Ama-H2 Receptor Blockers

-Delile

• Ayini ama-H2 Receptor blocker?
• Asebenza Kanjani ama-H2 Receptor blocker?
• Yimiphi Imiphumela emibi ye-H2 Receptor Blockers?
• Ama-H2 Receptor Blockers vs. Proton Pump Inhibitors (ama-PPIs)
• Ezinye Izindlela Zokwelapha
• Q:
• A:

Ngo-Ephreli 2020, kwacelwa ukuthi zonke izinhlobo zemithi kadokotela kanye ne-over-the-counter (OTC) ranitidine (Zantac) zisuswe emakethe yase-U.S. Lesi sincomo senziwe ngoba amazinga angamukeleki we-NDMA, i-carcinogen engahle (amakhemikhali abangela umdlavuza), atholakala kweminye imikhiqizo ye-ranitidine. Uma unikezwe i-ranitidine, khuluma nodokotela wakho mayelana nezinye izindlela eziphephile ngaphambi kokumisa umuthi. Uma uthatha i-OTC ranitidine, yeka ukuthatha lesi sidakamizwa bese ukhuluma nomhlinzeki wakho wezokunakekelwa kwezempilo mayelana nezinye izinketho. Esikhundleni sokuthatha imikhiqizo ye-ranitidine engasetshenzisiwe isiza sokubuyisa izidakamizwa, yilahle ngokwemiyalo yomkhiqizo noma ngokulandela i-FDA's.

Ayini ama-H2 Receptor blocker?

Ama-H2 receptor blockers ayisigaba semithi engasetshenziswa ukwelapha izimo ezibanga i-acid engaphezulu kwesisu. Le mithi iyatholakala ekhawunteni nangemithi kadokotela. Ama-block blockers ajwayelekile we-H2 afaka:

• i-nizatidine (i-Axid)
• i-famotidine (i-Pepcid, i-Pepcid AC)
• i-cimetidine (iTagamet, iTagamet HB)

Ama-H2 receptor blocker asetshenziswa kakhulu ekwelapheni i-gastritis, noma isisu esivuvukele, kanye nokwelapha izilonda ezine-peptic. Izilonda ze-Peptic yizilonda ezibuhlungu ezakha ulwelwesi lwesisu, umphimbo ophansi, noma i-duodenum, okuyingxenye yokuqala yamathumbu amancane. Zivame ukukhula njengomphumela wokuvuvukala kanye ne-asidi yesisu eseqile. Odokotela futhi bangancoma ama-H2 receptor blockers ukugcina izilonda zep peptic zingabuyi.

Ama-H2 receptor blockers nawo asetshenziswa kaningi ukukhulula izimpawu zesifo se-reflux se-gastroesophageal (GERD). I-GERD iyindlela engapheli ye-acid reflux, ebangela ukuthi okuqukethwe yisisu esine-asidi kubuyele emuva ku-esophagus. Ukuvezwa njalo kwesisu esiswini kungacasula isopha futhi kuholele ezimpawu ezingakhululekile, njengokuqaqamba kwenhliziyo, isicanucanu, noma inkinga yokugwinya.

Ama-H2 blockers angasetshenziselwa ukwelapha izimo ezingavamile kakhulu njenge-Zollinger-Ellison syndrome, isimo esibangela ukukhiqizwa okwandayo kwesisu esiswini

Odokotela futhi bangancoma ama-H2 receptor blockers ukusetshenziswa kwelebula. Lokhu kusho ukusebenzisa umuthi ukwelapha isimo umuthi ongavunyelwe ukuwelapha. Isibonelo, ama-H2 receptor blockers angasetshenziselwa ukwelapha izinkinga ze-pancreatic noma asetshenziswe ezimeni zokungezwani komzimba, noma engasetshenziswanga ngokwesiko ngalezi zinhloso.

Asebenza Kanjani ama-H2 Receptor blocker?

Uma uthatha i-H2 receptor blocker, izithako ezisebenzayo ziya kuma-receptors athile ebusweni bamaseli esisu akhiphe ama-acid. Imithi ivimbela ukusabela okuthile kwamakhemikhali kulawa maseli ukuze angakwazi ukukhiqiza i-asidi eningi. Ngokuya ngamaNational Institutes of Health, ama-H2 receptor blockers anciphisa uketshezi lwe-asidi esiswini esikhathini esingamahora angama-24 ngamaphesenti angama-70. Ngokunciphisa inani le-asidi esiswini, noma yiziphi izicubu ezilimele zivunyelwe isikhathi sokuphola.

Yimiphi Imiphumela emibi ye-H2 Receptor Blockers?

Iningi lemiphumela emibi ehlotshaniswa ne-H2 receptor blockers imnene futhi imvamisa iyancipha njengoba umuntu ethatha umuthi ngokuhamba kwesikhathi. Bangu-1.5% kuphela abantu abayeka ukuthatha ama-H2 receptor blocker ngenxa yemiphumela emibi.

Eminye yemiphumela emibi engahle yenzeke nge-H2 receptor blockers ifaka:

• ukuqunjelwa
• isifo sohudo
• ubunzima bokulala
• umlomo owomile
• isikhumba esomile
• ikhanda
• kukhala ezindlebeni
• ikhala eligobayo
• inkinga yokuchama

Shayela udokotela wakho uma unezinye izimpawu osola ukuthi kungenzeka kungenxa yokuthatha i-H2 receptor blocker.

Ezimweni ezingavamile, ama-H2 receptor blockers angadala imiphumela emibi kakhulu, efana:

• isikhumba esishisayo, esishisayo noma esikhulayo
• izinguquko embonweni
• ukudideka
• ukuyaluza
• ukuphefumula kanzima
• isifuba
• ukuqina kwesifuba
• ukushaya kwenhliziyo okungajwayelekile
• ukusangana
• imicabango yokuzibulala

Shayela udokotela wakho noma uye esibhedlela ngokushesha uma uhlangabezana nalezi zimpawu.

Ngaphandle kwemiphumela yabo emibi engaba khona, ama-H2 receptor blockers imvamisa ayindlela yokwelashwa esebenza kahle yezimo ezibanga i-acid engaphezulu kwesisu. Wena nodokotela wakho ningaxoxa ngobungozi obungaba khona futhi nibone ukuthi ngabe ama-H2 receptor blockers ayindlela engcono kakhulu yesimo sakho. Akufanele uyeke ukuthatha imishanguzo yakho ngaphandle kokukhuluma nodokotela wakho ngayo kuqala.

Ama-H2 Receptor Blockers vs. Proton Pump Inhibitors (ama-PPIs)

Ama-Proton pump inhibitors (ama-PPIs) ngolunye uhlobo lwemithi esetshenziselwa ukunciphisa isisu i-asidi nokwelapha i-acid reflux noma i-GERD. Izibonelo zama-PPIs zifaka phakathi i-esomeprazole (Nexium) ne-pantoprazole (Protonix).

Yomibili le mithi isebenza ngokuvimba nokunciphisa ukukhiqizwa kwe-asidi yesisu, kepha ama-PPI abhekwa njengamandla futhi asheshayo ekwehliseni isisu asidi. Kodwa-ke, ama-H2 receptor blockers anciphisa ngokukhethekile i-asidi ekhishwe kusihlwa, nokuyinto esivame ukufaka isandla ezilondeni ezinama-peptic. Kungakho ama-H2 receptor blocker enqunyelwe ngqo abantu abanezilonda noma abasengozini yokuwathola. Ama-PPI ajwayele ukunikezwa abantu abane-GERD noma i-acid reflux.

Odokotela imvamisa abakhuthazi ukuthatha zombili i-PPI ne-H2 receptor blocker ngasikhathi sinye. Ama-H2 receptor blockers angaphazamisa ukusebenza kwama-PPIs. Uma izimpawu zakho ze-GERD zingathuthuki ngokusebenzisa i-PPI, udokotela wakho angancoma i-H2 receptor blocker esikhundleni salokho.

Ezinye Izindlela Zokwelapha

Uma unezilonda ze-peptic noma i-GERD, udokotela wakho cishe uzokuncoma ukuthi ugweme ukuthatha imithi ethile nokuthi wenze izinguquko ezithile zendlela yokuphila ukuze unciphise izimpawu zakho.

Uma unezilonda ze-peptic, udokotela wakho angancoma ukuthi unciphise ukusetshenziswa kwakho kwezidakamizwa ezingezona ukuvuvukala (ama-NSAID), njenge-aspirin ne-ibuprofen. Ukusetshenziswa kaningi nokuhlala isikhathi eside kwalezi zinhlobo zemithi kungakhuphula ubungozi besifo se-peptic ulcer. Udokotela wakho angase asikisele ukuthi uthathe i-acetaminophen esikhundleni salokho. Kodwa-ke, akufanele uyeke ukuthatha noma yimiphi imithi ngaphandle kokukhuluma nodokotela wakho kuqala.

Ukwenza ukulungiswa kwendlela yokuphila kungasiza ekunciphiseni izimpawu zesilonda peptic. Lokhu kufaka phakathi:

• ukunciphisa ukusetshenziswa kotshwala
• ukugwema ukudla okubabayo
• ukunciphisa ukucindezeleka
• ukuyeka ukubhema

Uma une-GERD noma i-acid reflux, amakhambi wokuphila anganciphisa izimpawu afaka:

• ukudla ukudla okuncane okuningana ngosuku esikhundleni sezintathu ezinkulu
• ukugwema utshwala, ugwayi, nokudla neziphuzo ezaziwa ngokudala izimpawu
• iphakamisa ikhanda lombhede cishe ngama-intshi ama-6
• kudla amafutha amancane
• ukugwema ukulala phansi okungenani amahora amabili ngemuva kokudla
• ukugwema ukudla okulula ngaphambi kokulala

Khuluma nodokotela wakho uma izimpawu zakho zingathuthuki ngemithi noma ngamakhambi okuphila. Ungadinga ukwelashwa okunamandla noma ukuhlinzwa ukuqeda isilonda noma ukunciphisa i-acid reflux.

Kufanele ufune usizo lwezempilo ngokushesha uma kukhona kulezi zimpawu ezilandelayo:

• uba nobuhlungu besisu obubi kakhulu kunalokho ojwayele ukubuthola
• uba nomkhuhlane omkhulu
• uhlangabezana nokuhlanza okungakhululeki kalula
• uhlakulela isiyezi nokuba nekhanda elincane

Lezi yizimpawu zezinkinga ezivela ku-peptic ulcer disease ezidinga ukulungiswa ngokushesha.

Q:

Ngabe kukhona noma ngubani okungafanele athathe ama-H2 receptor blockers?

A:

Iziguli kuphela ezinokusabela okunzima noma okusongela ukuphila kuma-H2 blocker okufanele zikugweme ukuzithatha. Lesi sigaba semithi yisigaba B ekukhulelweni okusho ukuthi kuphephile ukuthatha ngesikhathi sokukhulelwa.