Amafutha e-Cannabidiol (i-CBD): iyini kanye nezinzuzo ezingaba khona

-Delile

• Usebenza Kanjani Uwoyela weCannabidiol
• Izinzuzo ezingaba khona zezempilo
• Imiphumela emibi engaba khona

Uwoyela weCannabidiol, owaziwa nangokuthi uwoyela we-CBD, kuyinto etholakala kulesi sitshalo Insangu insangu, eyaziwa ngensangu, ekwaziyo ukuqeda izimpawu zokukhathazeka, isiza ekwelapheni ukuqwasha nokuba nezinzuzo ekwelapheni isithuthwane.

Ngokungafani nezinye izidakamizwa ezisekelwe insangu, uwoyela we-cannabidiol awunayo i-THC, okuyiyona nto yensangu ebhekene nemiphumela ye-psychotropic, njengokulahlekelwa ukwazi nokuphazamiseka ngesikhathi nasendaweni, isibonelo. Ngakho-ke, uwoyela we-cannabidiol kungenzeka ukuthi usetshenziswe ekwenzeni imitholampilo. Funda ngeminye imiphumela yensangu.

Kodwa-ke, ezinye izifundo ziyadingeka ukucacisa izinzuzo zamafutha e-CBD enkingeni ngayinye, kanye nokuhlushwa okufanelekile kakhulu.

Usebenza Kanjani Uwoyela weCannabidiol

Ukusebenza kukawoyela we-cannabidiol ikakhulu kungenxa yomsebenzi wawo kuma-receptors amabili akhona emzimbeni, aziwa nge-CB1 ne-CB2. I-CB1 itholakala ebuchosheni futhi ihlobene nokulawulwa kokukhishwa kwe-neurotransmitter nomsebenzi we-neuronal, kuyilapho i-CB2 ikhona ezingxenyeni ze-lymphoid, ezibhekele izimpendulo zokuvuvukala nezithelelanayo.

Ngokusebenza kwi-receptor ye-CB1, i-cannabidiol iyakwazi ukuvimbela umsebenzi oweqile we-neuronal, esiza ukukhululeka nokunciphisa izimpawu ezihambisana nokukhathazeka, kanye nokulawula ukuqonda kobuhlungu, inkumbulo, ukusebenzisana kanye nekhono lokuqonda. Lapho usebenza kwi-receptor ye-CB2, i-cannabidiol iyasiza kwinqubo yokukhipha ama-cytokines ngamaseli omzimba, okusiza ukunciphisa izinhlungu nokuvuvukala.

Izinzuzo ezingaba khona zezempilo

Ngenxa yendlela uwoyela we-CBD enza ngayo emzimbeni, ukusetshenziswa kwayo kungaletha izinzuzo ezithile zezempilo futhi kubhekwe nasekwelapheni izifo ezithile:

• Isithuthwane: ezinye izifundo zikhombisile ukuthi uwoyela we-cannabidiol uyakwazi ukunciphisa imvamisa yokuquleka ngenxa yokuhlangana kwalesi sakhi nama-receptors wohlobo lwe-CB1 ebuchosheni, kanye namanye ama-receptor we-cannabidiol angaqondene;
• Ukucindezeleka kwangemva kwenhlekelele: ucwaningo olwenziwe nabantu abatholakale benengcindezi yangemva kokuhlukumezeka luthole ukuthi ukusetshenziswa kwe-cannabidiol kubangele ukuthuthuka kwezimpawu zokukhathazeka nokukhubazeka kwengqondo, uma kuqhathaniswa neqembu elaphathwa nge-placebo, lapho kwanda khona izimpawu;
• Ukuqwasha: ngokusebenza kumthethonqubo we-neuronal nokukhululwa kwama-neurotransmitters, uwoyela we-cannabidiol ungakhuthaza ukuphumula futhi, ngaleyo ndlela, usize ekwelapheni ukuqwasha. Kuphinde kwabonwa ocwaningweni lwamacala ukuthi ukusetshenziswa kwama-25 mg kawoyela we-cannabidiol wakwazi ukuthuthukisa ikhwalithi yokulala;
• Ukuvuvukala: ucwaningo olwenziwe ngamagundane lukhombise ukuthi i-cannabidiol ibisebenza ekuqedeni ubuhlungu obuhlobene nokuvuvukala, njengoba kubonakala kusebenzisana nama-receptors ahlobene nokuzwa kobuhlungu.

Bheka izinzuzo ze-cannabidiol kuvidiyo elandelayo:

Ngaphandle kwezinkomba, indlela yokusebenza, izakhiwo kanye nokungabikho kokugxila kwe-THC, okungenza uwoyela we-cannabidiol wamukeleke ngokwengeziwe emphakathini wezokwelapha nowesayensi, imiphumela yokusebenzisa lo oyili esikhathini eside ayikaqinisekiswa, futhi izifundo eziqhubekayo okudingekayo ukusiza ukufakazela imiphumela kawoyela we-CBD kubantu abaningi.

Ngo-2018, i- Ukuphathwa Kwezidakamizwa Zokudla (I-FDA) ivume ukusetshenziswa kwesidakamizwa, i-Epidiolex, esine-cannabidiol kuphela ekwelashweni kwesifo sokuwa, kepha i-ANVISA kuze kube manje ayikazibeki maqondana nokuthengiswa komuthi eBrazil.

Kuze kube manje, i-ANVISA igunyaze ukumakethwa kwe-Mevatyl, okuwumuthi osuselwa ku-cannabidiol futhi i-THC ekhonjiswe ikakhulukazi ukwelapha imisipha yemisipha engazibandakanyi eyenzeka kwi-multiple sclerosis futhi nokusetshenziswa kwayo okufanele kukhonjiswe ngudokotela. Bona okuningi ngeMevatyl nezinkomba zayo.

Imiphumela emibi engaba khona

Olunye ucwaningo luye lwathola ukuthi imiphumela emibi kawoyela we-cannabidiol ihlobene nokusetshenziswa okungafanele komkhiqizo, ikakhulukazi ngaphandle kokuboniswa ngudokotela noma ngokugxila okwengeziwe, ngokukhathala nokulala ngokweqile, isifo sohudo, ukuguquka kwesifiso nesisindo, ukucasula, isifo sohudo, ukuhlanza nokuphefumula. Ngaphezu kwalokho, kutholakele ukuthi imithamo ezinganeni ezingaphezulu kuka-200 mg we-cannabidiol ingazenza zibe zimbi izimpawu ezihlobene nokukhathazeka, ngaphezu kokukhuthaza isigqi senhliziyo esikhulayo nokushintsha kwemizwelo.

Kutholakale nokuthi i-cannabidiol ingaphazamisa ukusebenza kwe-enzyme ekhiqizwa isibindi, i-cytochrome P450, okuthi, phakathi kweminye imisebenzi, ibhekele ukuvalwa kwezinye izidakamizwa nobuthi. Ngakho-ke, i-CBD ingathinta imiphumela yezinye izidakamizwa, futhi yehlise nekhono lesibindi lokudiliza nokuqeda ubuthi, okungakhuphula ubungozi besibindi sobuthi.

Ngaphezu kwalokho, ukusetshenziswa kukawoyela we-cannabidiol akuboniswa kwabesifazane abakhulelwe, abahlela ukukhulelwa noma abancelisayo, ngoba kutholakale ukuthi i-CBD itholakala obisini lwebele, ngaphezu kokukwazi ukudluliselwa embungwini ngesikhathi sokukhulelwa .