Luyini uvivinyo lwe-GH futhi ludingeka nini

-Delile

• Yenzelwe ini
• Kwenziwa kanjani

I-hormone yokukhula, ebizwa nangokuthi i-GH noma i-somatotropin, iyi-hormone ebalulekile ekhiqizwa yi-pituitary gland esebenza ekukhuleni kwezingane nentsha futhi ibambe iqhaza ezinqubweni zomzimba zomzimba.

Lokhu kuhlolwa kwenziwa ngomthamo emasampulini egazi aqoqwe elebhu futhi kuvame ukucelwa ngudokotela we-endocrinologist lapho kukhona ukusola kokuntuleka kokukhiqizwa kwe-GH, ikakhulukazi ezinganeni ezethula ukukhula okungaphansi kwalokho obekulindelwe, noma ukukhiqizwa ngokweqile kwazo , ejwayelekile ku-gigantism noma i-acromegaly.

Ukusetshenziswa kwe-GH njengomuthi kuboniswa lapho kunokushoda ekukhiqizeni le hormone, ezinganeni noma kubantu abadala, njengoba kukhonjisiwe ngudokotela. Ukuze ufunde kabanzi mayelana nokuthi isetshenziswa kanjani, amanani nemiphumela ye-hormone yokukhula, hlola ilebula le-hormone GH.

Yenzelwe ini

Ukuhlolwa kwe-GH kuyacelwa uma usola:

• Ubunzima, okuwukushoda kwe-hormone yokukhula ezinganeni, okwenza isiqu esifushane. Qonda ukuthi kuyini nokuthi yini engadala ukufiphala;
• Ukushoda kwabantu abadala kwe-GH, kubangelwe ukukhiqizwa kwe-GH ngaphansi kokujwayelekile, okuholela ezimpawu ezifana nokukhathala, ukukhuphuka kwesisindo samafutha, ukwehla kwesisindo somzimba, ukwehla kwekhono lokuzivocavoca umzimba, ukwehla kwamathambo kanye nengozi eyengeziwe yokuthola izifo zenhliziyo;
• Ubuciko obukhulu, ebonakaliswa ngokweqile kwemfihlo ye-GH enganeni noma ebusheni, okudala ukukhula okuyihaba;
• I-Acromegaly, okuyisifo esibangelwa ukukhiqizwa ngokweqile kwe-GH kubantu abadala, okwenza ushintsho ekubukeni kwesikhumba, izandla, izinyawo nobuso. Bona futhi umehluko phakathi kwe-acromegaly ne-gigantism;

Ukuntuleka kwe-GH emzimbeni kungaba nezimbangela eziningi, njengezifo zofuzo, ukushintsha kobuchopho, okufana nezicubu, izifo noma ukuvuvukala noma ngenxa yomphumela oseceleni we-chemo noma imisebe yobuchopho, isibonelo. Ukweqisa kwe-GH, ngakolunye uhlangothi, kuvame ukwenzeka ngenxa ye-pituitary adenoma.

Kwenziwa kanjani

Ukulinganiswa kwehomoni ye-GH kwenziwa ngokuhlaziya amasampula egazi elabhorethri futhi kwenziwa ngezindlela ezi-2:

1. Isilinganiso se-GH esiyisisekelo: kwenziwa okungenani amahora angama-6 wokuzila izingane kanye namahora ayi-8 kwentsha kanye nabantu abadala, okuhlaziya inani laleli hormone kusampula yegazi lasekuseni;
2. Ukuhlolwa kokukhuthaza kwe-GH (ngeClonidine, i-Insulin, i-GHRH noma i-Arginine): kwenziwa ngokusetshenziswa kwemithi engakhuthaza ukuvimba kwe-GH, uma kwenzeka kusolwa ukungabi khona kwale hormone. Okulandelayo, ukuhlaziywa kwegazi kwe-GH kwenziwa ngemuva kwemizuzu engama-30, 60, 90 kanye ne-120 yokusebenzisa lesi sidakamizwa.

Ukuhlolwa kokukhuthaza kwe-GH kuyadingeka ngoba ukukhiqizwa kwehomoni ye-GH ngumzimba akufani, futhi kungaphazanyiswa yizinto eziningana, njengokuzila ukudla, ukucindezeleka, ukulala, ukudlala imidlalo noma lapho inani le-glucose egazini lehla. Ngakho-ke, eminye yemithi esetshenzisiwe yiClonidine, i-Insulin, i-Arginine, iGlucagon noma i-GHRH, ngokwesibonelo, ekhuthaza noma evimbela ukukhiqizwa kwehomoni.

Ngaphezu kwalokho, udokotela futhi anga-oda ezinye izivivinyo, njengokukalwa kwamahomoni afana ne-IGF-1 noma iphrotheni le-IGFBP-3, eliguquka ngokuhlukahluka kwe-GH: Ukuskena kwe-MRI kobuchopho, ukuhlola ushintsho ku-pituitary gland, futhi kungasiza ukukhomba imbangela yenkinga.