Yini i-mastocytosis, izinhlobo, izimpawu nokwelashwa

-Delile

• Izinhlobo ze-mastocytosis
• Izimpawu nezimpawu ze-mastocytosis
• Injani impatho

I-Mastocytosis yisifo esingajwayelekile esaziwa ngokwanda nokuqongelelwa kwamangqamuzana esikhumba nakwezinye izicubu zomzimba, okuholela ekubonakaleni kwamabala nezindawo ezincane ezibomvu ngokubomvu esikhunjeni ezishaya kakhulu, ikakhulukazi uma kunezinguquko kwezinga lokushisa futhi lapho isikhumba sihlangana nezingubo, isibonelo.

Amaseli amangqamuzana amangqamuzana akhiqizwa emnkantsheni wethambo, atholakala ezicutshini ezahlukahlukene zomzimba futhi ezingahlobana nokuphendula komzimba, ikakhulukazi ekuphenduleni okwaliwa. Kodwa-ke, ngokungafani ne-allergies, izimpawu nezimpawu ze-mastocytosis zihlala zikhona futhi azihlobene nezici ezibangela.

Kubalulekile ukuthi i-mastocytosis ikhonjwe futhi yelashwe ngokuyalelwa ngudokotela, ngoba kwezinye izimo ingaphinde ihlobane nezinye izifo ezibucayi zegazi, ezinjenge-acute leukemia, lymphoma, neutropenia engapheli kanye nezinguquko ze-myeloproliferative.

Izinhlobo ze-mastocytosis

I-Mastocytosis yenzeka lapho amangqamuzana ama-mast esakazeka futhi enqwabelana emzimbeni futhi, kuya ngokuthi lawa maseli aqoqwe kuphi, i-mastocytosis ingahlukaniswa nge:

• I-mastocytosis enqamulelayo, lapho amangqamuzana amangqamuzana anqwabelana khona esikhumbeni, okuholela ekubonakaleni kwezimpawu nezimpawu ezisikiwe, okuvame kakhulu ezinganeni;
• I-mastocytosis ehlelekile, lapho amangqamuzana omzimba anqwabelana kwezinye izicubu zomzimba, ikakhulukazi emnkantsheni wethambo, aphazamise ukukhiqizwa kwamangqamuzana egazi. Ngaphezu kwalokho, kulolu hlobo lwe-mastocytosis, amangqamuzana angama-mast anganqwabelana esibindi, ubende, ama-lymph node nasesiswini, futhi angaphazamisa, kwezinye izimo, ekusebenzeni kwesitho.

Kusukela ngesikhathi lapho kunenqwaba yamaseli omzimba esizeni, kuvela izimpawu nezimpawu ezibonisa izifo, futhi kubalulekile ukubonisana nodokotela ukuze kwenziwe izivivinyo zokuphothula ukuxilongwa bese kuqala ukwelashwa okufanele.

Izimpawu nezimpawu ze-mastocytosis

Izimpawu nezimpawu ze-mastocytosis zingahluka ngohlobo futhi zihlobene nokuhlushwa kwe-histamine ejikelezayo. Lokho kungenxa yokuthi amangqamuzana omzimba akhiwa ama-granules akhipha i-histamine. Ngakho-ke, ukuphakama kokuhlungwa kwamangqamuzana emile, kukhula ukugxila kwe-histamine, okuholela kwizimpawu nezimpawu ze-mastocytosis, okuyizona eziyinhloko:

• I-pigtic urticaria, okuyizindawo ezincane ezibomvu ngokubomvu esikhunjeni ezikwazi ukuluma;
• Isilonda se-Peptic;
• Ikhanda;
• Ukushaya kancane;
• Ukuhlanza;
• Uhudo olungamahlalakhona;
• Ubuhlungu besisu;
• Ukuzizwa unesiyezi lapho uvuka;
• Izingono neminwe endikindiki.

Kwezinye izimo, izimpawu ze-mastocytosis zingase zibe zimbi uma kunezinguquko ekushiseni, ngemuva kokudla ukudla okushisayo noma okubabayo noma iziphuzo, ngemuva kokuzivocavoca, ngemuva kokuthintana nezingubo noma ngenxa yokusebenzisa eminye imithi.

Ukuxilongwa kwe-mastocytosis kwenziwa ngokuhlolwa kwegazi okuhlose ukukhomba amazinga e-histamine ne-prostaglandin D2 egazini, okumele aqoqwe ngokushesha ngemuva kwenkinga, noma emchameni wamahora angama-24.

Ngaphezu kwalokho, esimweni se-mastocytosis esinqunyiwe, kungenziwa futhi ukuhlolwa kwe-histological, lapho kuqoqwa khona isampula elincane lesilonda bese lithunyelwa elabhorethri ukuze lihlaziywe futhi kubhekwe ukuthi kukhona yini inani elinyukile lamangqamuzana omzimba esikhunjeni. .

Injani impatho

Ukwelashwa kwe-mastocytosis kufanele kuqondiswe yi-immunoallergologist noma udokotela ojwayelekile ngokuya ngamazinga we-histamine ajikelezayo, umlando wezempilo womuntu kanye nezimpawu nezimpawu.

Ezimweni eziningi, udokotela angancoma ukusetshenziswa kwemithi yokuqeda izimpawu, ikakhulukazi ama-antihistamine nama-corticosteroid okhilimu namafutha. Kodwa-ke, lapho izimpawu ziba nzima kakhulu, ikakhulukazi uma kukhulunywa nge-systemic mastocytosis, ukwelashwa kungaba nzima kakhulu, futhi kwezinye izimo ukuhlinzwa kungadingeka.