I-A1 vs. A2 Ubisi - Ingabe Kunendaba?

-Delile

• Asho ukuthini la magama?
• Izimangalo ezingezinhle mayelana ne-A1 protein
• Thayipha isifo sikashukela sokuqala
• Isifo senhliziyo
• Isifo sokufa kwezinsana ngokuzumayo
• I-Autism
• Impilo yokugaya ukudla
• Okubalulekile

Imiphumela yezempilo yobisi ingaxhomeka ohlotsheni lwenkomo evela kuyo.

Njengamanje, ubisi lwe-A2 luthengiswa njengokukhetha okunempilo kunobisi olujwayelekile lwe-A1.

Abaxhasi bathi i-A2 inezinzuzo eziningana zezempilo futhi kulula kubantu abanobandlululo lobisi ukugaya.

Lo mbhalo ubheka ngenhloso isayensi engemuva kobisi lwe-A1 ne-A2.

Asho ukuthini la magama?

I-Casein yiqembu elikhulu kunawo wonke lamaprotheni obisi, akha cishe amaphesenti angama-80 wamaprotheni esewonke.

Kunezinhlobo eziningana ze-casein obisini. IBeta-casein ingeyesibili edume kakhulu futhi ikhona okungenani amafomu ahlukene ayi-13 ().

Izinhlobo ezimbili ezivame kakhulu yilezi:

• I-A1 beta-casein. Ubisi oluvela ezinhlotsheni zezinkomo ezavela enyakatho yeYurophu ngokuvamile luphakeme ku-A1 beta-casein. Lezi zinhlobo zifaka iHolstein, iFriesian, i-Ayrshire, neBritish Shorthorn.
• I-beta-casein engu-A2. Ubisi oluphakeme ku-A2 beta-casein lutholakala kakhulu ezinhlotsheni ezavela eChannel Islands naseningizimu yeFrance. Lokhu kufaka izinkomo zaseGuernsey, Jersey, Charolais, kanye neLimousin (,).

Ubisi olujwayelekile luqukethe zombili i-A1 ne-A2 beta-casein, kepha ubisi lwe-A2 luqukethe kuphela i-A2 beta-casein.

Ezinye izifundo ziphakamisa ukuthi i-A1 beta-casein ingaba yingozi nokuthi i-A2 beta-casein iyindlela ephephile.

Ngakho-ke, kukhona impikiswano yomphakathi neyesayensi ngalezi zinhlobo ezimbili zobisi.

Ubisi lwe-A2 lukhiqizwa futhi luthengiswe yi-A2 Milk Company futhi aluna-A1 beta-casein.

Ubisi lwe-A1 ne-A2 luqukethe izinhlobo ezahlukene zamaprotheni we-beta-casein. Olunye ucwaningo lukhombisa ukuthi ubisi lwe-A2 lungaba nempilo kulokhu okubili.

Izimangalo ezingezinhle mayelana ne-A1 protein

I-Beta-casomorphin-7 (BCM-7) iyi-peptide ye-opioid ekhishwe ngesikhathi sokugaywa kwe-A1 beta-casein (, 4).

Yisizathu sokuthi abanye abantu bakholelwe ukuthi ubisi olujwayelekile alunampilo encane kunobisi lwe-A2.

Amaqembu ambalwa ocwaningo asikisela ukuthi i-BCM-7 ingaxhunyaniswa nohlobo 1 lwesifo sikashukela, isifo senhliziyo, ukufa kwezinsana, i-autism, nezinkinga zokugaya ukudla (,,,).

Ngenkathi i-BCM-7 ingathinta uhlelo lwakho lokugaya ukudla, kusengakacaci ukuthi i-BCM-7 ifakwa egazini lakho kangakanani.

Ucwaningo alutholanga i-BCM-7 egazini labantu abadala abaphilile abaphuza ubisi lwenkomo, kodwa ukuhlolwa okumbalwa kukhombisa ukuthi i-BCM-7 ingaba khona ezinganeni (,,).

Ngenkathi i-BCM-7 icwaningwe kabanzi, imiphumela yayo yonke yezempilo ihlala ingacaci.

Thayipha isifo sikashukela sokuqala

Uhlobo lwesifo sikashukela sohlobo 1 luvame ukutholakala ezinganeni futhi lubonakala ngokuntuleka kwe-insulin.

Ucwaningo oluningi lukhombisa ukuthi ukuphuza ubisi lwe-A1 ngesikhathi sobuntwana kwandisa ubungozi bakho besifo sikashukela sohlobo 1 (,,,).

Kodwa-ke, lezi zifundo ziyabheka. Abakwazi ukufakazela ukuthi i-A1 beta-casein ibangela uhlobo lwesifo sikashukela sohlobo 1 - kuphela ukuthi labo abathola okuningi basengozini enkulu.

Ngenkathi ezinye izifundo zezilwane zingatholanga mehluko phakathi kwe-A1 ne-A2 beta-casein, ezinye zibonisa ukuthi i-A1 beta-casein ingaba nemiphumela evikelayo noma emibi kuhlobo 1 lwesifo sikashukela (,,,).

Kuze kube manje, azikho izivivinyo zomtholampilo kubantu eziphenye umphumela we-A1 beta-casein kuhlobo 1 sikashukela.

Isifo senhliziyo

Izifundo ezimbili zokuhlola zihlobanisa ukusetshenziswa kobisi lwe-A1 nengozi eyengeziwe yesifo senhliziyo (,).

Ukuhlolwa okukodwa konogwaja kukhombise ukuthi i-A1 beta-casein ikhuthaze ukwakheka kwamafutha emithanjeni yegazi elimele. Lokhu kwakhiwa kwakuphansi kakhulu lapho onogwaja bedla i-A2 beta-casein ().

Ukuqoqwa kwamafutha kungahle kuvimbe imithambo yegazi futhi kudale isifo senhliziyo. Noma kunjalo, ukubaluleka komuntu kwemiphumela kuxoxiswene ngakho ().

Kuze kube manje, izivivinyo ezimbili ziphenye imiphumela yobisi lwe-A1 ezintweni ezinobungozi besifo senhliziyo kubantu (,).

Kocwaningo olulodwa kubantu abadala abayi-15 abasengozini enkulu yesifo senhliziyo, akukho miphumela emibi eye yabonwa. I-A1 ne-A2 zibe nemiphumela efanayo ekusebenzeni kwesitsha segazi, umfutho wegazi, amafutha egazi, nezimpawu zokuvuvukala ().

Olunye ucwaningo alutholanga mahluko ophawulekayo emiphumeleni ye-A1 ne-A2 casein ku-cholesterol egazini ().

Isifo sokufa kwezinsana ngokuzumayo

Isifo sokufa kwezinsana okungazelelwe (SIDS) siyimbangela yokufa ejwayelekile ezinganeni ezingaphansi kwezinyanga eziyi-12 ubudala.

I-SIDS ukufa okungalindelekile kosana ngaphandle kwesizathu ().

Abanye abacwaningi bacabangele ukuthi i-BCM-7 ingahle ibandakanyeke kwezinye izimo ze-SIDS ().

Ucwaningo oluthile luthole amazinga aphezulu e-BCM-7 egazini lezinsana eziyeke ukuphefumula okwesikhashana ngesikhathi sokulala. Lesi simo, esaziwa ngokuthi i-apnea yokulala, sixhunyaniswe nengozi eyengeziwe ye-SIDS ().

Le miphumela ikhombisa ukuthi ezinye izingane zingazwela ku-A1 beta-casein etholakala obisini lwenkomo. Kodwa-ke, izifundo ezengeziwe ziyadingeka ngaphambi kokuba kufinyelelwe esiphethweni esiqinile.

I-Autism

I-Autism yisimo sengqondo esibonakala ngokungahlangani kwezenhlalo nokuziphatha okuphindaphindayo.

Ngomqondo, ama-peptides afana ne-BCM-7 angadlala indima ekuthuthukiseni i-autism. Kodwa-ke, izifundo azizisekeli zonke izindlela ezihlongozwayo (,,).

Ucwaningo olulodwa ezinganeni lwathola amazinga aphakeme e-BCM-7 kulolo lubisi lwenkomo oluphakanyisiwe uma kuqhathaniswa nalabo abanceliswa ibele. Ngokuphawulekile, amazinga we-BCM-7 ehle ngokushesha kwezinye zezinsana ngenkathi ehlala ephezulu kwezinye.

Kulabo abagcina la mazinga aphezulu, i-BCM-7 yayihlotshaniswa kakhulu nekhono lokukhubazeka lokuhlela nokwenza izinto ().

Olunye ucwaningo lukhombisa ukuthi ukuphuza ubisi lwenkomo kungazenza zibe zimbi izimpawu zokuziphatha ezinganeni ezine-autism. Kepha ezinye izifundo azitholanga miphumela ekuziphatheni (,,).

Kuze kube manje, azikho izivivinyo zabantu eziphenye ngqo imiphumela yobisi lwe-A1 ne-A2 ezinkomba ze-autism.

Izifundo ezimbalwa ziphakamisa ukuthi i-A1 beta-casein ne-peptide BCM-7 ingaxhunyaniswa nesifo sikashukela, isifo senhliziyo, i-autism ne-SIDS. Noma kunjalo, imiphumela ixubekile futhi kudingeka olunye ucwaningo.

Impilo yokugaya ukudla

Ukungabekezelelani kwe-Lactose ukungakwazi ukugaya ushukela wobisi ngokugcwele (i-lactose). Lokhu kuyimbangela evamile yokuqunjelwa, igesi nohudo.

Inani le-lactose ebisi lwe-A1 ne-A2 liyafana. Kodwa-ke, abanye abantu banomuzwa wokuthi ubisi lwe-A2 lubangela ukuqunjelwa okuncane kunobisi lwe-A1.

Eqinisweni, ucwaningo lukhombisa ukuthi izingxenye zobisi ngaphandle kwe-lactose zingadala ukungakhululeki kokugaya ukudla (,).

Ososayensi baye basikisela ukuthi amaprotheni athile obisi angabhekana nokungabekezelelani kwabanye ubisi.

Ucwaningo olulodwa kubantu abangu-41 lukhombisile ukuthi ubisi lwe-A1 lubangela izitulo ezithambile kunobisi lwe-A2 kwabanye abantu, kanti olunye ucwaningo kubantu abadala baseChina luthole ukuthi ubisi lwe-A2 luholele ekungaphatheni kahle kokugaya ukudla ngemuva kokudla (,).

Ngokwengeziwe, ucwaningo lwezilwane nolwabantu luphakamisa ukuthi i-A1 beta-casein ingakhuphula ukuvuvukala ohlelweni lokugaya ukudla (,,).

Ubufakazi obukhulayo bukhombisa ukuthi i-A1 beta-casein idala izimpawu ezimbi zokugaya ukudla kwabanye abantu.

Okubalulekile

Impikiswano mayelana nemiphumela yezempilo engaba khona yobisi lwe-A1 ne-A2 iyaqhubeka.

Ucwaningo luphakamisa ukuthi i-A1 beta-casein idala izimpawu ezimbi zokugaya ukudla kubantu abathile.

Kepha ubufakazi busebuthakathaka kakhulu ukuba kwenziwe noma iziphi iziphetho eziqinile mayelana nezixhumanisi okucatshangwa ukuthi ziphakathi kwe-A1 beta-casein nezinye izimo, ezinjengohlobo 1 sikashukela kanye ne-autism.

Lokho kusho ukuthi, ubisi lwe-A2 lungakulungela ukuzama uma ulwela ukugaya ubisi olujwayelekile.