I-Outlook Myeloid Leukemia Outlook kanye Nempilo Yakho Elindelwe

-Delile

• Izigaba ze-CML
• Izinketho zokwelashwa
• Umbono
• Amazinga okusinda jikelele
• Amanani okusinda ngesigaba

Ukuqonda i-myeloid leukemia engapheli

Ukufunda ukuthi unomdlavuza kungakucindezela. Kodwa izibalo zibonisa amazinga amahle okusinda kulabo abane-leukemia engapheli.

I-chronic myeloid leukemia, noma i-CML, uhlobo lomdlavuza oqala emnkantsheni wethambo. Ikhula kancane kumaseli akha igazi ngaphakathi kukomnkantsha futhi ekugcineni isakazeka ngegazi. Abantu bavame ukuba ne-CML isikhathi esithile ngaphambi kokubona noma yiziphi izimpawu noma bazi ukuthi banomdlavuza.

I-CML ibonakala idalwa yisakhi esingajwayelekile esikhiqiza i-enzyme eningi ebizwa nge-tyrosine kinase. Yize kungokofuzo, i-CML ayilona ifa.

Izigaba ze-CML

Kunezigaba ezintathu ze-CML:

• Isigaba esingapheli: Esigabeni sokuqala, amangqamuzana omdlavuza akhula kancane. Iningi labantu litholwa ngesikhathi sesigaba esingelapheki, imvamisa ngemuva kokuhlolwa kwegazi okwenziwe ngezinye izizathu.
• Isigaba esisheshayo: Amaseli we-leukemia akhula futhi akhule ngokushesha okukhulu esigabeni sesibili.
• Isigaba Blastic: Esigabeni sesithathu, amaseli angajwayelekile akalawuleki futhi aminyanisa amaseli ajwayelekile, anempilo.

Izinketho zokwelashwa

Ngesikhathi sesigaba esingelapheki, ukwelashwa kuvame ukuba nemithi yomlomo ebizwa nge-tyrosine kinase inhibitors noma ama-TKIs. Ama-TKIs asetshenziselwa ukuvimba isenzo seprotein tyrosine kinase futhi amise amangqamuzana omdlavuza ukuthi angakhuli futhi ande. Abantu abaningi abaphathwa ngama-TKI bazoya ekuxolelweni.

Uma ama-TKI engasebenzi, noma eyeka ukusebenza, khona-ke lowo muntu angangena esigabeni esisheshayo noma esiqhakazile. Ukufakelwa kwe-stem cell noma ukufakelwa umnkantsha wethambo imvamisa kuyisinyathelo esilandelayo. Lokhu kufakelwa ukuphela kwendlela yokwelapha i-CML, kepha kungaba nezinkinga ezinkulu. Ngalesi sizathu, ukufakelwa kwesinye isikhathi kwenziwa kuphela uma imithi ingasebenzi.

Umbono

Njengezifo eziningi, umbono walabo abane-CML uyahluka ngokuya ngezici eziningi. Ezinye zazo zifaka:

• bakusiphi isigaba
• iminyaka yabo
• impilo yabo iyonke
• ukubalwa kweplatelet
• noma ngabe ubende bukhulisiwe yini
• inani lokulimala kwamathambo kusuka ku-leukemia

Amazinga okusinda jikelele

Amazinga okusinda komdlavuza ngokuvamile alinganiswa ngezikhathi zeminyaka emihlanu. Ngokusho kweNational Cancer Institute, imininingwane ephelele ikhombisa ukuthi cishe amaphesenti angama-65.1 alabo abatholakala ukuthi bane-CML basaphila eminyakeni emihlanu kamuva.

Kepha imishanguzo emisha yokulwa ne-CML iyakhiwa futhi ihlolwe ngokushesha okukhulu, okwandisa amathuba okuthi amazinga okusinda esizayo angaphakama.

Amanani okusinda ngesigaba

Iningi labantu abane-CML bahlala esigabeni esingelapheki. Kwezinye izimo, abantu abangatholi ukwelashwa okusebenzayo noma abangaphenduli kahle ekwelashweni bazoya esigabeni esisheshayo noma esiqhakazile. Ukubuka ngalezi zigaba kuncike ekutheni ikuphi ukwelashwa asebekuzamile nokuthi iziphi izindlela zokwelapha imizimba yazo engazibekezelela.

Umbono unethemba elikhulu kulabo abasesigabeni esingapheli futhi abathola ama-TKIs.

Ngokuya ngocwaningo olukhulu lwango-2006 lomuthi omusha obizwa nge-imatinib (Gleevec), kube nezinga lokusinda elingamaphesenti angama-83 ngemuva kweminyaka emihlanu kulabo abathola lo muthi. Ucwaningo lwango-2018 lweziguli ezithatha umuthi i-imatinib ngokungaguquki luthole ukuthi amaphesenti angama-90 aphila okungenani iminyaka emihlanu. Olunye ucwaningo olwenziwa ngo-2010, lwakhombisa ukuthi umuthi obizwa ngokuthi i-nilotinib (Tasigna) wawusebenza ngempumelelo enkulu kuneGleevec.

Yomibili le mithi manje isiyindlela yokwelashwa ejwayelekile ngesikhathi sesigaba esingelapheki se-CML. Amazinga okusinda jikelele kulindeleke ukuthi ande njengoba abantu abaningi bethola le mithi kanye neminye emisha, esebenza kahle kakhulu.

Esigabeni esisheshisiwe, amazinga okusinda ayahlukahluka kakhulu ngokusho kokwelashwa.Uma umuntu ephendula kahle kuma-TKI, amanani acishe afane nalezo zesigaba esingapheli.

Kukonke, amazinga okusinda alabo abasesigabeni se-blastic hover angaphansi kwamaphesenti angama-20. Ithuba elihle lokusinda lifaka phakathi ukusebenzisa izidakamizwa ukubuyisela lowo muntu esigabeni esingelapheki bese uzama ukufakelwa kwe-stem cell.