Izimpawu zeParkinson's: Abesilisa vs. Abesifazane

-Delile

• Kwethulwa izimpawu
• Amandla engqondo nokunyakaza kwemisipha
• Ukuveza nokutolika imizwa
• Ukungafani kokulala
• Ukuvikelwa kwe-Estrogen
• Izinkinga zokwelashwa
• Ukubhekana ne-PD

Isifo sikaParkinson kwabesilisa nabesifazane

Amadoda amaningi kunabesifazane atholakala enesifo sikaParkinson's (PD) cishe nge-2 to 1 margin. Izifundo eziningana zisekela le nombolo, kufaka phakathi ucwaningo olukhulu kwi-American Journal of Epidemiology.

Imvamisa kunesizathu somzimba sokwehluka kwesifo phakathi kwabesilisa nabesifazane. Ukuba ngowesifazane kuvikela kanjani kwi-PD? Futhi abesifazane nabesilisa babhekana nezimpawu ze-PD ngokuhlukile?

Kwethulwa izimpawu

Abesifazane baba nePD kaningi kunamadoda. Lapho benza i-PD, iminyaka yokuqala iminyaka emibili kamuva kunamadoda.

Lapho abesifazane betholakala okokuqala, ukuthuthumela ngokuvamile kuyisifo esivelele. Uphawu lokuqala emadodeni imvamisa ukunyakaza okuhamba kancane noma okuqinile (i-bradykinesia).

Ifomu elibusayo lokuthuthumela kwe-PD lihlotshaniswa nokuqhubekela phambili kwesifo kancane kanye nekhwalithi ephezulu yempilo.

Kodwa-ke, abesifazane bavame ukubika ukwaneliseka okuncane ngezinga labo lempilo, noma ngabe banezimpawu ezifanayo.

Amandla engqondo nokunyakaza kwemisipha

I-PD ingathinta amandla engqondo nezinzwa kanye nokulawulwa kwemisipha.

Kunobunye ubufakazi bokuthi abesilisa nabesifazane bathinteka ngokwehlukile. Isibonelo, abesilisa babonakala benekhono elingcono lokuqonda ukuma kwendawo. Ngakolunye uhlangothi, abesifazane bagcina ukukhuluma ngokushelelayo.

Lezi zinhlobo zamakhono zithonywa hhayi kuphela ubulili, kodwa futhi "nohlangothi" lwezimpawu ze-PD. Uhlangothi lwesobunxele noma lwesokudla kwesibonakaliso semoto lukhombisa ukuthi iluphi uhlangothi lobuchopho olunokushoda okukhulu kwe-dopamine.

Isibonelo, ungaba nobunzima obuningi ngokulawulwa kwemisipha ohlangothini lwesobunxele lomzimba wakho uma unenkinga ye-dopamine ohlangothini lwesokunene sobuchopho bakho.

Amakhono ahlukene, njengamakhono endawo, abusa kakhulu ohlangothini oluthile lobuchopho.

Ukuveza nokutolika imizwa

Ukuqina kwe-PD kungadala ukuthi imisipha yobuso "iqhwa." Lokhu kuholela enkulumweni efana nomask. Ngenxa yalokhu, iziguli ezine-PD zinobunzima bokuveza imizwa ngobuso bazo. Futhi bangaqala ukuba nobunzima ekuhumusheni ubuso babanye.

Ucwaningo olulodwa luveza ukuthi bobabili abesilisa nabesifazane abane-PD bangaba nobunzima ekuhumusheni intukuthelo nokumangala, nokuthi amadoda maningi amathuba okuthi alahlekelwe yikhono lokuhumusha ukwesaba.

Kodwa-ke, abesifazane bangacasulwa kakhulu ukwehluleka kwabo ukutolika imizwa. Zonke iziguli ze-PD zingazuza ekukhulumeni nasekwelashweni ngokomzimba ukusiza ngalesi sibonakaliso.

Ukungafani kokulala

Isifo sokuhamba kwamehlo esheshayo (RBD) yisifo sokulala esenzeka ngesikhathi somjikelezo wokulala we-REM.

Ngokuvamile, umuntu olele akanayo ithoni yemisipha futhi akanyakazi ngesikhathi sokulala. Ku-RBD, umuntu anganyakazisa izitho futhi abonakale enza amaphupho akhe.

I-RBD ivela ngokungavamile, kepha kaningi kubantu abanezifo ezingenayo i-neurodegenerative. Cishe amaphesenti ayi-15 wabantu abane-PD nawo ane-RBD, ngokusho kwe-Internal Review of Psychiatry. Abesilisa banamathuba amaningi okuba nalesi simo kunabesifazane.

Ukuvikelwa kwe-Estrogen

Kungani kunokwehluka kwezimpawu ze-PD phakathi kwabesilisa nabesifazane? Kubukeka sengathi ukutholakala kwe-estrogen kuvikela abesifazane ekuqhubekeni kwe-PD ethile.

Ucwaningo olushicilelwe okutholakele ukuthi owesifazane ohlangabezana nokunqamuka kwesikhathi kokuya esikhathini, noma onezingane eziningi, kungenzeka ukuthi abambezele ukuqala kwezimpawu ze-PD. Lezi zombili izimpawu zokuvezwa kwe-estrogen esikhathini sokuphila kwakhe.

Okungakachazwa ngokugcwele ukuthi kungani i-estrogen inalo mphumela. Ucwaningo kwiAmerican Journal of Psychiatry lukhombisile ukuthi abesifazane bane-dopamine etholakala kakhulu ezindaweni ezibalulekile zobuchopho. I-Estrogen ingasebenza njenge-neuroprotectant yomsebenzi we-dopamine.

Izinkinga zokwelashwa

Abesifazane abane-PD bangahlangabezana nezinkinga eziningi ngenkathi belashwa izimpawu zabo ze-PD kunamadoda.

Abesifazane bathola ukuhlinzwa kaningi kunabesilisa, futhi izimpawu zabo ziba nzima kakhulu ngesikhathi behlinzwa. Futhi, ukuthuthuka okutholwe ngokuhlinzwa kungahle kungabi kuhle kangako.

Izidakamizwa zokwelapha izimpawu ze-PD nazo zingathinta abesifazane ngokuhlukile. Ngenxa yesisindo somzimba esiphansi, abesifazane bavame ukuvezwa ngemithamo ephezulu yemithi. Lokhu kube yinkinga nge-levodopa, omunye wemithi ejwayelekile kakhulu ye-PD.

Ukuvezwa okuphezulu kungaholela ekukhuleni kwezinga lemiphumela emibi, njenge-dyskinesia. IDyskinesia inzima ukwenza ukunyakaza ngokuzithandela.

Ukubhekana ne-PD

Abesilisa nabesifazane bavame ukuba nezimpendulo ezihlukile kokuhlangenwe nakho kokuphila ne-PD.

Abesifazane abane-PD bavame ukuzwa izinga eliphakeme lokudangala kunamadoda ane-PD. Ngakho-ke bathola imishanguzo yokulwa nengcindezi kaningi.

Abesilisa bangaba nezinkinga zokuziphatha nokuhlukumezeka, okufana nengozi enkulu yokuzula nokuziphatha okungafanele noma okuhlukumezayo. Abesilisa basemathubeni amaningi okuthola imishanguzo yokulwa nalokhu kuziphatha.