Umhlahlandlela Olula wohlelo lwe-Endocannabinoid

-Delile

• Isebenza kanjani?
• Ama-Endocannabinoids
• Ama-Endocannabinoid receptors
• Ama-enzyme
• Yimiphi imisebenzi yayo?
• Isebenzisana kanjani i-THC ne-ECS?
• I-CBD ihlangana kanjani ne-ECS?
• Kuthiwani ngokuntuleka kwe-endocannabinoid?
• Okubalulekile

Uhlelo lwe-endocannabinoid (ECS) luyisistimu eyinkimbinkimbi yokutshengiswa kwamaseli ekhonjwe ekuqaleni kweminyaka yama-1990 ngabaphenyi abahlola i-THC, i-cannabinoid eyaziwayo. Ama-cannabinoids ayizinhlanganisela ezitholakala ku-cannabis.

Ochwepheshe basazama ukuqonda ngokugcwele i-ECS. Kepha kuze kube manje, siyazi ukuthi lidlala indima ekulawuleni uhla lwemisebenzi nezinqubo, kufaka phakathi:

• lala
• isimo
• isifiso sokudla
• inkumbulo
• ukuzala nokuzala

I-ECS ikhona futhi iyasebenza emzimbeni wakho noma ungasebenzisi i-cannabis.

Funda ukuze ufunde kabanzi nge-ECS kufaka phakathi ukuthi isebenza kanjani futhi ixhumana kanjani nensangu.

Isebenza kanjani?

I-ECS ifaka izinto ezintathu eziyinhloko: i-endocannabinoids, ama-receptors, nama-enzyme.

Ama-Endocannabinoids

Ama-endocannabinoids, abizwa nangokuthi ama-cannabinoid endogen, angama-molecule enziwe ngumzimba wakho. Ziyafana nama-cannabinoids, kepha akhiqizwa ngumzimba wakho.

Ochwepheshe bathole ama-endocannabinoids amabili abalulekile kuze kube manje:

• i-anandamide (AEA)
• I-2-arachidonoylglyerol (2-AG)

Lokhu kusiza ukugcina imisebenzi yangaphakathi isebenza kahle. Umzimba wakho uzikhiqiza njengoba kudingeka, okwenza kube nzima ukwazi ukuthi yimaphi amazinga ajwayelekile ngakunye.

Ama-Endocannabinoid receptors

Lawa ma-receptors atholakala emzimbeni wakho wonke. Ama-Endocannabinoids azibophezela kuwo ukuze akhombise ukuthi i-ECS idinga ukuthatha isinyathelo.

Kunezinhlayiya ezimbili eziyinhloko ze-endocannabinoid:

• Ama-receptors e-CB1, atholakala kakhulu ohlelweni lwezinzwa oluphakathi
• Ama-receptors e-CB2, atholakala kakhulu ohlelweni lwakho lwezinzwa, ikakhulukazi amaseli omzimba

Ama-Endocannabinoids angabopha kunoma iyiphi i-receptor. Imiphumela ebangelwa yilokho okutholwa khona nokuthi i-endocannabinoid iyibophezela kuphi.

Isibonelo, ama-endocannabinoids angahle akhombe ama-CB1 receptors emgogodleni wokudambisa izinhlungu. Abanye bangabopha kwi-receptor ye-CB2 kumaseli akho omzimba ukukhombisa ukuthi umzimba wakho uhlangabezana nokuvuvukala, uphawu olujwayelekile lokuphazamiseka komzimba.

Ama-enzyme

Ama-enzyme anesibopho sokuphula ama-endocannabinoids uma esewenzile umsebenzi wawo.

Kukhona ama-enzyme amabili abhekene nalokhu:

• i-fatty acid i-amide hydrolase, ediliza i-AEA
• i-monoacylglycerol acid lipase, ejwayele ukwehla i-2-AG

Yimiphi imisebenzi yayo?

I-ECS iyinkimbinkimbi, futhi ochwepheshe abakazinqumi kahle ukuthi isebenza kanjani noma yonke imisebenzi yayo engaba khona.

ixhume i-ECS kulezi zinqubo ezilandelayo:

• iphango nokugaya ukudla
• umzimba
• ubuhlungu obungapheli
• ukuvuvukala nezinye izimpendulo zamasosha omzimba
• isimo
• ukufunda nokukhumbula
• ukulawula imoto
• lala
• umsebenzi wenhliziyo nemithambo yegazi
• ukwakheka kwemisipha
• ukulungiswa kwamathambo nokukhula
• ukusebenza kwesibindi
• umsebenzi wesistimu yokuzala
• ukucindezeleka
• ukusebenza kwesikhumba nemizwa

Le misebenzi yonke inikela kwi-homeostasis, ebhekisa ekusimeni kwemvelo yakho yangaphakathi.Isibonelo, uma amandla angaphandle, njengobuhlungu bokulimala noma umkhuhlane, elahla i-homeostasis yomzimba wakho, i-ECS yakho iyakhahlela ukusiza umzimba wakho ubuyele ekusebenzeni kwawo okuhle.

Namuhla, ochwepheshe bakholelwa ukuthi ukugcina i-homeostasis uma kuyindima eyinhloko ye-ECS.

Isebenzisana kanjani i-THC ne-ECS?

I-Tetrahydrocannabinol (iTHC) ingenye yama-cannabinoids amakhulu atholakala ku-cannabis. Yinkomponi ekuthola "phezulu."

Kanye emzimbeni wakho, i-THC ixhumana ne-ECS yakho ngokubopha kuma-receptors, njengama-endocannabinoids. Inamandla ngokwengxenye ngoba ingabopha kuwo womabili ama-CB1 ne-CB2 receptors.

Lokhu kuyivumela ukuthi ibe nemiphumela ehlukahlukene emzimbeni nasengqondweni yakho, eminye ifiseleka kakhulu kunabanye. Isibonelo, i-THC ingasiza ekunciphiseni ubuhlungu futhi ivuse nesifiso sakho sokudla. Kepha futhi kungadala ukuphambana nokukhathazeka kwezinye izimo.

Ochwepheshe njengamanje babheka izindlela zokukhiqiza zokwenziwa iTHC cannabinoids ezisebenzisana ne-ECS ngezindlela ezizuzisayo kuphela.

I-CBD ihlangana kanjani ne-ECS?

Enye i-cannabinoid enkulu etholakala ku-cannabis yi-cannabidiol (CBD). Ngokungafani ne-THC, i-CBD ayikwenzi "uphakeme" futhi imvamisa ayibangeli miphumela emibi.

Ochwepheshe abaqiniseki ngokuphelele ukuthi i-CBD ixhumana kanjani ne-ECS. Kepha bayazi ukuthi akubopheli kuma-CB1 noma ama-CB2 receptors ngendlela i-THC eyenza ngayo.

Esikhundleni salokho, abaningi bakholelwa ukuthi kusebenza ngokuvimbela ama-endocannabinoids ukuthi angahlehli. Lokhu kuvumela ukuthi babe nomphumela omningi emzimbeni wakho. Abanye bakholelwa ukuthi i-CBD ibophezela kumamukeli ongakatholakali okwamanje.

Ngenkathi imininingwane yokuthi isebenza kanjani isengaphansi kwempikiswano, ucwaningo lukhombisa ukuthi i-CBD ingasiza ngobuhlungu, isicanucanu, nezinye izimpawu ezihambisana nezimo eziningi.

Kuthiwani ngokuntuleka kwe-endocannabinoid?

Abanye ochwepheshe bakholelwa kumcabango owaziwa ngokuthi yi-clinical endocannabinoid deficiency (CECD). Le mbono iphakamisa ukuthi amazinga aphansi e-endocannabinoid emzimbeni wakho noma ukungasebenzi kwe-ECS angasiza ekuthuthukiseni izimo ezithile.

Ukubuyekezwa kweminyaka engaphezu kwengu-10 yocwaningo ngale ndaba kusikisela ukuthi lo mbono ungachaza ukuthi kungani abanye abantu beba ne-migraine, i-fibromyalgia, nesifo samathumbu esicasulayo.

Azikho kulezi zimo ezinembangela ecacile. Zibuye zivame ukumelana nokwelashwa futhi kwesinye isikhathi zenzeka eceleni komunye nomunye.

Uma i-CECD idlala noma yiluphi uhlobo lwendima kulezi zimo, ukukhomba i-ECS noma ukukhiqizwa kwe-endocannabinoid kungaba ukhiye olahlekile ekwelashweni, kepha kudingeka olunye ucwaningo.

Okubalulekile

I-ECS idlala indima enkulu ekugcineni izinqubo zakho zangaphakathi zizinzile. Kepha kusekuningi esingazi ngakho. Njengoba ochwepheshe bethuthukisa ukuqonda okungcono kwe-ECS, kungagcina kubambe ukhiye wokwelapha izimo eziningana.