Kuyini Ukushoda Kwe-Dopamine Syndrome?

-Delile

• Ziyini izimpawu?
• Yini ebangela lesi simo?
• Ubani osengozini?
• Kutholakala kanjani?
• Ilashwa kanjani?
• Kukuthinta kanjani ukulindela isikhathi sokuphila?

Ingabe lokhu kuvamile?

I-Dopamine defence syndrome yisimo esingajwayelekile sokuthola amafa esinamacala angama-20 kuphela aqinisekisiwe. Yaziwa nangokuthi i-dopamine Transporter defence syndrome kanye ne-infantile parkinsonism-dystonia.

Lesi simo sithinta amandla engane okuhambisa umzimba nemisipha yawo. Yize izimpawu zivame ukuvela ngesikhathi siseyinsana, kungenzeka zingabonakali kuze kube kamuva ebuntwaneni.

Izimpawu ziyefana nezinye izifo zokunyakaza, njengesifo sezingane i-Parkinson's disease. Ngenxa yalokhu, imvamisa Abanye abacwaningi bacabanga nokuthi kuvame kakhulu kunalokho obekucatshangwa ngaphambili.

Lesi simo siyaqhubeka, okusho ukuthi siya ngokuya sikhula ngokuhamba kwesikhathi. Alikho ikhambi, ngakho-ke ukwelashwa kugxila ekuphatheni izimpawu.

Qhubeka ufunde ukuze ufunde kabanzi.

Ziyini izimpawu?

Izimpawu ngokuvamile ziyafana kungakhathalekile ukuthi zikhula kangakanani. Lokhu kungafaka:

• amajaqamba
• ukuphazamiseka kwemisipha
• ukuthuthumela
• imisipha ihamba kancane (bradykinesia)
• ukuqina kwemisipha (ukuqina)
• ukuqunjelwa
• ubunzima bokudla nokugwinya
• kunzima ukukhuluma nokwakha amagama
• izinkinga zokubamba umzimba ume mpo
• ubunzima ngokulinganisela lapho umile futhi uhamba
• ukunyakaza kwamehlo okungalawuleki

Ezinye izimpawu zingafaka:

• isifo se-reflux se-gastroesophageal (GERD)
• izikhathi eziningi ze-pneumonia
• ubunzima bokulala

Yini ebangela lesi simo?

Ngokwe-National Library of Medicine yaseU.S., Lokhu kuphazamiseka kwezakhi zofuzo kubangelwa ukuguqulwa kwesimo se- SLC6A3 isakhi sofuzo. Lesi sakhi siyabandakanyeka ekwakhiweni kweprotheni yokuhambisa i-dopamine. Le phrotheni ilawula ukuthi ingakanani i-dopamine ethuthwa ivela ebuchosheni iye kumaseli ahlukile.

I-Dopamine ibandakanyeka kuyo yonke into kusuka ekuqondeni nasekuzizweleni, ekhonweni lokulawula ukunyakaza komzimba. Uma inani le-dopamine kumaseli liphansi kakhulu, lingathinta ukulawulwa kwemisipha.

Ubani osengozini?

Ukushoda kwe-Dopamine syndrome yisifo sofuzo, okusho ukuthi umuntu uzalwa enaso. Isici esiyinhloko sengozi ukwakheka kofuzo lwabazali bengane. Uma bobabili abazali banekhophi eyodwa yezinguquko SLC6A3 gene, ingane yabo izothola amakhophi amabili ohlobo olushintshiwe bese ifa lesi sifo.

Kutholakala kanjani?

Imvamisa, udokotela wengane yakho angenza ukuxilongwa ngemuva kokubona noma yiziphi izinselelo ezingaba nazo ngokulinganisela noma ukunyakaza. Udokotela uzoqinisekisa ukuxilongwa ngokuthatha isampula yegazi ukuhlola izimpawu zomzimba zofuzo.

Bangathatha nesampula ye-cerebrospinal fluid ukufuna ama-acid ahlobene ne-dopamine. Lokhu kwaziwa njenge.

Ilashwa kanjani?

Alukho uhlelo lokwelashwa olujwayelekile lwalesi simo. Ukuhlolwa nephutha kuvame ukudingeka ukunquma ukuthi imiphi imishanguzo engasetshenziselwa ukuphathwa kwezimpawu.

ube nempumelelo ethe xaxa ekuphatheni ezinye izinkinga zokunyakaza ezihlobene nokukhiqizwa kwe-dopamine. Isibonelo, i-levodopa isetshenziswe ngempumelelo ukukhulula izimpawu zesifo sika-Parkinson.

I-Ropinirole ne-pramipexole, okuyizitha ze-dopamine, zisetshenziselwe ukwelapha isifo sika-Parkinson kubantu abadala. Abaphenyi basebenzise lo muthi ku-dopamine defence syndrome. Kodwa-ke, kudingeka olunye ucwaningo ukuthola imiphumela emibi engaba khona yesikhashana neyesikhathi eside.

Amanye amasu okwelapha nokuphatha izimpawu afana nalawo ezinye izinkinga zokuhamba. Lokhu kufaka phakathi izinguquko zemithi nezindlela zokuphila ukwelashwa:

• ukuqina kwemisipha
• izifo zamaphaphu
• izinkinga zokuphefumula
• IGERD
• ukuqunjelwa

Kukuthinta kanjani ukulindela isikhathi sokuphila?

Izinsana nezingane ezine-dopamine Transporter defence syndrome zingaba nesikhathi esifushane sokuphila. Lokhu kungenxa yokuthi basengozini yokungenwa yizifo zamaphaphu ezisongela ukuphila nezinye izifo zokuphefumula.

Kwezinye izimo, umbono wengane uthandeka kakhulu uma izimpawu zawo zingaveli ngesikhathi sobuntwana.