Umlobi: Peter Berry
Usuku Lokudalwa: 12 Ujulayi 2021
Ukuvuselela Usuku: 13 Mhlawumbe 2024
Anonim
How to Inject ORENCIA (abatacept) ClickJect™ Autoinjector
Ividiyo: How to Inject ORENCIA (abatacept) ClickJect™ Autoinjector

-Delile

Yini u-Orencia?

I-Orencia ngumuthi kadokotela osetshenziswa ukwelapha lezi zimo:

  • Isifo samathambo (RA). I-Orencia ivunyelwe ukusetshenziswa kubantu abadala abane-RA esebenzayo ngokulingene. Ingathathwa yodwa noma ihlanganiswe nezinye izidakamizwa nazo ezisetshenziselwa ukwelapha i-RA.
  • I-Psoriatic arthritis (i-PsA). I-Orencia ivunyelwe ukusetshenziswa kubantu abadala abane-PsA. Ingathathwa yodwa noma ihlanganiswe nezinye izidakamizwa nazo ezisetshenziselwa ukwelapha i-PsA.
  • I-juvenile idiopathic arthritis (JIA). I-Orencia ivunyelwe ukusetshenziswa ezinganeni ezineminyaka engu-2 nangaphezulu nge-JIA esebenzayo ngokulingene. Ngalesi simo, i-Orencia ingasetshenziswa yodwa noma ihlanganiswe nomunye umuthi obizwa ngokuthi yi-methotrexate.

I-Orencia iqukethe i-abatacept yezidakamizwa, eyisidakamizwa se-biologic. I-biologics yenziwa ngamaseli aphilayo (njengalawo avela ezitshalweni noma ezilwaneni) kunamakhemikhali.

I-Orencia iza ngezindlela ezimbili: ifomu eliwuketshezi nefomu lempuphu. Ungaphuza umuthi nganoma iyiphi yalezi zindlela:


  • Ukufakwa ngaphakathi (IV). Ifomu le-powder le-Orencia lisetshenziselwa ukwenza isisombululo samanzi esifakwe emithanjeni yakho. Leli fomu le-Orencia litholakala ngamandla owodwa: ama-250 milligrams (mg).
  • Umjovo ongaphansi. Ifomu eliketshezi le-Orencia lijojowe ngaphansi kwesikhumba sakho. Leli fomu le-Orencia litholakala ngamandla owodwa: ama-milligram ayi-125 ngemililitha (mg / mL) ngayinye.

Ukusebenza ngempumelelo

Ezifundweni zomtholampilo, i-Orencia yayiphumelela ekwelapheni i-RA elinganiselayo neqinile. Lapho ihlanganiswa ne-methotrexate, u-Orencia wasebenza kahle ekuthuthukiseni izimpawu zesifo. Kulezi zifundo, izikolo ze-ACR (eziqanjwe nge-American College of Rheumatology) zisetshenzisiwe ukukala impendulo yabantu ekwelashweni. Ukuba nesilinganiso se-ACR esingu-20 kwakusho ukuthi izimpawu zeRA zabantu zazithuthuke ngo-20%.

Kubantu abathatha i-Orencia ngokuhlangana ne-methotrexate, ama-62% afinyelele kumaphuzu we-ACR angama-20 ngemuva kwezinyanga ezintathu. Kubantu abathatha i-methotrexate nge-placebo (ukwelashwa ngaphandle kwesidakamizwa esisebenzayo), ama-37% abe nomphumela ofanayo.


I-Orencia nayo isebenze kahle kubantu abathatha i-Orencia iyodwa, ngaphandle kwe-methotrexate. Kulabo abathatha i-Orencia iyodwa, ama-53% afinyelele kumaphuzu we-ACR angama-20 ngemuva kwezinyanga ezintathu. Kubantu abangatholanga ukwelashwa nge-Orencia noma i-methotrexate kodwa abathathe i-placebo, ama-31% abe nomphumela ofanayo.

Ngeminye imininingwane ngokusebenza kwe-Orencia kwezinye izimo, sicela ubheke isigaba esithi “Orencia uses” ngezansi.

Orencia ejwayelekile

I-Orencia itholakala kuphela njengomuthi wegama lomkhiqizo. Okwamanje ayitholakali ngendlela ye-biosimilar.

Umuthi we-biosimilar ucishe uqhathaniswe nomuthi ojwayelekile. Isidakamizwa esijwayelekile siyikhophi lomuthi ojwayelekile (lowo owenziwe ngamakhemikhali). Isidakamizwa se-biosimilar senziwa sifane nesidakamizwa se-biologic (esenziwe ngamaseli aphilayo).

Kokubili ama-generic kanye nama-biosimilars anokuphepha nokusebenza okufana nomuthi abenziwe ukuba bakopishe. Futhi, bathambekele ekubizeni ngaphansi kwezidakamizwa ezinegama lomkhiqizo.

Imiphumela emibi ye-Orencia

I-Orencia ingadala imiphumela emibi noma emibi. Uhlu olulandelayo luqukethe eminye yemiphumela emibi engase ivele ngenkathi uthatha i-Orencia. Lezi zinhlu azibandakanyi yonke imiphumela emibi engaba khona.


Ngeminye imininingwane ngemiphumela engemihle ye-Orencia, khuluma nodokotela wakho noma usokhemisi. Bangakunika amathiphu okuthi ungabhekana kanjani nanoma yimiphi imiphumela emibi engase ikukhathaze.

Imiphumela emibi ejwayelekile

Imiphumela emibi ejwayelekile ye-Orencia ingafaka:

  • izifo eziphezulu zokuphefumula, ezifana nomkhuhlane ovamile noma ukutheleleka kwesono
  • ikhanda
  • isicanucanu

Iningi lalemiphumela emibi ingahle ihambe ezinsukwini ezimbalwa noma emasontweni ambalwa. Uma zinzima kakhulu noma zingahambi, khuluma nodokotela wakho noma usokhemisi.

Imiphumela emibi kakhulu

Imiphumela emibi ebucayi evela e-Orencia ayijwayelekile, kodwa ingenzeka. Shayela udokotela wakho ngokushesha uma unemiphumela emibi kakhulu. Shayela u-911 uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha.

Imiphumela emibi ebucayi, okuxoxwa ngayo ngezansi ku- “Imininingwane yemiphumela emibi,” ingafaka okulandelayo:

  • izifo ezinzima, ezifana ne-pneumonia
  • ukusabela okweqile komzimba
  • ukuvuselelwa kwegciwane le-hepatitis B (ukuqhuma kwegciwane uma selivele lingaphakathi komzimba wakho)
  • umdlavuza

Imininingwane yomphumela oseceleni

Ungazibuza ukuthi kaningi kangakanani imiphumela emibi ethile eba khona ngalo muthi, noma ukuthi imiphumela ethile engemihle ihlobene nawo yini. Nayi eminye imininingwane ngemiphumela emibi eminingi lo muthi ongahle uyibangele noma ongabanga yiyo.

Izifo ezinzima

Ungaba nengozi enkulu yokuthola izifo ezinzima ngenkathi uthatha i-Orencia. Lokhu kungenxa yokuthi umuthi wenza amasosha akho omzimba angakwazi ukukuvikela ezifweni.

Ezifundweni zokwelashwa, ama-54% wabantu abathatha i-Orencia banezifo. Ukutheleleka kuthathwe njengokubi kuma-3% wabantu abathatha i-Orencia ezifundweni. Kulabo abathathe i-placebo (ukwelashwa ngaphandle kwesidakamizwa esisebenzayo), ama-48% ayenezifo. Ukutheleleka kuthathwe njengokubucayi kubantu abangu-1.9% abathathe i-placebo. Ukutheleleka okuvame kakhulu kuthinte amaphaphu abantu, isikhumba, umgudu wokuchama, ikholoni nezinso.

Izimpawu zokutheleleka zingahluka, kuya ngokuthi iyiphi ingxenye yomzimba wakho ethintekile. Zingafaka:

  • imfiva
  • ngizizwe ngikhathele kakhulu
  • ukukhwehlela
  • izimpawu ezinjengomkhuhlane
  • izindawo ezifudumele, ezibomvu, noma ezibuhlungu esikhunjeni sakho

Yazisa udokotela wakho uma unezimpawu zokutheleleka. Bangancoma izivivinyo ezithile ukuze babone ukuthi hlobo luni lokutheleleka onalo. Uma kudingeka, bazophinda bakunikeze nemithi yokwelapha ukutheleleka kwakho.

Kwezinye izimo, kungaba nzima ukuphatha izifo ezinzima ngenkathi uthatha i-Orencia. Uma unesifo, udokotela wakho angancoma ukuthi uyeke ukuthatha i-Orencia kuze kube yilapho ukutheleleka kwakho sekuphelile.

Futhi, udokotela wakho uzofuna ukuqinisekisa ukuthi awunaso isifo sofuba (TB) ngaphambi kokuba uqale ukuthatha i-Orencia. I-TB ithinta amaphaphu akho, futhi ingadala noma ingabangeli izimpawu. Uma kungabangeli izimpawu, ungahle ungazi ukuthi unesifo. Ukwazi ukuthi unesifo sofuba kuzosiza odokotela bakho ukunquma ukuthi i-Orencia iphephile yini ongayisebenzisa.

Ukusabela okweqile

Njengezidakamizwa eziningi, abanye abantu bangaba ne-allergen reaction ngemuva kokuthatha i-Orencia. Ezifundweni zomtholampilo, bangaphansi kuka-1% abantu abathatha i-Orencia baba ne-allergen reaction. Izimpawu zokuphendula okuncane komzimba zingabandakanya:

  • ukuqubuka kwesikhumba
  • ukulunywa
  • ukuqhuma (ukufudumala nokubomvu esikhunjeni sakho)

Ukusabela okweqile okwedlulele akuvamile kodwa kungenzeka. Izimpawu zokuphendula okweqile kakhulu zingabandakanya:

  • ukuvuvukala ngaphansi kwesikhumba sakho, imvamisa ezinkalweni zakho, izindebe, izandla, noma izinyawo
  • ukuvuvukala kolimi lwakho, umlomo, noma umphimbo
  • inkinga yokuphefumula

Shayela udokotela wakho ngokushesha uma une-reaction engathí sina yokungezwani ne-Orencia. Shayela u-911 uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha.

I-hepatitis B

Uma uke waba negciwane le-hepatitis B (HBV) esikhathini esedlule, ungaba sengozini yokuthi igciwane liqhume (livuseleleke) ngenkathi uthatha i-Orencia.

I-HBV ukutheleleka esibindini sakho okubangelwa igciwane. Abantu abane-HBV bavame ukuthatha imithi yokulawula ukutheleleka. Kodwa cishe akunakwenzeka ukusula ngokuphelele igciwane emzimbeni wakho.

I-Orencia ingadala ukuthi i-HBV ivuthe emzimbeni wakho. Lokhu kungenxa yokuthi i-Orencia inciphisa amandla omzimba wakho wokulwa nokutheleleka. Uma leli gciwane lisebenza futhi, izimpawu zakho ze-HBV zingabuya, futhi isimo singase sibe sibi kakhulu.

Izimpawu zokutheleleka nge-HBV zingafaka:

  • ukukhathala (ukungabi namandla)
  • imfiva
  • ukunciphisa ukudla
  • ukuzizwa ngibuthakathaka
  • ubuhlungu emalungeni noma emisipheni yakho
  • ukungakhululeki esiswini sakho (esiswini)
  • umchamo onombala omnyama
  • i-jaundice (okuphuzi kwesikhumba sakho noma okumhlophe kwamehlo akho)

Yazisa udokotela wakho ngokushesha uma unezimpawu ze-HBV. Udokotela wakho angafuna ukukuhlolela i-hepatitis B ngaphambi kokuba uqale i-Orencia. Uma unayo i-HBV, cishe bazokwelapha leli gciwane ngaphambi kokuqala i-Orencia. Ukwelapha i-HBV kuzosiza nokuthi izimpawu zakho ziphele.

Umdlavuza

Ungaba nengozi eyengeziwe yomdlavuza uma uthatha i-Orencia. Lesi sidakamizwa singathinta indlela amaseli akho asebenza ngayo futhi singakhuphula ukuthi amangqamuzana akho akhula futhi ande ngokushesha kangakanani (enza amaseli amaningi). Le miphumela ingadala umdlavuza.

Ezifundweni zokwelashwa, u-1.3% wabantu abathatha i-Orencia baba nomdlavuza. Kulabo abangathathi i-Orencia, kepha abathathe i-placebo (ukwelashwa ngaphandle kwesidakamizwa esisebenzayo), i-1.1% ibe nomphumela ofanayo. Ezimweni eziningi, umdlavuza uvele emaphashini nasegazini labantu.

Akwaziwa ukuthi umdlavuza ubangelwe ukusebenzisa i-Orencia. Kungenzeka ukuthi ezinye izinto zibe neqhaza ekuthuthukisweni kwayo.

Izimpawu zomdlavuza zingahluka ngokuya ngendawo yomzimba wakho ethintekile. Izimpawu zingafaka:

  • izinguquko zemizwa (njengokuphathwa yikhanda, ukuquleka, ukubona noma izinkinga zokuzwa, noma ukukhubazeka ebusweni bakho)
  • ukopha noma ukulimaza kalula kunokujwayelekile
  • ukukhwehlela
  • ukukhathala (ukungabi namandla)
  • imfiva
  • ukuvuvukala
  • izigaxa
  • ukukhuluphala noma ukuncipha

Tshela udokotela wakho uma unezimpawu zomdlavuza. Bazoncoma izivivinyo ezithile ukuze babone ukuthi ngabe unomdlavuza yini. Uma unomdlavuza, bazoncoma ukwelashwa ngawo. Bazobuye baxoxe nawe ukuthi ngabe kusaphephile yini kuwe ukuthatha i-Orencia.

Ukuqhuma kwesikhumba

Ezifundweni zokwelashwa, ukuqubuka kwesikhumba kwakungeyona imiphumela emibi kubantu abathatha i-Orencia. Kubantu abane-RA abathathe i-Orencia, ama-4% abe nokuqubuka ngesikhathi sokufunda. Kulabo abathathe i-placebo (ukwelashwa ngaphandle kwesidakamizwa esisebenzayo), ama-3% abe nokuqubuka. Ukuqhuma kwesikhumba okuncane futhi kungenzeka endaweni yomzimba wakho lapho i-Orencia ijojowe khona.

Kwezinye izimo, ukuqubuka kwesikhumba kungaba uphawu lokuphendula okweqile. (Bheka isigaba esithi “Allergic reaction” ngenhla.)

Uma unokuqubuka kwesikhumba okungapheli ngenkathi usebenzisa i-Orencia, tshela udokotela wakho. Bazokhuluma nawe mayelana nokuthi yini engase ibangele ukuqubuka kwesikhumba sakho. Bangase babuze ukuthi unezimpawu zempendulo engathí sina yokungezwani nezinto ezithile. Uma uthola ukungezwani komzimba, udokotela wakho uzokunika imithi yokwehlisa izimpawu zokungezwani komzimba, futhi kungenzeka ukuthi uyeke ukusebenzisa i-Orencia.

Ukuzuza kwesisindo (hhayi umphumela ohlangothini)

Ngesikhathi sokuhlolwa kwemitholampilo, ukuzuza kwesisindo kwakungeyona imiphumela emibi kubantu abathatha i-Orencia.

Uma ukhathazekile ngokuzuza kwesisindo ngenkathi usebenzisa i-Orencia, khuluma nodokotela wakho.

Ukulahleka kwezinwele (hhayi umphumela ohlangothini)

Ezifundweni zomtholampilo, ukulahleka kwezinwele kwakungeyona imiphumela emibi kubantu abathatha i-Orencia. Kepha ukulahleka kwezinwele kungenzeka kubantu abanezinhlobo ezithile zesifo samathambo, kufaka phakathi lezo ezingasetshenziswa ukwelapha i-Orencia.

Yazisa udokotela wakho uma ukhathazekile ngokulahleka kwezinwele, noma uma unezinwele ngenkathi usebenzisa i-Orencia. Bangancoma izivivinyo ukuzama ukuthola ukuthi kungani kwenzeka futhi banikeze izindlela zokukusiza ukuba ubhekane nomphumela oseceleni.

Ukukhathala (hhayi umphumela ohlangothini)

Ukukhathala (ukungabi namandla) kwakungeyona imiphumela emibi kubantu abathatha i-Orencia phakathi nezifundo zokwelashwa. Kodwa abanye abantu abanezinhlobo ezahlukene zesifo samathambo (njengalezo i-Orencia esetshenziselwa ukwelapha) bangathola ukukhathala.

Tshela udokotela wakho uma ukhathele okungapheli ngenkathi usebenzisa i-Orencia. Bazoncoma izivivinyo ezithile ukusiza ukuthola imbangela yokukhathala kwakho. Uma kudingeka, bangaphinde bakunikeze nemithi yokusiza ukukhulula ukukhathala kwakho.

Isilinganiso se-Orencia

Umthamo we-Orencia odokotela wakho abakunikezayo uzoncika ezicini ezithile. Lokhu kufaka phakathi:

  • uhlobo nobukhulu besimo osisebenzisa ukwelapha i-Orencia
  • isisindo sakho
  • ifomu le-Orencia oyithathayo

Imvamisa, udokotela wakho uzokuqala esilinganisweni esijwayelekile. Ngemuva kwalokho bazoyilungisa ngokuhamba kwesikhathi ukufinyelela inani elifanele wena. Udokotela wakho ekugcineni uzonikeza isilinganiso esincane kunazo zonke esihlinzeka ngomphumela oyifunayo.

Imininingwane elandelayo ichaza imithamo esetshenziswa kakhulu noma enconywayo. Kodwa-ke, qiniseka ukuthatha isilinganiso udokotela wakho akubekela sona. Udokotela wakho uzonquma isilinganiso esihle kakhulu ukuhlangabezana nezidingo zakho.

Amafomu wezidakamizwa namandla

I-Orencia iza ngezindlela ezimbili: impuphu noketshezi. Lawa mafomu anamandla ahlukene.

Ifomu lempuphu

Ifomu le-powder:

  • itholakala ngamandla owodwa: 250 mg (milligrams)
  • ixubene noketshezi ukwenza isixazululo osinikwa njenge-infravenous (IV) ukumnika (umjovo emthanjeni wakho onikezwa ngokuhamba kwesikhathi)

Ifomu le-Liquid

Ifomu eliwuketshezi:

  • itholakala ngamandla owodwa: 125 mg / mL (milligrams ngemililitha ngayinye)
  • unikezwa njengomjovo ongaphansi kwesikhumba (umjovo ngaphansi kwesikhumba sakho)
  • iza imijovo yengilazi ekhethiwe ebamba u-0.4 mL, 0.7 mL, no-1.0 mL ketshezi
  • ibuye ifike ku-1-mL vial efakwe kudivayisi ebizwa nge-ClickJect autoinjector

Isilinganiso se-rheumatoid arthritis

Umthamo we-Orencia wesifo samathambo (RA) ngokujwayelekile uncike ekutheni uwuthatha kanjani umuthi. Imithamo yokufakwa ngaphakathi kwe-intravenous (IV) kanye nomjovo ongaphansi uchazwe ngezansi.

Ukufakwa ngaphakathi

Umthamo we-Orencia wokufakwa ngakunye kwe-IV kuzoya ngesisindo somzimba wakho. Umthamo ojwayelekile we-Orencia ngu:

  • 500 mg wabantu abanesisindo esingaphansi kwamakhilogremu angama-60 (cishe amakhilogremu ayi-132)
  • 750 mg yabantu abanesisindo esingamakhilogremu angama-60 kuye kwayi-100 (cishe amakhilogremu ayi-132 kuye kwangama-220)
  • 1,000 mg yabantu abanesisindo esingaphezu kwamakhilogremu ayi-100 (cishe amakhilogremu angama-220

Ukumnika ngakunye kwe-IV kuzohlala cishe imizuzu engama-30.

Ngemuva komthamo wakho wokuqala we-Orencia, uzonikezwa imithamo emibili ngaphezulu njalo emavikini amabili. Ngemuva kwalokho, umthamo ngamunye unikezwa njalo emavikini amane.

Umjovo ongaphansi

Umthamo ojwayelekile we-Orencia womjovo ongaphansi komhlaba ngu: 125 mg kanye ngesonto ngalinye.

Umjovo wakho wokuqala ongaphansi kwesikhumba unganikezwa noma unganikezwa ngemuva kokuthi uthole umthamo wangaphambilini we-Orencia ngokufakwa kwe-IV. Uma ngabe ube nokufakwa kwe-IV kwe-Orencia, ngokujwayelekile uzothatha umjovo wakho wokuqala ongena ngaphansi kwesikhumba womuthi ngosuku olulandelayo lokwelashwa kwakho kwe-IV.

Isilinganiso se-psoriatic arthritis

Umthamo we-Orencia we-psoriatic arthritis (i-PsA) ngokujwayelekile uncike ekutheni uwuthatha kanjani umuthi. Imithamo yokufakwa ngaphakathi kwe-intravenous (IV) kanye nemijovo engaphansi ibuyekezwe ngezansi.

Ukufakwa ngaphakathi

Umthamo we-Orencia wokufakwa ngakunye kwe-IV kuzoya ngesisindo somzimba wakho. Umthamo ojwayelekile we-Orencia ngu:

  • 500 mg kulabo abanesisindo esingaphansi kwamakhilogremu angama-60 (cishe amakhilogremu ayi-132)
  • 750 mg kulabo abanesisindo esingamakhilogremu angama-60 kuye kwayi-100 (cishe amakhilogremu ayi-132 kuye kwayi-220
  • 1,000 mg kulabo abanesisindo esingaphezu kwamakhilogremu ayi-100 (cishe amakhilogremu angama-220)

Ukumnika ngakunye kwe-IV kuzohlala cishe imizuzu engama-30.

Ngemuva komthamo wakho wokuqala we-Orencia, uzonikezwa imithamo emibili ngaphezulu njalo emavikini amabili. Ngemuva kwalokho, umthamo ngamunye unikezwa njalo emavikini amane.

Umjovo ongaphansi

Umthamo ojwayelekile we-Orencia womjovo ongaphansi kwe-125 mg kanye ngesonto ngalinye.

Isilinganiso se-juvenile idiopathic arthritis

Umthamo we-Orencia we-juvenile idiopathic arthritis (JIA) uqobo uncike ekutheni uwuthatha kanjani umuthi. Imithamo yokufakwa ngaphakathi kwe-intravenous (IV) nemijovo engaphansi ibuyekezwe ngezansi.

Ukufakwa ngaphakathi

Umthamo we-Orencia wokumunyelwa ngakunye kwe-IV kungaxhomeka esisindweni somzimba wakho noma sengane yakho. Umthamo ojwayelekile we-Orencia ezinganeni ezineminyaka engu-6 nangaphezulu ngu:

  • 10 mg / kg (milligrams of drug per kilogram of weight body) kulabo abanesisindo esingaphansi kwamakhilogremu angama-75 (cishe amakhilogremu ayi-165)
  • 750 mg kulabo abanesisindo esingamakhilogremu angama-75 namakhilogremu ayi-100 (cishe amakhilogremu ayi-165 kuya kumakhilogremu angama-220)
  • I-1,000 mg yalabo abanesisindo esingaphezu kwe-100 kg (cishe amakhilogremu angama-220)

Isibonelo, umuntu onesisindo esingamakhilogremu angama-50 (cishe amakhilogremu ayi-110) uzothatha u-500 mg we-Orencia. Lawa angama-milligram ayi-10 wezidakamizwa ngekhilogremu ngalinye lesisindo somzimba wabo.

Ngemuva komthamo wakho wokuqala noma wengane yakho we-Orencia, kuzonikezwa imithamo emibili njalo emavikini amabili. Ngemuva kwalokho, umthamo ngamunye unikezwa njalo emavikini amane.

Ukuphathwa kwe-IV kwe-Orencia akunconywa ezinganeni ezineminyaka engaphansi kwengu-6 ubudala.

Umjovo ongaphansi

Umthamo we-Orencia womjovo ongaphansi uzoncika esisindweni somzimba wakho noma sowengane yakho. Umthamo ojwayelekile we-Orencia ezinganeni ezineminyaka engu-2 nangaphezulu ngu:

  • 50 mg yalabo abanesisindo esingamakhilogremu ayi-10 kuya ngaphansi kwamakhilogremu angama-25 (cishe amakhilogremu angama-22 kuye ngaphansi kwamakhilogremu angama-55)
  • I-87.5 mg yalabo abanesisindo esingama-25 kilograms kuya ngaphansi kwamakhilogremu ama-50 (cishe amakhilogremu angama-55 ukuya ngaphansi kwamakhilogremu ayi-110)
  • I-125 mg yalabo abanesisindo esingu-50 kilograms noma ngaphezulu (cishe amakhilogremu ayi-110 noma ngaphezulu)

Kubantu abaneminyaka engu-6 nangaphezulu, umjovo wabo wokuqala we-Orencia unganikezwa noma unganikezwa ngemuva kokuthola ukumuncwa kwe-IV komuthi. Uma ukumenyezelwa kwe-IV kwe-Orencia sekuvele kunikezwe, umjovo wokuqala ongaphansi komuthi uqobo unikezwa ngosuku olulandelayo ukumenyezelwa kwe-IV.

Umthamo wezingane

Umthamo ojwayelekile onconywayo we-Orencia uyahluka kuye ngokuthi uthathwe kanjani nesisindo somzimba salowo oyithathayo. Ngemininingwane engaphezulu mayelana nomthamo ezinganeni, bheka isigaba esithi "Isikali se-juvenile idiopathic arthritis" esigabeni ngenhla.

Kuthiwani uma ngiphuthelwa umthamo?

Lokho ozokwenzela isilinganiso esilahlekile kuncike ekutheni uyithatha kanjani i-Orencia. Kepha kuzimo zombili, izikhumbuzo zemithi zingasiza ekuqinisekiseni ukuthi awuphuthelwa umthamo.

Ukufakwa ngaphakathi

Uma uphuthelwe i-aphoyintimenti yokungeniswa kwakho kwe-IV kwe-Orencia, shayela umtholampilo wakho wezempilo ngokushesha. Bazohlelela i-aphoyintimenti entsha ukuze uthole ukwelashwa kwakho kwe-Orencia IV.

Umjovo ongaphansi

Uma uphuthelwe umjovo ongaphansi kwe-Orencia, shayela udokotela wakho khona manjalo. Zizokusiza ukuthi wakhe uhlelo olusha lomthamo ozolulandela.

Ngabe kuzodingeka ngisebenzise lesi sidakamizwa isikhathi eside?

Ungakwenza. Izimo i-Orencia esetshenziselwa ukwelapha izifo ezingamahlalakhona (zesikhathi eside). I-Orencia ingasetshenziswa isikhathi eside ukwelashwa uma wena nodokotela wakho nibona ukuthi umuthi uphephile futhi usebenza kahle kini.

I-Orencia isebenzisa

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuvumela imishanguzo kadokotela efana ne-Orencia ukwelapha izimo ezithile. I-Orencia igunyazwe yi-FDA ukwelapha izinhlobo ezintathu ezihlukene zesifo samathambo: isifo samathambo, i-psoriatic arthritis, ne-juvenile idiopathic arthritis.

I-Orencia yesifo samathambo

I-Orencia igunyazwe yi-FDA ukwelapha i-rheumatoid arthritis (RA) kubantu abadala. Isetshenziswa kakhulu kubantu abadala abanezimpawu eziqhubekayo zesifo.

I-RA isifo esizimele esidala umonakalo emajoyintini akho. Izimpawu ze-RA zingabandakanya ubuhlungu, ukuvuvukala nokuqina komzimba wakho wonke.

I-Orencia inconywa ngochwepheshe njengokwelapha i-RA. Udokotela wakho angafuna ukuthi uyisebenzise wedwa noma uhlanganiswe nezinye izidakamizwa, kufaka phakathi i-methotrexate. Lezi ezinye izidakamizwa kwesinye isikhathi zibizwa ngokuthi yimishanguzo yokuguqula isifo (i-DMARDs) yokuguqula izifo.

Ukusebenza kwesifo samathambo

Kwesinye isifundo somtholampilo, i-Orencia yanikezwa nge-methotrexate kubantu abangama-424 abane-RA elinganiselayo. I-Orencia yanikezwa ngomjovo we-intravenous (IV) (umjovo emithanjeni yabantu). Kulabo abathatha i-Orencia, abantu abangama-62% babe nokuncipha okungenani okungama-20% kwizimpawu zabo ze-RA ngemuva kwezinyanga ezintathu zokwelashwa. Kulabo abathatha i-placebo (ukwelashwa ngaphandle kwesidakamizwa esisebenzayo) nge-methotrexate, ama-37% abe nomphumela ofanayo.

Olunye ucwaningo lomtholampilo lubheke ukwelashwa kwe-Orencia kubantu abane-RA. Abantu banikezwe i-Orencia ne-methotrexate. Kepha kulolu cwaningo, inhlanganisela yemithi yanikezwa ngomjovo ongaphansi (umjovo ngaphansi kwesikhumba sabantu) eqenjini elilodwa. Futhi elinye iqembu lanikezwa imishanguzo ngokufakwa kwe-IV.

Ngemuva kwezinyanga ezintathu zokwelashwa, abantu abangama-68% abathatha imishanguzo ngomjovo ongena ngaphansi kwesikhumba okungenani banciphise ama-20% ezimpawu zabo ze-RA. Lokhu kuqhathaniswa nabantu abangama-69% abathathe imishanguzo ngokufakwa ngomjovo ngemithambo.

I-Orencia ye-psoriatic arthritis

I-Orencia igunyazwe yi-FDA ukwelapha abantu abadala abane-psoriatic arthritis (PsA). Isetshenziswa kakhulu kubantu abanezimpawu eziqhubekayo zesifo. Eqinisweni, izincomo zamanje ngochwepheshe ziphakamisa ukusebenzisa i-Orencia kulaba bantu.

I-PsA wuhlobo lwe-arthritis olwenzeka kubantu abane-psoriasis. Izimpawu zalesi simo zivame ukufaka amabala abomvu, anezikhumba ezinamakhasi, namalunga avuvukile.

Ukusebenza kwe-psoriatic arthritis

Kwesinye isifundo somtholampilo, i-Orencia yanikezwa abantu abangama-40 abane-PsA besebenzisa ukumnika okungaphakathi (IV) (umjovo emthanjeni wabo). Ngemuva kokulashwa amasonto angama-24, abantu abangu-47.5% abathatha i-Orencia okungenani banciphise amaphesenti angama-20 ezimpawu zabo ze-PsA. Kulabo abathatha i-placebo (ukwelashwa ngaphandle kwesidakamizwa esisebenzayo), i-19% ibe nomphumela ofanayo.

Kwesinye isifundo somtholampilo, i-Orencia yanikezwa abantu abangama-213 abane-PsA besebenzisa umjovo ongaphansi (umjovo ngaphansi kwesikhumba sabo). Ngemuva kokulashwa amasonto angama-24, ama-39.4% alabo abathathe i-Orencia okungenani banciphise ama-20% ezimpawu zabo ze-PsA. Kulabo abathatha i-placebo (ukwelashwa ngaphandle kwesidakamizwa esisebenzayo), ama-22.3% abe nomphumela ofanayo.

I-Orencia yesifo samathambo esentsha se-idiopathic

I-Orencia igunyazwe yi-FDA ukwelapha i-juvenile idiopathic arthritis (JIA) ejwayelekile. Lesi simo siyindlela ejwayelekile kakhulu ye-arthritis ezinganeni. Kubangela izinhlungu ezihlangene, ukuvuvukala nokuqina.

I-Orencia kufanele isetshenziswe ezinganeni lapho i-JIA ithinta khona izitho zazo eziningi zomzimba. Kuvunyelwe ukusetshenziswa ezinganeni ezineminyaka engu-2 nangaphezulu.

Ochwepheshe njengamanje bancoma ukusebenzisa i-Orencia kulaba bantu. Umuthi ungasetshenziswa wedwa noma uhlanganiswe ne-methotrexate.

Ukusebenza kahle kwe-juvenile idiopathic arthritis

Kwesinye isifundo somtholampilo, u-Orencia wanikezwa izingane eziyi-190 ezine-JIA ezazineminyaka engama-6 kuya kwengu-17 ubudala. Izingane zathola i-Orencia ngokumfakelwa ngomjovo (IV) (umjovo emthanjeni wazo). Iningi lezingane nalo lithole i-methotrexate. Ekupheleni kocwaningo, izingane ezingama-65% ezithatha i-Orencia okungenani zehliswe ngama-30% ezimpawu zazo ze-JIA.

Kwesinye isifundo somtholampilo, i-Orencia yanikezwa njengomjovo ongaphansi (umjovo ngaphansi kwesikhumba) ezinganeni ezingama-205 ezine-JIA. Phambilini izingane zazithole ezinye izidakamizwa zokwelapha i-JIA yazo, kepha zisenezimpawu zalesi simo. Ekupheleni kwesifundo, i-Orencia yayiphumelele ekwehliseni izimpawu ze-JIA. Imiphumela yalolu cwaningo yayifana nemiphumela yocwaningo lwe-IV lokumnika.

I-Orencia yezinye izimo

Ungazibuza ukuthi ngabe i-Orencia isetshenziselwa ezinye izimo. Ngezansi kunezimo u-Orencia kwesinye isikhathi angasetshenziswa ngaphandle kwelebula ukwelapha. Ukusetshenziswa kwelebuli engekho kusho ukuthi umuthi usetshenziselwa ukwelapha isimo noma ngabe akuvunyelwe yi-FDA ukwenza kanjalo.

I-Orencia ye-lupus (ukusetshenziswa kwelebula)

I-Orencia ayivunyelwe i-FDA ukwelapha i-lupus, kepha kwesinye isikhathi iyasetshenziswa ngaphandle kwelebula yalesi simo.

Abanye ochwepheshe bakholelwa ukuthi i-Orencia ingasiza ekunciphiseni izimpawu ze-lupus. Kodwa izifundo zakamuva zomtholampilo azikwazanga ukukhombisa ukuthi i-Orencia isithuthukisa kahle kanjani lesi simo. Imininingwane eminingi iyadingeka ukwazi ngokuqinisekile ukuthi ngabe i-Orencia iphephile futhi iyasebenza yini kubantu abane-lupus.

Khuluma nodokotela wakho uma une-lupus futhi unentshisekelo yokuthatha i-Orencia. Bazoxoxa nawe ngezinketho zakho zokwelashwa futhi bakunikeze umuthi ophephile futhi osebenza kuwe.

I-Orencia ye-ankylosing spondylitis (ngaphansi kokucwaninga)

I-Orencia ayivunyelwe yi-FDA ukwelapha i-ankylosing spondylitis (AS). Futhi, ochwepheshe abatusi ukusebenzisa lesi sidakamizwa ukwelapha lesi sifo.

Kepha ezinye izifundo ziyenziwa ukuhlola ukuthi i-Orencia ingayiphatha kahle kanjani i-AS. Imininingwane eminingi iyadingeka ukwazi ngokuqinisekile ukuthi umuthi uphephile futhi uyasebenza yini ukwelapha i-AS.

Khuluma nodokotela wakho uma une-AS futhi unentshisekelo yokuthatha i-Orencia. Bazoxoxa ngomlando wakho wokwelashwa bancome nemithi engcono kakhulu kuwe.

I-Orencia yezingane

I-Orencia igunyazwe yi-FDA ukuthi isetshenziswe ezinganeni ezinesifo samathambo sezingane ezinesilinganiso esiphakathi kuya kwesinzima (i-JIA). Ukuthola eminye imininingwane, bheka isigaba se- "Orencia for juvenile idiopathic arthritis" esigabeni ngenhla.

Ukusetshenziswa kwe-Orencia nezinye izidakamizwa

I-Orencia ingasetshenziswa yodwa noma ihlanganiswe nezinye izidakamizwa. Udokotela wakho uzokuncoma uma udinga ukuthatha eminye imithi ne-Orencia ukwelapha isimo sakho. Lokhu kungenzeka kakhulu kwenzeke kubantu abane-rheumatoid arthritis noma i-juvenile idiopathic arthritis.

I-Orencia nezinye izidakamizwa zesifo samathambo

I-Orencia igunyazwe yi-FDA ukwelapha abantu abadala abane-arthritis ye-rheumatoid (RA) esezingeni eliphakathi nendawo. Umuthi ungasetshenziswa wedwa noma uhlanganiswe neminye imithi. Kodwa-ke, uma isetshenziswa nezinye izidakamizwa, leyo mithi akufanele ibe seqenjini lemithi ebizwa ngama-anti-TNFs. (Bheka isigaba esithi "Ukusebenzisana kwe-Orencia" ngezansi ukuthola eminye imininingwane.)

Ezifundweni zomtholampilo, i-Orencia yasebenza kahle lapho ithathwa nezinye izidakamizwa ngabantu abadala abane-RA elinganiselayo neqinile. Izidakamizwa ezivame kakhulu ezinikezwa i-Orencia kwakuyimishanguzo yokuguqula izifo (i-DMARD), kufaka phakathi i-methotrexate.

I-Orencia nezinye izidakamizwa ze-juvenile idiopathic arthritis

I-Orencia igunyazwe yi-FDA ukwelapha izingane ezine-juvenile idiopathic arthritis (JIA). Umuthi uvunyelwe ukusetshenziswa wedwa noma uhlanganiswe ne-methotrexate.

Ezifundweni zokwelashwa, u-Orencia wasebenza kahle ekwelapheni i-JIA ezinganeni lapho umuthi unikezwa nge-methotrexate. Ngenxa yalokhu, ochwepheshe njengamanje bancoma ukuthi i-Orencia isetshenziswe nge-methotrexate kunokuba iyodwa ukwelapha i-JIA.

Ezinye izindlela eziya e-Orencia

Ezinye izidakamizwa ziyatholakala ezingelapha isimo sakho. Ezinye zingakulungela kangcono kunabanye. Uma unentshisekelo yokuthola enye indlela ye-Orencia, khuluma nodokotela wakho. Bangakutshela ngeminye imithi engakusebenzela kahle.

Qaphela: Eminye yemithi efakwe kuhlu lapha isetshenzisiwe ngaphandle kwelebula ukwelapha lezi zimo ezithile.

Ezinye izindlela zesifo samathambo

Izibonelo zezinye izidakamizwa ezingasetshenziswa ukwelapha i-rheumatoid arthritis (RA) zifaka:

  • i-methotrexate (i-Otrexup, i-Rasuvo, i-Trexall, i-Xatmep)
  • i-sulfasalazine (i-Azulfidine, i-Azulfidine EN)
  • i-hydroxychloroquine (i-Plaquenil)
  • i-adalimumab (Humira)
  • isitifiketi se-certolizumab (Cimzia)
  • i-etanercept (Enbrel)
  • golimumab (Simponi)
  • infliximab (i-Remicade, i-Inflectra, i-Renflexis)
  • i-tofacitinib (Xeljanz)

Ezinye izindlela ze-psoriatic arthritis

Izibonelo zezinye izidakamizwa ezingasetshenziswa ukwelapha i-psoriatic arthritis (PsA) zifaka:

  • i-methotrexate (i-Otrexup, i-Rasuvo, i-Trexall, i-Xatmep)
  • i-sulfasalazine (i-Azulfidine, i-Azulfidine EN)
  • i-cyclosporine (iGengraf, Neoral, Sandimmune)
  • leflunomide (Arava)
  • i-apremilast (Otezla)
  • i-adalimumab (Humira)
  • isitifiketi se-certolizumab (Cimzia)
  • i-etanercept (Enbrel)
  • golimumab (Simponi)
  • infliximab (i-Remicade, i-Inflectra, i-Renflexis)
  • ustekinumab (Stelara)
  • secukinumab (Cosentyx)
  • ixekizumab (Taltz)
  • brodalumab (Siliq)
  • i-tofacitinib (Xeljanz)

Ezinye izindlela zentsha ye-idiopathic arthritis

Izibonelo zezinye izidakamizwa ezingasetshenziswa ukwelapha i-juvenile idiopathic arthritis (JIA) zifaka:

  • i-methotrexate (i-Otrexup, i-Rasuvo, i-Trexall, i-Xatmep)
  • i-sulfasalazine (i-Azulfidine, i-Azulfidine EN)
  • leflunomide (Arava)
  • i-adalimumab (Humira)
  • i-etanercept (Enbrel)
  • golimumab (Simponi)
  • infliximab (i-Remicade, i-Inflectra, i-Renflexis)
  • i-tocilizumab (Actemra)

I-Orencia vs. Humira

Ungase uzibuze ukuthi i-Orencia iqhathanisa kanjani neminye imithi enikezwe ukusetshenziswa okufanayo. Lapha sibheka ukuthi u-Orencia noHumira bafana futhi bahlukile kanjani.

Jikelele

I-Orencia iqukethe i-abatacept yezidakamizwa. I-Humira iqukethe isidakamizwa i-adalimumab. Le mithi isebenza ngokuhlukile emzimbeni wakho, futhi ingeyezigaba ezahlukahlukene zemithi.

Isebenzisa

I-Orencia neHumira bobabili bavunyelwe yi-Food and Drug Administration (FDA) ukwelapha i-rheumatoid arthritis (RA) ne-psoriatic arthritis (PsA) kubantu abadala. Le mithi nayo ivunyelwe ukwelapha i-juvenile idiopathic arthritis (JIA) ezinganeni ezineminyaka engu-2 nangaphezulu.

I-Humira nayo ivunyelwe yi-FDA ukuphatha le mibandela elandelayo:

  • i-ankylosing spondylitis kubantu abadala
  • Isifo sikaCrohn kubantu abadala nezingane ezineminyaka engama-6 nangaphezulu
  • i-ulcerative colitis kubantu abadala
  • i-plaque psoriasis kubantu abadala
  • i-hidradenitis suppurativa kubantu abadala nezingane ezineminyaka eyi-12 nangaphezulu
  • I-uveitis kubantu abadala nasezinganeni ezineminyaka engu-2 nangaphezulu

Amafomu wezidakamizwa nokuphathwa

I-Orencia iza ngezindlela ezimbili, ezinamandla ahlukene. Lawa mafomu ami kanje:

  • ifomu lempuphu
    • itholakala ngamandla owodwa: 250 mg (milligrams)
    • ixubene noketshezi ukwenza isixazululo osinikwa njenge-infravenous (IV) ukumnika (umjovo emthanjeni wakho onikezwa ngokuhamba kwesikhathi)
  • ifomu eliwuketshezi
    • itholakala ngamandla owodwa: 125 mg / mL (milligrams ngemililitha ngayinye)
    • unikezwa njengomjovo ongaphansi kwesikhumba (umjovo ngaphansi kwesikhumba sakho)
    • iza imijovo yengilazi ekhethiwe ebamba u-0.4 mL, 0.7 mL, no-1.0 mL ketshezi
    • ibuye ifike ku-1-mL vial efakwe kudivayisi ebizwa nge-ClickJect autoinjector

I-Humira iza njengesisombululo esinikezwa ngomjovo ongaphansi (umjovo ngaphansi kwesikhumba sakho). Itholakala ngamandla amabili alandelayo:

  • 100 mg / mL: iza ngezimbiza ezibamba u-0.8 mL, 0.4 mL, 0.2 mL, no-0.1 mL wesisombululo
  • 50 mg / mL: iza ngezimbiza ezibamba u-0.8 mL, 0.4 mL, no-0.2 mL wesisombululo

Imiphumela emibi kanye nezingozi

I-Orencia neHumira ziqukethe izidakamizwa ezahlukahlukene. Kodwa yomibili le mithi ithinta indlela amasosha akho omzimba asebenza ngayo. Ngakho-ke, yomibili le mithi ingadala imiphumela emibi efanayo. Ngezansi kunezibonelo zale miphumela emibi.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi ejwayelekile engenzeka nge-Orencia, neHumira, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

  • Kungenzeka nge-Orencia:
    • isicanucanu
  • Kungenzeka ngeHumira:
    • ukusabela kwesikhumba endaweni ezungeze indawo yakho yokujova
    • ukuqubuka kwesikhumba
  • Kungenzeka nge-Orencia neHumira:
    • izifo eziphezulu zokuphefumula, ezifana nomkhuhlane ovamile noma ukutheleleka kwesono
    • ikhanda

Imiphumela emibi kakhulu

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona ne-Orencia, neHumira, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

  • Kungenzeka nge-Orencia:
    • izifo ezinzima, ezifana ne-pneumonia
  • Kungenzeka ngeHumira:
    • izinkinga ngohlelo lwakho lwezinzwa (ukuba ndikindiki noma ukuncinza, izinguquko kumbono wakho, ubuthakathaka ezingalweni noma emilenzeni, noma isiyezi)
    • amazinga aphansi amaseli athile egazi, njengamaseli amhlophe egazi nama-platelets
    • izinkinga zenhliziyo, njengokuhluleka kwenhliziyo
    • izifo ezibucayi, njengesifo sofuba (TB) *
    • izinkinga zesibindi, njengokuhluleka kwesibindi
  • Kungenzeka nge-Orencia neHumira:
    • izifo ezinzima
    • umdlavuza *
    • ukuvuselelwa kwegciwane le-hepatitis B (ukuvuleka kwegciwane uma selivele lingaphakathi komzimba wakho)
    • ukusabela okweqile komzimba

Ukusebenza ngempumelelo

Kokubili i-Orencia neHumira kuvunyelwe yi-FDA ukwelapha isifo samathambo, i-psoriatic arthritis, kanye ne-juvenile idiopathic arthritis. Ukusebenza kwazo zombili izidakamizwa ekwelapheni lezi zimo kuqhathaniswa ngezansi.

Ukuphumelela ekwelapheni isifo samathambo

U-Orencia noHumira baqhathaniswe ngqo esifundweni somtholampilo njengezindlela zokwelashwa kwesifo samathambo (RA).

Kulolu cwaningo, abantu abadala abangama-646 abane-RA elinganiselayo kuya kwelikhulu babethatha u-Orencia noma uHumira: abantu abangu-318 bathatha i-Orencia, kwathi abantu abangama-328 bathatha uHumira. Womabili la maqembu abantu nawo athathe i-methotrexate. Ngemuva kweminyaka emibili yokwelashwa, yomibili le mithi yayisebenza ngendlela efanayo ekwelapheni i-RA.

Kulabo abathatha i-Orencia, abantu abangu-59.7% babe nokuncipha okungenani okungama-20% kwizimpawu zabo zeRA. Kubantu abathatha iHumira, ama-60.1% abe nomphumela ofanayo.

Ukuphumelela ekwelapheni i-psoriatic arthritis

U-Orencia noHumira abakaze baqhathaniswe ngqo ezivivinyweni zokwelashwa njengezindlela zokwelashwa ze-psoriatic arthritis (PsA). Kepha izifundo ezihlukile zithole ukuthi yomibili le mithi iyasebenza ukwelapha lesi simo.

Ukuphumelela ekwelapheni i-juvenile idiopathic arthritis

U-Orencia noHumira baqhathaniswa nokubuyekezwa kwezifundo njengezindlela zokwelashwa ze-juvenile idiopathic arthritis (JIA). Ngemuva kwalesi sibuyekezo, ochwepheshe bathola ukuthi yomibili le mithi yayinokuphepha nokusebenza ngendlela efanayo.

Izindleko

U-Orencia noHumira bobabili yizidakamizwa ezinamagama. Okwamanje azikho izinhlobo ze-biosimilar ze-Orencia ezitholakalayo. Umuthi we-biosimilar ucishe uqhathaniswe nomuthi ojwayelekile. Isidakamizwa esijwayelekile siyikhophi lomuthi ojwayelekile (lowo owenziwe ngamakhemikhali). Isidakamizwa se-biosimilar senziwa sifane nesidakamizwa se-biologic (esenziwe ngamaseli aphilayo).

Isidakamizwa se-biosimilar to Humira siyatholakala ngendlela enikezwa ukumnika okufakwa emthanjeni (IV). Ochwepheshe batusa ukusebenzisa ama-biosimilars ukwelapha i-RA, i-PsA, ne-JIA uma kuphephile futhi kusebenza esimweni sakho. Khuluma nodokotela wakho ukuthola ukuthi ngabe i-biosimilar ikulungele yini.

Imithi enegama lomkhiqizo imvamisa ibiza ngaphezu kwezindleko zemithi ye-biosimilar.

Ngokuya ngokulinganiselwa ku-GoodRx.com, uHumira ubiza okungaphezulu kancane kuka-Orencia. Inani langempela ozolikhokhela noma imuphi umuthi lincike ohlelweni lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

I-Orencia vs. Enbrel

Ungase uzibuze ukuthi i-Orencia iqhathanisa kanjani neminye imithi enikezwe ukusetshenziswa okufanayo. Lapha sibheka ukuthi i-Orencia ne-Enbrel zifana kanjani futhi zehlukile.

Jikelele

I-Orencia iqukethe i-abatacept yezidakamizwa. I-Enbrel iqukethe i-etanercept yezidakamizwa. Le mithi ingeyezigaba ezahlukahlukene zemithi, futhi isebenza ngokuhlukile emzimbeni wakho.

Isebenzisa

I-Orencia ne-Enbrel zivunyelwe yi-Food and Drug Administration (FDA) ukwelapha isifo samathambo (RA) kanye ne-psoriatic arthritis (PsA) kubantu abadala. Zombili lezi zidakamizwa nazo zivunyelwe ukwelapha i-juvenile idiopathic arthritis (JIA) ezinganeni ezineminyaka engu-2 nangaphezulu.

I-Enbrel nayo ivunyelwe yi-FDA ukuphatha ezinye izimo ezimbili:

  • i-ankylosing spondylitis kubantu abadala
  • i-plaque psoriasis kubantu abadala nezingane ezineminyaka engama-4 nangaphezulu

Amafomu wezidakamizwa nokuphathwa

I-Orencia iza ngezindlela ezimbili, ezinamandla ahlukene. Lawa mafomu ami kanje:

  • ifomu lempuphu
    • itholakala ngamandla owodwa: 250 mg (milligrams)
    • ixubene noketshezi ukwenza isixazululo osinikwa njenge-infravenous (IV) ukumnika (umjovo emthanjeni wakho onikezwa ngokuhamba kwesikhathi)
  • ifomu eliwuketshezi
    • itholakala ngamandla owodwa: 125 mg / mL (milligrams ngemililitha ngayinye)
    • unikezwa njengomjovo ongaphansi kwesikhumba (umjovo ngaphansi kwesikhumba sakho)
    • iza imijovo yengilazi ekhethiwe ebamba u-0.4 mL, 0.7 mL, no-1.0 mL ketshezi
    • ibuye ifike ku-1-mL vial efakwe kudivayisi ebizwa nge-ClickJect autoinjector

I-Enbrel inikezwa ngomjovo ongaphansi. Iza ngezindlela ezilandelayo:

  • ifomu lempuphu
    • itholakala ngamandla owodwa: 25 mg
    • ixubene noketshezi ukwenza isixazululo
  • ifomu eliwuketshezi
    • itholakala ngamandla owodwa: 50 mg / mL
    • iza ngezigubhu eziphethe u-0.5 mL no-1.0 mL ketshezi

Imiphumela emibi kanye nezingozi

I-Orencia ne-Enbrel ziqukethe izidakamizwa ezahlukahlukene. Kodwa yomibili le mithi isebenza kumasosha akho omzimba. Ngakho-ke, yomibili le mithi ingadala imiphumela emibi efanayo. Ngezansi kunezibonelo zale miphumela emibi.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi ejwayelekile engenzeka nge-Orencia noma nge-Enbrel.

  • Kungenzeka nge-Orencia:
    • izifo ezifana nomkhuhlane noma isifo sesono
    • ikhanda
    • isicanucanu
  • Kungenzeka nge-Enbrel:
    • ukusabela kwesikhumba endaweni ezungeze indawo yakho yokujova
  • Kungenzeka nge-Orencia ne-Enbrel:
    • ayikho imiphumela emibi evamile eyabiwe

Imiphumela emibi kakhulu

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona ne-Orencia, ne-Enbrel, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

  • Kungenzeka nge-Orencia:
    • akukho miphumela emibi eyingqayizivele eyingqayizivele
  • Kungenzeka nge-Enbrel:
    • izinkinga ngezinhlelo zakho zemizwa (i-multiple sclerosis, ukuqubuka, ukuvuvukala kwezinzwa)
    • amazinga aphansi amaseli athile egazi, njengamaseli amhlophe egazi nama-platelets
    • izinkinga zenhliziyo, njengokuhluleka kwenhliziyo
    • izinkinga zesibindi, njengokuhluleka kwesibindi
    • izifo ezibucayi, njengesifo sofuba (TB) *
  • Kungenzeka nge-Orencia ne-Enbrel:
    • umdlavuza *
    • ukuvuselelwa kwegciwane le-hepatitis B (ukuvuleka kwegciwane uma selivele lingaphakathi komzimba wakho)
    • izifo ezinzima, ezifana ne-pneumonia
    • ukusabela okweqile komzimba

Ukusebenza ngempumelelo

Kokubili i-Orencia ne-Enbrel zivunyelwe yi-FDA ukwelapha i-rheumatoid arthritis, i-psoriatic arthritis, kanye ne-juvenile idiopathic arthritis. Ukusebenza kwazo zombili izidakamizwa ekwelapheni lezi zimo kuqhathaniswa ngezansi.

Ukuphumelela ekwelapheni isifo samathambo

Le mithi ayikaze iqhathaniswe ngqo ezivivinyweni zokwelashwa. Kodwa izifundo ezehlukene zithole ukuthi bobabili i-Orencia ne-Enbrel bayasebenza ekwelapheni isifo samathambo (RA).

Ukuphumelela ekwelapheni i-psoriatic arthritis

Le mithi ayikaze iqhathaniswe ngqo ezivivinyweni zokwelashwa. Kepha izifundo ezihlukile zithole ukuthi bobabili i-Orencia ne-Enbrel bayasebenza ekwelapheni i-psoriatic arthritis (PsA).

Ukuphumelela ekwelapheni i-juvenile idiopathic arthritis

Ukubuyekezwa kwezifundo kubheke ukuthi u-Orencia no-Enbrel basebenza kahle kanjani ekwelapheni i-juvenile idiopathic arthritis (JIA) ezinganeni. Ekupheleni kokubuyekeza, ochwepheshe bavumile ukuthi yomibili le mithi inokuphepha nokusebenza okufananayo ekwelapheni lesi simo.

Izindleko

I-Orencia ne-Enbrel zombili izidakamizwa zomuthi. Okwamanje azikho izinhlobo ze-biosimilar ze-Orencia ezitholakalayo. Umuthi we-biosimilar ucishe uqhathaniswe nomuthi ojwayelekile. Isidakamizwa esijwayelekile siyikhophi lomuthi ojwayelekile (lowo owenziwe ngamakhemikhali). Isidakamizwa se-biosimilar senziwa sifane nesidakamizwa se-biologic (esenziwe ngamaseli aphilayo).

Umuthi we-biosimilar to Enbrel utholakala ngendlela enikezwa ukumnika okufakwa emthanjeni (IV). Ochwepheshe batusa ukusebenzisa ama-biosimilars ukwelapha i-RA, i-PsA, ne-JIA uma kuphephile futhi kusebenza esimweni sakho. Khuluma nodokotela wakho ukuthola ukuthi ngabe i-biosimilar ikulungele yini.

Imithi enegama lomkhiqizo imvamisa ibiza ngaphezu kwezindleko zemithi ye-biosimilar.

Ngokuya ngokulinganiselwa ku-GoodRx.com, i-Enbrel ingabiza kancane kune-Orencia. Intengo yangempela ozoyikhokhela noma yimuphi umuthi izoncika ohlelweni lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

I-Orencia notshwala

Akukho ukuxhumana okwaziwayo phakathi kwe-Orencia notshwala. Kodwa ukuphuza utshwala obuningi kungazenza zibe zimbi kakhulu izimpawu zakho zesifo samathambo kanye nokuqhubekela phambili kwesifo. Futhi, utshwala bungasebenzisana nezinye izidakamizwa ozisebenzisayo.

Khuluma nodokotela wakho ngokuthi kungakanani utshwala obuphephile ukuthi ungabuphuza. Bazoxoxa ngokwelashwa kwakho kwamathambo manje bese beluleka ngokuthi ngabe utshwala buphephile yini ukuthi ungabudla.

Ukusebenzisana kwe-Orencia

U-Orencia angaxhumana neminye imithi eminingana. Ingasebenzisana nezithasiselo ezithile kanye nokudla okuthile.

Ukuxhumana okuhlukile kungadala imiphumela ehlukile. Isibonelo, ukuxhumana okuthile kungaphazamisa ukusebenza kwesidakamizwa. Okunye ukuxhumana kungakhuphula imiphumela emibi noma kuyenze ibe nzima kakhulu.

I-Orencia neminye imithi

Ngezansi kukhona uhlu lwemithi engasebenzisana ne-Orencia. Lezi zinhlu aziqukethe yonke imishanguzo engaxhumana ne-Orencia.

Ngaphambi kokuthatha i-Orencia, khuluma nodokotela wakho nosokhemisi. Batshele ngayo yonke imishanguzo oyinikezwa ngudokotela, i-counter-counter, nezinye izidakamizwa oziphuzayo. Batshele futhi nganoma yimaphi amavithamini, amakhambi, nezithako ozisebenzisayo. Ukwabelana ngalolu lwazi kungakusiza ugweme ukuhlangana okungenzeka.

Uma unemibuzo mayelana nokuhlangana kwezidakamizwa okungakuthinta, buza udokotela wakho noma usokhemisi.

Ama-anti-TNF

Ama-anti-TNFs yiqembu lemithi ejwayele ukusetshenziselwa ukwelapha i-rheumatoid arthritis (RA), psoriatic arthritis (PsA), ne-juvenile idiopathic arthritis (JIA). Le mithi isebenza ngokunamathisela nokuvimba ukusebenza kweprotheni ebizwa nge-tumor necrosis factor (TNF).

Izibonelo zemithi elwa ne-TNF zifaka:

  • i-adalimumab (Humira)
  • i-etanercept (Enbrel)
  • infliximab (i-Remicade)

Kokubili i-Orencia ne-anti-TNFs kwehlisa amandla omzimba wakho wokulwa nezifo ezintsha noma ezikhona.Ukuthatha le mithi ndawonye kungandisa ingozi yakho yokuthola izifo ezintsha futhi kwehlise ikhono lakho lokulwa nezifo esezivele zingaphakathi komzimba wakho.

Khuluma nodokotela wakho uma uthatha noma uhlela ukuqala ukuthatha umuthi olwa ne-TNF ngenkathi usebenzisa i-Orencia. Udokotela wakho angaxoxa ngezidingo zakho zokwelashwa futhi ancome nemithi ephephile ongayiphuza.

Eminye imithi ye-rheumatic

Kokubili i-Orencia neminye imithi ye-rheumatic, kufaka phakathi i-Xeljanz, kuthinta amasosha akho omzimba. Le mithi yehlisa amandla omzimba wakho wokulwa nezifo. Ukuthatha i-Orencia nezinye izidakamizwa ze-rheumatic kungehlisa amandla omzimba wakho kakhulu. Lokhu kungandisa ubungozi bokutheleleka.

Tshela udokotela wakho uma uthatha noma imuphi omunye umuthi we-rheumatic ngaphandle kwe-Orencia. Udokotela wakho angalawula ukuhlolwa ukuze abheke ukuthi amasosha omzimba wakho asebenza kahle kangakanani futhi ancoma uhlelo oluhle kakhulu lokwelashwa kwakho.

I-Orencia namakhambi nezithako

Awekho amakhambi noma izithasiselo ezaziyo ukuxhumana no-Orencia. Kodwa-ke, kusamele uhlole udokotela wakho noma usokhemisi ngaphambi kokusebenzisa noma iziphi izithasiselo ngenkathi uthatha i-Orencia.

Usebenza kanjani u-Orencia

I-Orencia ivunyelwe ukwelapha izifo ezithile ezizimele. Isebenza emzimbeni wakho ukusiza ukunciphisa izimpawu nokunciphisa ukuqhubeka (ukuwohloka) kwalezi zifo.

Ziyini izifo ezizimele?

Amasosha omzimba wakho avikela umzimba wakho ezifweni. Lokhu ikwenza ngokuhlasela amabhaktheriya namagciwane angena ngaphakathi noma asevele angaphakathi komzimba wakho.

Kodwa kwesinye isikhathi amasosha akho omzimba ayadideka, bese eqala ukuhlasela amaseli akho. Uma ingayeki, idala izifo ezizimele. Ngalezi zifo, amasosha akho omzimba ahlasela amaseli akha izicubu zomzimba wakho nezitho zomzimba.

I-rheumatoid arthritis (RA), i-psoriatic arthritis (i-PsA), ne-juvenile idiopathic arthritis (JIA) zonke ziyizimo ezizimele. Lokhu kusho ukuthi uma unalezi zimo, amasosha akho omzimba ahlasela owakho umzimba.

Wenzani u-Orencia?

I-Orencia isebenza ngokunamathisela kuma-protein amabili (abizwa nge-CD80 ne-CD86) atholakala kumaseli athile omzimba. Amaprotheni e-CD80 ne-CD86 enza kusebenze olunye uhlobo lwamaseli omzimba, abizwa ngama-T cell. Amaseli wakho we-T awuhlobo oluthile lweseli olusiza amasosha akho omzimba ukulwa nezifo.

Ngokunamathisela kula maprotheni, i-Orencia imisa amaseli we-T ukuthi asebenze kahle. Lokhu kuvimbela amasosha omzimba wakho ekuhlaseleni amangqamuzana akho, izicubu, nezitho zomzimba.

I-Orencia isiza ukubambezela ukuqhubeka (ukuwohloka) kwesifo samathambo, i-psoriatic arthritis, kanye ne-juvenile idiopathic arthritis. Umuthi futhi wehlisa izimpawu zale mibandela, kukwenze uzizwe ungcono.

Kuthatha isikhathi esingakanani ukusebenza?

I-Orencia izoqala ukusebenza emzimbeni wakho ngokushesha nje lapho uqala ukuyithatha. Kepha isifo samathambo, i-psoriatic arthritis, kanye ne-juvenile idiopathic arthritis yizimo ezithatha isikhathi ukwelapha. Ezifundweni zomtholampilo, abantu baba nokuthuthuka ezingeni labo lobuhlungu nasemsebenzini jikelele ezinyangeni ezi-3 zokuqala ukwelashwa. Kodwa-ke, impendulo yomuntu ngamunye ku-Orencia izohluka.

I-Orencia ihloselwe ukuthathwa njengomuthi wesikhathi eside. Kusebenza nsuku zonke emzimbeni wakho ukugcina isimo sakho siphathwa. Uma uyeka ukukuthatha ngokungazelelwe, izimpawu zakho zingabuya futhi.

Ungayeki ukuthatha i-Orencia ngemuva kokuxazululwa kwezimpawu zakho. Uma ufuna ukuyeka ukuthatha lo muthi, khuluma nodokotela wakho. Bazohlola isimo sakho bese bebona ukuthi usadinga ukuthatha i-Orencia.

Orencia nokukhulelwa

Azikho izifundo ezanele kubantu zokwazi ngokuqinisekile ukuthi i-Orencia iphephile ukusetshenziswa ngesikhathi sokukhulelwa. Izifundo zezilwane ziphakamisa ukuthi i-Orencia ingathinta umbungu okhulayo uma isetshenziswe ngesikhathi sokukhulelwa. Kepha izifundo ezilwaneni azihlali zibikezela ukuthi kwenzekani kubantu.

Yazisa udokotela wakho uma ukhulelwe noma ukhulelwe ngenkathi usebenzisa i-Orencia. Bazoxoxa ngezinketho zakho zokwelashwa futhi bancome ukuthi ukusebenzisa i-Orencia kuphephile ukuthi ukwenze ngesikhathi sokukhulelwa.

Irejista yokukhulelwa iyatholakala kwabesifazane abathathe noma abathatha i-Orencia ngesikhathi sokukhulelwa. Uma ukhulelwe futhi uthatha i-Orencia, udokotela wakho angakucela ukuthi ubhalise. Indawo yokubhalisa ivumela odokotela ukuthi baqoqe imininingwane ngokuphepha kokusetshenziswa kwe-Orencia kwabesifazane abakhulelwe. Ukuthola eminye imininingwane ngerejista, shayela ku-877-311-8972 noma uvakashele iwebhusayithi yokubhalisa.

I-Orencia nokulawulwa kokuzalwa

Akwaziwa ukuthi i-Orencia iphephile yini ukuyithatha ngesikhathi sokukhulelwa. Uma wena noma umlingani wakho ocansini ungakhulelwa, khuluma nodokotela wakho ngezidingo zakho zokulawulwa kokuzalwa ngenkathi usebenzisa lesi sidakamizwa.

I-Orencia nokuncelisa ibele

Azikho izifundo eziye zabheka ukuphepha kokusetshenziswa kwe-Orencia kwabesifazane abancelisayo. Ucwaningo ezilwaneni lukhombisile ukuthi i-Orencia idlulela ebisini lwebele lwezilwane ezinikezwa umuthi. Kodwa akwaziwa ukuthi umuthi uthinta izilwane ezidla lolo bisi lwebele.

Khumbula ukuthi izifundo ezilwaneni azibikezeli njalo ukuthi kwenzekani kubantu.

Tshela udokotela wakho uma uncelisa noma uhlela ukuncelisa ngenkathi uthatha i-Orencia. Bazokuncoma indlela ephephe kakhulu kuwe yokondla ingane yakho.

Izindleko ze-Orencia

Njengayo yonke imithi, izindleko ze-Orencia zingahluka.

Intengo yangempela ozoyikhokha incike ohlelweni lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

Usizo lwezezimali nolomshuwalense

Uma udinga ukwesekwa kwezezimali ukukhokhela i-Orencia, noma uma udinga usizo lokuqonda ukutholakala komshuwalense wakho, usizo luyatholakala.

IBristol-Myers Squibb, umkhiqizi we-Orencia, unikela ngohlelo lwe-copay kubantu abasebenzisa ifomu lokuzijolela le-Orencia. Ukuthola eminye imininingwane nokuthola ukuthi uyakufanelekela yini ukwesekwa, shayela ku-800-ORENCIA (800-673-6242) noma uvakashele iwebhusayithi yohlelo.

Uma uthola i-Orencia nge-infravenous (IV) infusions, ungaxhumana nethimba le-Bristol-Myers Squibb Access Support ukuze ufunde ngezinketho zokonga izindleko. Ukuthola eminye imininingwane, shayela ku-800-861-0048 noma uvakashele iwebhusayithi yohlelo.

Ungayithatha kanjani i-Orencia

Kufanele uthathe i-Orencia ngokusho kwemiyalo kadokotela wakho noma yomhlinzeki wezempilo.

I-Orencia ngokufakwa ngaphakathi

Kwezinye izimo, udokotela wakho angancoma ukuthi uthole i-Orencia ngokumnika ngomjovo (IV) (umjovo emthanjeni wakho onikezwa ngokuhamba kwesikhathi).

Kulokhu, uzodinga ukuhlela i-aphoyintimenti emtholampilo wakho wokunakekelwa kwezempilo. Uma ususemtholampilo ukumfakelwa kwakho, abasebenzi bezokwelapha bazokusa egumbini elintofontofo. Bazofaka inaliti emthanjeni wakho bese bexhuma inaliti esikhwameni esigcwele uketshezi oluqukethe i-Orencia.

Ukumnika kwakho kuzothatha cishe imizuzu engama-30. Ngalesi sikhathi, uketshezi oluqukethe i-Orencia luzosuka esikhwameni se-IV, ludlule enaliti, luye emthanjeni wakho.

Ngemuva kokuthi uthole lonke uketshezi lwe-Orencia, inaliti izosuswa emthanjeni wakho. Udokotela wakho angafuna ukukuqapha isikhashana ngaphambi kokuba uphume emtholampilo. Lokhu kwenziwa ukuqinisekisa ukuthi awunayo imiphumela emibi ngemuva kokuthola i-Orencia.

I-Orencia ithathwe ngomjovo ongaphansi

Udokotela wakho angancoma ukuthi uthole i-Orencia ngomjovo ongaphansi (umjovo ngaphansi kwesikhumba sakho).

Ekuqaleni, umhlinzeki wakho wezokunakekelwa kwempilo angafuna ukukunika umjovo wakho we-Orencia. Lokhu kubavumela ukuthi bachaze inqubo yokujova futhi bakubonise kahle ukuthi ungayenza kanjani. Ngemuva kokuthi udokotela wakho ukukhombisile ukuthi ungayijova kanjani i-Orencia imijovo, bangase bakucele ukuthi uqale uzinike imijovo yomuthi.

Umjovo ngamunye we-Orencia ungenziwa ngamadivayisi amabili ahlukene: isirinji ekhethiwe noma i-autoinjector ekhethiwe ye-ClickJect. Idivayisi ngayinye izofika nenani eliqondile le-Orencia enikezwe udokotela wakho. Ngeke kudingeke ulinganise isilinganiso sakho se-Orencia ngomjovo ngamunye. Abahlinzeki bakho bezokunakekela impilo bazokunikeza imiyalo yesinyathelo nesinyathelo yokuthi uyisebenzisa kanjani idivayisi oyinikiwe.

Buza udokotela wakho uma ungaqiniseki ngokuthi ungayifaka kanjani i-Orencia. Bazobuyekeza inqubo kanye nawe. Ungavakashela iwebhusayithi ye-Orencia ukuze ufunde kabanzi mayelana nokuthi ungazifaka kanjani umuthi ngokwakho.

Ukuthatha nini

Uma usuqale ukuthatha i-Orencia okokuqala, uzothola isheduli yokulinganisa. Kufanele uthathe i-Orencia ngokuya ngalelo hlelo.

Izikhumbuzi zemithi zingasiza ekuqinisekiseni ukuthi ulandela uhlelo lwakho lokulinganisa.

Imibuzo ejwayelekile nge-Orencia

Nazi izimpendulo zemibuzo ebuzwa njalo nge-Orencia.

Ngingathatha i-Orencia uma ngine-COPD?

Ungahle ukwazi. I-Orencia kwesinye isikhathi inconywa ukuthi isetshenziswe kubantu abanezinhlobo zesifo samathambo abanesifo esingapheliyo se-pulmonary disease (COPD). Kepha laba bantu kufanele babhekwe ngeso lokhozi ngenkathi besebenzisa lesi sidakamizwa.

Uma une-COPD, ukuthatha i-Orencia kungandisa ingozi yokuba nemiphumela ethile emibi. Eqinisweni, kungandisa ingozi yokuba nobunzima obukhulu ngokuphefumula. Uma une-COPD futhi usebenzisa lesi sidakamizwa, udokotela wakho angakuqapha eduze ukuze aqiniseke ukuthi i-Orencia iphephile kuwe.

Tshela udokotela wakho uma une-COPD futhi unenkinga yokuphefumula ngenkathi uthatha i-Orencia. (Bheka isigaba esithi “Okumele kuqashelwe” ngezansi ukuthola eminye imininingwane.) Udokotela wakho angancoma ukuthi ngabe i-Orencia iphephile ukuthi ungayisebenzisa. Uma kungaphephile, bazokunika eminye imithi ephephe kuwe.

Ngingayithola yini imigomo yokugoma ngenkathi ngisebenzisa i-Orencia?

Ungahle ukwazi ukuthola imigomo ethile ngesikhathi sokwelashwa kwe-Orencia. Kodwa-ke, akufanele uthole imigomo ebukhoma ngenkathi uthatha i-Orencia, noma izinyanga ezintathu ngemuva komthamo wakho wokugcina.

Imishanguzo ebukhoma iqukethe uhlobo olubuthaka lwegciwane noma amagciwane. Ngenkathi uthatha i-Orencia, amasosha akho omzimba awakwazi ukulwa nezifo njengoba kwenzeka ngokujwayelekile. Uma uthola umuthi wokugoma obukhoma ngenkathi uthatha i-Orencia, ungathola ukutheleleka umgomo okuhloselwe ukukuvikela kuwo.

Uma uthola umuthi wokugoma ongaphili ngesikhathi sokwelashwa kwe-Orencia, kungenzeka kungasebenzi nokukuvikela ekuthelelekeni okuhloselwe lokho. Kodwa usavunyelwe ukuthola lezi zinhlobo zemithi yokugoma ngesikhathi sokwelashwa.

Qiniseka ukuthi yonke imigomo yakho noma yengane yakho isesikhathini ngaphambi kokuqala ukwelashwa kwe-Orencia. Uma unemibuzo mayelana nokuthi yimiphi imigomo edingekayo, khuluma nodokotela wakho. Bazoncoma uma ukugoma kungahlehliswa.

Uma ngithola ukutheleleka ngenkathi ngisebenzisa i-Orencia, ngingayithatha yini i-antibiotic?

Yebo. Akukho ukuxhumana okwaziwayo phakathi kwe-Orencia nama-antibiotics.

Uma uthola ukutheleleka okusha ngenkathi uthatha i-Orencia, buza udokotela wakho uma udinga ukuthatha i-antibiotic. Bangakunika i-antibiotic esebenza kahle lapho ithathwa ne-Orencia.

Ngingahamba no-Orencia ekhaya?

Kuya ngokuthi udokotela wakho uncoma kanjani ukuthi uthathe i-Orencia.

Udokotela wakho angafuna ukuthi uthathe i-Orencia ngokumfakelwa ngemithambo (IV). Lokhu kusho ukuthi umhlinzeki wezokunakekelwa kwempilo uzobeka inaliti emthanjeni wakho, futhi uzothola umuthi ngenaliti njengokumnika. Kulokhu, awukwazi ukuthatha u-Orencia ekhaya. Uzodinga ukuvakashela umtholampilo wezempilo ukuze uthole ukwelashwa kwakho.

Ngaphandle kwalokho, udokotela wakho angafuna ukuthi uthathe i-Orencia ngomjovo ongaphansi. Kulokhu, i-Orencia izofakwa ngenaliti ngaphansi kwesikhumba sakho. Umjovo wokuqala kufanele wenziwe emtholampilo wezokunakekelwa kwempilo ngabasebenzi bezokwelapha. Kepha ngemuva kwalokhu, uzokwazi ukujova u-Orencia ekhaya.

Ngingayisebenzisa i-Orencia uma nginesifo sikashukela?

Yebo, kodwa kuzodingeka uqaphele uma uthatha i-Orencia ngokumfakelwa ngomjovo (IV). Kulokhu, i-Orencia inikezwa njengomjovo emthanjeni wakho.

Ifomu le-Orencia elisetshenziselwa ukumunca i-IV liqukethe i-maltose. Le nto ayisebenzi emzimbeni wakho ukwelapha isimo sakho, kepha ithinta indlela amanye amadivayisi alinganisa ngayo amazinga kashukela egazini lakho. Lapho uvezwa ku-maltose, ezinye iziqaphi ze-glucose (ushukela wegazi) zingakhombisa ukuthi unamazinga aphezulu kashukela kunalokhu okwenzayo.

Yazisa udokotela wakho uma unesifo sikashukela futhi uthatha i-Orencia ngokusebenzisa i-IV infusions. Bazokuncoma indlela engcono kakhulu yokukala amazinga kashukela egazini lakho ngesikhathi sokwelashwa.

Ngabe i-Orencia ingasiza ekulahlekelweni izinwele?

U-Orencia akakhombisanga ukuthi uyasebenza ekunqandeni ukulahleka kwezinwele. Yize ucwaningo olulodwa lomtholampilo luhlole ukusetshenziswa kwalo ekulahlekelweni izinwele, lolu cwaningo lwaluluncane futhi lufaka abantu abayi-15 kuphela.

Khuluma nodokotela wakho uma ukhathazekile ngokulahleka kwezinwele. Bazokweluleka ngokuthi ungabhekana kanjani nakho futhi bangakunikeza nemithi yokuyilawula.

Ngingakwazi ukuhamba uma ngithatha i-Orencia?

Yebo, ungahamba, kepha kufanele uqiniseke ukuthi awuphuthelwa yimithamo yakho ye-Orencia.

Uma uthola u-Orencia emtholampilo wezempilo, khuluma nomhlinzeki wakho wezokunakekelwa kwezempilo ngezinhlelo zakho zokuhamba. Bazoqinisekisa ukuthi uhlelo lwakho lwesilinganiso aluphazamisi uhambo lwakho.

Uma uzijova nge-Orencia, qiniseka ukuthi uyakwazi ukuthatha umuthi uma uzodinga umthamo wakho ngenkathi ungekho ekhaya. Buza udokotela wakho noma usokhemisi ukuthi ungakupakisha kanjani futhi ukugcine kanjani i-Orencia ngenkathi usohambweni.

Ngabe ngidinga ukugunyazwa kwangaphambili ukuthola i-Orencia?

Kuya ngohlelo lwakho lomshuwalense. Izinhlelo eziningi zomshuwalense zicela ukugunyazwa kwangaphambili ngaphambi kokuthi ube nokutholakala komshwalense we-Orencia.

Ukucela ukugunyazwa kwangaphambili, udokotela wakho uzogcwalisa amaphepha enkampanini yakho yomshuwalense. Inkampani yomshwalense izobe isibukeza la maphepha bese ikwazisa ukuthi uhlelo lwakho luzobhekela i-Orencia.

Izinyathelo zokuqapha ze-Orencia

Ngaphambi kokuthatha i-Orencia, khuluma nodokotela wakho ngomlando wakho wezempilo. I-Orencia kungenzeka ingakulungeli uma unezimo ezithile zezokwelapha noma ezinye izinto ezithinta impilo yakho. Lokhu kufaka phakathi:

  • Ukusetshenziswa kwemithi elwa ne-TNF. Uma uthatha imishanguzo elwa ne-TNF (efaka iHumira, i-Enbrel, ne-Remicade) ne-Orencia, ikhono lomzimba wakho lokulwa nezifo lingancipha kakhulu. Lokhu kwandisa ubungozi bokutheleleka okuyingozi, futhi kwesinye isikhathi okusongela impilo. Khuluma nodokotela wakho ngayo yonke imithi oyiphuzayo ngaphambi kokuqala i-Orencia.
  • Umlando wezifo eziphindaphindayo noma ezifihlekile. Uma unezifo eziphindaphindayo (izifo ezibuyela kaningi), ukuthatha i-Orencia kungakhuphula ubungozi bokuphindeka kaningi. Uma unanoma yikuphi ukutheleleka okufihlekile (ukutheleleka ngaphandle kwanoma yiziphi izimpawu), ukuthatha i-Orencia kungakhuphula ubungozi bokuqhamuka kokutheleleka. Ukutheleleka okuvamile okufihlekile kufaka isifo sofuba (i-TB) kanye ne-hepatitis B virus. Khuluma nodokotela wakho ngomlando wakho wezifo ngaphambi kokuqala i-Orencia.
  • Isidingo sokugoma. Uma uthola imigomo ngenkathi uthatha i-Orencia, imigomo kungenzeka ingasebenzi kahle emzimbeni wakho. Khuluma nodokotela wakho nganoma yimiphi imithi yokugoma ongayidinga ngaphambi kokuba uqale ukuthatha i-Orencia.
  • Isifo esingapheliyo se-pulmonary disease (COPD). Uma une-COPD, ukuthatha i-Orencia kungazenza zibe zimbi izimpawu zakho ze-COPD. Ngenxa yalokhu, ungadinga ukuqashwa okuseduze uma uthatha lo muthi. Uma unomlando we-COPD, khuluma nodokotela wakho ngaphambi kokuba uqale ukuthatha i-Orencia.
  • Ukusabela okweqile kwe-Orencia. Akufanele uthathe i-Orencia uma ngabe uke waba nokungezwani okunamandla nomuthi esikhathini esedlule. Uma ungenaso isiqiniseko sokuthi ngabe uke waba nokungezwani komzimba okunzima, khuluma nodokotela wakho ngaphambi kokuqala i-Orencia.
  • Ukukhulelwa. Ukusetshenziswa kwe-Orencia ngesikhathi sokukhulelwa akuzange kufundwe kubantu. Khuluma nodokotela wakho mayelana nokuthi i-Orencia iphephile ukuyisebenzisa ngesikhathi sokukhulelwa. Ngeminye imininingwane, bheka isigaba se- "Orencia nokukhulelwa" ngenhla.
  • Ukuncelisa ibele. Akwaziwa kahle ukuthi i-Orencia iphephile yini ukuyithatha ngenkathi uncelisa. Ngeminye imininingwane, sicela ubheke isigaba esithi “Orencia nokuncelisa ibele” ngenhla.

Qaphela: Ukuthola eminye imininingwane ngemiphumela emibi engaba khona ye-Orencia, bona isigaba se- "Orencia side effects" esigabeni ngenhla.

Ukudlula ngokweqile kwe-Orencia

Ukusebenzisa okungaphezu kwesilinganiso esinconyiwe se-Orencia kungaholela emiphumeleni emibi kakhulu. Ngeminye imininingwane ngemiphumela emibi kakhulu, sicela ubheke isigaba se- "Orencia side effects" ngenhla.

Okufanele ukwenze uma kwenzeka ukweqisa ngokweqile

Uma ucabanga ukuthi uthathe kakhulu lo muthi, shayela udokotela wakho. Ungashayela futhi i-American Association of Poison Control Centers ku-800-222-1222 noma usebenzise ithuluzi labo eliku-inthanethi. Kepha uma izimpawu zakho zinzima, shayela ku-911 noma uye egumbini lezimo eziphuthumayo eliseduze ngokushesha.

Ukuphelelwa isikhathi kwe-Orencia, ukugcina nokulahla

Lapho uthola i-Orencia ekhemisi, usokhemisi uzokwengeza usuku lokuphelelwa yisikhathi kwilebula esebhodleleni. Lolu suku luvame unyaka owodwa kusukela ngosuku abakhipha ngalo umuthi.

Usuku lokuphelelwa isikhathi lusiza ukuqinisekisa ukusebenza komuthi ngalesi sikhathi. Isimo samanje se-Food and Drug Administration (i-FDA) ukugwema ukusebenzisa imishanguzo ephelelwe yisikhathi. Uma usebenzise umuthi ongasetshenziswanga osudlulile esikhathini sokuphelelwa yisikhathi, khuluma nosokhemisi wakho mayelana nokuthi usengakwazi yini ukuwusebenzisa.

Isitoreji

Ukuthi umuthi uhlala ulungile isikhathi eside kangakanani kungancika ezintweni eziningi, kufaka phakathi ukuthi uwugcina kanjani futhi kuphi umuthi.

I-Orencia kufanele igcinwe esiqandisini ezingeni lokushisa lika-36 ° F kuye ku-46 ° F (2 ° C kuye ku-8 ° C). Kufanele ugcine umuthi uvikelekile ekukhanyeni futhi ugcinwe ngaphakathi kwephakeji yoqobo. Akufanele uvumele i-Orencia (ngaphakathi noma imijovo ekhethiwe noma ama-autoinjectors we-ClickJect) iqhwa.

Ukulahlwa

Uma ungasadingi ukuthatha i-Orencia futhi unemithi esele, kubalulekile ukuyilahla ngokuphepha. Lokhu kusiza ukuvimbela abanye, kufaka phakathi izingane nezilwane ezifuywayo, ekuthatheni lesi sidakamizwa ngengozi. Kuyasiza futhi ukugcina umuthi ungalimazi imvelo.

Iwebhusayithi ye-FDA inikeza amathiphu amaningi awusizo ngokulahlwa kwemithi. Ungabuza futhi usokhemisi wakho imininingwane yokuthi ungayilahla kanjani imithi yakho.

Imininingwane yobungcweti ye-Orencia

Imininingwane elandelayo inikezwa odokotela nabanye ochwepheshe bezempilo.

Izinkomba

I-Orencia yisidakamizwa se-biologic esiboniswe ekwelapheni i:

  • esebenzayo, elinganiselayo kuya kwesifo samathambo esibi (RA) kubantu abadala
  • i-psoriatic arthritis esebenzayo (i-PsA) kubantu abadala
  • esebenzayo, elinganiselayo kuya kweye-polyarticular juvenile idiopathic arthritis (JIA) ezinganeni ezineminyaka engu-2 nangaphezulu

Ukwelashwa nge-RA, i-Orencia ingasetshenziswa yodwa, noma njenge-polytherapy uma ihlanganiswe nemithi yokulungisa izifo (i-DMARD) yokuguqula izifo. Ngokwelashwa kwe-JIA, i-Orencia ingasetshenziswa yodwa noma ihlanganiswe ne-methotrexate.

Akunandaba ukuthi isimo siphethwe kanjani, i-Orencia akufanele ihlinzekwe ngokubambisana nomuthi olwa ne-TNF.

Indlela yokusebenza

I-Orencia ibophezela kuma-cell-protein CD80 ne-CD86, atholakala kulwelwesi lweseli lwamaseli akhombisa i-antigen. Lokhu kubopha kuvimbela ukukhuthazwa kweprotheni ye-CD28. I-CD28 ibalulekile ukwenza kusebenze ama-T-lymphocyte. Ukwenza kusebenze ama-T-lymphocyte kudlala indima ebalulekile ku-pathogenesis ye-RA ne-PsA.Ukuvimba lokhu kusebenze kunciphisa ukuqhubeka kwalezi zifo.

Ucwaningo lwe-in-vitro lukhombisa ukuthi ukubophezelwa ku-CD80 naku-CD86 kuneminye imiphumela yeselula. Ngokukhomba ama-T-lymphocyte, i-Orencia inciphisa ukwanda kwawo. Futhi kuvimbela ukukhiqizwa kwama-cytokines abalulekile abalulekile ekuphenduleni kwamagciwane amaningana. Lawa ma-cytokines afaka i-TNF-alpha, i-INF-gamma, ne-IL-2.

Futhi, amamodeli wezilwane akhombise imiphumela eyengeziwe ebonwe ngemuva kokuphathwa kwe-Orencia. Ucwaningo luveze ukuthi i-Orencia inganciphisa ukuvuvukala futhi yehlise ukukhiqizwa kwama-antibodies alwa ne-collagen. Kungakhawulela nokukhiqizwa kwama-antigen akhombe i-INF-gamma. Ukuthi lezi zenzo zibalulekile ekusebenzeni komtholampilo kwe-Orencia kuhlala kungaziwa.

I-Pharmacokinetics ne-metabolism

I-pharmacokinetics kanye ne-metabolism ye-Orencia kuyahluka ngokuya ngesimo eselashwa. Futhi ziyahlukahluka ngokususelwa kumzila wokuphatha.

Ucwaningo kubo bonke abantu abaneziguli lubonisa ukuthambekela kokususwa kwezidakamizwa okuphezulu ngesisindo somzimba esiphezulu. Kodwa-ke, akukho mehluko obalulekile ekususweni obikiwe ekusetshenzisweni kwabantu bobudala obuhlukile noma ubulili. Ezifundweni, ukusetshenziswa kwe-methotrexate, anti-TNFs, NSAIDs, noma i-corticosteroids akubanga ukwehluka okuphawulekayo ekuvunyweni.

RA: Ukuphathwa kwemithambo

Imithamo eminingi ka-10 mg / kg ezigulini ezine-rheumatoid arthritis (RA) iholele ekugxileni okuphezulu kwe-295 mcg / mL. Isikhathi sokuphila se-Terminal sigcinwa ngosuku lwe-13.1, ngokuvunyelwa kwe-0.22 mL / h / kg.

Ezigulini ezine-RA, i-Orencia inokukhula okulinganayo phakathi kwesilinganiso nokuhlushwa okuphezulu. Ubudlelwano phakathi komthamo nendawo engaphansi kwejika (AUC) bulandela umkhuba ofanayo. Futhi, ivolumu yokusabalalisa ifinyelela isilinganiso esingu-0.07 L / kg.

Ukulandela imithamo eminingi ka-10 mg / kg, isimo esingaguquguquki siyabonakala ngosuku lwama-60. Ukuhlungwa okuzinzile komkhombe kufinyelelwe kuma-24 mcg / mL.

Ukuphathwa kwanyanga zonke kwe-Orencia akubangeli ukugcwala okuhlelekile kwemithi.

RA: Ukuphathwa kwesikhumba

Lapho ilawulwa ngendlela engaphansi, i-Orencia ifinyelela ubuncane kanye nokugxila okungu-32.5 mcg / mL kanye no-48.1 mcg / mL, ngokulandelana, ngosuku lwama-85. 2.

Ukususwa okuhleliwe kufinyelela ku-0.28 mL / h / kg, ngevolumu yokwabiwa kwesilinganiso esingu-0.11 L / kg. I-bioavailability engaphansi kwe-subcutaneous yi-78.6%., Nge-half-life terminal yezinsuku eziyi-14.3.

I-PsA: Ukuphathwa okufakwayo

I-Orencia ikhombisa i-pharmacokinetics eqondile emithamo ephakathi kuka-3 mg / kg no-10 mg / kg. Lapho ilawulwa ku-10 mg / kg, i-Orencia ifinyelela ukugxila okungaguquguquki kwesimo ngosuku lwama-57. Ukuhlungwa komkhombe wejometri kungu-24.3 mcg / mL ngosuku lwe-169.

I-PsA: Ukuphathwa kwesikhumba

Ukuphathwa kwesikhumba kwe-Orencia 125 mg masonto onke kuholela ekugxilisweni komkhombe wejometri we-25.6 mcg / mL ngosuku lwe-169. Isimo esizinzile sifinyelelwa ngosuku lwama-57.

I-JIA: Ukuphathwa okungena ngaphakathi

Ezinganeni ezineminyaka engama-6 kuya kwengu-17, i-Orencia ifinyelela ubuncane kanye nokugxila okungu-11.9 mcg / mL no-217 mcg / mL, ngokulandelana, esimweni esizinzile. Ukususwa okushiwo ngu-0.4 mL / h / kg.

Izifundo ze-Pharmacokinetics zezingane ezineminyaka engaphansi kwengu-6 ubudala azitholakali njengoba i-Orencia nge-infusion efakwa ngaphakathi ingavunyelwe ukuthi isetshenziswe kulesi sabantu.

I-JIA: Ukuphathwa kwesikhumba

Ezinganeni ezineminyaka emi-2 kuya kwengu-17, ukuphathwa kwesikhumba kwe-Orencia masonto onke kufinyelela esimweni esiqinile ngosuku lwama-85.

Ukugxila okuphakathi kwe-Orencia kuyahluka ngokuya ngomthamo. Ngosuku lwe-113, i-Orencia ifinyelela ekugxileni kwe-44.4 mcg / mL, 46.6 mcg / mL, ne-38.5 mcg / mL kumithamo ye-50 mg, 87.5 mg, no-125 mg, ngokulandelana.

Izimo

Akukho ukuphikisana kokusetshenziswa kwe-Orencia. Kodwa-ke, ezinye izindlela zokuqapha kufanele zithathwe ngaphambi nangesikhathi sokuphathwa kwayo. Ngeminye imininingwane, bheka isigaba se- "Orencia izinyathelo zokuqapha" ngenhla.

Isitoreji

Lapho ihlinzekwa njengesitsha esine-lyophilized powder, i-Orencia kufanele ifakwe esiqandisini ezingeni lokushisa lika-36 ° F kuye ku-46 ° F (2 ° C kuye ku-8 ° C). I-vial kufanele igcinwe ngaphakathi kwephakeji layo langempela futhi ivikelwe ekukhanyeni ukugwema ukonakala.

Amasirinji agcwalisiwe noma ama-autoinjectors we-ClickJect e-Orencia kufanele futhi afakwe esiqandisini ezingeni lokushisa lika-36 ° F kuye ku-46 ° F (2 ° C kuye ku-8 ° C). Amazinga okushisa kufanele alawulwe ukuvimbela ukubanda kwesisombululo. Futhi, lawa madivayisi kufanele agcinwe ngaphakathi kokupakisha kwawo kwasekuqaleni futhi avikelwe ekukhanyeni ukugwema ukonakala.

Ukuzikhulula: IMedical News Namuhla yenze yonke imizamo yokuqinisekisa ukuthi yonke imininingwane iyiqiniso, iphelele futhi ihambisana nesikhathi. Kodwa-ke, le ndatshana akufanele isetshenziswe njengokungena esikhundleni solwazi nobungoti bochwepheshe bezokunakekelwa kwezempilo onelayisense. Kufanele uhlale uthintana nodokotela wakho noma omunye uchwepheshe wezokunakekelwa kwempilo ngaphambi kokuthatha noma imuphi umuthi. Imininingwane yezidakamizwa equkethwe lapha ingashintsha futhi ayihloselwe ukumboza konke ukusetshenziswa okungaba khona, izinkomba, izixwayiso, izexwayiso, ukuxhumana kwezidakamizwa, ukungezwani komzimba, noma imiphumela emibi. Ukungabikho kwezixwayiso noma olunye ulwazi lomuthi othile awukhombisi ukuthi inhlanganisela yezidakamizwa noma yezidakamizwa iphephile, iyasebenza, noma ilungele zonke iziguli noma konke ukusetshenziswa okuthile.

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