Ukulahleka Kwezinwele kanye ne-Testosterone

-Delile

• Izinhlobo ezahlukahlukene ze-testosterone
• Isimo sempandla
• I-DHT: I-hormone ngemuva kokulahleka kwezinwele
• I-DHT nezinye izimo
• Yizakhi zofuzo zakho
• Izinganekwane: Ubuhle nokulahleka kwezinwele
• Ukulahleka kwezinwele kwabesifazane
• Ukwelashwa kokulahleka kwezinwele

Ukwaluka okuyinkimbinkimbi

Ubudlelwano phakathi kwe-testosterone nokulahleka kwezinwele buyinkimbinkimbi. Inkolelo evamile ukuthi amadoda anempandla anezinga eliphakeme le-testosterone, kodwa ingabe lokhu kuyiqiniso ngempela?

Impandla yamadoda, noma i-alopecia ye-androgenic, ithinta abesilisa abalinganiselwa ezigidini ezingama-50 nabesifazane abayizigidi ezingama-30 e-United States, ngokusho kweNational Institutes of Health (NIH). Ukulahleka kwezinwele kungenxa yokuncipha kwezintambo zezinwele kanye nomthelela oba khona emjikelezweni wokukhula. Izinwele ezintsha ziba muhle futhi zicoleke kuze kube yilapho kungekho nezinwele ezisele nhlobo futhi nezinduku zibalele. Lokhu kulahleka kwezinwele kudalwa ama-hormone nezakhi ezithile zofuzo.

Izinhlobo ezahlukahlukene ze-testosterone

I-testosterone ikhona emzimbeni wakho ngezindlela ezahlukahlukene. Kukhona i-testosterone "yamahhala" engaboshelwe kuma-protein emzimbeni wakho. Le yindlela ye-testosterone etholakala kakhulu ukusebenza emzimbeni.

I-testosterone nayo ingaboshelwa ku-albhamuin, iphrotheni egazini. Iningi le-testosterone liboshelwe kumaprotheni we-sex-binding globulin (SHBG) protein futhi alisebenzi. Uma unezinga eliphansi le-SHBG, ungaba nezinga eliphakeme le-testosterone yamahhala egazini lakho.

IDihydrotestosterone (DHT) yenziwa nge-testosterone nge-enzyme. I-DHT inamandla aphindwe kahlanu kune-testosterone. I-DHT isetshenziswa kakhulu ngumzimba ku-prostate, isikhumba, nezinwele zezinwele.

Isimo sempandla

Impandla yamadoda (MPB) inesimo esihlukile.Uboya bezinwele obuphambili buyehla, ikakhulukazi ezinhlangothini, bakhe isimo se-M. Ubumpandla lobu ngaphambili. Umqhele wekhanda, owaziwa nangokuthi i-vertex, nawo uba nempandla. Ekugcineni lezi zindawo zombili zijoyina isimo se- "U". I-MPB inganweba ngisho nasezinweleni zesifuba, ezingancipha njengoba ukhula. Ngokumangazayo, izinwele ezindaweni ezihlukene emzimbeni zingasabela ngokuhlukile ekuguqulweni kwamahomoni. Isibonelo, ukukhula kwezinwele ebusweni kungathuthuka ngenkathi ezinye izindawo ziba yimpandla.

I-DHT: I-hormone ngemuva kokulahleka kwezinwele

I-Dihydrotestosterone (DHT) yenziwa nge-testosterone nge-enzyme ebizwa nge-5-alpha reductase. Kungenziwa futhi kusuka ku-DHEA, i-hormone evame kakhulu kwabesifazane. I-DHT itholakala esikhunjeni, ezinhlakeni zezinwele, nakwindlala yesinye. Izenzo ze-DHT kanye nokuzwela kwezinwele zezinwele ku-DHT yikhona okubangela ukulahleka kwezinwele.

I-DHT nayo isebenza ku-prostate. Ngaphandle kwe-DHT, i-prostate ayikhuli ngokujwayelekile. Nge-DHT eningi kakhulu, indoda ingahlakulela i-benign prostate hypertrophy, eyaziwa nangokuthi i-prostate ekhulisiwe.

I-DHT nezinye izimo

Kunobunye ubufakazi bokuhlobana phakathi kwempandla nomdlavuza wendlala yesinye nezinye izifo. IHarvard Medical School ibika ukuthi amadoda anempandla ye-vertex anengozi ephindwe ka-1.5 yokuthola umdlavuza wendlala yabesilisa kunamadoda angenamabala. Ingcuphe yesifo semithambo yenhliziyo ibuye ibe ngaphezu kwamaphesenti angama-23 emadodeni anezindawo ezinempandla ze-vertex. Uphenyo luyaqhubeka lokuthi ngabe kukhona ukuxhumana phakathi kwamazinga e-DHT nesifo se-metabolic, isifo sikashukela, nezinye izimo zempilo.

Yizakhi zofuzo zakho

Akuyona inani le-testosterone noma le-DHT elidala impandla; wubuzwela bezinwele zakho. Lokho kuzwela kunqunywa ngofuzo. Uhlobo lwe-AR lwenza i-receptor ezinhlakeni zezinwele ezisebenzisana ne-testosterone ne-DHT. Uma ama-receptors akho ebucayi ikakhulukazi, axhonywa kalula ngamanani amancane we-DHT, futhi ukulahleka kwezinwele kwenzeka kalula njengomphumela. Ezinye izakhi zofuzo nazo zingadlala indima.

Iminyaka yobudala, ingcindezi, nezinye izinto kungathinta ukuthi ngabe ulahlekelwa yini izinwele. Kepha izakhi zofuzo zidlala indima enkulu, futhi amadoda anezihlobo eziseduze zesilisa ezine-MPB asengozini enkulu kakhulu yokuzithuthukisa i-MPB uqobo.

Izinganekwane: Ubuhle nokulahleka kwezinwele

Kukhona izinganekwane eziningi laphaya ngamadoda okugunda. Esinye sazo ukuthi amadoda ane-MPB aphilile kakhulu futhi anamazinga aphezulu we-testosterone. Lokhu akunjalo ngempela. Amadoda ane-MPB empeleni angaba namazinga aphansi ajikelezayo e-testosterone kepha amazinga aphezulu we-enzyme eguqula i-testosterone ibe yi-DHT. Ngenye indlela, ungahle ube nezakhi zofuzo ezikunikeza izintambo zezinwele ezizwela kakhulu ku-testosterone noma ku-DHT.

Ukulahleka kwezinwele kwabesifazane

Abesifazane nabo bangathola ukulahleka kwezinwele ngenxa ye-androgenetic alopecia. Yize abesifazane benamazinga aphansi kakhulu we-testosterone kunabesilisa, kunokwanele okungenzeka kubangele ukulahleka kwezinwele ze-androgenetic.

Abesifazane bahlangabezana nephethini ehlukile yokulahleka kwezinwele. Ukuncipha kwenzeka ngaphezulu kwesihloko sekhanda ngephethini "yesihlahla sikaKhisimusi", kepha izinwele zangaphambili azinciphi. Ukulahleka kwezinwele zephethini yabesifazane (i-FPHL) nakho kungenxa yezenzo ze-DHT kuzinwele zezinwele.

Ukwelashwa kokulahleka kwezinwele

Izindlela eziningana zokwelapha i-MPB ne-FPHL zibandakanya ukuphazamisa izenzo ze-testosterone ne-DHT. I-Finasteride (Propecia) isidakamizwa esivimbela i-5-alpha reductase enzyme eguqula i-testosterone ibe yi-DHT. Kuyingozi ukusetshenziswa kwabesifazane abangakhulelwa, futhi kungahle kube nemiphumela emibi ngokocansi yalesi sidakamizwa kwabesilisa nabesifazane.

Enye i-5-alpha reductase inhibitor ebizwa nge-dutasteride (Avodart) njengamanje ibhekwa njengokwelapha okungahle kube khona kwe-MPB. Njengamanje isemakethe yokwelashwa kwe-prostate ekhulisiwe.

Ezinye izinketho zokwelashwa ezingabandakanyi i-testosterone noma i-DHT zifaka:

• i-minoxidil (Rogaine)
• ketoconazole
• ukwelashwa kwe-laser
• ukuhlinzwa kokufakwa kwezinwele