayi, njengokutheleleka nge-polyomavirus. Lokhu kungaba kubi kakhulu, futhi kubulale nokufa.

Izexwayiso kwamanye amaqembu

Kwabesifazane abakhulelwe: ICyclosporine yisigaba C somuthi wokukhulelwa. Lokho kusho izinto ezimbili:

  1. Ukucwaninga ngezilwane kukhombise imiphumela emibi embungwini lapho umama ethatha umuthi.
  2. Akuzange kube nezifundo ezanele ezenziwe ebantwini ukuze kuqinisekiswe ukuthi umuthi ungawuthinta kanjani umbungu.

Khuluma nodokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. ICyclosporine kufanele isetshenziswe ngesikhathi sokukhulelwa kuphela uma inzuzo engaba khona ibeka ubungozi enganeni.

Kwabesifazane abancelisayo: ICyclosporine idlula obisini lwebele futhi ingadala imiphumela emibi kakhulu. Tshela udokotela wakho uma uncelisa. Wena nodokotela wakho kudingeka ninqume ukuthi uzoncelisa noma uzothatha i-cyclosporine.

Ama-capsules wegama lomkhiqizo ane-ethanol (utshwala). I-Ethanol nezinye izinto ezikulesi sidakamizwa zingadlula ubisi lwebele futhi zidale imiphumela emibi enganeni enceliswa ibele.

Okwabadala: Uma uneminyaka engama-65 noma ngaphezulu, kungenzeka ukuthi uthuthukise umfutho wegazi ophakeme uma usebenzisa i-cyclosporine. Njengoba ukhula, izitho zakho, njengesibindi sakho nezinso, azisebenzi kahle njengakuqala. Ukuvimbela ukulimala kwezinso, udokotela wakho angakuqala ngomthamo ophansi.

Okwezingane:

  • Obani abaye bafakelwa izinso, isibindi, noma inhliziyo: Izingane ezineminyaka engu-6 nangaphezulu ezithola ukufakelwa izitho ezithile futhi zaphathwa nge-cyclosporine azizange zibe nemiphumela engemihle engajwayelekile.
  • Obani abane-arthritis ye-rheumatoid noma i-psoriasis: Lesi sidakamizwa asikaze sisungulwe njengesiphephile noma esisebenzayo ukuthi sisetshenziswe kubantu abangaphansi kweminyaka eyi-18 abanesifo samathambo noma i-psoriasis.

ICyclosporine ingaxhumana neminye imithi

ICyclosporine ingaxhumana neminye imithi eminingana. Ukuxhumana okuhlukile kungadala imiphumela ehlukile. Isibonelo, ezinye zingaphazamisa ukuthi usebenza kanjani umuthi, kanti ezinye zingadala imiphumela emibi eyengeziwe.

Ngezansi kunohlu lwemithi engasebenzisana ne-cyclosporine. Lolu hlu aluqukethe yonke imishanguzo engasebenzisana ne-cyclosporine.

Ngaphambi kokuthatha i-cyclosporine, qiniseka ukuthi utshela udokotela kanye nosokhemisi ngayo yonke imishanguzo kadokotela, i-counter-counter, nezinye izidakamizwa oziphuzayo. Batshele futhi nganoma yimaphi amavithamini, amakhambi, nezithako ozisebenzisayo. Ukwabelana ngalolu lwazi kungakusiza ugweme ukuhlangana okungenzeka.

Uma unemibuzo mayelana nokuhlangana kwezidakamizwa okungakuthinta, buza udokotela wakho noma usokhemisi.

Imithi elwa namagciwane

Ukuthatha i-cyclosporine ngama-antibiotic athile kungaholela engcupheni eyengeziwe yokulimala kwezinso. Izibonelo zale mithi zifaka:

  • ciprofloxacin
  • i-gentamicin
  • umagazine
  • i-trimethoprim / sulfamethoxazole
  • vancomycin

Ama-antibiotic alandelayo angaholela emazingeni aphezulu e-cyclosporine emzimbeni wakho. Lokhu kungandisa ingozi yemiphumela emibi. Izibonelo zale mithi zifaka:

  • azithromycin
  • kucofe
  • erythromycin
  • iquinupristin / dalfopristin

Ama-antibiotic alandelayo anganciphisa inani le-cyclosporine emzimbeni wakho. Lokhu kungadala ukuthi i-cyclosporine ingasebenzi njengoba kufanele. Lapho i-cyclosporine isetshenziselwa ukuvimbela ukwenqatshwa kwezitho, lokhu kungaholela ekwenqabelweni kwesitho esitshalwe kabusha. Le mithi ihlanganisa:

  • nafcillin
  • phumlani

Izidakamizwa ezingezona ukuvuvukala (ama-NSAID)

Ukuthatha i-cyclosporine ngalezi zidakamizwa kungandisa ingozi yokulimala kwezinso. Izibonelo zale mithi zifaka:

  • ibuprofen
  • sulindac
  • umabhebhana
  • lindokuhle

Ama-fungal

Ukuthatha i-cyclosporine ngemithi ethile yokulwa nokubola kungaholela emazingeni aphezulu we-cyclosporine emzimbeni wakho. Lokhu kungadala ukwanda kwemiphumela emibi noma kukhuphule ingozi yokulimala kwezinso. Izibonelo zale mithi zifaka:

  • amphotericin B
  • ketoconazole
  • i-fluconazole
  • itraconazole
  • voriconazole

I-Terbinafine, enye i-antifungal, inganciphisa inani le-cyclosporine emzimbeni wakho. Lokhu kungadala ukuthi i-cyclosporine ingasebenzi kahle njengoba kufanele. Lapho i-cyclosporine isetshenziselwa ukuvimbela ukwenqatshwa kokufakelwa, lokhu kungaholela ekwenqabelweni kwesitho esifakelwe kabusha.

Izidakamizwa ze-acid reflux

Ukuthatha i-cyclosporine ngalezi zidakamizwa kungandisa ingozi yokulimala kwezinso. Izibonelo zale mithi zifaka:

  • i-ranitidine
  • cimetidine

Izidakamizwa zokuvimbela inzalo

Ukuthatha i-cyclosporine ngezidakamizwa ezisetshenziselwa ukulawulwa kokuzalwa kungakhuphula inani le-cyclosporine emzimbeni wakho. Lokhu kungadala imiphumela emibi eyingozi.

Isidakamizwa sokucindezela ukuzivikela

Ukuthatha tacrolimus nge-cyclosporine kungandisa ingozi yokulimala kwezinso.

Izidakamizwa eziphezulu ze-cholesterol

Ukuthatha i-cyclosporine ngezidakamizwa ezilandelayo ze-cholesterol kungandisa ingozi yokulimala kwezinso:

  • fenofibrate
  • umagazine

Uma uthatha i-cyclosporine nezinye izidakamizwa ze-cholesterol, ukuminyana kwalezi zidakamizwa emzimbeni wakho kunganda. Lokhu kungadala imiphumela emibi efana nobuhlungu bemisipha nobuthakathaka. Le mithi ihlanganisa:

  • mthombeni
  • simvastatin
  • umabhebhana
  • pravastatin
  • i-fluvastatin

Izidakamizwa zomfutho wegazi

Ukuthatha le mithi nge-cyclosporine kungakhuphula inani le-cyclosporine emzimbeni wakho. Lokhu kungadala imiphumela emibi eyingozi. Izibonelo zale mithi zifaka:

  • umabhebhana
  • mthokozisi
  • sibongile

ICorticosteroid

Ukuthatha imethylprednisolone nge-cyclosporine kungakhuphula inani le-cyclosporine emzimbeni wakho. Lokhu kungadala imiphumela emibi eyingozi.

Ama-anticonvulsants

Ukuthatha le mithi nge-cyclosporine kungehlisa inani le-cyclosporine emzimbeni wakho. Lokhu kungadala ukuthi i-cyclosporine ingasebenzi kahle njengoba kufanele. Lapho i-cyclosporine isetshenziselwa ukuvimbela ukwenqatshwa kwezitho, lokhu kungaholela ekwenqabelweni kwesitho esitshalwe kabusha. Izibonelo zale mithi zifaka:

  • carbamazepine
  • umagazine
  • lindokuhle
  • mthombeni

Amakhambi

Ukuthatha Isibungu iSt nge-cyclosporine kungehlisa inani le-cyclosporine emzimbeni wakho. Lokhu kungadala ukuthi i-cyclosporine ingasebenzi kahle njengoba kufanele. Lapho kusetshenziswa i-cyclosporine ukuvimbela ukwaliwa kwesitho, lokhu kungaholela ekwenqabelweni kwesitho esifakelwe kabusha.

Izidakamizwa ze-gout

Ukuthatha ingulube nge-cyclosporine kungakhuphula inani le-cyclosporine emzimbeni wakho. Lokhu kungandisa ingozi yemiphumela emibi.

Ukuthatha colchicine nge-cyclosporine kungandisa ingozi yokulimala kwezinso.

Izidakamizwa ze-HIV

Uma uthatha imishanguzo ebizwa nge-protease inhibitors ukwelapha i-HIV, hlola udokotela wakho ngaphambi kokuthatha i-cyclosporine. Udokotela wakho angadinga ukunciphisa umthamo wakho we-cyclosporine ukuvikela imiphumela emibi engabangelwa ukuthatha le mithi nge-cyclosporine. Izibonelo zale mithi zifaka:

  • indimvir
  • umagazine
  • i-ritonavir
  • sphiwe

Izidakamizwa ezinciphisa uketshezi

Ungathathi i-cyclosporine ngalezi zidakamizwa. Kungakhuphula inani le-potassium emzimbeni wakho futhi kungadala imiphumela emibi. Le miphumela emibi ingafaka ukushaya kwenhliziyo okuncane, ukukhathala, ubuthakathaka bemisipha, nesicanucanu. Izibonelo zale mithi zifaka:

  • unqobile
  • amiloride

Izidakamizwa zomdlavuza

Ukuthatha i-cyclosporine ngemithi ethile esetshenziselwa ukwelapha umdlavuza kungakhuphula inani laleyo mithi emzimbeni wakho. Lokhu kungandisa ingozi yemiphumela emibi. Izibonelo zale mithi zifaka:

  • busisiwe
  • doxorubicin
  • etoposide
  • umagazine

Ukuthatha melphalan, omunye umuthi womdlavuza, one-cyclosporine ungandisa ingozi yokulimala kwezinso.

Ezinye izidakamizwa

Ukuthatha i-cyclosporine nganoma yimiphi imithi ebhalwe ngezansi kungadala inani elinyukile laleyo mithi emzimbeni wakho. Lokhu kungandisa ingozi yemiphumela emibi. Izibonelo zale mithi zifaka:

  • nxumalo
  • aliskiren
  • busentan
  • dabigatran
  • I-digoxin
  • webhilo
  • umabhebhana
  • sirolimus

Eminye imishanguzo ingakhuphula inani le-cyclosporine emzimbeni wakho. Lokhu kungadala imiphumela emibi eyingozi. Izibonelo zale mithi zifaka:

  • amiodarone
  • bromocriptine
  • danazol
  • imatinib
  • metoclopramide
  • nefazodone

Eminye imithi inganciphisa inani le-cyclosporine emzimbeni wakho. Lokhu kungadala ukuthi i-cyclosporine ingasebenzi kahle njengoba kufanele. Lapho i-cyclosporine isetshenziselwa ukuvimbela ukwenqatshwa kwezitho, lokhu kungaholela ekwenqabelweni kwesitho esitshalwe kabusha. Izibonelo zale mithi zifaka:

  • busentan
  • okotobe
  • uhlu
  • sulpulazone
  • i-ticlopidine

Ukucatshangelwa okubalulekile kokuthatha i-cyclosporine

Gcina lokhu kubheka engqondweni uma udokotela wakho ekuhlolela i-cyclosporine.

Jikelele

  • Thatha i-cyclosporine ngasikhathi sinye nsuku zonke.
  • Musa ukuchoboza, ukuhlafuna, noma ukusika ama-cyclosporine capsules.
  • Qaphela ukuthi ungathola iphunga lapho uvula isitsha okokuqala. Lokhu kuzonyamalala ngokuhamba kwesikhathi.

Isitoreji

  • Gcina ekamelweni lokushisa eliphakathi kuka-68 ° F no-77 ° F (20 ° C no-25 ° C).
  • Gcina lesi sidakamizwa kude nokushisa okulula nokushisa okuphezulu.
  • Ungawugcini lo muthi ezindaweni ezinomswakama noma ezinomswakama, njengezindlu zangasese.

Ukugcwalisa kabusha

Imibhalo kadokotela yalomuthi iyagcwaliseka. Akufanele udinge umuthi omusha kadokotela ukuze lo muthi uphinde ugcwaliswe. Udokotela wakho uzobhala inani lama-refill eligunyazwe kudokotela wakho.

Ukuvakasha

Lapho uhamba nemithi yakho:

  • Ngaso sonke isikhathi phatha imithi yakho. Lapho undiza, ungalokothi uwufake esikhwameni esihloliwe. Yigcine esikhwameni sakho sokuthwala.
  • Ungakhathazeki ngemishini ye-X-ray yesikhumulo sezindiza. Abakwazi ukulimaza umuthi wakho.
  • Ungadinga ukukhombisa abasebenzi bezindiza ilebula lekhemisi lemithi yakho. Ngaso sonke isikhathi phatha isitsha sokuqala esinelebula kadokotela.
  • Ungafaki lo muthi egumbini legilavu ​​lemoto yakho noma uwushiye emotweni. Qinisekisa ukugwema ukwenza lokhu lapho isimo sezulu sishisa kakhulu noma sibanda kakhulu.
  • Khuluma nosokhemisi wakho ngaphambi kokuhamba ukuze uqiniseke ukuthi unele lo muthi. Ngokuya ngokuthi uhambela kuphi, ungaba nenkinga yokuthola lo muthi.

Ukuzilawula

Uma uthatha i-generic cyclosporine noma isidakamizwa esinegama ngaphandle kweSandimmune, gwema ukukhanya kwelanga ngokweqile noma amadokodo okushuka.

Ukuqapha komtholampilo

Udokotela wakho angakuhlola ngokuhlolwa kwegazi okuthile ngaphambi nangesikhathi sokwelashwa nge-cyclosporine. Lokhu kwenzelwa ukuthi kuqinisekiswe ukuthi kuphephile ukuthi ungathatha. Ukuhlolwa kungenziwa ukubheka izinto ezinjengezakho:

  • amazinga we-cyclosporine
  • ukusebenza kwesibindi
  • ukusebenza kwezinso
  • amazinga e-cholesterol
  • izinga le-magnesium
  • izinga le-potassium

Ukutholakala

Akuwona wonke amakhemisi agcina lo muthi. Lapho ugcwalisa incwadi kadokotela, qiniseka ukuthi ushayela phambili ukuze uqiniseke ukuthi ikhemisi lakho liyawuphatha.

Ngaphambi kokugunyazwa

Izinkampani eziningi zomshuwalense zidinga ukugunyazwa kwangaphambili kwalomuthi. Lokhu kusho ukuthi udokotela wakho uzodinga ukuthola imvume enkampanini yakho yomshuwalense ngaphambi kokuba inkampani yakho yomshuwalense ikhokhele incwadi kadokotela.

Ingabe zikhona ezinye izindlela?

Kuneminye imithi etholakalayo yokwelapha isimo sakho. Ezinye zingakulungela kangcono kunabanye. Khuluma nodokotela wakho ngezinye izinketho zezidakamizwa ezingakusebenzela.

Ukuzikhulula: I-Healthline yenze yonke imizamo yokuqinisekisa ukuthi lonke ulwazi luyiqiniso, luphelele futhi lusesikhathini. Kodwa-ke, le ndatshana akufanele isetshenziswe njengokungena esikhundleni solwazi nobungoti bochwepheshe bezokunakekelwa kwezempilo onelayisense. Kufanele uhlale uthintana nodokotela wakho noma omunye uchwepheshe wezokunakekelwa kwempilo ngaphambi kokuthatha noma imuphi umuthi. Imininingwane yezidakamizwa equkethwe lapha ingashintsha futhi ayihloselwe ukumboza konke ukusetshenziswa okungaba khona, izinkomba, izixwayiso, izexwayiso, ukuxhumana kwezidakamizwa, ukungezwani komzimba, noma imiphumela emibi. Ukungabikho kwezixwayiso noma olunye ulwazi lomuthi othile awukhombisi ukuthi inhlanganisela yezidakamizwa noma yezidakamizwa iphephile, iyasebenza, noma ilungele zonke iziguli noma konke ukusetshenziswa okuthile.

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