Ukuhlolwa kwe-Pharmacogenetic
-Delile
- Kuyini ukuhlolwa kwe-pharmacogenetic?
- Kusetshenziselwa ini?
- Kungani ngidinga ukuhlolwa kwe-pharmacogenetic?
- Kwenzekani ngesikhathi sokuhlolwa kwe-pharmacogenetic?
- Ngabe kukhona engizodinga ukukwenza ukulungiselela isivivinyo?
- Ingabe zikhona izingozi esivivinyweni?
- Isho ukuthini imiphumela?
- Ngabe kukhona okunye engidinga ukukwazi ngokuhlolwa kwe-pharmacogenetic?
- Izinkomba
Kuyini ukuhlolwa kwe-pharmacogenetic?
I-Pharmacogenetics, ebizwa nangokuthi i-pharmacogenomics, isifundo sokuthi izakhi zofuzo zikuthinta kanjani ukuphendula komzimba emithini ethile. Izakhi zofuzo ziyingxenye ye-DNA edluliselwe isuka kumama nobaba wakho. Ziphethe imininingwane enquma izici zakho ezihlukile, njengokuphakama nombala wamehlo. Izakhi zofuzo zakho zingathinta nokuthi umuthi othile ungaphepha futhi usebenze kanjani kuwe.
Izakhi zofuzo kungaba yisizathu sokuthi umuthi ofanayo kumthamo ofanayo uzothinta abantu ngezindlela ezihluke kakhulu. Izakhi zofuzo nazo zingaba yisizathu sokuthi abanye abantu babe nemiphumela emibi emithini, kanti abanye abanayo.
Ukuhlolwa kwe-Pharmacogenetic kubheka izakhi zofuzo ezithile ukusiza ukuthola izinhlobo zemithi nemithamo engakulungela.
Amanye amagama: i-pharmacogenomics, i-pharmacogenomic testing
Kusetshenziselwa ini?
Ukuhlolwa kwe-Pharmacogenetic kungasetshenziselwa uku:
- Thola ukuthi umuthi othile ungakusiza yini
- Thola ukuthi isilinganiso esingcono kakhulu kungaba yini kuwe
- Qagela ukuthi uzoba nomthelela ongemuhle emithini
Kungani ngidinga ukuhlolwa kwe-pharmacogenetic?
Umhlinzeki wakho wezokunakekelwa kwempilo anga-oda lezi zivivinyo ngaphambi kokuqala umuthi othile, noma uma usebenzisa umuthi ongasebenzi futhi / noma odala imiphumela emibi.
Ukuhlolwa kwe-Pharmacogenetic kutholakala kuphela kwinani elilinganiselwe lemithi. Ngezansi kunemithi nezakhi zofuzo ezingahlolwa. (Amagama ezakhi zofuzo avame ukunikezwa ngezinhlamvu nezinombolo.)
Umuthi | Izakhi zofuzo |
---|---|
I-Warfarin: igazi elincanyana | I-CYP2C9 ne-VKORC1 |
I-Plavix, igazi elincanyana | CYP2C19 |
Izidambisi, imithi yesithuthwane | I-CYP2D6, CYPD6 CYP2C9, CYP1A2, SLC6A4, HTR2A / C |
I-Tamoxifen, ukwelashwa komdlavuza webele | I-CYPD6 |
Ama-antipsychotic | I-DRD3, CYP2D6, CYP2C19, CYP1A2 |
Ukwelashwa kokuphazamiseka kokunakwa | I-D4D4 |
I-Carbamazepine, ukwelashwa kwesifo sokuwa | I-HLA-B 1502 |
Abacavir, ukwelashwa kwe-HIV | I-HLA-B 5701 |
Ama-opioid | I-OPRM1 |
Izitatimende, imithi elapha i-cholesterol ephezulu | SLCO1B1 |
Ukwelashwa kwe-leukemia yengane kanye nokuphazamiseka okuthile okuzenzakalelayo | I-TMPT |
Kwenzekani ngesikhathi sokuhlolwa kwe-pharmacogenetic?
Ukuhlola kuvame ukwenziwa egazini noma ematheni.
Ukuhlolwa kwegazi, uchwepheshe wezokunakekelwa kwempilo uzothatha isampuli yegazi emthanjeni osengalweni yakho, esebenzisa inaliti encane. Ngemuva kokuthi kufakwe inaliti, kuzoqoqwa inani elincane legazi kufakwe ithubhu yokuhlola noma isitsha. Ungase uzizwe uluma kancane lapho inaliti ingena noma iphuma. Lokhu ngokuvamile kuthatha imizuzu engaphansi kwemihlanu.
Ukuhlolwa kwamathe, buza umhlinzeki wakho wezokunakekelwa kwempilo ngemiyalo yokuthi ungasinikeza kanjani isampula sakho.
Ngabe kukhona engizodinga ukukwenza ukulungiselela isivivinyo?
Imvamisa awudingi amalungiselelo akhethekile okuhlolwa kwegazi. Uma uthola ukuhlolwa kwamathe, akufanele udle, ungaphuzi, noma ubheme imizuzu engama-30 ngaphambi kokuhlolwa.
Ingabe zikhona izingozi esivivinyweni?
Kunengozi encane kakhulu yokuhlolwa kwegazi. Ungaba nobuhlungu obuncane noma ukulimaza lapho kufakwe khona inaliti, kepha izimpawu eziningi ziyaphela ngokushesha.
Ayikho ingozi yokuhlolwa ngamathe.
Isho ukuthini imiphumela?
Uma uhlolwe ngaphambi kokuqala ukwelashwa, ukuhlolwa kungakhombisa ukuthi kungenzeka yini ukuthi umuthi uzosebenza kahle kanye / noma uma usengozini yemiphumela emibi kakhulu. Ezinye izivivinyo, njengalezo zemithi ethile elapha isithuthwane kanye ne-HIV, zingakhombisa ukuthi ngabe usengozini yemiphumela emibi esongela impilo. Uma kunjalo, umhlinzeki wakho uzozama ukuthola enye indlela yokwelashwa.
Ukuhlolwa okwenzeka ngaphambi nangesikhathi uthola ukwelashwa kungasiza umhlinzeki wakho wezokunakekelwa kwempilo ukuthola isilinganiso esifanele.
Uma unemibuzo ngemiphumela yakho, khuluma nomhlinzeki wakho wezokunakekelwa kwempilo.
Funda kabanzi mayelana nokuhlolwa kwelabhorethri, ububanzi bezinkomba, nemiphumela yokuqonda.
Ngabe kukhona okunye engidinga ukukwazi ngokuhlolwa kwe-pharmacogenetic?
Ukuhlolwa kwe-Pharmacogenetic kusetshenziselwa kuphela ukuthola impendulo yomuntu kumuthi othize. Akuyona into efanayo nokuhlolwa kofuzo. Ukuhlolwa okuningi kofuzo kusetshenziselwa ukuxilonga izifo noma ubungozi besifo, ukukhomba ubudlelwane bomndeni, noma ukukhomba umuntu ophenyweni lobugebengu.
Izinkomba
- UHefti E, uBlanco J. Ukubhala Ukuhlolwa kwe-Pharmacogenomic nge-Current Procedure Terminology (CPT) Amakhodi, Ukubuyekezwa Kwemikhuba Yangaphambilini Namanje. J AHIMA [Inthanethi]. I-2016 Jan [icashunwe ngo-2018 Jun 1]; 87 (1): 56-9. Kutholakala kusuka: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998735
- Ukuhlolwa Kwelebhu Ku-inthanethi [i-Intanethi]. IWashington DC: I-American Association for Clinical Chemistry; c2001–2018. Izivivinyo ze-Pharmacogenetic; [kubuyekezwe i-2018 Jun 1; kukhonjiwe ngo-2018 Jun 1]; [cishe izikrini ezi-2]. Kutholakala kusuka: https://labtestsonline.org/tests/pharmacogenetic-tests
- Ukuhlolwa Kwelebhu Ku-inthanethi [i-Intanethi]. IWashington DC: I-American Association for Clinical Chemistry; c2001–2018. Umkhathi Wokuhlolwa Kofuzo; [kubuyekezwe i-2017 Nov 6; kukhonjiwe ngo-2018 Jun 1]; [cishe izikrini ezi-2]. Kutholakala kusuka: https://labtestsonline.org/articles/genetic-testing?start=4
- IMayo Clinic: Isikhungo Sezokwelapha Ezizimele [i-Intanethi]. IMayo Foundation for Medical Education and Research; c1998–2018. Ukuhlolwa Kwezidakamizwa Nezidakamizwa; [kucashunwe ngo-2018 Juni 1]; [cishe izikrini ezi-3]. Kutholakala kusuka: http://mayoresearch.mayo.edu/center-for-individualized-medicine/drug-gene-testing.asp
- IMayo Clinic: Isikhungo Sezokwelapha Ezizimele [i-Intanethi]. IMayo Foundation for Medical Education and Research; c1998–2018. Ukuhlolwa kweCYP2D6 / Tamoxifen Pharmacogenomic Lab; [kucashunwe ngo-2018 Juni 1]; [cishe izikrini ezi-5].Kutholakala kusuka: http://mayoresearch.mayo.edu/center-for-individualized-medicine/cyp2d6-tamoxifen.asp
- IMayo Clinic: Isikhungo Sezokwelapha Ezizimele [i-Intanethi]. IMayo Foundation for Medical Education and Research; c1998–2018. I-HLA-B 1502 / Carbamazepine Pharmacogenomic Lab Test; [kucashunwe ngo-2018 Juni 1]; [cishe izikrini ezi-4]. Kutholakala ku: http://mayoresearch.mayo.edu/center-for-individualized-medicine/hlab1502-carbamazephine.asp
- IMayo Clinic: Isikhungo Sezokwelapha Ezizimele [i-Intanethi]. IMayo Foundation for Medical Education and Research; c1998–2018. Ukuhlolwa kwe-HLA-B * 5701 / Abacavir Pharmacogenomic Lab; [kucashunwe ngo-2018 Juni 1]; [cishe izikrini ezi-4]. Kutholakala ku: http://mayoresearch.mayo.edu/center-for-individualized-medicine/hlab5701-abacavir.asp
- IMayo Clinic: I-Mayo Medical Laboratories [i-Intanethi]. IMayo Foundation for Medical Education and Research; c1995–2018. I-ID Yokuhlola: I-PGXFP: Iphaneli ye-Pharmacogenomics egxile kakhulu: Isifanekiso; [kucashunwe ngo-2018 Juni 1]; [cishe izikrini ezi-3]. Kutholakala kusuka: https://www.mayomedicallaboratories.com/test-catalog/Specimen/65566
- Isikhungo Somdlavuza Kazwelonke [i-Inthanethi]. I-Bethesda (MD): UMnyango Wezempilo kanye Nezinsizakalo Zabantu e-U.S. Isichazamazwi seNCI Semigomo Yomdlavuza: isakhi sofuzo; [kucashunwe ngo-2018 Juni 1]; [cishe izikrini ezi-3]. Kutholakala kusuka: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q;=gene
- I-National Heart, Lung, ne-Blood Institute [i-Intanethi]. I-Bethesda (MD): UMnyango Wezempilo kanye Nezinsizakalo Zabantu e-U.S. Ukuhlolwa Kwegazi; [kucashunwe ngo-2018 Juni 1]; [cishe izikrini ezi-3]. Kutholakala kusuka: https://www.nhlbi.nih.gov/health-topics/blood-tests
- I-NIH National Institute of General Medical Sciences [i-Intanethi]. I-Bethesda (MD): UMnyango Wezempilo kanye Nezinsizakalo Zabantu e-U.S. I-Pharmacogenomics; [kubuyekezwe u-2017 Oct; kukhonjiwe ngo-2018 Jun 1]; [cishe izikrini ezi-4]. Kutholakala kusuka: https://www.nigms.nih.gov/education/Pages/factsheet-pharmacogenomics.aspx
- I-NIH U.S. National Library of Medicine: Isethenjwa Sasekhaya se-Genetics [Internet]. I-Bethesda (MD): UMnyango Wezempilo kanye Nezinsizakalo Zabantu e-U.S. Yini i-pharmacogenomics ?; I-2018 Meyi 29 [icashunwe ngo-2018 Jun 1]; [cishe izikrini ezi-4]. Kutholakala kusuka: https://ghr.nlm.nih.gov/primer/genomicresearch/pharmacogenomics
- Impilo ye-UF: University of Florida Health [Internet]. Inyuvesi yaseFlorida; c2018. Izakhi zofuzo zakho zithonya kanjani ukuthi yimiphi imithi ekufanele; 2016 Jan 11 [kubuyekezwe 2018 Jun 1; kukhonjiwe ngo-2018 Jun 1]; [cishe izikrini ezi-2]. Kutholakala kusuka: https://ufhealth.org/blog/how-your-genes-influence-what-medicines-are-right-you
- Isibhedlela se-UW Health American Family Children [Internet]. UMadison (WI): Izibhedlela zase-University of Wisconsin kanye neGunya Lemitholampilo; c2018. Impilo Yezingane: Pharmacogenomics; [kucashunwe ngo-2018 Juni 1]; [cishe izikrini ezi-4]. Kutholakala kusuka: https://www.uwhealthkids.org/kidshealth/en/parents/pharmacogenomics.html/
Imininingwane ekulesi siza akufanele isetshenziswe esikhundleni sezokunakekelwa kwezokwelapha noma iseluleko. Xhumana nomhlinzeki wezempilo uma unemibuzo ngempilo yakho.