Amadokhumenti Athi Iphilisi Elisha Eligunyazwe I-FDA Lokwelapha I-Endometriosis Lingaba Ushintsho Lomdlalo

-Delile

• U-Orilissa ubelapha kanjani ubuhlungu be-endometriosis?
• Iyini imiphumela emibi?
• Iphuzu eliyinhloko?
• Buyekeza kwe-

Ngasekuqaleni kwaleli sonto, i-Food and Drug Administration igunyaze umuthi omusha ongenza ukuthi ukuphila ne-endometriosis kube lula kubantu abangaphezu kwamaphesenti ayishumi besifazane abaphila nalesi simo esibuhlungu, futhi kwesinye isikhathi esidumazayo.(Okuhlobene: ULena Dunham Wayene-Hysterectomy Ephelele Yokumisa Ubuhlungu Bakhe be-Endometriosis)

Ukuvuselela okusheshayo: "I-Endometriosis yisifo esithinta abesifazane abaneminyaka yokuzala lapho ulwelwesi lwesibeletho lukhula ngaphandle kwesibeletho," kusho uSanjay Agarwal, M.D., uprofesa wezokubelethisa, izifo zabesifazane, kanye nesayensi yokuzala e-UC San Diego Health. "Izimpawu zingahlukahluka kakhulu kepha zivame ukuhlotshaniswa nezikhathi ezibuhlungu nobuhlungu ngokuya ocansini-lezi zimpawu zingaba yimbi." (I-Endometriosis ingase futhi ibangele ukungazali. Ngasekuqaleni kwalo nyaka, u-Halsey wakhuluma ngokuqandisa amaqanda akhe eneminyaka engu-23 ngenxa ye-endometriosis yakhe.)

Njengoba kunikezwe i-endometriosis ethinta abesifazane abayizigidi ezingama-200 emhlabeni wonke, odokotela basazi okuncane okushaqisayo ngokuthi yini ebanga izilonda ezibuhlungu. "Asinaso isiqiniseko sokuthi kungani abanye besifazane beyithuthukisa kanti abanye bangayenzi noma kungani kwabanye besifazane ingaba yisimo esibucayi kanti kwabanye ingaba yisimo esibuhlungu kakhulu esiqeda amandla," kusho uZev Williams, MD, Ph.D. ., isikhulu seDivision of Reproductive Endocrinology and Infertility at Columbia University Medical Center.

Odokotela abakwaziyo ukuthi “i-estrogen ivame ukwenza isifo nezimpawu zibe zimbi kakhulu,” kusho uDkt. Agarwal, yingakho i-endometriosis ivame ukudala izikhathi ezibuhlungu kakhulu. Kungumjikelezo ononya, engeza uDkt Williams. "Izilonda zidala ukuvuvukala, okwenza umzimba ukhiqize i-estrogen, okudala ukuvuvukala okwengeziwe, nokunye," kuchaza yena. (Okuhlobene: UJulianne Hough Ukhuluma Ngokuzabalaza Kwakhe Nge-Endometriosis)

"Enye yezinhloso zokwelashwa ukuzama ukunqamula lowo mjikelezo ngokusebenzisa imithi enciphisa ukuvuvukala noma ukuba khona kwe-estrogen," kusho uDkt. Williams. "Esikhathini esedlule besikwenza lokhu njengezinto ezifana namaphilisi okuvimbela inzalo agcina amazinga esifazane e-estrogen ephansi noma ngokusebenzisa imishanguzo efana neMotrin, okuyizinto ezilwa nokuvuvukala."

Enye indlela yokwelapha ukuvimba umzimba ekukhiqizeni i-estrogen eningi kwasekuqaleni—indlela eyayisenziwa ngomjovo ngaphambili, kusho uDkt. Williams. Yile ndlela kanye u-Orilissa, umuthi osanda kugunyazwa i-FDA, osebenza ngayo-ngaphandle kwefomu lephilisi lansuku zonke.

Odokotela bathi leli philisi, elagunyazwa yi-FDA ekuqaleni kwaleli sonto futhi okulindeleke ukuthi libe khona ekuqaleni kuka-Agasti, lingase lishintshe kakhulu kwabesifazane abane-endometriosis emaphakathi kuya kokuqina. "Lena yinto enkulu emhlabeni wezempilo yabesifazane," kusho uDkt. Agarwal. "Ukuqamba okusha emkhakheni we-endometriosis bekulokhu kungekho amashumi eminyaka, futhi izindlela zokwelapha esizenzayo beziyinselele," kusho yena. Yize lesi sidakamizwa siyizindaba ezijabulisayo, inani leziguli ezingekho emshwalense akulona. Ukunikezwa kwalesi sidakamizwa amasonto amane kuzobiza u- $ 845 ngaphandle komshwalense, kubika i- IChicago Tribune.

U-Orilissa ubelapha kanjani ubuhlungu be-endometriosis?

“Ngokuvamile ubuchopho bubangela ukuba izindlala ezikhiqiza amaqanda zenze i-estrogen, evuselela ulwelwesi lwesibeletho-nezilonda ze-endometriosis-zikhule,” kuchaza uDkt. U-Orilissa ucindezela ngobumnene i-endometriosis-triggering estrogen "ngokuvimba ubuchopho ekuthumeleni isignali esibelethweni ukukhiqiza i-estrogen," esho.

Njengoba amazinga e-estrogen ancipha, nobuhlungu be-endometriosis buyaphela. Ezivivinyweni zomtholampilo ezihlolwe yi-FDA zika-Orilissa, ezazibandakanya abesifazane abacishe babe yi-1,700 abanezinhlungu ezilinganiselwe nezibuhlungu ze-endometriosis, umuthi wehlise kakhulu izinhlobo ezintathu zobuhlungu be-endometriosis: ubuhlungu bansuku zonke, ubuhlungu besikhathi, nobuhlungu ngesikhathi socansi.

Iyini imiphumela emibi?

Ukwelashwa kwamanje kwe-endometriosis kuvame ukuza nemiphumela emibi njengokuphuma kwegazi okungajwayelekile, induna, ukuzuza kwesisindo nokudangala. "Ngenxa yokuthi lesi sidakamizwa esisha sicindezela i-estrogen ngobumnene, akufanele sibe nemiphumela emibi efanayo neminye imithi engaba nayo," kusho uDkt Agarwal, owayengumphenyi wezokwelapha ohlelweni locwaningo.

Imiphumela eminingi emibi mincane - kepha ngoba ibangela ukwehla kwe-estrogen, u-Orilissa angadala izimpawu ezifana nokuya esikhathini njengokukhanya okushisayo, yize ochwepheshe bethi abukho ubufakazi bokuthi bungakukhahlela esikhathini sokuqala kokuya esikhathini.

Ingcuphe enkulu ukuthi umuthi ungadala ukwehla kwamathambo. Eqinisweni, i-FDA incoma ukuthi umuthi kufanele uthathwe kuphela iminyaka engaphezulu kwemibili, noma ngomthamo ophansi kakhulu. "Ukukhathazeka ngokuncipha kwamathambo ukuthi kungaholela ekuqhekekeni," kusho uDkt Williams. "Lokhu kubakhathaza kakhulu abesifazane uma bengaphansi kweminyaka engama-35 futhi sebeseminyakeni yokwakha ubukhulu bamathambo abo." (Izindaba ezinhle: Ukuzivocavoca kungasiza ukugcina amathambo akho futhi kwehlise ukukhumuzeka kwamathambo.)

Ngakho-ke, ngabe lokho kusho ukuthi u-Orilissa uyi-band-aid yeminyaka emibili kuphela engcono kakhulu? Cishe ukuthi. Lapho ususiyekile lesi sidakamizwa, ochwepheshe bathi ubuhlungu bungase buqale ukubuya kancane. Kepha ngisho neminyaka emibili engenazinhlungu ibalulekile. "Umgomo wokuphathwa kwama-hormone ukuzama ukubambezela ukukhula kwezilonda ze-endometriosis ukuze kutholakale izimpawu futhi kungavimbela isidingo sokuhlinzwa noma ukubambezeleka lapho ukuhlinzwa kungadingeka khona," kusho uDkt Williams.

Ngemuva kokuthi usikhiphile isikhathi sakho usebenzisa lo muthi, amadokhumenti amaningi angancoma ukubuyela ekwelashweni njengokulawulwa kokubeletha ukusiza ukuvimba lokho kubuya, kusho uDkt Williams.

Iphuzu eliyinhloko?

U-Orilissa akayona inhlamvu yomlingo, futhi ayilona ikhambi le-endometriosis (ngeshwa, ayikho neyodwa). Kodwa iphilisi elisanda kuvunywa limele isinyathelo esikhulu phambili ekwelashweni, ikakhulukazi kwabesifazane ababhekene nobuhlungu obukhulu, kusho uDkt. Agarwal. "Lesi yisikhathi esimnandi kakhulu sabesifazane abane-endometriosis."

Buyekeza kwe-