Ukuhlolwa kweSmooth Muscle Antibody (SMA)

-Delile

• Kuyini ukuhlolwa okubushelelezi kwemisipha yomzimba (SMA)?
• Kusetshenziselwa ini?
• Kungani ngidinga ukuhlolwa kwe-SMA?
• Kwenzekani ngesikhathi sokuhlolwa kwe-SMA?
• Ngabe kukhona engizodinga ukukwenza ukulungiselela isivivinyo?
• Ingabe zikhona izingozi esivivinyweni?
• Isho ukuthini imiphumela?
• Ngabe kukhona okunye engidinga ukukwazi mayelana nokuhlolwa kwe-SMA?
• Izinkomba

Kuyini ukuhlolwa okubushelelezi kwemisipha yomzimba (SMA)?

Lokhu kuhlolwa kubheka amasosha omzimba abushelelezi (ama-SMAs) egazini. I-anti-antibody yemisipha ebushelelezi (uhlobo lwe-antibody eyaziwa njenge-autoantibody. Imvamisa amasosha akho omzimba enza amasosha omzimba ahlasele izinto zangaphandle njengamagciwane namagciwane. I-autoantibody ihlasela amaseli nezicubu zomzimba ngephutha. Ama-SMA ahlasela izicubu zemisipha ebushelelezi esibindini nakwezinye izingxenye zomzimba.

Uma ama-SMAs atholakala egazini lakho, kungenzeka ukuthi une-hepatitis ezenzakalelayo. I-autoimmune hepatitis yisifo lapho amasosha omzimba ehlasela izicubu zesibindi. Kunezinhlobo ezimbili ze-hepatitis ezenzakalelayo:

• Thayipha 1, uhlobo oluvame kakhulu lwesifo. Uhlobo lwe-1 luthinta abesifazane abaningi kunabesilisa. Kubuye kuvame kakhulu kubantu abanesinye isifo sokuzimela.
• Thayipha 2, uhlobo olungajwayelekile lwesifo. Uhlobo lwe-2 luhlasela kakhulu amantombazane aphakathi kweminyaka engu-2 no-14.

I-hepatitis ezenzakalelayo ingaphathwa ngemithi ecindezela amasosha omzimba. Ukwelashwa kusebenza kakhulu lapho ukugula kutholakala kusenesikhathi. Ngaphandle kokwelashwa, i-autoimmune hepatitis ingadala izinkinga ezinkulu zempilo, kufaka phakathi i-cirrhosis nokuhluleka kwesibindi.

Amanye amagama: i-anti-bushelelezi yemisipha yomzimba, i-ASMA, i-actin antibody, i-ACTA

Kusetshenziselwa ini?

Ukuhlolwa kwe-SMA kusetshenziselwa ikakhulukazi ukuxilonga i-hepatitis ezenzakalelayo. Ibuye isetshenziselwe ukuthola ukuthi ngabe ukuphazamiseka kunguhlobo 1 noma uhlobo 2.

Ukuhlolwa kwe-SMA nakho kusetshenziswa kaningi nezinye izivivinyo ukusiza ukuqinisekisa noma ukukhipha ukuxilongwa kwe-hepatitis ezenzakalelayo. Lezi ezinye izivivinyo zifaka:

• Ukuhlolwa kwama-antibody F-actin. I-F-actin yiprotheni etholakala ezicubu zomzimba ezibushelelezi zesibindi nakwezinye izingxenye zomzimba. Ama-antibodies e-F-actin ahlasela lezi zicubu ezinempilo.
• Ukuhlolwa kwe-ANA (antinuclear antibody). Ama-ANA ngama-antibody ahlasela i-nucleus (maphakathi) yamaseli athile anempilo.
• I-ALT (alanine transaminase) ne-AST (aspartate aminotransferase). I-ALT ne-AST ngama-enzyme amabili enziwe isibindi.

Kungani ngidinga ukuhlolwa kwe-SMA?

Ungasidinga lesi sivivinyo uma wena noma ingane yakho unezimpawu zesifo sokusha kwesibindi esizimele. Lokhu kufaka phakathi:

• Ukukhathala
• I-jaundice (isimo esidala ukuthi isikhumba namehlo akho abe phuzi)
• Ubuhlungu besisu
• Ubuhlungu obuhlangene
• Isicanucanu
• Ukuqhuma kwesikhumba
• Ukuphelelwa isifiso sokudla
• Umchamo onombala omnyama

Kwenzekani ngesikhathi sokuhlolwa kwe-SMA?

Uchwepheshe wezempilo uzothatha isampula yegazi emthanjeni osengalweni yakho, esebenzisa inaliti encane. Ngemuva kokuthi kufakwe inaliti, kuzoqoqwa inani elincane legazi kufakwe ithubhu yokuhlola noma isitsha. Ungase uzizwe uluma kancane lapho inaliti ingena noma iphuma. Lokhu ngokuvamile kuthatha imizuzu engaphansi kwemihlanu.

Ngabe kukhona engizodinga ukukwenza ukulungiselela isivivinyo?

Awudingi amalungiselelo akhethekile wokuhlolwa kwe-SMA.

Ingabe zikhona izingozi esivivinyweni?

Kunengozi encane kakhulu yokuhlolwa kwegazi. Ungaba nobuhlungu obuncane noma ukulimaza lapho kufakwe khona inaliti, kepha izimpawu eziningi ziyaphela ngokushesha.

Isho ukuthini imiphumela?

Uma imiphumela yakho ikhombisa inani eliphakeme lama-antibodies e-SMA, mhlawumbe kusho ukuthi unohlobo lwe-1 lwe-hepatitis ezenzakalelayo. Inani eliphansi kungasho ukuthi unohlobo lwesi-2 lwesifo.

Uma engekho ama-SMAs atholakele, kusho ukuthi izimpawu zakho zesibindi zibangelwa okuthile okuhlukile kune-autoimmune hepatitis. Umhlinzeki wakho wezokunakekelwa kwempilo uzodinga uku-oda izivivinyo eziningi ukwenza ukuxilongwa.

Uma unemibuzo ngemiphumela yakho, khuluma nomhlinzeki wakho wezokunakekelwa kwempilo.

Funda kabanzi mayelana nokuhlolwa kwelabhorethri, ububanzi bezinkomba, nemiphumela yokuqonda.

Ngabe kukhona okunye engidinga ukukwazi mayelana nokuhlolwa kwe-SMA?

Uma imiphumela yakho ikhombisile ukuthi wena noma ingane yakho inamasosha omzimba we-SMA, umhlinzeki wakho anga-oda i-biopsy yesibindi ukuqinisekisa ukutholakala kwesifo sokusha kwesibindi okuzenzakalelayo. I-biopsy inqubo esusa isampula elincane lezicubu zokuhlolwa.

Izinkomba

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