Ukushoda kwe-Factor VII

-Delile

• Iyiphi indima edlalwa yi-factor VII ekunqandeni igazi okujwayelekile?
• 1. IVasoconstriction
• 2. Ukwakhiwa kwepulaki leplatelet
• 3. Ukwakhiwa kwepulagi ye-fibrin
• 4. Ukupholisa amanxeba nokubhujiswa kwepulagi ye-fibrin
• Yini ebangela ukuntuleka kwe-factor VII?
• Ziyini izimpawu zokushoda kwe-factor VII?
• Kutholakala kanjani ukuntuleka kwe-factor VII?
• Lashwa kanjani i-factor VII?
• Ukulawula ukuphuma kwegazi
• Ukwelashwa kwezimo ezingaphansi
• Ukwelashwa kokuqapha ngaphambi kokuhlinzwa
• Uyini umbono wesikhathi eside?

Ukubuka konke

Ukushoda kwe-Factor VII yisifo sokuvala igazi esidala ukopha ngokweqile noma isikhathi eside ngemuva kokulimala noma ukuhlinzwa. Ngokushoda kwe-factor VII, umzimba wakho awukhiqizi i-factor VII eyanele, noma okuthile kuphazamisa i-factor VII yakho, imvamisa esinye isimo sezokwelapha.

I-Factor VII yiprotheni ekhiqizwa esibindini edlala indima ebalulekile ekusizeni igazi lakho ukuba limile. Kungenye yezinto ezicishe zibe ngu-20 zokujiya ezihilelekile enqubweni eyinkimbinkimbi yokunqanda igazi. Ukuqonda ukushoda kwe-factor VII, kuyasiza ukuqonda indima ye-VII edlala ekunqandeni kwegazi okujwayelekile.

Iyiphi indima edlalwa yi-factor VII ekunqandeni igazi okujwayelekile?

Inqubo ejwayelekile yokuvala igazi yenzeka ngezigaba ezine:

1. IVasoconstriction

Lapho kusikwa umthambo wegazi, umthambo wegazi owonakele ngokushesha uncipha ekunciphiseni ukopha. Ngemuva kwalokho, umthambo wegazi olimele ukhipha iprotheni ebizwa ngokuthi yi-tissue factor egazini. Ukukhishwa kwesici sezicubu kusebenza njengocingo lwe-SOS, kusayina amaplatelets egazi nezinye izinto ezijiyisayo ukubika endaweni yokulimala.

2. Ukwakhiwa kwepulaki leplatelet

Ama-platelets egazini legazi angabokuqala ukufika endaweni yokulimala. Bayanamathela ezicutshini ezilimele, futhi komunye nomunye, bakha ipulaki lesikhashana, elithambile enxebeni. Le nqubo yaziwa njenge-hemostasis eyinhloko.

3. Ukwakhiwa kwepulagi ye-fibrin

Lapho ipulaki lesikhashana selikhona, izinto zokuvala igazi zihamba ngendlela eyinkimbinkimbi yokuphendula ukuze kudedelwe i-fibrin, iphrotheni elukhuni, elinezintambo. I-Fibrin izigoqa ngaphakathi nangaphakathi kweqhwa elithambile ize ibe lukhuni olungenakunyibilika. Leli hlwili elisha livala umthambo wegazi ophukile, futhi lenza isembozo sokuvikela ukukhula kwezicubu ezintsha.

4. Ukupholisa amanxeba nokubhujiswa kwepulagi ye-fibrin

Ngemuva kwezinsuku ezimbalwa, i-fibrin clot iqala ukuncipha, idonse imiphetho yesilonda ndawonye ukusiza izicubu ezintsha zikhule ngaphezu kwesilonda. Njengoba izicubu zakhiwa kabusha, i-fibrin clot iyancibilika bese iyangena.

Uma i-factor VII ingasebenzi kahle, noma incane kakhulu kuyo, i-fibrin clot enamandla ayikwazi ukwakheka kahle.

Yini ebangela ukuntuleka kwe-factor VII?

Ukushoda kwe-factor VII kungazuzwa njengefa noma kungatholwa. Uhlobo olutholwe njengefa aluvamile. Angaphansi kwamakhulu amabili amacala abhaliwe abikiwe. Bobabili abazali bakho kumele baphathe isakhi sofuzo ukuze uthinteke.

Ukushoda kwe-factor VII, ngokuhlukile, kwenzeka ngemuva kokuzalwa. Kungenzeka ngenxa yemithi noma izifo eziphazamisa i-factor VII yakho. Izidakamizwa ezingaphazamisa noma zinciphise umsebenzi we-factor VII zifaka:

• ama-antibiotic
• izinciphisi zegazi, njenge-warfarin
• eminye imithi yomdlavuza, efana ne-interleukin-2 therapy
• I-antithymocyte globulin therapy esetshenziselwa ukwelapha i-aplastic anemia

Izifo nezimo zezokwelapha ezingaphazamisa i-factor VII zifaka:

• isifo sesibindi
• myeloma
• sepsis
• i-aplastic anemia
• ukuntuleka kukavithamini K

Ziyini izimpawu zokushoda kwe-factor VII?

Izimpawu ziyahluka kusuka komoya kuya kokukhulu, kuya ngamazinga akho we-factor VII. Izimpawu ezincane zingafaka:

• ukulimaza kanye nezicubu ezithambile zokopha
• isikhathi esopha isikhathi eside emanxebeni noma ekukhishweni kwamazinyo
• ukopha emalungeni
• ukuphuma kwamakhala
• izinsini ezophayo
• izikhathi ezinzima zokuya esikhathini

Ezimweni ezimbi kakhulu, izimpawu zingafaka:

• ukubhujiswa kwe-cartilage emajoyini avela eziqeshini zokopha
• ukopha emathunjini, esiswini, emisipheni noma ekhanda
• ukopha ngokweqile ngemuva kokubeletha

Kutholakala kanjani ukuntuleka kwe-factor VII?

Ukuxilongwa kusekelwe emlandweni wakho wezokwelapha, noma imuphi umlando womndeni wezinkinga zokopha, nokuhlolwa kwebhu.

Ukuhlolwa kweLab ngokushoda kwe-factor VII kufaka:

• izilinganiso zokuhlola ukuthola izinto ezingekho noma ezingenzi kahle
• i-factor VII yokulinganisa ukukala ukuthi unani le-VII, nokuthi lisebenza kahle kangakanani
• isikhathi se-prothrombin (PT) ukukala ukusebenza kwezinto I, II, V, VII, no-X
• isikhathi esinqunyelwe se-prothrombin (PTT) ukukala ukusebenza kwezici VIII, IX, XI, XII, kanye nezici ze-von Willebrand
• izivivinyo ze-inhibitor ukuthola ukuthi amasosha akho omzimba ahlasela yini izici zakho zokujiya

Lashwa kanjani i-factor VII?

Ukwelashwa kokushoda kwe-factor VII kugxile koku:

• ukulawula ukopha
• ukuxazulula izimo ezingaphansi
• ukwelashwa kokuqapha ngaphambi kokuhlinzwa noma izinqubo zamazinyo

Ukulawula ukuphuma kwegazi

Ngesikhathi seziqephu zokopha, unganikezwa ukufakwa kokuthambisa kwegazi ukukhulisa ikhono lakho lokujiya. Ama-Clotting agents asetshenziswa kakhulu afaka:

• i-prothrombin eyinkimbinkimbi yabantu
• siphamandla
• i-plasma efriziwe entsha
• into ephindaphindekayo yabantu VIIa (NovoSeven)

Ukwelashwa kwezimo ezingaphansi

Lapho ukopha sekulawulwa, kufanele kulungiswe izimo ezonakalisa ukusebenza kwe-factor VII, njengemithi noma izifo.

Ukwelashwa kokuqapha ngaphambi kokuhlinzwa

Uma uhlela ukuhlinzwa, udokotela wakho angakunika imishanguzo ukunciphisa ingozi yokopha ngokweqile. I-Desmopressin nasal spray ivame ukunikezwa ukukhipha zonke izitolo ezitholakalayo ze-factor VII ngaphambi kokuhlinzwa okuncane. Ekuhlinzweni okungathi sína ngokwengeziwe, udokotela wakho angakunika ukumnika kwe-clotting factor.

Uyini umbono wesikhathi eside?

Uma unefomu oyitholile lokuntuleka kwe-factor VII, kungenzeka ukuthi kubangelwa yimithi noma isimo esingaphansi. Umbono wakho wesikhathi eside uncike ekulungiseni izinkinga eziwumsuka. Uma unefomu elibi kakhulu lokuthola i-factor VII, kuzodingeka usebenze eduze nodokotela wakho kanye nesikhungo sakho sendawo se-hemophilia ukuphatha izingozi zokopha.